Gene

KWMTBOMO12469

Pre Gene Modal

BGIBMGA001494

Annotation

PREDICTED:_solute_carrier_family_25_member_46-A-like_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr21(+):4560983-4569447      View in EpiBrowser

Full name

Lysine--tRNA ligase      

Alternative Name

Lysyl-tRNA synthetase

Location in the cell

PlasmaMembrane   Reliability : 3.324

CDS

ATGGCAGGTTTCGGAGATCATTCCGGTTATAACCGACCGTTTGGTTTAGATCCTAATCGAGAAACGAATGATTTATACGATACCCGTTACCAGCAGATTTATGGGTACCATACTCCAATTACTGAAGAGTTTCAAGGACCACCTCTTGTTATGGATGAAAACCCAGATGAAGATAACAATGCTTATATAACAACCGCAATAAGTGTAGCAAGTCTTTTAACAGAGAATTTGTTAAGTCATCCATTCATTGTACTCAGAAGACAATGTCAGGTCCATAACAATCTAAGGAACTATCACATAGTTCCTTACACTCTGTTACCTGTAGTAGTGAGACTACACAGGAGACAAGATGTCACAACTCTCTGGAAAGGGATTGGCTCCACTTGCATTGTGAGGGGTTTGAATTTAGCCGTTGAAGATGCTGTAGCCAAGGGCACTGGTTGGCCTAAGGAGGTGAACAAGTGCAATTCTGTTTTGCAATTTGTCCAGCACATAGCTCTAAAAAGCCTAAGTTTGGCATTAATAACTCCATTCTATTCTGCGAGCTTGGTAGAAACAGTGCAGAGTGATATCGCCAGTGACAAACCAGCTCTATTTGATGTGTTCAGAGAGGGATTTGTTCGTATACTCGAGTGGGGCACACCCAGTAAAGGACGCATGTTACCAATATGGGCAATTGTACTACCTACTGTAGCCCTAGGCGTTTCTAAATATATCTCACATATTACACTGAGAAGTTTAACTGCAAGAATACTCCGGTTCCAACAACGGCATAGGCATGAGCTGAGCGATTCATACAATTACAGCAAAAATGTACAGAATCCTCTTATAGAAGATATCAATCTGAAAGCAAACATTTTCTCATTTATTACTATGGAAATACTTTTTTATCCAGTGGAGACTATAATACATAGACTTCATATACAGGGTACTAGAACAATCATTGATAATTTAGACACAGGAACATCAGTGACACCTATTCTAACAGGATATGAAGGTTTCATGGACTGTTATAATACAACAATAGCCCGGGAAGGAATTTCAGGGTTGTACAAAGGGTTTGGTGCGCTAGTACTGCAGCTTGTAGCTCATATTTCAATAATTAAACTCACTACAATTGTAGTTACTGAAATAACGAACCTGTTGAAGCCTGTCAAGTCTCCTACAAACTCTGATGATCATACACAACAAAAGTACTTGTTTAATTAG

Protein

MAGFGDHSGYNRPFGLDPNRETNDLYDTRYQQIYGYHTPITEEFQGPPLVMDENPDEDNNAYITTAISVASLLTENLLSHPFIVLRRQCQVHNNLRNYHIVPYTLLPVVVRLHRRQDVTTLWKGIGSTCIVRGLNLAVEDAVAKGTGWPKEVNKCNSVLQFVQHIALKSLSLALITPFYSASLVETVQSDIASDKPALFDVFREGFVRILEWGTPSKGRMLPIWAIVLPTVALGVSKYISHITLRSLTARILRFQQRHRHELSDSYNYSKNVQNPLIEDINLKANIFSFITMEILFYPVETIIHRLHIQGTRTIIDNLDTGTSVTPILTGYEGFMDCYNTTIAREGISGLYKGFGALVLQLVAHISIIKLTTIVVTEITNLLKPVKSPTNSDDHTQQKYLFN

Catalytic Activity

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)

Similarity

Belongs to the mitochondrial carrier (TC 2.A.29) family.

Uniprot

A0A3S2PHC9   A0A212FLC2   S4PS34   A0A2H1W9F0   A0A2A4JM08   A0A194PZA2   + More
A0A194RPN1   A0A2P8ZC01   A0A0T6BFM2   Q16XZ0   A0A1S4FK72   A0A1Q3G2F2   A0A182HS89   A0A023F9P1   A0A182V973   A0A182LE70   Q7PQY0   U5ERT7   A0A182XAF0   A0A182U9G6   A0A182RTI5   A0A182PL56   A0A2M4BPF6   A0A182LV47   A0A182NR60   A0A2M4AI87   A0A2M3Z8A0   A0A2M4BNR0   A0A2M4BNR5   A0A2M4AHR6   A0A2M4AHW7   N6TKY0   T1HS92   A0A0P4VLB5   A0A182K3D9   W5JQ94   A0A224XRE7   A0A0K8TMY9   A0A182Y414   A0A0V0G7A8   A0A069DT22   A0A0L0CIM7   R4FKT1   A0A1A9UQB6   A0A1B0GA09   A0A0K8V3K1   A0A182QXK9   A0A1A9X8S6   A0A1B0C3A9   A0A034WLM3   A0A0A1XR71   A0A1A9ZEH7   W8CDN6   B4PXA5   A0A1I8NH60   A0A1I8NH52   Q9VXK8   A0A1I8PSJ5   A0A1I8PSG3   B4JX37   A0A1J1J6D2   B3NXG3   A0A336KEK8   A0A182VZV3   B4L6Y3   B4R5K6   A0A1W4VG58   A0A067QQG7   A0A0M4EN53   A0A0A9X8A3   B4MJ77   B3MPW7   A0A1B6DH59   A0A0P9AXA5   B4MA55   A0A0P8YKV4   A0A2R7WJ47   B4HCQ9   D6W807   A0A3B0K191   A0A087ZU62   A0A182GYW9   A0A1B6I2G2   E0VRK5   E2BNR4   A0A0N0BHY1   A0A1Y1LJK4   B0W6T3   A0A084VB74   A0A182FPH8   A0A2A3EH13   A0A1J1J949   E2AE71   A0A151I9T7   A0A026WGK3   A0A151HYQ5   A0A1W4WQ62   F4X481   A0A158N9I2  

EC Number

6.1.1.6

Pubmed

22118469    23622113    26354079    29403074    17510324    25474469    + More
20966253    12364791    14747013    17210077    23537049    27129103    20920257    23761445    26369729    25244985    26334808    26108605    25348373    25830018    24495485    17994087    17550304    25315136    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    24845553    25401762    26823975    18362917    19820115    26483478    20566863    20798317    28004739    24438588    24508170    30249741    21719571    21347285   

EMBL

RSAL01000033    RVE51513.1    AGBW02007840    OWR54490.1    GAIX01000275    JAA92285.1    + More
ODYU01007046    SOQ49472.1    NWSH01001068    PCG72816.1    KQ459585    KPI98373.1    KQ459896    KPJ19364.1    PYGN01000109    PSN54025.1    LJIG01000806    KRT86134.1    CH477529    EAT39488.1    GFDL01001048    JAV33997.1    APCN01000254    GBBI01000993    JAC17719.1    AAAB01008859    EAA08135.6    GANO01003568    JAB56303.1    GGFJ01005816    MBW54957.1    AXCM01000657    GGFK01007121    MBW40442.1    GGFM01003917    MBW24668.1    GGFJ01005578    MBW54719.1    GGFJ01005579    MBW54720.1    GGFK01006999    MBW40320.1    GGFK01007062    MBW40383.1    APGK01020335    KB740193    KB631669    ENN81079.1    ERL85193.1    ACPB03019084    GDKW01003182    JAI53413.1    ADMH02000776    ETN65075.1    GFTR01005845    JAW10581.1    GDAI01002313    JAI15290.1    GECL01002200    JAP03924.1    GBGD01001641    JAC87248.1    JRES01000325    KNC32263.1    GAHY01002364    JAA75146.1    CCAG010018793    GDHF01018835    JAI33479.1    AXCN02001472    JXJN01024889    GAKP01003393    JAC55559.1    GBXI01001214    JAD13078.1    GAMC01001631    JAC04925.1    CM000162    EDX01868.1    AE014298    AY051504    AAF48551.1    AAK92928.1    CH916376    EDV95313.1    CVRI01000072    CRL07530.1    CH954180    EDV46922.1    UFQS01000372    UFQT01000372    SSX03274.1    SSX23640.1    CH933812    EDW06129.1    CM000366    EDX18051.1    KK853048    KDR12085.1    CP012528    ALC49346.1    GBHO01030285    GBHO01030284    GDHC01019906    GDHC01012543    JAG13319.1    JAG13320.1    JAP98722.1    JAQ06086.1    CH963738    EDW72166.2    CH902621    EDV44729.1    GEDC01012281    JAS25017.1    KPU81721.1    CH940655    EDW66114.2    KPU81719.1    KK854868    PTY19351.1    CH479397    EDW29846.1    KQ971307    EFA11016.1    OUUW01000011    SPP86442.1    JXUM01098402    KQ564417    KXJ72322.1    GECU01026585    JAS81121.1    DS235478    EEB16011.1    GL449444    EFN82673.1    KQ435737    KOX76892.1    GEZM01055671    JAV72988.1    DS231849    EDS36914.1    ATLV01006052    KE524335    KFB35218.1    KZ288260    PBC30446.1    CRL07529.1    GL438827    EFN68304.1    KQ978264    KYM95839.1    KK107260    QOIP01000001    EZA54199.1    RLU27262.1    KQ976715    KQ976461    KYM76928.1    KYM84711.1    GL888628    EGI58749.1    ADTU01009655   

Proteomes

UP000283053    UP000007151    UP000218220    UP000053268    UP000053240    UP000245037    + More
UP000008820    UP000075840    UP000075903    UP000075882    UP000007062    UP000076407    UP000075902    UP000075900    UP000075885    UP000075883    UP000075884    UP000019118    UP000030742    UP000015103    UP000075881    UP000000673    UP000076408    UP000037069    UP000078200    UP000092444    UP000075886    UP000092443    UP000092460    UP000092445    UP000002282    UP000095301    UP000000803    UP000095300    UP000001070    UP000183832    UP000008711    UP000075920    UP000009192    UP000000304    UP000192221    UP000027135    UP000092553    UP000007798    UP000007801    UP000008792    UP000008744    UP000007266    UP000268350    UP000005203    UP000069940    UP000249989    UP000009046    UP000008237    UP000053105    UP000002320    UP000030765    UP000069272    UP000242457    UP000000311    UP000078542    UP000053097    UP000279307    UP000078540    UP000192223    UP000007755    UP000005205   

PRIDE

Q9VXK8   

Pfam

PF00153   Mito_carr        + More
PF03366   YEATS
PF17793   AHD
PF00096   zf-C2H2
PF07776   zf-AD
PF00152   tRNA-synt_2
PF01336   tRNA_anti-codon

Interpro

IPR018108   Mitochondrial_sb/sol_carrier        + More
IPR023395   Mt_carrier_dom_sf       
IPR039158   SLC25A46       
IPR005033   YEATS       
IPR038704   YEAST_sf       
IPR040930   AF-9_AHD       
IPR013087   Znf_C2H2_type       
IPR036236   Znf_C2H2_sf       
IPR012934   Znf_AD       
IPR004365   NA-bd_OB_tRNA       
IPR004364   aa-tRNA-synt_II       
IPR018149   Lys-tRNA-synth_II_C       
IPR012340   NA-bd_OB-fold       
IPR006195   aa-tRNA-synth_II       
IPR002313   Lys-tRNA-ligase_II       

SUPFAM

SSF103506   SSF103506        + More
SSF57667   SSF57667       
SSF50249   SSF50249       

Gene 3D

1.50.40.10     2.60.40.1970    

CDD

cd00775  LysRS_core

ProteinModelPortal

A0A3S2PHC9   A0A212FLC2   S4PS34   A0A2H1W9F0   A0A2A4JM08   A0A194PZA2   + More
A0A194RPN1   A0A2P8ZC01   A0A0T6BFM2   Q16XZ0   A0A1S4FK72   A0A1Q3G2F2   A0A182HS89   A0A023F9P1   A0A182V973   A0A182LE70   Q7PQY0   U5ERT7   A0A182XAF0   A0A182U9G6   A0A182RTI5   A0A182PL56   A0A2M4BPF6   A0A182LV47   A0A182NR60   A0A2M4AI87   A0A2M3Z8A0   A0A2M4BNR0   A0A2M4BNR5   A0A2M4AHR6   A0A2M4AHW7   N6TKY0   T1HS92   A0A0P4VLB5   A0A182K3D9   W5JQ94   A0A224XRE7   A0A0K8TMY9   A0A182Y414   A0A0V0G7A8   A0A069DT22   A0A0L0CIM7   R4FKT1   A0A1A9UQB6   A0A1B0GA09   A0A0K8V3K1   A0A182QXK9   A0A1A9X8S6   A0A1B0C3A9   A0A034WLM3   A0A0A1XR71   A0A1A9ZEH7   W8CDN6   B4PXA5   A0A1I8NH60   A0A1I8NH52   Q9VXK8   A0A1I8PSJ5   A0A1I8PSG3   B4JX37   A0A1J1J6D2   B3NXG3   A0A336KEK8   A0A182VZV3   B4L6Y3   B4R5K6   A0A1W4VG58   A0A067QQG7   A0A0M4EN53   A0A0A9X8A3   B4MJ77   B3MPW7   A0A1B6DH59   A0A0P9AXA5   B4MA55   A0A0P8YKV4   A0A2R7WJ47   B4HCQ9   D6W807   A0A3B0K191   A0A087ZU62   A0A182GYW9   A0A1B6I2G2   E0VRK5   E2BNR4   A0A0N0BHY1   A0A1Y1LJK4   B0W6T3   A0A084VB74   A0A182FPH8   A0A2A3EH13   A0A1J1J949   E2AE71   A0A151I9T7   A0A026WGK3   A0A151HYQ5   A0A1W4WQ62   F4X481   A0A158N9I2  

PDB

4C9Q     E-value=0.0160614,     Score=90

KEGG

101743465    K03454 solute carrier family 25, member 46 | (RefSeq) solute carrier family 25 member 46-like

GO

GO:0016021   GO:0090149   GO:0005741   GO:0006355   GO:0005634   GO:0003676   GO:0008270   GO:0005737   GO:0006430   GO:0005524   GO:0004824  

PANTHER

PTHR21252   PTHR23195  

Subcellular location

Nucleus  

Length:

402

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

25.34436

Exp number, first 60 AAs:

0.00471

Total prob of N-in:

0.04020

outside

1  -  402

 

 

Pi

50.254339

Theta

153.502769

Tajima's D

-0.431333

CLR

14.47765

CSRT

0.259737013149343

Interpretation

Uncertain