Gene

KWMTBOMO12443  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002365

Annotation

Endoprotease_FURIN_[Spodoptera_frugiperda]

Location

Bomo_Chr21(-):3942599-4046419      View in EpiBrowser

Full name

Furin-like protease 2      

Location in the cell

Extracellular   Reliability : 3.398

CDS

ATGAACGTGGCGCCAGCATGGCAAAAGGGATATACAGGCAAGGGCGTTGTAGTGTCAATATTAGATGACGGAATACAAACAAACCATCCAGATTTAGCACAGAATTACGATCCTCTAGCATCGACGGACATAAACGGCAACGATGATGACCCTATGCCACAGGACAATGGCGACAATAAACACGGCACAAGGTGTGCAGGCGAAGTCGCAGCTGTCGCTTACAATCGCTACTGTGGTGTGGGTATTGCCTACAACGCCAGCATAGGAGGAGTTAGGATGTTAGATGGAATTGTCAATGATGCAGTAGAAGCAAGAGCGTTGGGATTGAATCCAGATCATATTGACATCTATAGCGCTTCCTGGGGACCGGAAGACGATGGCAAAACAGTTGACGGTCCTGGACCTTTGGCCAGAAGAGCATTTATATATGGTGTTACGAGCGGTCGTCGTGGCAAAGGCTCTATCTTTGTCTGGGCTTCCGGTAACGGCGGAAGGCACACCGATTCATGTAACTGTGACGGCTACACAAACAGCATATTTACTCTATCGATATCTAGTGCAACACAAGGAGGCTACAAACCTTGGTATCTCGAAGAATGTTCTTCCACTTTAGCTACCACTTACAGTTCGGGTACTCCGGGTCACGACAAAAGTGTGGCGACTGTTGATATGGACGGTAGACTGAGGGCTGACCACATTTGTACAGTAGAACACACGGGAACTTCAGCTTCTGCACCATTAGCAGCTGGAATATGTGCTTTAGCTCTTGAAGCAAATCCTGAATTAACATGGAGAGATATGCAATATCTGGTTGTAATGACGTCTAGGCCTGAACCGTTAGAAAGAGAAAAGGGTTGGATCATCAATGGAGTCAAGAGGAAAGTTAGTCACAAATTCGGATACGGTCTTATGGATGCCACGGAAATGGTAAATTTGGCCGAGCAGTGGGTAACGGTTCCACCTCAACATATCTGTAAATCGCAGGAGTTGAACGAAGACAAGTCGATGGACTCTACTTTGGGCAATTCATTAAGGACATATATGGATGTAACTGGATGCAGTGGTACGGTGAATGAAGTGCGTTACCTAGAACATGTCCAATGTAAAATATCGTTGAGGTTCTTCCCCCGTGGTAACCTGCGTATATTATTAACTTCACCAATGGGTACTGTATCAACATTATTGTTCGAACGACCTCGTGACGTGGCTAGTTCTACCTTCGACGATTGGCCATTTTTGAGCGTTCATTTTTGGGGAGAACAAGCAGAAGGTAGATGGACATTAGAAATAATAAACGCCGGCAAAAGGCACGTGAACCAGGCGGGCGTTCTCAAGAAATGGCAGCTGATATTCTACGGAACTGTCATAGATCCCGTTCGGTTACGATCAAAGAGACCGTCGCCATTTGCACCGTCATACGCGTTTCCAACGGCAGCGGATGGCTACGACACAATCAGTGATTCTTTTTACAATACTGACGCGTTTGCTAATTACCAGAACTTTCCAAATTTATTCGCCGCTGGGTCCAACCCGGAAAAGGCGGTAGCCCGTCTCGACGGACATAACGTCCCTTCACCGCATGGGGAAAATGTCCTCGCCGATAGTAATGACAAGCGCGTCATGCACGACTGTGATCCCGAATGCGATTCTCAAGGATGCTACGGAAAAGGACCGTCCCAATGTGTGGCTTGTAAACATTACCGTTTAGATGACACGTGCGTTTCTCGTTGCCCACCGAGAAGCTATGCCAATCAAGGGGGAGTTTGTTGGCAATGTCACGAATCGTGTGAAACTTGCATGGGACCGGGGCAAGATTCATGTTTCACATGTGCTCCGGCTCATTTTTTAGTGGCAGATTTGGCTGTTTGCCTACAACAATGTCCTGATGGATATTGGGAGGACACAGATTCTGCAACTTGTCGGCCTTGTGCAGCTCATTGTGCGACTTGTTCGGAAAGAGCGAATGCGTGCACGTCGTGTGAACATCACCTACTCCTGCACGAGGGCAGCTGTCTGGTCACATGTCCGGCAGCGCACTACGAAACCGACGATTACACTTGCGCCAAATGCCACAATTCGTGTGACACATGCGTTGGACCAAAGGAAAACCAATGCATAACTTGTCACACTACAAATTACGTGTTAGATGGTAGCTGTGTGGCGACATGTCCAGGCGGATATTACGTGGACAAAAAAAGGAAGGAATGCGTGAGGTGTCCAGTTGGATGTGCGACTTGCACAAGCGCTTTCTGTCTCACATGCGAAACAAATTGGGAAATAAATAAGAAGGGGAGATGTCTCCCAGCTGGATCTGATCGATGTTCGACCGGACAATTCATAGATAAACTCGGCTGTAGCAGATGTGACGACGCTTGTGAATCGTGCTATGGAGAGGGCGAAGGACACTGTCTAACTTGTCCATCGCCTAATTTGCTAGAAGATTACAGATGCGTTCCGGAATGTAGCAGCGGATATTACGCGGAGGCCGGTCGGTGCATTCGCTGCGTGCACGGTTGTACTGAATGCGTTTCAAGACTCAACTGTACCAGCTGTGCTGGGTCCCTGAGACTGCAGTCTGGAGCTTGCAGGACTTCATGCGCTGATGGGTACTACGCTGATCGCGGCGCCTGTTCCAAGTGCTATTTATCTTGCCGGACATGTATTGGGCCCCGTCGCGATCAGTGCGCGTCCTGCCCTCAGGGTTGGAGGCTAGCCGCTGGAGAATGTCACCCCGAATGTCCTCAAGGATTCTACAAAAGCGACGACGGCTGCCGTCATTGTCACCACTACTGCCGGGAGTGCTCGGACTCCGGTCCGCTACACTGCACGTCGTGTCCGCCTCGTTTCGTGTTAGACGGCGGGCTTTGTATGGAGTGCCTCGGCTCTCAGTACTACGAGGCGGGCAATGGAACGTGCAGCACGTGCGATCCGTCGTGTCGCACCTGCTACGGTTCGGGACAGTTCAGTTGTACAGGATGCTCCAGGCCGCTGAGGCTCGATAGATTAAACAATCAGTGCGTTCCGTGTTGTACGGACAGGGGGACGACGACCTCGCCCGGGACCGAATGCTGCCATTGTCATCCCGAAACTGGTGAATGCATTAACTCATCGGTGGCGGGAAAACGTCGTATAGCCGAATGGGGCGCTCTGCACACAGTGGAGAACGCTCGCAGTACGTCAGCTCCCAGCGCCGCCGCGATAACCGTCATGGTGTGTCTGTCCGCCGGTGCACTGTTCTTTGTCGTGCTGATGATACTACAGTGGCGTTCACCGCGCGACAAGCGAACACGAACCCGCGGGCTCGTCTACTACCCCCTCGCCTACAACGACGACGGCAAGGTTGTCGTCCTTGCTCCGCATACGGCGTTCCCCTCAAGCGAGAGCAGGACGGAGGAACTACACGAGCACGAAGACGAACCGTTGCTCGAACATTCCACATAG

Protein

MNVAPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYDPLASTDINGNDDDPMPQDNGDNKHGTRCAGEVAAVAYNRYCGVGIAYNASIGGVRMLDGIVNDAVEARALGLNPDHIDIYSASWGPEDDGKTVDGPGPLARRAFIYGVTSGRRGKGSIFVWASGNGGRHTDSCNCDGYTNSIFTLSISSATQGGYKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGRLRADHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVMTSRPEPLEREKGWIINGVKRKVSHKFGYGLMDATEMVNLAEQWVTVPPQHICKSQELNEDKSMDSTLGNSLRTYMDVTGCSGTVNEVRYLEHVQCKISLRFFPRGNLRILLTSPMGTVSTLLFERPRDVASSTFDDWPFLSVHFWGEQAEGRWTLEIINAGKRHVNQAGVLKKWQLIFYGTVIDPVRLRSKRPSPFAPSYAFPTAADGYDTISDSFYNTDAFANYQNFPNLFAAGSNPEKAVARLDGHNVPSPHGENVLADSNDKRVMHDCDPECDSQGCYGKGPSQCVACKHYRLDDTCVSRCPPRSYANQGGVCWQCHESCETCMGPGQDSCFTCAPAHFLVADLAVCLQQCPDGYWEDTDSATCRPCAAHCATCSERANACTSCEHHLLLHEGSCLVTCPAAHYETDDYTCAKCHNSCDTCVGPKENQCITCHTTNYVLDGSCVATCPGGYYVDKKRKECVRCPVGCATCTSAFCLTCETNWEINKKGRCLPAGSDRCSTGQFIDKLGCSRCDDACESCYGEGEGHCLTCPSPNLLEDYRCVPECSSGYYAEAGRCIRCVHGCTECVSRLNCTSCAGSLRLQSGACRTSCADGYYADRGACSKCYLSCRTCIGPRRDQCASCPQGWRLAAGECHPECPQGFYKSDDGCRHCHHYCRECSDSGPLHCTSCPPRFVLDGGLCMECLGSQYYEAGNGTCSTCDPSCRTCYGSGQFSCTGCSRPLRLDRLNNQCVPCCTDRGTTTSPGTECCHCHPETGECINSSVAGKRRIAEWGALHTVENARSTSAPSAAAITVMVCLSAGALFFVVLMILQWRSPRDKRTRTRGLVYYPLAYNDDGKVVVLAPHTAFPSSESRTEELHEHEDEPLLEHST

Description

Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.

Catalytic Activity

Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.

Cofactor

Ca(2+)

Similarity

Belongs to the peptidase S8 family.
Belongs to the peptidase S8 family. Furin subfamily.

Keywords

Alternative splicing   Cleavage on pair of basic residues   Complete proteome   Disulfide bond   Glycoprotein   Hydrolase   Membrane   Protease   Reference proteome   Repeat   Serine protease   Signal   Transmembrane   Transmembrane helix   Zymogen  

Feature

chain  Furin-like protease 2
splice variant  In isoform A.

Uniprot

H9IYN1   Q26489   A0A2A4K7Y7   A0A437BM12   A0A194PYD1   A0A212F4A7   + More
A0A194RFY5   A0A0A1XGS4   A0A0A1X1M3   A0A0K8U8C6   W8APW3   A0A0L0BQD1   T1P9R1   A0A1I8Q1I4   A0A1Q3FU12   A0A1Q3FTV5   A0A1Q3FUD1   A0A1Q3FTU0   A0A1B6GHW2   W4VRF9   A0A2M4DS50   A0A2M3Z0N1   A0A2M4DS69   A0A2M4A589   A0A2M4B9D5   A0A2M4B9F8   A0A2M4B9B2   A0A2M4A5Q5   A0A2M4A4R7   A0A1B6CCM9   A0A2H1W496   A0A0L7LUE0   A0A2C9GWR4   A0A1J1IF38   E0V9N9   A0A3B0K7Y0   E1JJL4   A0A0R3P116   Q29GI8   B4NCL2   A0A0R3P6H0   P30432   P30432-2   A0A0R3P5B9   B4M1S6   A0A0Q9WMJ9   A0A158NEY8   B4PXS5   A0A1I8Q1H9   B3NX47   A0A0R1EGT9   A0A0R1EEA9   A0A0R1EG80   A0A195FL77   A0A0Q5T532   A0A0Q5T754   A0A437B8F0   B4JKM2   B4R5T4   A0A151IEG1   A0A336LIK8   A0A2A4JGI8   A0A336LJ86   A0A2H1WK85   A0A212FLJ6   A0A2M4CJY4   A0A195BWS1   A0A026X0H0   B4L8R4   A0A0P8ZKG0   A0A0Q9XGD4   A0A0Q9XJA6   B3N0S2   A0A0Q9XRF1   A0A0M4ELX6   E2BLN8   A0A0C9QQN8   A0A194PZ75   A0A1W4VVH0   A0A1W4VTY2   A0A1W4VUQ9   A0A1W4VHD4   E2AVN1   A0A2M4CHY2   A0A2M4CI92   A0A336LJV0   F4WVD8   A0A0C9QJY7   A0A151XIV9   W5JF16   E9ID68   A0A195EN83   A0A2A3EGB8   A0A2J7QX97   A0A182QSE6   A0A182XHH2   A0A067RUA5   A0A0N0U668   A0A2H8TUQ2  

EC Number

3.4.21.75

Pubmed

19121390    26354079    22118469    25830018    24495485    26108605    + More
26227816    20566863    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    15632085    17994087    23185243    1512259    7880443    12537569    18057021    21347285    17550304    24508170    20798317    21719571    20920257    23761445    21282665    24845553   

EMBL

BABH01037900    Z68888    CAA93116.1    NWSH01000051    PCG80179.1    RSAL01000033    + More
RVE51494.1    KQ459585    KPI98346.1    AGBW02010411    OWR48567.1    KQ460211    KPJ16512.1    GBXI01004172    JAD10120.1    GBXI01009632    JAD04660.1    GDHF01029508    JAI22806.1    GAMC01018483    JAB88072.1    JRES01001522    KNC22262.1    KA645434    AFP60063.1    GFDL01004017    JAV31028.1    GFDL01004015    JAV31030.1    GFDL01004012    JAV31033.1    GFDL01004014    JAV31031.1    GECZ01007763    JAS62006.1    GANO01003419    JAB56452.1    GGFL01016196    MBW80374.1    GGFM01001305    MBW22056.1    GGFL01016237    MBW80415.1    GGFK01002655    MBW35976.1    GGFJ01000508    MBW49649.1    GGFJ01000501    MBW49642.1    GGFJ01000503    MBW49644.1    GGFK01002802    MBW36123.1    GGFK01002391    MBW35712.1    GEDC01026106    JAS11192.1    ODYU01006244    SOQ47911.1    JTDY01000105    KOB78841.1    CVRI01000047    CRK97614.1    DS234995    EEB10108.1    OUUW01000015    SPP88772.1    AE014298    ACZ95309.1    CH379064    KRT06942.1    EAL32121.2    CH964239    EDW82571.2    KRT06944.1    KRT06945.1    M94375    L33831    BT021414    AY070553    KRT06943.1    CH940651    EDW65630.1    KRF82320.1    KRF82319.1    ADTU01013412    ADTU01013413    CM000162    EDX01911.1    CH954180    EDV46876.2    KRK06434.1    KRK06436.1    KRK06435.1    KRK06433.1    KQ981490    KYN41168.1    KQS30223.1    KQS30224.1    KQS30225.1    RSAL01000126    RVE46569.1    CH916370    EDW00125.1    CM000366    EDX18084.1    KQ977871    KYM99195.1    UFQT01000021    SSX17944.1    NWSH01001572    PCG70828.1    SSX17946.1    ODYU01009227    SOQ53495.1    AGBW02007756    OWR54611.1    GGFL01001478    MBW65656.1    KQ976401    KYM92418.1    KK107064    EZA60894.1    CH933815    EDW08039.1    CH902644    KPU75290.1    KRG07562.1    KRG07564.1    KRG07565.1    KRG07567.1    KRG07561.1    EDV34801.1    KRG07566.1    CP012528    ALC48584.1    GL449036    EFN83372.1    GBYB01002977    JAG72744.1    KPI98343.1    GL443146    EFN62505.1    GGFL01000782    MBW64960.1    GGFL01000777    MBW64955.1    SSX17945.1    GL888387    EGI61759.1    GBYB01003844    JAG73611.1    KQ982080    KYQ60346.1    ADMH02001671    ETN61480.1    GL762454    EFZ21411.1    KQ978625    KYN29621.1    KZ288254    PBC30823.1    NEVH01009384    PNF33201.1    AXCN02000011    KK852463    KDR23424.1    KQ435735    KOX77124.1    GFXV01006180    MBW17985.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053268    UP000007151    UP000053240    + More
UP000037069    UP000095300    UP000037510    UP000075900    UP000183832    UP000009046    UP000268350    UP000000803    UP000001819    UP000007798    UP000008792    UP000005205    UP000002282    UP000008711    UP000078541    UP000001070    UP000000304    UP000078542    UP000078540    UP000053097    UP000009192    UP000007801    UP000092553    UP000008237    UP000192221    UP000000311    UP000007755    UP000075809    UP000000673    UP000078492    UP000242457    UP000235965    UP000075886    UP000076407    UP000027135    UP000053105   

PRIDE

H9IYN1    E1JJL4    P30432   

Pfam

PF00082   Peptidase_S8        + More
PF14843   GF_recep_IV
PF01483   P_proprotein
PF16470   S8_pro-domain
PF15913   Furin-like_2

Interpro

IPR000209   Peptidase_S8/S53_dom        + More
IPR032778   GF_recep_IV       
IPR015500   Peptidase_S8_subtilisin-rel       
IPR006212   Furin_repeat       
IPR036852   Peptidase_S8/S53_dom_sf       
IPR008979   Galactose-bd-like_sf       
IPR022398   Peptidase_S8_His-AS       
IPR009030   Growth_fac_rcpt_cys_sf       
IPR002884   P_dom       
IPR023827   Peptidase_S8_Asp-AS       
IPR023828   Peptidase_S8_Ser-AS       
IPR034182   Kexin/furin       
IPR032815   S8_pro-domain       
IPR038466   S8_pro-domain_sf       
IPR000742   EGF-like_dom       
IPR011031   Multihaem_cyt       

SUPFAM

SSF57184   SSF57184        + More
SSF49785   SSF49785       
SSF52743   SSF52743       

Gene 3D

2.60.120.260     3.40.50.200     3.30.70.850    

CDD

cd04059  Peptidases_S8_Protein_converta
cd00064  FU

ProteinModelPortal

H9IYN1   Q26489   A0A2A4K7Y7   A0A437BM12   A0A194PYD1   A0A212F4A7   + More
A0A194RFY5   A0A0A1XGS4   A0A0A1X1M3   A0A0K8U8C6   W8APW3   A0A0L0BQD1   T1P9R1   A0A1I8Q1I4   A0A1Q3FU12   A0A1Q3FTV5   A0A1Q3FUD1   A0A1Q3FTU0   A0A1B6GHW2   W4VRF9   A0A2M4DS50   A0A2M3Z0N1   A0A2M4DS69   A0A2M4A589   A0A2M4B9D5   A0A2M4B9F8   A0A2M4B9B2   A0A2M4A5Q5   A0A2M4A4R7   A0A1B6CCM9   A0A2H1W496   A0A0L7LUE0   A0A2C9GWR4   A0A1J1IF38   E0V9N9   A0A3B0K7Y0   E1JJL4   A0A0R3P116   Q29GI8   B4NCL2   A0A0R3P6H0   P30432   P30432-2   A0A0R3P5B9   B4M1S6   A0A0Q9WMJ9   A0A158NEY8   B4PXS5   A0A1I8Q1H9   B3NX47   A0A0R1EGT9   A0A0R1EEA9   A0A0R1EG80   A0A195FL77   A0A0Q5T532   A0A0Q5T754   A0A437B8F0   B4JKM2   B4R5T4   A0A151IEG1   A0A336LIK8   A0A2A4JGI8   A0A336LJ86   A0A2H1WK85   A0A212FLJ6   A0A2M4CJY4   A0A195BWS1   A0A026X0H0   B4L8R4   A0A0P8ZKG0   A0A0Q9XGD4   A0A0Q9XJA6   B3N0S2   A0A0Q9XRF1   A0A0M4ELX6   E2BLN8   A0A0C9QQN8   A0A194PZ75   A0A1W4VVH0   A0A1W4VTY2   A0A1W4VUQ9   A0A1W4VHD4   E2AVN1   A0A2M4CHY2   A0A2M4CI92   A0A336LJV0   F4WVD8   A0A0C9QJY7   A0A151XIV9   W5JF16   E9ID68   A0A195EN83   A0A2A3EGB8   A0A2J7QX97   A0A182QSE6   A0A182XHH2   A0A067RUA5   A0A0N0U668   A0A2H8TUQ2  

PDB

1P8J     E-value=1.57853e-151,     Score=1379

KEGG

101741158    K08654 proprotein convertase subtilisin/kexin type 5 [EC:3.4.21.-] | (RefSeq) furin-like protease 2

GO

GO:0004252   GO:0016021   GO:0005886   GO:0051048   GO:0006508   GO:0009396   GO:0005622   GO:0015934   GO:0005216   GO:0045211   GO:0005975   GO:0004553  

Subcellular location

Membrane  

Length:

1146

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

22.95659

Exp number, first 60 AAs:

9e-05

Total prob of N-in:

0.00672

outside

1  -  1063

TMhelix

1064  -  1086

inside

1087  -  1146

 

 

Pi

213.461858

Theta

178.545172

Tajima's D

0.564621

CLR

0.414994

CSRT

0.527323633818309

Interpretation

Uncertain