Gene

KWMTBOMO12533  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001458

Annotation

PREDICTED:_MAP_kinse-ERK_kinase_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr21(-):6271787-6278744      View in EpiBrowser

Full name

Dual specificity mitogen-activated protein kinase kinase dSOR1      

Location in the cell

Cytoplasmic   Reliability : 1.928 Nuclear   Reliability : 2.283

CDS

ATGAGTAAGATGTCAAAGAACAAACTGAATTTGACCCTTCCACCAGGGTCAATAGACACAAACCCAGCTGCCACGCCATCTAACATGACACCACAGCTCAAATCTGCTACTGCAAATGAGCGGCAAGGGTTAGCAGGCAAGTCAAAGACAAGTATAGAGGCTTTAACTGAGAGACTGGAGCAAATTGAGATGGATGATACTCAGAGGCGCAGGATAGAAGTATTCCTCTGTCAGAAAGAGAAGATTGGAGAGCTGAGTGATGATGACTTTGAGAAGCTTGGTGAATTAGGCCAAGGCAACGGTGGAGTTGTAATGAAAGTTCGTCACAAATCTACCGGACTCATCATGGCACGCAAGTTGATTCATCTCGAAGTGAAACCGGCTATAAAAAAGCAGATAATCAGAGAGTTAAAAGTACTTCATGAATGTAACTTTGCACATATAGTTGGCTTCTATGGAGCATTCTATAGTGATGGCGAGATCTCTATATGCATGGAATACATGGATGGAGGGTCATTGGATCTTATATTGAAGAAGGCGGGAAGAATTCCTGAATCTATTTTAGGAACAATCACATCAGCAGTTCTCAAAGGTTTGAGCTACCTTCGCGATAAGCACGCCATCATGCACCGTGACGTGAAGCCATCGAATATACTTGTTAACAGCAATGGCGAGATTAAGATCTGTGATTTCGGTGTTTCGGGGCAGCTGATAGATTCAATGGCTAATTCTTTTGTTGGTACCAGGAGCTATATGTCACCGGAGCGTCTGCAAGGCACTCATTACTCAGTGCAGTCAGATATCTGGTCGTTGGGTTTGTCTCTAGTCGAAATGGCCATTGGAATGTATCCAATTCCACCTCCTGACGCTAAAACATTGGCAGCTATATTTGGTGGGCAGAATGAGGACCACTCACCGGGCCAGGCGCCGAATTCACCGCGTCCGATGGCCATATTCGAGCTCTTAGATTACATAGTTAATGAACCACCACCGAAGCTTCCATCTGGCATCTTCTCTGATGAATTTAAAGATTTCGTGGATCGCTGTCTCAAGAAAAATCCTGATGAGAGAGCGGACTTGAAGACTTTAATGAATCACGAGTGGATCCGGAAGGCGGAAGCCGAGAAGGTGGACATCGCTGGATGGGTGTGCAAGACCATGGACCTAATGCCTTCCACGCCGAACTCCAACGTGTCTCCTTTTTCTTCATAA

Protein

MSKMSKNKLNLTLPPGSIDTNPAATPSNMTPQLKSATANERQGLAGKSKTSIEALTERLEQIEMDDTQRRRIEVFLCQKEKIGELSDDDFEKLGELGQGNGGVVMKVRHKSTGLIMARKLIHLEVKPAIKKQIIRELKVLHECNFAHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPESILGTITSAVLKGLSYLRDKHAIMHRDVKPSNILVNSNGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLAAIFGGQNEDHSPGQAPNSPRPMAIFELLDYIVNEPPPKLPSGIFSDEFKDFVDRCLKKNPDERADLKTLMNHEWIRKAEAEKVDIAGWVCKTMDLMPSTPNSNVSPFSS

Description

Required downstream of Raf in the sevenless (sev), torso (tor), and Drosophila EGF receptor homolog (DER) signal transduction pathways. Involved in both positive regulation (at the posterior terminus) and negative regulation (at the anterior domain) of tll, as in other terminal class gene products, maybe via the ERK-A kinase.

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Similarity

Belongs to the protein kinase superfamily.
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.

Keywords

ATP-binding   Complete proteome   Developmental protein   Kinase   Nucleotide-binding   Phosphoprotein   Reference proteome   Transferase   Tyrosine-protein kinase  

Feature

chain  Dual specificity mitogen-activated protein kinase kinase dSOR1

Uniprot

H9IW27   Q3C2L3   A0A1B0YTK3   A0A2A4K810   A0A437BLD8   A0A194Q2U1   + More
A0A212FH26   A0A1B6DRN6   A0A0V0GBK7   A0A0N0PB42   A0A069DU79   A0A146LZS6   A0A0K8S8J4   A0A0P4VSG6   A0A0A9WA33   A0A2J7QBH2   A0A1W4WQA2   A0A1B6L7R2   A0A1Y1N922   A0A1B6M815   A0A034W397   A0A2J7QBH3   A0A0K8UNX0   A0A1B6M735   A0A1B6LDZ5   D3TQU3   A0A1A9UE06   A0A1B0BCT3   A0A1B6EQP8   A0A067R7Y6   A0A1B6GXS1   A0A0K8TLS1   T1PBX3   A0A1A9WL63   A0A1I8PEJ9   W8BLV6   A0A2J7RSM5   Q16L96   A0A0A1XRA6   E0VS88   A0A084W0A0   B0X8U7   A0A1I8MAG9   A0A1Q3F670   A0A182IU89   T1HFU2   A0A232EFJ8   A0A1B6KQ38   B4NCB4   A0A182VEF1   A0A182XPK5   Q7PUQ2   B4M1J3   D6W868   A0A182YQL0   A0A1I8PET7   A0A182T190   A0A182MKB8   A0A182R533   A0A3B0J7P5   A0A0T6BEW3   A0A182VWB3   A0A0L0BLM6   Q29IC0   B4GW88   A0A154PGT2   B3MZP8   A0A2M4AS89   A0A0L7R9K2   B4L1U0   A0A2P8XP02   A0A2A3E5K6   B4JL63   A0A182U668   W5JHU2   A0A0C9RH05   A0A0Q9WDR4   A0A182JSL9   J3JW77   A0A182PZK6   A0A3L8DUG0   A0A0P8ZJ35   A0A0R3P3F6   A0A336MZ51   A0A182NR32   B4PWU6   B3NT88   A0A1W4VU10   A0A0M9A611   A0A1B0GLP9   A0A0R1ECJ0   A0A0Q5T3Z3   A0A1W4VUT4   Q24324   N6T2E9   Q8ISD3   B4ILP4   X2JAZ3   A0A1L8DMH8   A0A0K8TWM4  

EC Number

2.7.12.2

Pubmed

19121390    16360949    26354079    22118469    26334808    26823975    + More
27129103    25401762    28004739    25348373    20353571    24845553    26369729    25315136    24495485    17510324    25830018    20566863    24438588    28648823    17994087    12364791    14747013    17210077    18362917    19820115    25244985    26108605    15632085    29403074    20920257    23761445    22516182    30249741    17550304    8381718    12694293    10731132    12537572    12537569    23537049    12537568    12537573    12537574    16110336    17569856    17569867   

EMBL

BABH01006068    AB183870    BAE46742.1    KU358551    ANO46361.1    NWSH01000083    + More
PCG79790.1    RSAL01000035    RVE51310.1    KQ459564    KPI99653.1    AGBW02008561    OWR53027.1    GEDC01008961    JAS28337.1    GECL01000657    JAP05467.1    KQ461068    KPJ09895.1    GBGD01001632    JAC87257.1    GDHC01005531    GDHC01002756    JAQ13098.1    JAQ15873.1    GBRD01016220    JAG49606.1    GDKW01000521    JAI56074.1    GBHO01038291    GBHO01038289    GBHO01038288    GBHO01038287    JAG05313.1    JAG05315.1    JAG05316.1    JAG05317.1    NEVH01016298    PNF25933.1    GEBQ01020219    JAT19758.1    GEZM01014455    JAV92097.1    GEBQ01007914    JAT32063.1    GAKP01010347    JAC48605.1    PNF25936.1    GDHF01023925    JAI28389.1    GEBQ01008273    JAT31704.1    GEBQ01018077    JAT21900.1    EZ423795    ADD20071.1    JXJN01012111    GECZ01029551    JAS40218.1    KK852643    KDR19551.1    GECZ01002550    JAS67219.1    GDAI01002286    JAI15317.1    KA646267    AFP60896.1    GAMC01006762    GAMC01006760    GAMC01006758    GAMC01006756    JAB99797.1    NEVH01000252    PNF43837.1    CH477914    EAT35087.1    GBXI01004949    GBXI01000872    JAD09343.1    JAD13420.1    DS235746    EEB16244.1    ATLV01019105    KE525262    KFB43644.1    DS232504    EDS42703.1    GFDL01011985    JAV23060.1    ACPB03018819    NNAY01005021    OXU17098.1    GEBQ01026411    JAT13566.1    CH964239    EDW82473.1    AAAB01008987    EAA01212.5    CH940651    EDW65547.1    KQ971307    EFA11195.1    AXCM01001187    OUUW01000003    SPP78137.1    LJIG01001509    KRT85431.1    JRES01001701    KNC20848.1    CH379063    EAL32733.2    CH479194    EDW26972.1    KQ434900    KZC11053.1    CH902635    EDV33849.1    GGFK01010344    MBW43665.1    KQ414624    KOC67547.1    CH933810    EDW06743.2    PYGN01001613    PSN33740.1    KZ288386    PBC26459.1    CH916370    EDW00316.1    ADMH02001468    ETN62470.1    GBYB01012472    JAG82239.1    KRF82278.1    BT127495    AEE62457.1    AXCN02001479    QOIP01000004    RLU24115.1    KPU74787.1    KRT06271.1    UFQT01003022    SSX34439.1    CM000162    EDX02830.1    CH954180    EDV46268.1    KQ435735    KOX77186.1    AJWK01009757    KRK06975.1    KQS29903.1    D13782    AY135075    AY135076    AY135077    AY135078    AY135079    AY135080    AY135081    AY135082    AY135083    AY135084    AY135085    AY135086    AY135087    AY135088    AY135089    AY135090    AY135091    AY135092    AY135093    AE014298    AY058692    APGK01047273    KB741077    KB632432    ENN74309.1    ERL95554.1    AY135138    AAN17606.1    CH480883    EDW54751.1    AHN59515.1    GFDF01006418    JAV07666.1    GDHF01033633    JAI18681.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053268    UP000007151    UP000053240    + More
UP000235965    UP000192223    UP000078200    UP000092460    UP000027135    UP000095301    UP000091820    UP000095300    UP000008820    UP000009046    UP000030765    UP000002320    UP000075880    UP000015103    UP000215335    UP000007798    UP000075903    UP000076407    UP000007062    UP000008792    UP000007266    UP000076408    UP000075901    UP000075883    UP000075900    UP000268350    UP000075920    UP000037069    UP000001819    UP000008744    UP000076502    UP000007801    UP000053825    UP000009192    UP000245037    UP000242457    UP000001070    UP000075902    UP000000673    UP000075881    UP000075886    UP000279307    UP000075884    UP000002282    UP000008711    UP000192221    UP000053105    UP000092461    UP000000803    UP000019118    UP000030742    UP000001292   

PRIDE

H9IW27    Q3C2L3    Q24324    X2JAZ3   

Pfam

PF00069   Pkinase

Interpro

IPR017441   Protein_kinase_ATP_BS        + More
IPR008271   Ser/Thr_kinase_AS       
IPR011009   Kinase-like_dom_sf       
IPR000719   Prot_kinase_dom       

SUPFAM

SSF56112   SSF56112       

ProteinModelPortal

H9IW27   Q3C2L3   A0A1B0YTK3   A0A2A4K810   A0A437BLD8   A0A194Q2U1   + More
A0A212FH26   A0A1B6DRN6   A0A0V0GBK7   A0A0N0PB42   A0A069DU79   A0A146LZS6   A0A0K8S8J4   A0A0P4VSG6   A0A0A9WA33   A0A2J7QBH2   A0A1W4WQA2   A0A1B6L7R2   A0A1Y1N922   A0A1B6M815   A0A034W397   A0A2J7QBH3   A0A0K8UNX0   A0A1B6M735   A0A1B6LDZ5   D3TQU3   A0A1A9UE06   A0A1B0BCT3   A0A1B6EQP8   A0A067R7Y6   A0A1B6GXS1   A0A0K8TLS1   T1PBX3   A0A1A9WL63   A0A1I8PEJ9   W8BLV6   A0A2J7RSM5   Q16L96   A0A0A1XRA6   E0VS88   A0A084W0A0   B0X8U7   A0A1I8MAG9   A0A1Q3F670   A0A182IU89   T1HFU2   A0A232EFJ8   A0A1B6KQ38   B4NCB4   A0A182VEF1   A0A182XPK5   Q7PUQ2   B4M1J3   D6W868   A0A182YQL0   A0A1I8PET7   A0A182T190   A0A182MKB8   A0A182R533   A0A3B0J7P5   A0A0T6BEW3   A0A182VWB3   A0A0L0BLM6   Q29IC0   B4GW88   A0A154PGT2   B3MZP8   A0A2M4AS89   A0A0L7R9K2   B4L1U0   A0A2P8XP02   A0A2A3E5K6   B4JL63   A0A182U668   W5JHU2   A0A0C9RH05   A0A0Q9WDR4   A0A182JSL9   J3JW77   A0A182PZK6   A0A3L8DUG0   A0A0P8ZJ35   A0A0R3P3F6   A0A336MZ51   A0A182NR32   B4PWU6   B3NT88   A0A1W4VU10   A0A0M9A611   A0A1B0GLP9   A0A0R1ECJ0   A0A0Q5T3Z3   A0A1W4VUT4   Q24324   N6T2E9   Q8ISD3   B4ILP4   X2JAZ3   A0A1L8DMH8   A0A0K8TWM4  

PDB

5KKR     E-value=8.39924e-150,     Score=1360

KEGG

692467    K04368 mitogen-activated protein kinase kinase 1 [EC:2.7.12.2] | (RefSeq) Mek; MAP kinse-ERK kinase

PATHWAY

04013    MAPK signaling pathway - fly - Bombyx mori (domestic silkworm)
04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)
04140    Autophagy - animal - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04320    Dorso-ventral axis formation - Bombyx mori (domestic silkworm)

GO

GO:0004674   GO:0005524   GO:0004672   GO:0007362   GO:0005635   GO:0007298   GO:0009953   GO:0042386   GO:0007173   GO:0008286   GO:0000793   GO:0070371   GO:0051607   GO:0045500   GO:0042461   GO:0008543   GO:0004708   GO:0033314   GO:0008293   GO:0007095   GO:0071481   GO:0007430   GO:0048010   GO:0000187   GO:0005737   GO:0023014   GO:0032147   GO:0031098   GO:0016021   GO:0007465   GO:0007623   GO:0006468   GO:0005829   GO:0004713   GO:0004697   GO:0008270   GO:0045211   GO:0005975   GO:0004553  

Length:

403

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.23833

Exp number, first 60 AAs:

0.00016

Total prob of N-in:

0.03615

outside

1  -  403

 

 

Pi

248.824681

Theta

171.264018

Tajima's D

0.995834

CLR

0.474215

CSRT

0.657117144142793

Interpretation

Uncertain