Silkworm Genome Informatics Database

Gene

KWMTBOMO12461 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001490

Annotation

45_kDa_immunophilin_FKBP45_[Bombyx_mori]

Location

Bomo_Chr21(+):4421493-4426609 View in EpiBrowser

Full name

FK506-binding protein + More
46 kDa FK506-binding nuclear protein

Alternative Name

Peptidyl-prolyl cis-trans isomerase
Rotamase

Location in the cell

Nuclear Reliability : 4.668

CDS

ATGTTTTGGGGATTAATAATGGAACCCAACAAACGGTACACCCAAGTGGTGGAGAAGCCGTTCCACATTTCACAGGCTGCTATGGACACATCAACTGGTGATAATGAGCCATGTCAAGTGATGGTTGTTGTTGATGGAAAGAACTTTCTCGTGTGCACTCTCCAGAAAAACAAATGCATTCAAGTTCCACTTGACTTGTATTTCAAAACAGGAGACTCTATTGCCTTTTTGACTAATGGTAAATGCAATGTACATCTAACTGGATACTTGGACCCTGAGTTTGAGGATGAGCAGTCAGAGGATGAGGAAGAGGTTGAAGAAGAAGAGGAAGAAACTTCAGCACCTATCAACAACAAAAGGAAACTTGAAAACAATACTAATGCTACTGCCAGCAAGAAAGCCAAGCCAGATAAAAAAACTGCAAAAAAAACAGCTGCAGCTGAGAGCTCAGATGATGATGATGATGATGATGAGGAAGATCAACTTCAGAAATTGTTGGATGGTGAAGATATTGACACAGATGAAAATGATGACTCATTCAAAATGAATACTTCTGGTGATGCTAGTGATGATGAAGATGAAGAGGATTCTGATGAAGAAGAAGGTGATGATGATGATAAAGATGAAGAGTCTGAGGAGGCTGAAACCACTTTGGATACAAGTAAGGAAGAATCCAAAGTTGATACTTCCAAGCTTACCAAGTCACAGAAACGGAGACTCAAGAAGAAACAAAAGCAACAAGAAAAAGCCCAAGGACAGGTGAATGGTGTTGACAAACCCAAGAAAGAGAAAGCAGAACCACAAAAAACTGAAAAGAAAAAGGCTGCAGCTAAAAAAGAAAATGAGGAGGGTCCAATTGAAAAAAAGGAGAAGAAAGCTCTCAGTGGTGGAGTACAAATTGAGGACCTGAAACTTGGTAATGGTCCTGTTGCTAAGCCAGGCAAAGTTGTCATGGTCTACTATGAAGGTCGCCTTAAACAAAACAACAAAATGTTTGACAACTGCCTCAAGGGACCTGGATTCAAGTTCCGTCTTGGCGCAAAAGAGGTCATTAGCGGCTGGGATGTTGGTGTTTCTGGTATGAAAGTCGGAGGCAAAAGGAAGATTATCTGCCCTCCCGGCATGGCGTATGGTGCAAAAGGCTCTCCTCCAGTTATTCCACCTAACTCCACCTTAGTATTTGAAGTTGAATTGAAGAATGTTAAGTGA

Protein

MFWGLIMEPNKRYTQVVEKPFHISQAAMDTSTGDNEPCQVMVVVDGKNFLVCTLQKNKCIQVPLDLYFKTGDSIAFLTNGKCNVHLTGYLDPEFEDEQSEDEEEVEEEEEETSAPINNKRKLENNTNATASKKAKPDKKTAKKTAAAESSDDDDDDDEEDQLQKLLDGEDIDTDENDDSFKMNTSGDASDDEDEEDSDEEEGDDDDKDEESEEAETTLDTSKEESKVDTSKLTKSQKRRLKKKQKQQEKAQGQVNGVDKPKKEKAEPQKTEKKKAAAKKENEEGPIEKKEKKALSGGVQIEDLKLGNGPVAKPGKVVMVYYEGRLKQNNKMFDNCLKGPGFKFRLGAKEVISGWDVGVSGMKVGGKRKIICPPGMAYGAKGSPPVIPPNSTLVFEVELKNVK

Catalytic Activity

[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)

Similarity

Belongs to the FKBP-type PPIase family.

Keywords

DNA-binding Isomerase Nucleus Phosphoprotein Rotamase

Feature

chain 46 kDa FK506-binding nuclear protein

Uniprot

Q4JI71 A0A3S2P3K6 S4P542 A0A2A4JNK4 A0A2H1WHJ0 Q26486 + More

EC Number

5.2.1.8

Pubmed

19121390 23622113 7527037

EMBL

BABH01005868 DQ085777 AAY86706.1 RSAL01000033 RVE51506.1 GAIX01005724 + More
JAA86836.1 NWSH01000891 PCG73655.1 ODYU01008712 SOQ52533.1 U15038

Proteomes

UP000005204 UP000283053 UP000218220

PRIDE

Q4JI71 Q26486

Pfam

PF00254 FKBP_C + More
PF17800 NPL

Interpro

IPR023566   PPIase_FKBP        + More
IPR041232   NPL
IPR001179   PPIase_FKBP_dom

ProteinModelPortal

Q4JI71 A0A3S2P3K6 S4P542 A0A2A4JNK4 A0A2H1WHJ0 Q26486 + More

PDB

4DZ3 E-value=1.65153e-21, Score=253

KEGG

692771 K14826 FK506-binding nuclear protein [EC:5.2.1.8] | (RefSeq) Fkbp45; 45 kDa immunophilin FKBP45

GO

GO:0003755 GO:0003677 GO:0005634 GO:0006457 GO:0005622 GO:0005840 GO:0006412 GO:0015934 GO:0005216 GO:0016021 GO:0045211 GO:0005975 GO:0004553

PANTHER

PTHR43811:SF19

Subcellular location

Nucleus

Length:

402

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00064

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00147

outside

1 - 402

Pi

201.51337

Theta

185.834888

Tajima's D

0.285863

CLR

0.221921

CSRT

0.448977551122444

Interpretation

Uncertain

Source	Sequence	Identity	Evalue
26822097	TGDSIAFITNGK	100.00	1e-18
26280517	YPIEHGIITNWDDMEK	100.00	1e-18
27102218	MFDNCIK	100.00	1e-18
28467696	YTQSNSVCFAR	100.00	1e-18
26822097	VVMVYYEGR	100.00	0.002
26280517	EANIAAYSGKPINF	100.00	0.002
24402669	EVIIEGIQVEEEGIPDIIR	100.00	0.002
27102218	VVMVYYEGR	100.00	0.002
28467696	EVISFSK	100.00	0.002
28556443	EVISGWDVGVSGMK	100.00	0.002
28556443	EVISGWDVGVSGMK	100.00	0.002
28556443	CIQVPLDLYFK	100.00	0.002
28556443	CIQVPLDLYFK	100.00	0.002
28556443	MFWGLIMEPNK	100.00	0.003
28556443	MFWGLIMEPNK	100.00	0.003
26822097	KAISGGVQIEDIK	100.00	0.005
26280517	IVETYAFGDKK	100.00	0.005
28467696	KIHSQQISAPAGIGR	100.00	0.005
26822097	IIDGEDIDTDENDDSFK	100.00	0.012
26280517	IGAIDATVHTTMASR	100.00	0.012
27102218	AISGGVQIEDIK	100.00	0.012
28467696	IICIIVGDQNDVAAFK	100.00	0.012
28556443	IICPPGMAYGAK	100.00	0.012
28556443	EVISGWDVGVSGMK	100.00	0.012
28556443	VVMVYYEGR	100.00	0.012

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics