Gene

KWMTBOMO12532

Pre Gene Modal

BGIBMGA001513

Annotation

PREDICTED:_furin-like_convetase_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr21(+):6070805-6079702      View in EpiBrowser

Full name

Furin-like protease 1, isoform 1-CRR      

Alternative Name

Kex2-like endoprotease 1
dKLIP-1

Location in the cell

Extracellular   Reliability : 1.843 Nuclear   Reliability : 1.348

CDS

ATGTGGGGTGAAAATCCGCTGGGCGAGTGGCAACTGGAGGTCACAAATGAAGGCCGCTACATGGAAGCCGGCACTTTAACTCAATGGGAGCTGATTTTCTACGGAACAGAGACACCGGCTCAGGAGCAAGACGTGTCACCGGAGACCAACTCTTTGGGTGAAAATTCTCGGGTTGACACGAAACCTTGGACCTTGTCTGAGCCTGAATCTATTGAAGAAGTAAGACAGAACGCCATTGATGATGATCTGGCTCTCGTTTGGCATGACTCTCAAACGATCCGTGAAGAGAATCCAGTCGGTGCTGGAGACGTCGACACGGGACAGTACGCCGCTAGCGCCGCGGGCTGCGCCACCCACGCTCCGCAGCCGCCGCATACCTGCATAGAATGCGCGAAGGGCTTGCATTTGTACAACGGGCGGTGCTACTCACGTTGTCCGGACGGTACGTACGCCAATGAGATCTCGATGGAACGGAGCTCCAGAAGACGTAACCTTACAATTTTTTCTGAGGGTTCCCTTAGCAAGCGGCAAGACGGGTCACTAAAATCGTCAGCTCTGGAGGCTTTAGACATGGAACCGTATGCGAACTCAACTAAAGATCCTTTGATTTGCCTACCATGCCATTACACCTGTGCCACGTGCGCAGGTCCTCACGACAGTCAATGTGTATCTTGTCTAGACGACGCGGAGTTGTTCAACTCGACAGATTCGGTTCTCAAGTTCTATTGCTACCCAAAAAAGGTCGTGTCACAGATAAGCGACGTCAACTGGCATTATAGATTGAATGTCGTCCTTTCCCTAGTTTTGTTCTGTATTTGTTTTATTTCTCTTTATTTTATTATATCGTGGACCCTGAAATGGTTTTACGGTACGAACAATTACAATTCGAACATCGCGTACAACAAATTATCGTCGGACGAAAAACAGCAAAGCGCTTCCGAGGTCGAGGAAGAGATCCGGTTGGCTCTGAAGGATTACAGTGAGGGCGAGACAGAAGATGATCTAAATTTATAG

Protein

MWGENPLGEWQLEVTNEGRYMEAGTLTQWELIFYGTETPAQEQDVSPETNSLGENSRVDTKPWTLSEPESIEEVRQNAIDDDLALVWHDSQTIREENPVGAGDVDTGQYAASAAGCATHAPQPPHTCIECAKGLHLYNGRCYSRCPDGTYANEISMERSSRRRNLTIFSEGSLSKRQDGSLKSSALEALDMEPYANSTKDPLICLPCHYTCATCAGPHDSQCVSCLDDAELFNSTDSVLKFYCYPKKVVSQISDVNWHYRLNVVLSLVLFCICFISLYFIISWTLKWFYGTNNYNSNIAYNKLSSDEKQQSASEVEEEIRLALKDYSEGETEDDLNL

Description

Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.

Catalytic Activity

Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.

Cofactor

Ca(2+)

Similarity

Belongs to the peptidase S8 family.
Belongs to the peptidase S8 family. Furin subfamily.

Keywords

Alternative splicing   Cleavage on pair of basic residues   Complete proteome   Disulfide bond   Glycoprotein   Golgi apparatus   Hydrolase   Membrane   Protease   Reference proteome   Serine protease   Signal   Transmembrane   Transmembrane helix   Zymogen  

Feature

chain  Furin-like protease 1, isoform 1-CRR

Uniprot

A0A1E1WNT8   A0A2A4JTN4   A0A437BLV5   A0A2H1WYJ9   A0A2A4JSW4   A0A212F132   + More
A0A194PYH4   A0A2J7PM83   A0A0T6B0U1   A0A1L8DJ27   A0A1L8DJ92   A0A1B6C415   A0A224XK28   A0A1Y1KWI5   A0A034VHS7   A0A2H4N0P7   A0A1W6EVS5   A0A1I8PLP7   A0A1B6EPA7   Q5QDM4   I5APT0   Q17EV1   A0A1B6L3K3   A0A1Q3G0V1   Q16926   A0A3B0K7F6   A0A1I8MU29   T1PJ76   A0A1B6H7M9   A0A2S2NKX1   A0A158P1F2   A0A2H8U075   A0A0P5N8V2   A0A0N8ASC2   A0A0P5GAN4   A0A0Q9WLP1   A0A0P5PCZ8   A0A0P5JB96   A0A0P6HCS7   A0A0P5LRL7   A0A0M4F2I2   A0A0P5GE64   A0A2M4BB49   A0A0R1E5W8   A0A2M4BBD6   A0A2M4BBB0   A0A2M4CUS9   A0A2M4CJJ1   A0A1I8JVB2   Q7PXC3   A0A0P5UCP7   Q1LZ40   A0A2M3Z5G8   A0A423ST97   A0A0A9ZBC7   V5IB95   V5H7R8   P30430   A0A293M166   A0A0P5YQS3   A0A0P5PKW8   A0A139WPK4   A0A0P8ZYW4   A0A088AAQ3   A0A1W4VK02   A0A293MYV8   E9GW88   A0A0K2UFU4   A0A0P5GJU5   A0A164LVR4   U4UME4   N6T225   A0A171A4N1   A0A0R3NK09   A0A0R3NJT9   A0A2T7NF47   B4GL59   A0A0P4WFA9   A0A1B6LWC5   A0A1B0GCW9  

EC Number

3.4.21.75

Pubmed

22118469    26354079    28004739    25348373    15544942    15632085    + More
17994087    17510324    8650241    25315136    21347285    17550304    12364791    14747013    17210077    25401762    25765539    1545235    8491178    10731132    12537572    18362917    19820115    18057021    21292972    23537049   

EMBL

GDQN01002618    GDQN01002399    JAT88436.1    JAT88655.1    NWSH01000634    PCG75136.1    + More
RSAL01000035    RVE51309.1    ODYU01012033    SOQ58118.1    PCG75135.1    AGBW02010967    OWR47458.1    KQ459585    KPI98386.1    NEVH01024418    PNF17448.1    LJIG01022461    KRT80455.1    GFDF01007653    JAV06431.1    GFDF01007654    JAV06430.1    GEDC01029050    JAS08248.1    GFTR01008057    JAW08369.1    GEZM01077633    JAV63227.1    GAKP01016893    JAC42059.1    KY653074    ATU47268.1    KY563396    ARK19805.1    GECZ01030000    GECZ01006849    JAS39769.1    JAS62920.1    AY682745    AAV74200.1    CM000070    EIM52965.2    CH477279    EAT45000.1    GEBQ01021727    JAT18250.1    GFDL01001616    JAV33429.1    L46373    AAC37262.1    OUUW01000008    SPP83990.1    KA648170    AFP62799.1    GECU01037000    JAS70706.1    GGMR01005168    MBY17787.1    ADTU01006445    ADTU01006446    GFXV01007606    MBW19411.1    GDIQ01145610    JAL06116.1    GDIQ01247683    JAK04042.1    GDIQ01243794    JAK07931.1    CH940650    KRF82871.1    GDIQ01206798    GDIQ01132577    GDIQ01117331    JAL19149.1    GDIQ01202199    GDIQ01069534    JAK49526.1    GDIQ01021367    JAN73370.1    GDIQ01166996    JAK84729.1    CP012526    ALC45295.1    GDIQ01243793    JAK07932.1    GGFJ01001070    MBW50211.1    CM000160    KRK04473.1    GGFJ01001202    MBW50343.1    GGFJ01001185    MBW50326.1    GGFL01004928    MBW69106.1    GGFL01001352    MBW65530.1    AAAB01008987    EAA01324.4    GDIP01114937    JAL88777.1    BT025186    ABF02288.1    GGFM01003009    MBW23760.1    QCYY01002810    ROT67420.1    GBHO01016547    GBHO01003116    GBHO01002963    GBHO01002961    JAG27057.1    JAG40488.1    JAG40641.1    JAG40643.1    GANP01015827    JAB68641.1    GANP01011359    JAB73109.1    M81431    L12370    L12369    L12372    AE014297    GFWV01009049    MAA33778.1    GDIP01054992    JAM48723.1    GDIQ01148322    JAL03404.1    KQ971307    KYB29761.1    CH902617    KPU79816.1    KPU79818.1    KPU79819.1    GFWV01020383    MAA45111.1    GL732569    EFX76306.1    HACA01019574    CDW36935.1    GDIQ01241425    JAK10300.1    LRGB01003123    KZS04479.1    KB632384    ERL94287.1    APGK01047137    APGK01047138    APGK01047139    KB741077    ENN74154.1    GEMB01001503    JAS01653.1    KRT01227.1    KRT01226.1    PZQS01000013    PVD19786.1    CH479185    EDW38283.1    GDRN01075266    JAI63082.1    GEBQ01011986    JAT27991.1    CCAG010002242    CCAG010002243   

Proteomes

UP000218220    UP000283053    UP000007151    UP000053268    UP000235965    UP000095300    + More
UP000001819    UP000008820    UP000268350    UP000095301    UP000005205    UP000008792    UP000092553    UP000002282    UP000075903    UP000007062    UP000283509    UP000000803    UP000007266    UP000007801    UP000005203    UP000192221    UP000000305    UP000076858    UP000030742    UP000019118    UP000245119    UP000008744    UP000092444   

PRIDE

Q1LZ40    P30430   

Pfam

PF00082   Peptidase_S8        + More
PF01483   P_proprotein
PF16470   S8_pro-domain

Interpro

IPR034182   Kexin/furin        + More
IPR023828   Peptidase_S8_Ser-AS       
IPR023827   Peptidase_S8_Asp-AS       
IPR002884   P_dom       
IPR009030   Growth_fac_rcpt_cys_sf       
IPR022398   Peptidase_S8_His-AS       
IPR008979   Galactose-bd-like_sf       
IPR036852   Peptidase_S8/S53_dom_sf       
IPR006212   Furin_repeat       
IPR015500   Peptidase_S8_subtilisin-rel       
IPR000209   Peptidase_S8/S53_dom       
IPR038466   S8_pro-domain_sf       
IPR032815   S8_pro-domain       

SUPFAM

SSF57184   SSF57184        + More
SSF52743   SSF52743       
SSF49785   SSF49785       

Gene 3D

2.60.120.260     3.40.50.200     3.30.70.850    

CDD

cd00064  FU
cd04059  Peptidases_S8_Protein_converta

ProteinModelPortal

A0A1E1WNT8   A0A2A4JTN4   A0A437BLV5   A0A2H1WYJ9   A0A2A4JSW4   A0A212F132   + More
A0A194PYH4   A0A2J7PM83   A0A0T6B0U1   A0A1L8DJ27   A0A1L8DJ92   A0A1B6C415   A0A224XK28   A0A1Y1KWI5   A0A034VHS7   A0A2H4N0P7   A0A1W6EVS5   A0A1I8PLP7   A0A1B6EPA7   Q5QDM4   I5APT0   Q17EV1   A0A1B6L3K3   A0A1Q3G0V1   Q16926   A0A3B0K7F6   A0A1I8MU29   T1PJ76   A0A1B6H7M9   A0A2S2NKX1   A0A158P1F2   A0A2H8U075   A0A0P5N8V2   A0A0N8ASC2   A0A0P5GAN4   A0A0Q9WLP1   A0A0P5PCZ8   A0A0P5JB96   A0A0P6HCS7   A0A0P5LRL7   A0A0M4F2I2   A0A0P5GE64   A0A2M4BB49   A0A0R1E5W8   A0A2M4BBD6   A0A2M4BBB0   A0A2M4CUS9   A0A2M4CJJ1   A0A1I8JVB2   Q7PXC3   A0A0P5UCP7   Q1LZ40   A0A2M3Z5G8   A0A423ST97   A0A0A9ZBC7   V5IB95   V5H7R8   P30430   A0A293M166   A0A0P5YQS3   A0A0P5PKW8   A0A139WPK4   A0A0P8ZYW4   A0A088AAQ3   A0A1W4VK02   A0A293MYV8   E9GW88   A0A0K2UFU4   A0A0P5GJU5   A0A164LVR4   U4UME4   N6T225   A0A171A4N1   A0A0R3NK09   A0A0R3NJT9   A0A2T7NF47   B4GL59   A0A0P4WFA9   A0A1B6LWC5   A0A1B0GCW9  

PDB

1P8J     E-value=0.00212272,     Score=96

KEGG

692448    K01349 furin [EC:3.4.21.75] | (RefSeq) furin-like convetase

GO

GO:0004252   GO:0016021   GO:0097688   GO:0005886   GO:0097090   GO:0000139   GO:0008039   GO:0001941   GO:0016020   GO:0016486   GO:0005802   GO:0030173   GO:0016485   GO:0006508   GO:0043565   GO:0004674   GO:0008270   GO:0045211   GO:0005975   GO:0004553  

Subcellular location

Golgi apparatus membrane  

Length:

337

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

22.61963

Exp number, first 60 AAs:

0.00071

Total prob of N-in:

0.44658

outside

1  -  262

TMhelix

263  -  285

inside

286  -  337

 

 

Pi

217.477782

Theta

178.004845

Tajima's D

0.630843

CLR

0.006658

CSRT

0.551972401379931

Interpretation

Uncertain