Gene

KWMTBOMO12560  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001525

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_tyrosine--tRNA_ligase?_cytoplasmic_[Bombyx_mori]

Location

Bomo_Chr21(+):7126784-7128615      View in EpiBrowser

Full name

Tyrosine--tRNA ligase       + More
Tyrosine--tRNA ligase, cytoplasmic      

Alternative Name

Tyrosyl-tRNA synthetase

Location in the cell

Cytoplasmic   Reliability : 3.356

CDS

ATGGCTACCTGGCAAGAAAAGAAGCATTTAATAACACGGAATTTACAAGAGGTCTTAGGTGACGATAAGCTTACTGAAATCTTAAAACAGAGAGATTTAAAAATATATTGGGGTACAGCTACTACTGGAAGACCTCATGTGGCCTATTTTGTTCCAATGTTGAAGATAGCTGATTTCTTGAAGGCTGGCTGTGAGGTTACTATATTATTTGCTGATTTACATGCTTATTTGGATAATATGAAGGCTCCTTGGGAGCTTTTAGCACTTCGCACTCAATATTATGAAGCTGCTATAAAGGCAATGCTTACATCTATTGGTGTCCCACTTGAAAAACTGAAGTTTGTACGTGGTACAGAGTACCAGCTTAGTAAAGAGTATACATTAGATGTCTATAGATTATCATCGGTTGTAACAGAACATGATGCTAAGAAAGCCGGAGCAGAAGTTGTAAAACAAGTAGAACATCCATTACTTAGTGGACTTCTCTATCCAAACCTCCAAGCTTTGGATGAAGAGTACTTAAAAGTTGATGCTCAATTTGGTGGAGTTGATCAAAGAAAGATATTTACAATGTCAGAAAAGTTTTTACCTCAATTAGGGTATGCAAAAAGAATTCATCTGATGAACCCTATGGTACCTGGTCTAACAGGAGGTAAAATGTCAGCCTCTGAAGCTGATAGTAAAATAGATCTATTGGACACACCAACAAATGTTAAAAAAAAGCTAAAAAAAGCTTTCTGTGAGCCTGGTAACATTAGTGATAATGGTGTGTTGTCATTCACTAAGCATGTTGTCTTCCCACTGATGAAAGAAGGTGAGACATTTAAGATAAAACGTTCTGCCGAGCATGGTGGTGATGCTAATTATTCAAAATATGAGGATTTAGAAACTGCATTTGCAAACCAAGAAATTCATCCAGGAGATTTGAAGGCTTCAGCTGAGGATGCAATAAACAAACTTTTGGCACCTATACAAGATACTTTCAACGACCCTCAATTACAAGAATTAACAAAAAAGGCTTATCCACCGCCAACAAAGGTCAAAGGTAATATTAATCAAGCTGTGGATGATGTAACTCCATCAAAACTTGATATAAGAGTAGGGCACATTGTGGAAGTGTCTAGACATCCAGATGCAGATGCTCTTTATGTAGAAAAGATTGATGTTGGTGAAGATGAACCAAGAACTATTGTTTCTGGATTAGTCAACTTTGTACCCATTGAAGAAATGCAAGACAGAGATGTTGTAGTTTTATGTAATTTGAAAGCAGCTAAAATGCGTGGAGTTGAGTCAAAGGGCATGGTTCTTTGTGCATCTGTAGATGAGCCAAAACAAGTAGAACCACTGCTACCTCCAAAAGGAACTAAAGCTGGTGATAGAATTGTAGTAGAAGAATATGACACTGGTGAACCTGATGAGGTTTTAAATCCCAAAAAGAAGGTTTGGGAAAAGTTGCAAGCTGATTTAAAAACGAATGATAATTTAACAGCGGTCTGGCAAGGTAATAAGTTAGTAAGTAAAATTAATGGAAACCCTGTGACTACAAAAAGCATGAAAAATGCTCCCATTAAATAA

Protein

MATWQEKKHLITRNLQEVLGDDKLTEILKQRDLKIYWGTATTGRPHVAYFVPMLKIADFLKAGCEVTILFADLHAYLDNMKAPWELLALRTQYYEAAIKAMLTSIGVPLEKLKFVRGTEYQLSKEYTLDVYRLSSVVTEHDAKKAGAEVVKQVEHPLLSGLLYPNLQALDEEYLKVDAQFGGVDQRKIFTMSEKFLPQLGYAKRIHLMNPMVPGLTGGKMSASEADSKIDLLDTPTNVKKKLKKAFCEPGNISDNGVLSFTKHVVFPLMKEGETFKIKRSAEHGGDANYSKYEDLETAFANQEIHPGDLKASAEDAINKLLAPIQDTFNDPQLQELTKKAYPPPTKVKGNINQAVDDVTPSKLDIRVGHIVEVSRHPDADALYVEKIDVGEDEPRTIVSGLVNFVPIEEMQDRDVVVLCNLKAAKMRGVESKGMVLCASVDEPKQVEPLLPPKGTKAGDRIVVEEYDTGEPDEVLNPKKKVWEKLQADLKTNDNLTAVWQGNKLVSKINGNPVTTKSMKNAPIK

Description

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).

Catalytic Activity

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)

Similarity

Belongs to the class-I aminoacyl-tRNA synthetase family.

Keywords

Aminoacyl-tRNA synthetase   ATP-binding   Complete proteome   Cytoplasm   Ligase   Nucleotide-binding   Protein biosynthesis   Reference proteome   RNA-binding   tRNA-binding  

Feature

chain  Tyrosine--tRNA ligase, cytoplasmic

Uniprot

A0A1Q1NKL1   A0A0L7L0M1   A0A212F2C1   A0A2A4J416   A0A437BC07   A0A2H1V1Y3   + More
A0A0N0PB49   A0A194Q2V4   S4PIX7   A0A067QQ26   A0A2R7WL99   A0A0T6AWQ5   N6U9Q1   A0A1B6GRI3   A0A1W4WFK0   A0A1W4WEJ6   J9JX11   A0A0A9W919   A0A1B6LHN1   E0W243   A0A1B6CRD0   A0A1B6EG96   A0A232EZB2   A0A154P1K5   A0A226DY58   A0A0P6G5F6   A0A0P5KCY2   A0A0P5GAD4   R4WDR5   A0A0N8E539   A0A0P5C1R6   A0A0P5J700   A0A0P5JEW5   A0A162CDJ2   A0A0P5T5Y8   A0A3Q0IQ83   K7IWT5   A0A0P5PFA2   A0A0P5S1K4   A0A0P5AWM7   A0A1D2MJY5   A0A0P5MMV4   A0A0P5TXH6   A0A0P5R443   A0A0P5KGX7   A0A0P5K6J0   A0A0P5SF28   A0A0P5R4L5   A0A0P5L040   A0A0P6FYF0   A0A0P5NMA0   A0A0P5M985   A0A0N8DJ62   A0A0N8DUP0   A0A0P6H1Q3   A0A0P5CYV1   A0A0K8V3C3   A0A0P5BUJ4   A0A0P5C4Y6   A0A1L8DRW5   A0A1Y1NDU0   D6WN21   A0A034VYI4   A0A195BYZ0   A0A0K8TT27   T1IG90   A0A0C9R3E9   A0A0A1WV12   A0A1L8DRS0   R4FP84   A0A0A1WFH4   A0A2A3E7P7   A0A2L2Y648   A0A1W4UH29   A0A091G4P1   A0A2I0TFD4   W8BXW9   A0A1I8PHA3   A0A0L0C0U6   A0A2C9JL91   U4UC18   E9GLT2   A0A226PDJ7   A0A2I9LPW5   A0A1L8ECR7   A0A226MMQ7   A0A0P4VIM4   E2ABW5   U3JCV9   A0A1V4JI02   A0A158NL75   H0YSY0   A0A310SPF1   Q5ZJ08   F1NJU7   A0A1I8NGW6   A0A0N8EJJ3   T1PIN7   A0A0V0G413   A0A0P5T6E6  

EC Number

6.1.1.1

Pubmed

28134300    26227816    22118469    26354079    23622113    24845553    + More
23537049    25401762    26823975    20566863    28648823    23691247    20075255    27289101    28004739    18362917    19820115    25348373    26369729    25830018    26561354    24495485    26108605    15562597    21292972    24621616    29248469    27129103    20798317    21347285    20360741    15642098    15592404    25315136   

EMBL

KU955849    AQM56846.1    JTDY01003819    KOB68960.1    AGBW02010772    OWR47873.1    + More
NWSH01003290    PCG66609.1    RSAL01000092    RVE47957.1    ODYU01000122    SOQ34362.1    KQ461068    KPJ09915.1    KQ459564    KPI99668.1    GAIX01000024    JAA92536.1    KK853069    KDR11830.1    KK855030    PTY20396.1    LJIG01022636    KRT79512.1    APGK01037606    APGK01037607    KB740948    ENN77376.1    GECZ01004816    GECZ01000758    JAS64953.1    JAS69011.1    ABLF02010670    GBHO01039320    GBHO01039317    GBRD01008130    GBRD01008129    GDHC01018063    GDHC01014091    JAG04284.1    JAG04287.1    JAG57691.1    JAQ00566.1    JAQ04538.1    GEBQ01016828    JAT23149.1    DS235874    EEB19699.1    GEDC01021331    JAS15967.1    GEDC01000336    JAS36962.1    NNAY01001516    OXU23721.1    KQ434796    KZC05741.1    LNIX01000009    OXA50213.1    GDIQ01038113    JAN56624.1    GDIQ01186053    JAK65672.1    GDIQ01265424    GDIQ01077399    JAJ86300.1    AK417774    BAN20989.1    GDIQ01060956    JAN33781.1    GDIP01181587    JAJ41815.1    GDIQ01231648    GDIQ01205649    GDIQ01149485    GDIQ01094794    GDIQ01029870    JAK46076.1    GDIQ01203504    JAK48221.1    LRGB01000944    KZS14482.1    GDIP01137098    JAL66616.1    AAZX01000588    GDIQ01135436    JAL16290.1    GDIQ01098242    JAL53484.1    GDIP01193542    JAJ29860.1    LJIJ01001012    ODM93357.1    GDIQ01154377    JAK97348.1    GDIP01122696    JAL81018.1    GDIQ01107983    JAL43743.1    GDIQ01184306    JAK67419.1    GDIQ01194705    JAK57020.1    GDIQ01096648    JAL55078.1    GDIQ01105591    JAL46135.1    GDIQ01177101    JAK74624.1    GDIQ01041170    JAN53567.1    GDIQ01140335    JAL11391.1    GDIQ01158912    JAK92813.1    GDIP01028551    JAM75164.1    GDIQ01090148    JAN04589.1    GDIQ01038115    JAN56622.1    GDIP01179735    JAJ43667.1    GDHF01018892    JAI33422.1    GDIP01179736    JAJ43666.1    GDIP01179734    JAJ43668.1    GFDF01004967    JAV09117.1    GEZM01005660    JAV96001.1    KQ971343    EFA03247.1    GAKP01011463    JAC47489.1    KQ978501    KYM93545.1    GDAI01000523    JAI17080.1    ACPB03006814    GBYB01007307    JAG77074.1    GBXI01012034    JAD02258.1    GFDF01004945    JAV09139.1    GAHY01001009    JAA76501.1    GBXI01017129    JAC97162.1    KZ288340    PBC27767.1    IAAA01002067    LAA03477.1    KL447759    KFO76863.1    KZ511241    PKU32485.1    GAMC01002378    JAC04178.1    JRES01001060    KNC25925.1    KB632288    ERL91479.1    GL732551    EFX79630.1    AWGT02000094    OXB77784.1    GFWZ01000438    MBW20428.1    GFDG01002325    JAV16474.1    MCFN01000643    OXB56430.1    GDKW01001901    JAI54694.1    GL438386    EFN69060.1    AGTO01020969    LSYS01007350    OPJ71704.1    ADTU01019276    ADTU01019277    ABQF01049632    ABQF01049633    KQ761619    OAD57322.1    AJ720626    AADN05000596    GDIQ01020524    JAN74213.1    KA647798    AFP62427.1    GECL01003429    JAP02695.1    GDIP01130346    JAL73368.1   

Proteomes

UP000037510    UP000007151    UP000218220    UP000283053    UP000053240    UP000053268    + More
UP000027135    UP000019118    UP000192223    UP000007819    UP000009046    UP000215335    UP000076502    UP000198287    UP000076858    UP000079169    UP000002358    UP000094527    UP000007266    UP000078542    UP000015103    UP000242457    UP000192221    UP000053760    UP000095300    UP000037069    UP000076420    UP000030742    UP000000305    UP000198419    UP000198323    UP000000311    UP000016665    UP000190648    UP000005205    UP000007754    UP000000539    UP000095301   

PRIDE

Q5ZJ08   

Pfam

PF00579   tRNA-synt_1b        + More
PF01588   tRNA_bind

Interpro

IPR002547   tRNA-bd_dom        + More
IPR012340   NA-bd_OB-fold       
IPR002305   aa-tRNA-synth_Ic       
IPR002307   Tyr-tRNA-ligase       
IPR014729   Rossmann-like_a/b/a_fold       
IPR036282   Glutathione-S-Trfase_C_sf       

SUPFAM

SSF50249   SSF50249        + More
SSF47616   SSF47616       

Gene 3D

3.40.50.620    

CDD

cd00805  TyrRS_core

ProteinModelPortal

A0A1Q1NKL1   A0A0L7L0M1   A0A212F2C1   A0A2A4J416   A0A437BC07   A0A2H1V1Y3   + More
A0A0N0PB49   A0A194Q2V4   S4PIX7   A0A067QQ26   A0A2R7WL99   A0A0T6AWQ5   N6U9Q1   A0A1B6GRI3   A0A1W4WFK0   A0A1W4WEJ6   J9JX11   A0A0A9W919   A0A1B6LHN1   E0W243   A0A1B6CRD0   A0A1B6EG96   A0A232EZB2   A0A154P1K5   A0A226DY58   A0A0P6G5F6   A0A0P5KCY2   A0A0P5GAD4   R4WDR5   A0A0N8E539   A0A0P5C1R6   A0A0P5J700   A0A0P5JEW5   A0A162CDJ2   A0A0P5T5Y8   A0A3Q0IQ83   K7IWT5   A0A0P5PFA2   A0A0P5S1K4   A0A0P5AWM7   A0A1D2MJY5   A0A0P5MMV4   A0A0P5TXH6   A0A0P5R443   A0A0P5KGX7   A0A0P5K6J0   A0A0P5SF28   A0A0P5R4L5   A0A0P5L040   A0A0P6FYF0   A0A0P5NMA0   A0A0P5M985   A0A0N8DJ62   A0A0N8DUP0   A0A0P6H1Q3   A0A0P5CYV1   A0A0K8V3C3   A0A0P5BUJ4   A0A0P5C4Y6   A0A1L8DRW5   A0A1Y1NDU0   D6WN21   A0A034VYI4   A0A195BYZ0   A0A0K8TT27   T1IG90   A0A0C9R3E9   A0A0A1WV12   A0A1L8DRS0   R4FP84   A0A0A1WFH4   A0A2A3E7P7   A0A2L2Y648   A0A1W4UH29   A0A091G4P1   A0A2I0TFD4   W8BXW9   A0A1I8PHA3   A0A0L0C0U6   A0A2C9JL91   U4UC18   E9GLT2   A0A226PDJ7   A0A2I9LPW5   A0A1L8ECR7   A0A226MMQ7   A0A0P4VIM4   E2ABW5   U3JCV9   A0A1V4JI02   A0A158NL75   H0YSY0   A0A310SPF1   Q5ZJ08   F1NJU7   A0A1I8NGW6   A0A0N8EJJ3   T1PIN7   A0A0V0G413   A0A0P5T6E6  

PDB

4QBT     E-value=4.08332e-141,     Score=1286

KEGG

101740690    K01866 tyrosyl-tRNA synthetase [EC:6.1.1.1] | (RefSeq) tyrosine--tRNA ligase, cytoplasmic

PATHWAY

00970    Aminoacyl-tRNA biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0005737   GO:0006437   GO:0000049   GO:0005524   GO:0004831   GO:0006412   GO:0006418   GO:0017101   GO:0016301   GO:0005829   GO:0016604   GO:0000166   GO:0004812   GO:0005975   GO:0004553  

Subcellular location

Cytoplasm  

Length:

524

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.185

Exp number, first 60 AAs:

0.12769

Total prob of N-in:

0.01508

outside

1  -  524

 

 

Pi

131.899729

Theta

165.007874

Tajima's D

-0.664467

CLR

515.931143

CSRT

0.208239588020599

Interpretation

Uncertain