Gene

KWMTBOMO12449  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002363

Annotation

PREDICTED:_pre-mRNA-splicing_factor_RBM22_isoform_X1_[Amyelois_transitella]

Location

Bomo_Chr21(-):4269382-4272484      View in EpiBrowser

Full name

Pre-mRNA-splicing factor RBM22      

Alternative Name

RNA-binding motif protein 22

Location in the cell

Nuclear   Reliability : 3.319

CDS

ATGGCTACATCGAAGTCAACAAACACATACAATCGTCAGAATTGGGAAGACGCCGATTTTCCAATATTGTGCCAAACATGTCTTGGAGATAACCCTTACATTAGAATGACTAAAGAAAAATACGGTAAAGAATGTAAAATATGCTCAAGACCTTTCACAGTGTTTCGATGGTGTCCCGGAGCAAGAATGCGTTTCAAGAAAACAGAAATATGTCAGACCTGTTCGAAACTGAAAAATGTTTGTCAAACATGTTTATTGGATTTGGAATATGGTCTGCCAATCCAAGTGAGAGATGCTGCATTAAAAGTTCAGGATGACCTACCTCGAAACGAAGTAAACAAGGAATATTACATACAAAACTTGGAGAGTCAGCTGTCTAACTCTGATCCAACACAGCCAACCAATTCTCTAAAATCTAAAGGATCGTCCGATTTGTTGGTGCGGTTAGCTAGAACAGCTCCATATTATAAGAGGAATAGACCGCACGTGTGCTCGTTTTGGGTCAAAGGAGAATGTAGACGAGGGGAAGAATGTCCGTATCGTCACGAGAAGCCAACAGATCCTGATGATCCACTAGCTGATCAGAACATTAAAGACAGGTATTATGGTGTAAATGATCCAGTAGCTGAGAAGCTTATGCGTCGTGCTGCTGCAATGCCTGCTCTACCTCCACCTGAAGACAAAACTGTTACTACCTTGTATGTTGGTAATCTTCCTGATAATGTCACTGAGGACGAGCTTAGAGGCCACTTTTACCAATATGGTGAAATTAGATGTTTGACTCTTGTACCTCGAGCCCAGTGTGCCTTTGTGCAATATACTTCAAGAAATGCTGCAGAACATGCTGCAGAAAAGACTTTCAATCGTCTTGTTATTTTTGGCAAGAGACTGACAATCAAATGGGGTAAATCGCAAGGACGACAAGGACTTACTGAGAAGAATGATGGTGTACCCATGTTGGAACCAGTTCCTGGATTGCCTGGGACGTTGCCACCACCCCCTGCATATTTACATCCATTCCCGCCACAAATGCCACCACCCCCGAACCGTCCGAACGATTTCTTCAACTTGCACCACTATGGTGGTCCGGGCTGGGGACCGTGGGGTCCGCCTGGCATGGCGCCGCCCCCGCCTCCGGCTCCGCTCCCGGCCCCGCTCCGCCTGCACTACCCTAGCCAGGACCCCGCGCGTCTCGGGGCCCACGCACACACCAACGCGCCGCAAATTTAG

Protein

MATSKSTNTYNRQNWEDADFPILCQTCLGDNPYIRMTKEKYGKECKICSRPFTVFRWCPGARMRFKKTEICQTCSKLKNVCQTCLLDLEYGLPIQVRDAALKVQDDLPRNEVNKEYYIQNLESQLSNSDPTQPTNSLKSKGSSDLLVRLARTAPYYKRNRPHVCSFWVKGECRRGEECPYRHEKPTDPDDPLADQNIKDRYYGVNDPVAEKLMRRAAAMPALPPPEDKTVTTLYVGNLPDNVTEDELRGHFYQYGEIRCLTLVPRAQCAFVQYTSRNAAEHAAEKTFNRLVIFGKRLTIKWGKSQGRQGLTEKNDGVPMLEPVPGLPGTLPPPPAYLHPFPPQMPPPPNRPNDFFNLHHYGGPGWGPWGPPGMAPPPPPAPLPAPLRLHYPSQDPARLGAHAHTNAPQI

Description

Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.

Subunit

Component of the pre-catalytic and catalytic spliceosome complexes. Component of the postcatalytic spliceosome P complex.

Similarity

Belongs to the SLT11 family.

Keywords

Complete proteome   Cytoplasm   Developmental protein   Metal-binding   mRNA processing   mRNA splicing   Nucleus   Reference proteome   RNA-binding   Spliceosome   Zinc   Zinc-finger  

Feature

chain  Pre-mRNA-splicing factor RBM22

Uniprot

H9IYM9   A0A2A4JZD6   A0A437BLZ6   A0A2H1W9Y3   A0A194RFX9   A0A194Q028   + More
S4NSX0   A0A212FK43   A0A0L7LIH4   A0A2P8Z4J5   A0A2J7Q028   A0A0L7QQG2   A0A1B6ME92   A0A1B6I9I3   E2ABI2   A0A1B6F802   A0A310SFR3   A0A026WDM4   A0A195DV40   A0A2A3E1N9   A0A088AA93   A0A154PFY2   T1HSL9   A0A151I648   A0A158NSN0   A0A195EWS4   U4UP50   A0A1Y1N1G3   A0A0A9WE08   A0A023F4S6   A0A224XBU7   A0A0P4VVH9   A0A0V0G8K8   A0A069DUC6   K7IV25   E9ISD3   A0A0C9RMA2   A0A3P8VR60   A0A1A7WFT3   E2C802   A0A3B4DXG8   G9KKG3   A0A3Q2ZQ23   A0A0D9SCD2   A0A1A8S5V8   A0A1A8QKL7   A0A1A8DU49   A0A1A8UF43   Q6P616   A0A2K6V3K5   A0A1A8I096   A0A2I4B7K1   A0A2K5EFV4   A0A2K5RS79   U3DF69   H2LJT2   A0A3P9JU52   A0A0S7LE07   A0A3B3BEC6   A0A341ADM5   A0A3Q7Q430   A0A2D0SY08   A0A1S3CVF3   A0A0P6JBH5   A0A1U7QIN5   A0A250Y0K3   H0UXE0   A0A2K6CJJ1   A0A2K6MK02   G1T1G7   G1PCS9   G3RAZ8   G1LD30   G1RHG3   A0A2K5Z0B5   A0A452ESB3   G3SYJ2   A0A2U3V6I4   A0A3Q7NMY5   A0A340WLW8   A0A2R9B305   A0A096N735   A0A2Y9FAQ6   A0A2K6R5N5   A0A2Y9HM80   M3WPJ5   A0A2K5NNP0   A0A2Y9ISK1   A0A3Q7TSP1   A0A3P4LT42   A0A2Y9PSH0   A0A1U7TVT4   F2Z4G3   M3YQP8   A0A2K5HTL7   A0A384AMW6   A0A452SKA6   A0A3Q7W055   H2PH39   A0A384C7D3  

Pubmed

19121390    26354079    23622113    22118469    26227816    29403074    + More
20798317    24508170    30249741    21347285    23537049    28004739    25401762    26823975    25474469    27129103    26334808    20075255    21282665    24487278    23236062    25243066    17554307    29451363    28087693    21993624    22398555    20010809    22722832    25362486    17975172    19393038    24813606   

EMBL

BABH01037876    NWSH01000372    PCG76873.1    RSAL01000033    RVE51496.1    ODYU01007251    + More
SOQ49863.1    KQ460211    KPJ16507.1    KQ459585    KPI98349.1    GAIX01013872    JAA78688.1    AGBW02008159    OWR54086.1    JTDY01001003    KOB75144.1    PYGN01000199    PSN51415.1    NEVH01020327    PNF21931.1    KQ414786    KOC60857.1    GEBQ01005752    JAT34225.1    GECU01024100    JAS83606.1    GL438255    EFN69209.1    GECZ01023434    JAS46335.1    KQ765605    OAD53866.1    KK107260    QOIP01000001    EZA54063.1    RLU26895.1    KQ980322    KYN16612.1    KZ288466    PBC25444.1    KQ434896    KZC10732.1    ACPB03008326    KQ976400    KYM92661.1    ADTU01025062    ADTU01025063    KQ981948    KYN32601.1    KB632308    ERL91926.1    GEZM01015396    JAV91689.1    GBHO01038841    GBHO01038839    GBRD01002990    GDHC01002015    JAG04763.1    JAG04765.1    JAG62831.1    JAQ16614.1    GBBI01002733    JAC15979.1    GFTR01006561    JAW09865.1    GDKW01000010    JAI56585.1    GECL01001766    JAP04358.1    GBGD01001334    JAC87555.1    AAZX01001182    GL765332    EFZ16520.1    GBYB01008106    JAG77873.1    HADW01003442    HADX01015570    SBP04842.1    GL453506    EFN75920.1    JP016794    AES05392.1    AQIB01086595    HAEH01018030    HAEI01011551    SBS13641.1    HAEF01020224    HAEG01013082    SBR94007.1    HADZ01012423    HAEA01007874    SBQ36354.1    HADY01016083    HAEJ01006263    SBS46720.1    CR761977    BC062518    HAED01005064    HAEE01011240    SBQ91094.1    GAMS01011110    GAMR01007493    GAMQ01005997    GAMP01009972    JAB12026.1    JAB26439.1    JAB35854.1    JAB42783.1    GBYX01174170    JAO87661.1    GEBF01001980    JAO01653.1    GFFV01002831    JAV37114.1    AAKN02010073    AAGW02027421    AAGW02027422    AAPE02018683    CABD030041695    ACTA01096661    ADFV01033842    LWLT01000008    AJFE02102361    AHZZ02030202    AANG04003171    CYRY02002257    VCW66914.1    AEYP01000949    ABGA01017759    ABGA01017760    NDHI03003371    PNJ77512.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053240    UP000053268    UP000007151    + More
UP000037510    UP000245037    UP000235965    UP000053825    UP000000311    UP000053097    UP000279307    UP000078492    UP000242457    UP000005203    UP000076502    UP000015103    UP000078540    UP000005205    UP000078541    UP000030742    UP000002358    UP000265120    UP000008237    UP000261440    UP000264800    UP000029965    UP000008143    UP000233220    UP000192220    UP000233020    UP000233040    UP000008225    UP000001038    UP000265180    UP000265200    UP000261560    UP000252040    UP000286641    UP000221080    UP000079169    UP000189706    UP000005447    UP000233120    UP000233180    UP000001811    UP000001074    UP000001519    UP000008912    UP000001073    UP000233140    UP000291000    UP000007646    UP000245320    UP000265300    UP000240080    UP000028761    UP000233200    UP000248481    UP000011712    UP000233060    UP000248482    UP000286640    UP000248483    UP000189704    UP000009136    UP000000715    UP000233080    UP000261681    UP000291022    UP000286642    UP000001595    UP000261680    UP000291021   

PRIDE

H9IYM9    F2Z4G3   

Pfam

PF00076   RRM_1

Interpro

IPR035979   RBD_domain_sf        + More
IPR000571   Znf_CCCH       
IPR012677   Nucleotide-bd_a/b_plait_sf       
IPR000504   RRM_dom       
IPR036855   Znf_CCCH_sf       
IPR039171   Cwc2/Slt11       

SUPFAM

SSF90229   SSF90229        + More
SSF54928   SSF54928       

Gene 3D

3.30.70.330    

ProteinModelPortal

H9IYM9   A0A2A4JZD6   A0A437BLZ6   A0A2H1W9Y3   A0A194RFX9   A0A194Q028   + More
S4NSX0   A0A212FK43   A0A0L7LIH4   A0A2P8Z4J5   A0A2J7Q028   A0A0L7QQG2   A0A1B6ME92   A0A1B6I9I3   E2ABI2   A0A1B6F802   A0A310SFR3   A0A026WDM4   A0A195DV40   A0A2A3E1N9   A0A088AA93   A0A154PFY2   T1HSL9   A0A151I648   A0A158NSN0   A0A195EWS4   U4UP50   A0A1Y1N1G3   A0A0A9WE08   A0A023F4S6   A0A224XBU7   A0A0P4VVH9   A0A0V0G8K8   A0A069DUC6   K7IV25   E9ISD3   A0A0C9RMA2   A0A3P8VR60   A0A1A7WFT3   E2C802   A0A3B4DXG8   G9KKG3   A0A3Q2ZQ23   A0A0D9SCD2   A0A1A8S5V8   A0A1A8QKL7   A0A1A8DU49   A0A1A8UF43   Q6P616   A0A2K6V3K5   A0A1A8I096   A0A2I4B7K1   A0A2K5EFV4   A0A2K5RS79   U3DF69   H2LJT2   A0A3P9JU52   A0A0S7LE07   A0A3B3BEC6   A0A341ADM5   A0A3Q7Q430   A0A2D0SY08   A0A1S3CVF3   A0A0P6JBH5   A0A1U7QIN5   A0A250Y0K3   H0UXE0   A0A2K6CJJ1   A0A2K6MK02   G1T1G7   G1PCS9   G3RAZ8   G1LD30   G1RHG3   A0A2K5Z0B5   A0A452ESB3   G3SYJ2   A0A2U3V6I4   A0A3Q7NMY5   A0A340WLW8   A0A2R9B305   A0A096N735   A0A2Y9FAQ6   A0A2K6R5N5   A0A2Y9HM80   M3WPJ5   A0A2K5NNP0   A0A2Y9ISK1   A0A3Q7TSP1   A0A3P4LT42   A0A2Y9PSH0   A0A1U7TVT4   F2Z4G3   M3YQP8   A0A2K5HTL7   A0A384AMW6   A0A452SKA6   A0A3Q7W055   H2PH39   A0A384C7D3  

PDB

6ID1     E-value=7.39787e-140,     Score=1274

KEGG

101740781    K12872 pre-mRNA-splicing factor RBM22/SLT11 | (RefSeq) pre-mRNA-splicing factor RBM22

PATHWAY

03040    Spliceosome - Bombyx mori (domestic silkworm)

GO

GO:0003723   GO:0046872   GO:0000398   GO:0005634   GO:0043009   GO:0017070   GO:0005737   GO:0000974   GO:0071007   GO:0045292   GO:0036002   GO:0071006   GO:0033120   GO:0035690   GO:0046827   GO:0042307   GO:0048306   GO:0003676   GO:0000166   GO:0005622   GO:0015934   GO:0005216   GO:0016021   GO:0045211   GO:0005975   GO:0004553  

PANTHER

PTHR14089  

Subcellular location

Nucleus   Nearly exclusively nuclear. May be shuttling between the nucleus and the cytosol.   With evidence from 2 publications.
Cytoplasm   Nearly exclusively nuclear. May be shuttling between the nucleus and the cytosol.   With evidence from 2 publications.

Length:

409

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.000660000000000001

Exp number, first 60 AAs:

0.00051

Total prob of N-in:

0.04058

outside

1  -  409

 

 

Pi

225.147958

Theta

191.320647

Tajima's D

0.27331

CLR

0

CSRT

0.451127443627819

Interpretation

Uncertain