Gene

KWMTBOMO12442  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002355

Annotation

Bifunctional_methylenetetrahydrofolate_dehydrogenase/cyclohydrolase?_mitochondrial_[Papilio_machaon]

Location

Bomo_Chr21(+):3819150-3822333      View in EpiBrowser

Location in the cell

Cytoplasmic   Reliability : 1.945 Mitochondrial   Reliability : 1.873

CDS

ATGAGAAGTCACACATACATTGATTCCTTGGGCTCTGCCAGCATCATGGCGCGTATCCTCGATGGCAAAGCACTTGCTATGGAGATAAAGAAGGAGCTGAAGCAAAAAATAGCACAGTGGGTGAGTCTTGGAAACCGAGCGCCCACCATTCGCTGTATAATTGTTGGCGATGACCCAGCGAGCCACACCTATGTCAGGAACAAAGTTGAAGCCGCAAAATTTGTGGGCATCGATGCATTAACAATTAACAGGGACAGTGATATAACCGAAGAACAACTTCTCTCTGAGATCCAAAATTTAAATGAAGATAATAGTGTTGATGGAATTCTCGTCCAATTACCTGTACCTGATACAATTAATGAGAGGAGAGTTTGCGATGCTATTGCTCCTGAAAAAGATATCGATGGTTTCCACATAATCAACATCGGAAGGCTGTGTGTGGATCTACCTACCATTGTGCCGGCTACAGCATTGGCTGTAGTGGAAATGCTGAAAAGATTTAACATCGACACATTCGGTCGCAACGCGGTCGTGATAGGTCGTTCCAAAAACGTCGGTATGCCTATAGCTATGATGCTGCATAGCGACAAGAGACACGAAAGCGGATTAGGGATGGACGCTACCGTAACCATCTGCCATCGTTACACGCCAAAAGACAAACTGGAAGCATATTGTCGGAACGCTGATATCATTATCACCGCTACCGGTTTGCCCAAATTAATCAAAGCGGATATGGTGAAACCGGGCGCTACGATAATAGACGTTGGCATTACAAGAATAACCGATGAAAATGGAAAGTCTAGACTCGTCGGGGACGTTGATTACGAAGAAGTATCTAAGATCGCCGGTGCTATAACTCCAGTTCCCGGCGGAGTGGGTCCTATGACCGTGGCGATGCTGATGCATAACACATTCCAAGCAGCTCAGAGTCAAGCAAACAAATCCAATTAA

Protein

MRSHTYIDSLGSASIMARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQANKSN

Uniprot

H9IYM1   A0A2A4K8Z4   A0A3S2LQ25   A0A2H1VMW1   A0A194RGD9   A0A194Q023   + More
A0A212F9K8   I4DRE1   A0A336MQG7   A0A336LQF1   T1DGQ4   A0A2M4BVC8   A0A2M4BVJ7   A0A2M3Z4G0   A0A182FLP3   A0A2M3Z4J1   T1E8H6   A0A2M4A235   A0A2M4CTT0   B0WDF0   A0A1Q3FHA6   A0A1Q3FHD2   A0A1A9Z6I6   A0A023ERE2   A0A1S4G338   A0A182ND91   Q16F77   A0A1B0GGJ8   D3TPH5   A0A182HEM5   A0A1A9V0D6   A7UTF7   A0A1I8MH51   A0A1I8MH50   A0A1B0CEH0   A0A182YPR9   A0A182WAY4   T1PNE5   A0A1I8MH59   A0A023EN06   A0A1A9YR99   W8BM65   A0A182HFB8   A0A182LLQ5   Q7PHT4   A0A084W180   A0A034VG54   A0A0C9PI39   A0A1L8DZN2   A0A034VKE6   A0A0A1XBW6   A0A182MBN9   A0A1I8PQC5   A0A1I8PQ71   A0A0K8TTX9   A0A023EP26   Q0IEF8   R7TMV7   A0A0K8W701   A0A0K8WL41   A0A0K8WEF6   D6WUR7   A0A091SSP4   B4NL93   N6TDW5   A0A182PVB4   W5N2G4   A0A2J7PDE7   A0A0T6AV37   A0A093P0G3   A0A151N579   A0A1B8Y8J3   A0A093QT07   A0A067RE48   A0A2P8ZNM3   A0A452HB80   R0K936   A0A093HWC7   A0A0L0CE32   A0A087R264   A0A1U8CVC2   A0A3B3QCB0   A0A151N5H6   A0A091PB02   A0A1S3HGZ1   A0A093EI54   A0A091L0W0   A0A3P8VWH8   A0A0A0AJM7   A0A1B6ETF3   A0A093QN91   A0A091QPN5   A0A093J3W0   A0A091WCL0   R7UT61   A0A091H216   A0A091T5X6   A0A093EY16   A0A091MN28   F6ZS18  

Pubmed

19121390    26354079    22118469    22651552    24330624    24945155    + More
17510324    20353571    26483478    12364791    14747013    17210077    25315136    25244985    24495485    20966253    24438588    25348373    25830018    26369729    23254933    18362917    19820115    17994087    23537049    22293439    20431018    24845553    29403074    28562605    26108605    29240929    24487278   

EMBL

BABH01037918    LC366023    BBC53721.1    NWSH01000051    PCG80180.1    RSAL01000033    + More
RVE51492.1    ODYU01003424    SOQ42169.1    KQ460211    KPJ16514.1    KQ459585    KPI98344.1    AGBW02009565    OWR50410.1    AK405080    BAM20481.1    UFQT01001832    SSX31925.1    UFQT01000115    SSX20276.1    GALA01001571    JAA93281.1    GGFJ01007811    MBW56952.1    GGFJ01007810    MBW56951.1    GGFM01002656    MBW23407.1    GGFM01002664    MBW23415.1    GAMD01002172    JAA99418.1    GGFK01001494    MBW34815.1    GGFL01004576    MBW68754.1    DS231897    EDS44521.1    GFDL01008108    JAV26937.1    GFDL01008106    JAV26939.1    GAPW01002377    JAC11221.1    CH478498    EAT32889.1    CCAG010006689    EZ423327    ADD19603.1    JXUM01035647    JXUM01151840    KQ571311    KQ561068    KXJ68206.1    KXJ79808.1    AAAB01008942    EDO64016.1    AJWK01008866    KA649595    AFP64224.1    GAPW01002830    JAC10768.1    GAMC01004365    JAC02191.1    JXUM01036772    JXUM01036773    JXUM01036774    KQ561105    KXJ79689.1    EAA44412.3    ATLV01019244    KE525266    KFB43974.1    GAKP01016681    JAC42271.1    GBYB01000568    JAG70335.1    GFDF01002195    JAV11889.1    GAKP01016682    JAC42270.1    GBXI01006339    JAD07953.1    AXCM01010523    GDAI01000193    JAI17410.1    GAPW01002883    JAC10715.1    CH477691    EAT37237.1    AMQN01011953    AMQN01011954    KB309204    ELT95208.1    GDHF01005495    JAI46819.1    GDHF01000522    JAI51792.1    GDHF01002890    JAI49424.1    KQ971363    EFA07809.2    KK485136    KFQ61742.1    CH964272    EDW84296.2    APGK01041496    APGK01041497    KB740994    KB632356    ENN75943.1    ERL93399.1    AHAT01017245    NEVH01026389    PNF14360.1    LJIG01022796    KRT78670.1    KL225121    KFW67680.1    AKHW03004011    KYO31958.1    KV460381    OCA19320.1    KL431109    KFW91651.1    KK852562    KDR21308.1    PYGN01000008    PSN58111.1    KB742619    EOB06322.1    KL206808    KFV85931.1    JRES01000519    KNC30457.1    KL226056    KFM07568.1    KYO31957.1    KK670420    KFQ04556.1    KL244970    KFV14216.1    KK764453    KFP45922.1    KL872182    KGL94709.1    GECZ01028527    GECZ01019906    JAS41242.1    JAS49863.1    KL672314    KFW85447.1    KK800824    KFQ28591.1    KK601672    KFW06552.1    KK735164    KFR12860.1    AMQN01007383    AMQN01007384    KB300556    ELU06551.1    KL521750    KFO89876.1    KK437751    KFQ69245.1    KK612139    KFV46759.1    KK833161    KFP78075.1    AAMC01118666    AAMC01118667    AAMC01118668    AAMC01118669   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053240    UP000053268    UP000007151    + More
UP000069272    UP000002320    UP000092445    UP000075884    UP000008820    UP000092444    UP000069940    UP000249989    UP000078200    UP000007062    UP000095301    UP000092461    UP000076408    UP000075920    UP000092443    UP000075882    UP000030765    UP000075883    UP000095300    UP000014760    UP000007266    UP000007798    UP000019118    UP000030742    UP000075885    UP000018468    UP000235965    UP000054081    UP000050525    UP000008143    UP000027135    UP000245037    UP000291020    UP000053584    UP000037069    UP000053286    UP000189705    UP000261540    UP000085678    UP000265120    UP000053858    UP000053258    UP000053605   

PRIDE

H9IYM1   

Pfam

PF02882   THF_DHG_CYH_C        + More
PF00763   THF_DHG_CYH
PF05485   THAP
PF00554   RHD_DNA_bind
PF12796   Ank_2
PF16179   RHD_dimer

Interpro

IPR000672   THF_DH/CycHdrlase        + More
IPR020630   THF_DH/CycHdrlase_cat_dom       
IPR036291   NAD(P)-bd_dom_sf       
IPR020631   THF_DH/CycHdrlase_NAD-bd_dom       
IPR020867   THF_DH/CycHdrlase_CS       
IPR006612   THAP_Znf       
IPR008967   p53-like_TF_DNA-bd       
IPR002110   Ankyrin_rpt       
IPR033926   IPT_NFkappaB       
IPR013783   Ig-like_fold       
IPR011539   RHD_DNA_bind_dom       
IPR000451   NFkB/Dor       
IPR014756   Ig_E-set       
IPR002909   IPT_dom       
IPR032397   RHD_dimer       
IPR036770   Ankyrin_rpt-contain_sf       
IPR037059   RHD_DNA_bind_dom_sf       
IPR020683   Ankyrin_rpt-contain_dom       

SUPFAM

SSF51735   SSF51735        + More
SSF48403   SSF48403       
SSF81296   SSF81296       
SSF49417   SSF49417       

Gene 3D

1.25.40.20     2.60.40.10     2.60.40.340    

CDD

cd01080  NAD_bind_m-THF_DH_Cyclohyd
cd01177  IPT_NFkappaB
cd00204  ANK

ProteinModelPortal

H9IYM1   A0A2A4K8Z4   A0A3S2LQ25   A0A2H1VMW1   A0A194RGD9   A0A194Q023   + More
A0A212F9K8   I4DRE1   A0A336MQG7   A0A336LQF1   T1DGQ4   A0A2M4BVC8   A0A2M4BVJ7   A0A2M3Z4G0   A0A182FLP3   A0A2M3Z4J1   T1E8H6   A0A2M4A235   A0A2M4CTT0   B0WDF0   A0A1Q3FHA6   A0A1Q3FHD2   A0A1A9Z6I6   A0A023ERE2   A0A1S4G338   A0A182ND91   Q16F77   A0A1B0GGJ8   D3TPH5   A0A182HEM5   A0A1A9V0D6   A7UTF7   A0A1I8MH51   A0A1I8MH50   A0A1B0CEH0   A0A182YPR9   A0A182WAY4   T1PNE5   A0A1I8MH59   A0A023EN06   A0A1A9YR99   W8BM65   A0A182HFB8   A0A182LLQ5   Q7PHT4   A0A084W180   A0A034VG54   A0A0C9PI39   A0A1L8DZN2   A0A034VKE6   A0A0A1XBW6   A0A182MBN9   A0A1I8PQC5   A0A1I8PQ71   A0A0K8TTX9   A0A023EP26   Q0IEF8   R7TMV7   A0A0K8W701   A0A0K8WL41   A0A0K8WEF6   D6WUR7   A0A091SSP4   B4NL93   N6TDW5   A0A182PVB4   W5N2G4   A0A2J7PDE7   A0A0T6AV37   A0A093P0G3   A0A151N579   A0A1B8Y8J3   A0A093QT07   A0A067RE48   A0A2P8ZNM3   A0A452HB80   R0K936   A0A093HWC7   A0A0L0CE32   A0A087R264   A0A1U8CVC2   A0A3B3QCB0   A0A151N5H6   A0A091PB02   A0A1S3HGZ1   A0A093EI54   A0A091L0W0   A0A3P8VWH8   A0A0A0AJM7   A0A1B6ETF3   A0A093QN91   A0A091QPN5   A0A093J3W0   A0A091WCL0   R7UT61   A0A091H216   A0A091T5X6   A0A093EY16   A0A091MN28   F6ZS18  

PDB

5ZF1     E-value=1.64178e-165,     Score=1494

KEGG

101741628    K13403 methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase

PATHWAY

00670    One carbon pool by folate - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004488   GO:0016787   GO:0004477   GO:0035999   GO:0046653   GO:0004487   GO:0003677   GO:0005634   GO:0005737   GO:0003700   GO:0016021   GO:0003824   GO:0009396   GO:0005622   GO:0015934   GO:0005216   GO:0045211   GO:0005975   GO:0004553   GO:0055114  

PANTHER

PTHR10025   PTHR24169  

Length:

316

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.46581

Exp number, first 60 AAs:

0.00550999999999999

Total prob of N-in:

0.04615

outside

1  -  316

 

 

Pi

152.386063

Theta

208.960765

Tajima's D

-1.286334

CLR

259.5045

CSRT

0.0890455477226139

Interpretation

Uncertain