Gene

KWMTBOMO12499  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001502

Annotation

geranylgeranyltransferase_type_I_beta_subunit_[Bombyx_mori]

Location

Bomo_Chr21(+):5044505-5057323      View in EpiBrowser

Full name

Geranylgeranyl transferase type-1 subunit beta      

Alternative Name

Geranylgeranyl transferase type I subunit beta
Type I protein geranyl-geranyltransferase subunit beta

Location in the cell

Extracellular   Reliability : 1.538 PlasmaMembrane   Reliability : 1.724

CDS

ATGAATAACGAAGGAAACAAGGATATGGCTCATCGTCAGCACGTAAAATATTTCATGAGATTTTTGAATATTTTGCCTTCGTCTCTATCATCACACGATACTACAAGAGTTACAATAGCATATTTCTCTGTTGCCGGCCTGGATGTCTTAGGATCCATATCAGCAATATCTCTTGATCTGAGATCCAGGATTATTGAATGGTTGTATAGGCTTCAAGTACATCCTGATAAGGAAACGGGCGACATGTCACTATGCGGCTTCCAAGGCTCCTCAACGATAAACATAAGACTGGATCCGGATAACAATCAATTTCGATGCGGCCATCTAGCGATGACGTACACTGGTCTGTGCATACTGCTGGCGTTGGGCGATGACCTATCGAGAATCAACAGAACAGCCTTAATTCAAGGCGTGAAAGCGTTGCAGACGGACGAAGGGAACTTCTCGGCAACCCTGTCGGGCTGCGAGTCGGACATGCGGTTCGTGTATTGCGCTGCGTGTATCAGTTACATATTGAACGATTGGTCCGGCTTCGATATAGAGAAGGCCACAGATTACGTCATTAAATCTATAGGCTACGACTATGGCATCGCTCAATGTCCCGAGCTAGAATCCCACGGGGGTACGACGTTTTGTGCTCTGGCAACACTAGCGCTAACCGACCAATTGGACAAGCTATCCGAAGCGCAGATCGACGGTCTGAAGCGTTGGTTGGTTTACCGGCAAATCGACGGTTTTCAGGGGAGACCGAATAAGCCGGTCGACACGTGCTACAGTTTCTGGGTGGGCGCCTCGTTGAAGATACTGAACGCTTTACAGCTGACGAACTACGGCAGCAATAGGAGGTACGTGTACGAGACGCAGGATATGGTCGTGGGGGGTTTCTCGAAATGGCCGGACACGTGCACGGACCCCATGCACACGTATTTGGGCCTGTCCGGTTTGAGTTTGATAGGCGAGAGCGGTCTTCTAGAGATAGAACCAAGATTGAACATAACGAAACGGGCCTACGAACATTTGAAGTGTCTGCACGAACAGTGGGTGTCGTAG

Protein

MNNEGNKDMAHRQHVKYFMRFLNILPSSLSSHDTTRVTIAYFSVAGLDVLGSISAISLDLRSRIIEWLYRLQVHPDKETGDMSLCGFQGSSTINIRLDPDNNQFRCGHLAMTYTGLCILLALGDDLSRINRTALIQGVKALQTDEGNFSATLSGCESDMRFVYCAACISYILNDWSGFDIEKATDYVIKSIGYDYGIAQCPELESHGGTTFCALATLALTDQLDKLSEAQIDGLKRWLVYRQIDGFQGRPNKPVDTCYSFWVGASLKILNALQLTNYGSNRRYVYETQDMVVGGFSKWPDTCTDPMHTYLGLSGLSLIGESGLLEIEPRLNITKRAYEHLKCLHEQWVS

Description

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B (By similarity).

Catalytic Activity

geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]

Cofactor

Zn(2+)

Subunit

Heterodimer of FNTA and PGGT1B. PGGT1B mediates interaction with substrate peptides (By similarity).

Similarity

Belongs to the protein prenyltransferase subunit beta family.

Keywords

Complete proteome   Metal-binding   Prenyltransferase   Reference proteome   Repeat   Transferase   Zinc  

Feature

chain  Geranylgeranyl transferase type-1 subunit beta

Uniprot

D6RVZ4   A0A2A4K3P8   A0A2H1VLZ2   A0A0N0PB21   A0A194PZD2   A0A212F8B3   + More
H9IW71   A0A067RGQ2   A0A0K8TS57   A0A2J7PZS7   A0A084WH47   A0A2M4BRL2   A0A182F3H7   W5JAS0   A0A2M4AR28   A0A2M4CI48   A0A2M4BSG2   A0A2M4BRN7   Q17K57   A0A182M0T3   A0A182VUE6   A0A1Q3FCJ0   A0A1B6LQY0   A0A1Q3FCE5   A0A224XF49   B0XBT8   A0A182IUM4   A0A182YDS6   A0A023EQT2   A0A182RIR4   A0A182K8A7   A0A182L0H4   A0A069DTC3   A0A182SN11   A0A182HEH4   A0A182QX37   A0A182VD82   A0A1Q3FCI3   A0A1B6I2N9   A0A182U3Y5   Q7Q4H9   A0A182IC45   A0A182XFW1   A0A182PLT3   A0A182NU16   A0A1Y1KZU9   R4FLG1   A0A1L8DU25   A0A1B6GZH9   T1E9L3   A0A2R7VW16   A0A0L0C702   A0A0F7Z9D9   T1DBS6   A0A0B8RXM5   A0A2H6N614   A7SXB0   A0A1I8N947   W8BKP7   A0A1I8PKF4   A0A034VHI2   A0A0K8ULX0   A0A2Y9DLS1   A0A0A9WT78   A0A402FDF6   A0A384DL33   G1L1G2   A0A3Q7XAV5   D2HGS9   A0A0K8SRS5   A0A218UU77   H0YSW7   A0A1S3PK25   E2QZU5   A0A3Q7T2L3   A0A0Q9WBJ4   A0A0A1X7I4   G3ST05   B4LS59   A0A060W4I7   A0A3B4CCS5   F7BSD0   L5KLY1   A0A1S3W9P7   A0A369S4S4   A0A0Q3LTJ8   A0A286XNF3   W5MRC0   A0A341BAC8   A0A2U4BT74   A0A2Y9PLG6   Q5EAD5   A0A452G303   F6W1R0   A0A1A9UPJ5   A0A340WR36   A0A2Y9F6M6   M3X221   A0A2Y9I0N3   G1PXD6  

EC Number

2.5.1.59

Pubmed

26354079    22118469    19121390    24845553    26369729    24438588    + More
20920257    23761445    17510324    25244985    24945155    20966253    26334808    26483478    12364791    14747013    17210077    28004739    26108605    23758969    25727380    25476704    17615350    25315136    24495485    25348373    25401762    26823975    24813606    20010809    20360741    16341006    17994087    25830018    24755649    17495919    23258410    30042472    21993624    16305752    19892987    17975172   

EMBL

AB568272    BAJ09607.1    NWSH01000166    PCG78885.1    ODYU01003290    SOQ41855.1    + More
KQ461068    KPJ09878.1    KQ459585    KPI98403.1    AGBW02009774    OWR49949.1    BABH01005937    KK852693    KDR18308.1    GDAI01000414    JAI17189.1    NEVH01020332    PNF21830.1    ATLV01023789    KE525346    KFB49541.1    GGFJ01006586    MBW55727.1    ADMH02001920    ETN60498.1    GGFK01009925    MBW43246.1    GGFL01000836    MBW65014.1    GGFJ01006587    MBW55728.1    GGFJ01006588    MBW55729.1    CH477228    EAT47035.1    AXCM01003842    GFDL01009750    JAV25295.1    GEBQ01013826    GEBQ01009402    JAT26151.1    JAT30575.1    GFDL01009887    JAV25158.1    GFTR01005330    JAW11096.1    DS232653    EDS44467.1    GAPW01002135    JAC11463.1    GBGD01001992    JAC86897.1    JXUM01131599    JXUM01131600    KQ567733    KXJ69303.1    AXCN02000809    GFDL01009816    JAV25229.1    GECU01026510    JAS81196.1    AAAB01008964    EAA12255.4    APCN01000775    GEZM01068580    JAV66884.1    ACPB03003214    GAHY01002124    JAA75386.1    GFDF01004143    JAV09941.1    GECZ01001936    JAS67833.1    GAMD01001247    JAB00344.1    KK854121    PTY11652.1    JRES01000827    KNC28050.1    GBEX01001354    JAI13206.1    GAAZ01000959    GBKC01001429    GBKD01000865    JAA96984.1    JAG44641.1    JAG46753.1    GBSH01001148    JAG67877.1    IACI01056842    LAA25406.1    DS469882    EDO31665.1    GAMC01007214    GAMC01007213    JAB99342.1    GAKP01017370    GAKP01017368    GAKP01017366    JAC41582.1    GDHF01024622    JAI27692.1    GBHO01032590    GDHC01003939    JAG11014.1    JAQ14690.1    BDOT01000203    GCF54493.1    ACTA01043943    ACTA01051943    GL192821    EFB19790.1    GBRD01009762    JAG56062.1    MUZQ01000127    OWK57295.1    ABQF01045107    AAEX03007707    CH940649    KRF81842.1    GBXI01007190    GBXI01002049    JAD07102.1    JAD12243.1    EDW64745.1    FR904341    CDQ60159.1    KB030673    ELK11573.1    NOWV01000075    RDD41434.1    LMAW01003152    KQK73725.1    AAKN02023039    AAKN02023040    AHAT01002849    BT020634    LWLT01000010    AANG04002524    AAPE02000259   

Proteomes

UP000218220    UP000053240    UP000053268    UP000007151    UP000005204    UP000027135    + More
UP000235965    UP000030765    UP000069272    UP000000673    UP000008820    UP000075883    UP000075920    UP000002320    UP000075880    UP000076408    UP000075900    UP000075881    UP000075882    UP000075901    UP000069940    UP000249989    UP000075886    UP000075903    UP000075902    UP000007062    UP000075840    UP000076407    UP000075885    UP000075884    UP000015103    UP000037069    UP000001593    UP000095301    UP000095300    UP000248480    UP000288954    UP000261680    UP000291021    UP000008912    UP000286642    UP000197619    UP000007754    UP000087266    UP000002254    UP000286640    UP000008792    UP000007646    UP000193380    UP000261440    UP000002280    UP000010552    UP000079721    UP000253843    UP000051836    UP000005447    UP000018468    UP000252040    UP000245320    UP000248483    UP000009136    UP000291000    UP000002281    UP000078200    UP000265300    UP000248484    UP000011712    UP000248481    UP000001074   

PRIDE

D6RVZ4    H9IW71    Q5EAD5   

Pfam

PF00432   Prenyltrans

Interpro

IPR008930   Terpenoid_cyclase/PrenylTrfase        + More
IPR001330   PFTB_repeat       
IPR041960   GGTase_I_beta       

SUPFAM

SSF48239   SSF48239       

CDD

cd02895  GGTase-I

ProteinModelPortal

D6RVZ4   A0A2A4K3P8   A0A2H1VLZ2   A0A0N0PB21   A0A194PZD2   A0A212F8B3   + More
H9IW71   A0A067RGQ2   A0A0K8TS57   A0A2J7PZS7   A0A084WH47   A0A2M4BRL2   A0A182F3H7   W5JAS0   A0A2M4AR28   A0A2M4CI48   A0A2M4BSG2   A0A2M4BRN7   Q17K57   A0A182M0T3   A0A182VUE6   A0A1Q3FCJ0   A0A1B6LQY0   A0A1Q3FCE5   A0A224XF49   B0XBT8   A0A182IUM4   A0A182YDS6   A0A023EQT2   A0A182RIR4   A0A182K8A7   A0A182L0H4   A0A069DTC3   A0A182SN11   A0A182HEH4   A0A182QX37   A0A182VD82   A0A1Q3FCI3   A0A1B6I2N9   A0A182U3Y5   Q7Q4H9   A0A182IC45   A0A182XFW1   A0A182PLT3   A0A182NU16   A0A1Y1KZU9   R4FLG1   A0A1L8DU25   A0A1B6GZH9   T1E9L3   A0A2R7VW16   A0A0L0C702   A0A0F7Z9D9   T1DBS6   A0A0B8RXM5   A0A2H6N614   A7SXB0   A0A1I8N947   W8BKP7   A0A1I8PKF4   A0A034VHI2   A0A0K8ULX0   A0A2Y9DLS1   A0A0A9WT78   A0A402FDF6   A0A384DL33   G1L1G2   A0A3Q7XAV5   D2HGS9   A0A0K8SRS5   A0A218UU77   H0YSW7   A0A1S3PK25   E2QZU5   A0A3Q7T2L3   A0A0Q9WBJ4   A0A0A1X7I4   G3ST05   B4LS59   A0A060W4I7   A0A3B4CCS5   F7BSD0   L5KLY1   A0A1S3W9P7   A0A369S4S4   A0A0Q3LTJ8   A0A286XNF3   W5MRC0   A0A341BAC8   A0A2U4BT74   A0A2Y9PLG6   Q5EAD5   A0A452G303   F6W1R0   A0A1A9UPJ5   A0A340WR36   A0A2Y9F6M6   M3X221   A0A2Y9I0N3   G1PXD6  

PDB

1TNZ     E-value=1.4356e-90,     Score=848

KEGG

100463493    K11713 geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59] | (RefSeq) geranylgeranyltransfe

GO

GO:0016740   GO:0003824   GO:0018342   GO:0005953   GO:0018344   GO:0016021   GO:0004661   GO:0035050   GO:0001955   GO:0008270   GO:0004662   GO:0005840   GO:0006412   GO:0005622   GO:0045211   GO:0005975   GO:0004553  

Length:

349

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

8.72927000000001

Exp number, first 60 AAs:

6.43845

Total prob of N-in:

0.29488

outside

1  -  349

 

 

Pi

303.427455

Theta

185.423537

Tajima's D

0.707305

CLR

0.310617

CSRT

0.570121493925304

Interpretation

Uncertain