Gene

KWMTBOMO12549

Annotation

PREDICTED:_protein_giant-lens_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr21(-):6893385-6895663      View in EpiBrowser

Full name

Protein giant-lens      

Alternative Name

Protein argos
Protein strawberry

Location in the cell

Extracellular   Reliability : 2.619 Nuclear   Reliability : 2.09

CDS

ATGGTTTCGGAGGACGATTTGCCCGATTGCCGACCGCGACAAGTCTGCAGTAAGGTTGACCTCTACGACGCTTCCCAGCCGTGGATAGAGAAGAAATGTCGGTGCTTAGGACACAGGCCGTGTTCGAGCGAACTGTCGGCCGACGACAACCACACGCTGGCCGACAAGACGACCTTGTACAAAACTTGCGAGCCAGTGAAGAGGTTGCCTAAATGCCGTTACTTCAAGGACGCAGCGTGGATCATCTACACGTTTGCCGATACGAACGCGACTCAGCAGATCGTCAACTGTCACTGCCCCAAGTTCTCGGTCACGTACCTGCTAAAGAAGCTACCGTACACGGCATCTAGCGGCGAACAAGGGAACCAGTACCAGTTTGGTTGCTCACCACAAAGCAGGCTTCGTTGCTCAAGGAAGGAGCCTTGTAAGTTGTTCAGCGCGAGACGACGTCACGAGCAGATCGACGAAGTCAACGCCAATACCATCTGCCAGTGTCCAAGGGACCACAGCTGCCCTAGGCATCACACAGAGCCCGGAGTCCTCCCGGGAATCACGTACGCTTCAGAAGACATCCGTACGTACCACGGTTACTGCATGCAGGAACCACCCCCGGATACCTTCAGATTCGTCGGAGATAAAGATTGA

Protein

MVSEDDLPDCRPRQVCSKVDLYDASQPWIEKKCRCLGHRPCSSELSADDNHTLADKTTLYKTCEPVKRLPKCRYFKDAAWIIYTFADTNATQQIVNCHCPKFSVTYLLKKLPYTASSGEQGNQYQFGCSPQSRLRCSRKEPCKLFSARRRHEQIDEVNANTICQCPRDHSCPRHHTEPGVLPGITYASEDIRTYHGYCMQEPPPDTFRFVGDKD

Description

Regulates cell determination; development of ommatidia and optic lobe. Is a signaling molecule involved in the process of axon pathfinding in the eye. Part of the Ras pathway regulating programmed cell death in pupal eyes; activated by lozenge (lz). Antagonist for the Egfr receptor (gurken). Inhibits Egfr signaling without interacting directly with the receptor, but instead by sequestering the Egfr-activating ligand spitz (spi).

Subunit

Interacts with spi.

Keywords

3D-structure   Complete proteome   Developmental protein   Disulfide bond   Glycoprotein   Reference proteome   Repeat   Secreted   Sensory transduction   Signal   Vision  

Feature

chain  Protein giant-lens

Uniprot

A0A2H1WIK7   A0A2A4K5D3   A0A0L7LE11   A0A437AZ79   S4PKA5   A0A0N1INR3   + More
A0A194Q8C7   A0A212FHP7   A0A023F5E1   A0A2J7RJV2   E0VSE1   A0A1B6GJ24   A0A1B6C8E4   A0A2R7VVN0   A0A2H8TTM0   D6W711   J9JV84   A0A423SDZ5   A0A444SU57   N6TB96   A0A2P8YIP8   A0A1D2NKM3   A0A1Y1N3L0   A0A026WDS8   A0A0M9A484   A0A087ZU64   E2AE84   A0A0L7QMX5   A0A0J7KEV0   E2BPY4   E9IW61   A0A443STD1   A0A151II72   F4X469   A0A151JV90   A0A195E299   A0A151I443   J9K6A5   A0A3S3SI66   A0A151XGJ1   A0A0K2SXX8   A0A0C9Q0H4   A0A1B0A6Z4   A0A1A9W3A4   A0A1B0B6M9   A0A1A9YSS2   A0A1A9UIF8   A0A0L0C0Z0   A0A1B0GA92   A0A0K8WCQ0   A0A0A1XG65   B3M4I1   A0A034WA98   A0A0Q5UJX5   T1PK50   A0A0J9UMJ1   B4HJN6   B3NHZ6   O44429   A0A1W4UTN0   A0A0M5IYQ0   A0A0M5J458   Q00805   B4PKE5   W8C1C0   B4H221   A0A3B0KFH1   Q29EI0   T1JU56   Q86SB5   B4LI50   B4MMH7   A0A232FEY3   A0A087TU56   B4J0W0   B4L9J4   A0A2P6KM42   A0A1V9Y3Q3   A0A131XJJ6   A0A087V027   A0A1W0WHL2   A0A132A7X3   A0A1D1W803   A0A1D1V7V2  

Pubmed

26227816    23622113    26354079    22118469    25474469    20566863    + More
18362917    19820115    23537049    29403074    27289101    28004739    24508170    30249741    20798317    21282665    21719571    26108605    25830018    17994087    25348373    22936249    9461626    25315136    1628618    1606617    1286772    10731132    12537572    12537569    10200472    15329724    15879554    18500331    17550304    24495485    15632085    12963110    28648823    28327890    28049606    26555130    27649274   

EMBL

ODYU01008906    SOQ52898.1    NWSH01000166    PCG78870.1    JTDY01001538    KOB73619.1    + More
RSAL01000250    RVE43491.1    GAIX01004610    JAA87950.1    KQ461068    KPJ09904.1    KQ459564    KPI99660.1    AGBW02008483    OWR53245.1    GBBI01002364    JAC16348.1    NEVH01002988    PNF41101.1    DS235750    EEB16297.1    GECZ01026594    GECZ01011682    GECZ01007325    JAS43175.1    JAS58087.1    JAS62444.1    GEDC01027594    JAS09704.1    KK854107    PTY11399.1    GFXV01005798    MBW17603.1    KQ971307    EFA11599.2    ABLF02037400    QCYY01003689    ROT62422.1    SAUD01022974    RXG56938.1    APGK01036840    KB740943    KB632399    ENN77534.1    ERL94873.1    PYGN01000568    PSN44112.1    LJIJ01000015    ODN05818.1    GEZM01016435    JAV91275.1    KK107260    QOIP01000001    EZA54212.1    RLU26519.1    KQ435737    KOX76897.1    GL438827    EFN68317.1    KQ414868    KOC59973.1    LBMM01008336    KMQ88963.1    GL449669    EFN82247.1    GL766449    EFZ15187.1    NCKV01000388    RWS30760.1    KQ977510    KYN02256.1    GL888628    EGI58737.1    KQ981713    KYN37335.1    KQ979814    KYN19024.1    KQ976461    KYM84700.1    ABLF02026414    NCKU01000721    RWS14435.1    KQ982169    KYQ59477.1    HACA01001253    CDW18614.1    GBYB01007338    JAG77105.1    JXJN01009171    JRES01001060    KNC25927.1    CCAG010002713    CCAG010002714    CCAG010002715    CCAG010002716    CCAG010002717    GDHF01003383    JAI48931.1    GBXI01004387    JAD09905.1    CH902618    EDV40475.1    GAKP01007877    JAC51075.1    CH954178    KQS44096.1    KA648338    AFP62967.1    CM002912    KMZ00056.1    CH480815    EDW41763.1    EDV52082.2    AF038405    AAB92420.1    CP012525    ALC43986.1    ALC44844.1    X65161    M91381    S55367    AE014296    AY122224    CM000159    EDW94843.2    GAMC01007034    JAB99521.1    CH479203    EDW30373.1    OUUW01000012    SPP87100.1    CH379070    EAL30081.2    CAEY01000468    AB089249    BAC56702.1    CH940647    EDW68594.2    CH963847    EDW73322.2    NNAY01000309    OXU29314.1    KK116743    KFM68645.1    CH916366    EDV95781.1    CH933816    EDW17369.1    MWRG01008867    PRD27410.1    MNPL01000074    OQR80362.1    GEFH01001288    JAP67293.1    KK122540    KFM82966.1    MTYJ01000100    OQV14694.1    JXLN01011300    KPM07071.1    BDGG01000015    GAV07634.1    BDGG01000003    GAU96855.1   

Proteomes

UP000218220    UP000037510    UP000283053    UP000053240    UP000053268    UP000007151    + More
UP000235965    UP000009046    UP000007266    UP000007819    UP000283509    UP000288706    UP000019118    UP000030742    UP000245037    UP000094527    UP000053097    UP000279307    UP000053105    UP000005203    UP000000311    UP000053825    UP000036403    UP000008237    UP000288716    UP000078542    UP000007755    UP000078541    UP000078492    UP000078540    UP000285301    UP000075809    UP000092445    UP000091820    UP000092460    UP000092443    UP000078200    UP000037069    UP000092444    UP000007801    UP000008711    UP000001292    UP000095301    UP000192221    UP000092553    UP000000803    UP000002282    UP000008744    UP000268350    UP000001819    UP000015104    UP000008792    UP000007798    UP000215335    UP000054359    UP000001070    UP000009192    UP000192247    UP000186922   

PRIDE

Q00805   

Pfam

PF11581   Argos

Interpro

IPR021633   Argos        + More
IPR020891   UPF0758_CS       

ProteinModelPortal

A0A2H1WIK7   A0A2A4K5D3   A0A0L7LE11   A0A437AZ79   S4PKA5   A0A0N1INR3   + More
A0A194Q8C7   A0A212FHP7   A0A023F5E1   A0A2J7RJV2   E0VSE1   A0A1B6GJ24   A0A1B6C8E4   A0A2R7VVN0   A0A2H8TTM0   D6W711   J9JV84   A0A423SDZ5   A0A444SU57   N6TB96   A0A2P8YIP8   A0A1D2NKM3   A0A1Y1N3L0   A0A026WDS8   A0A0M9A484   A0A087ZU64   E2AE84   A0A0L7QMX5   A0A0J7KEV0   E2BPY4   E9IW61   A0A443STD1   A0A151II72   F4X469   A0A151JV90   A0A195E299   A0A151I443   J9K6A5   A0A3S3SI66   A0A151XGJ1   A0A0K2SXX8   A0A0C9Q0H4   A0A1B0A6Z4   A0A1A9W3A4   A0A1B0B6M9   A0A1A9YSS2   A0A1A9UIF8   A0A0L0C0Z0   A0A1B0GA92   A0A0K8WCQ0   A0A0A1XG65   B3M4I1   A0A034WA98   A0A0Q5UJX5   T1PK50   A0A0J9UMJ1   B4HJN6   B3NHZ6   O44429   A0A1W4UTN0   A0A0M5IYQ0   A0A0M5J458   Q00805   B4PKE5   W8C1C0   B4H221   A0A3B0KFH1   Q29EI0   T1JU56   Q86SB5   B4LI50   B4MMH7   A0A232FEY3   A0A087TU56   B4J0W0   B4L9J4   A0A2P6KM42   A0A1V9Y3Q3   A0A131XJJ6   A0A087V027   A0A1W0WHL2   A0A132A7X3   A0A1D1W803   A0A1D1V7V2  

PDB

3CGU     E-value=1.67971e-56,     Score=552

KEGG

101740423    K02104 protein giant-lens (argos) | (RefSeq) protein giant-lens

PATHWAY

04013    MAPK signaling pathway - fly - Bombyx mori (domestic silkworm)
04320    Dorso-ventral axis formation - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0007474   GO:2000737   GO:0007482   GO:0009948   GO:0060233   GO:0070373   GO:0009950   GO:0005615   GO:0043065   GO:0035215   GO:0050768   GO:0048019   GO:0016318   GO:0005154   GO:0042802   GO:0007175   GO:0007455   GO:0001654   GO:0042059   GO:0007476   GO:0007472   GO:0007601   GO:0050896  

Subcellular location

Secreted  

Length:

214

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00244

Exp number, first 60 AAs:

0

Total prob of N-in:

0.03732

outside

1  -  214

 

 

Pi

136.094905

Theta

180.495375

Tajima's D

-0.861204

CLR

186.933195

CSRT

0.164591770411479

Interpretation

Uncertain