Gene

KWMTBOMO12441

Pre Gene Modal

BGIBMGA002354

Annotation

Furin-like_protease_2_[Papilio_machaon]

Location

Bomo_Chr21(+):3564631-3599853      View in EpiBrowser

Full name

Furin-like protease 2      

Location in the cell

Extracellular   Reliability : 3.664

CDS

ATGAGGCAATCTAGCGCACCGTCTTTTCCTGATCCACTGTTCAAAGAGCAGTGGTATTTGAATGGTGGCGCAGCTGATGGTCTCGATATGAATGTCGGGTATGCTTGGAGGAAGGGCTATACGGGGAAAGGTGTCGTCATTACTATACTCGATGATGGCATACAGCCTAATCACCCGGATCTATCACAGAATTACGATCCGGCCGCTTCAACTGACATAAACGGGAACGATACGGACCCGACACCACAGGACAATGGCGACAATAAACACGGGACCCGTTGTGCAGGAGAGGTAGCTGCCGTCGCTTATAACCGATACTGTGGCGTTGGTATAGCATACAATGCTAGCATTGGAGGAGTGAGAATGCTGGATGGCGTTGTAAACGACGCAGTGGAAGCTCAAGCACTCGGATTTAACACGCATCATATTGATATATATAGTGCGTCGTGGGGACCGGAGGACGACGGAAAAACTGTCGACGGCCCGGGTCCTTTAGCTCGAAGAGCGTTTATCAACGGAGTAACGAACGGAAGAGGGGGAAAAGGATCCATATTCATATGGGCATCAGGAAACGGGGGGCGGCACACTGACTCTTGTAACTGCGACGGGTATGCTAATAGCATATTCACTATATCCATATCTAGCGCAACGCAAGGAGGGTACAAGCCTTGGTATTTAGAAGAATGCTCTTCGACTTTAGCTTCAACGTATAGTTCAGGTACACCAGGACGAGATAAAAGCGTTGCAACCGTTGATATGGACGTCCAATTACGAGCGGAGCATATCTGCACGGTCGACCATACGGGTACCTCAGCATCCGCACCATTGGCTGCAGGAATTTGTGCATTAGCTTTAGAAGCTAATCCGCTATTGTCGTGGAGAGATATGCAGCATTTAATTGTAATGACGTCACGTTCTCAACCCCTAGAAAAAGAAGAAGGGTGGATCGTGAATGGTGTTAAAAGAAAAGTTAGTCATAAATTCGGTTACGGACTGATGGATGCAGCTCAAATGGTCAATCTAGCTGAGCAGTGGACTAATGTGGCGCCTCAGCACATTTGTAAATCCCAAGAAATAAACGAAGACAAATCCATTGAAACGTCTTTCGGTTATACGATATCTGTACACATGGACGTGAATGGGTGCAGCGGGACGACAAACGAGGTCAGATTTTTGGAACACGTTCAATGTAAAATTTCGTTAAGCTTTTTTCCGAGAGGTAATTTACGAATATTGCTTACATCACCGATGGGAACCACATCTACGCTTCTATTCGAAAGGACCCATGACGCAATTAGTTCGAATTTCGACGACTGGCCGTTTTTGAGCGTTCATTTCTGGGGTGAAAACGCCGAAGGGAGATGGACTTTGCAAATTATAAATGCGGGCAATACTCACGCGACGCAAGCTGGAGTATTGAAGAAATGGCAATTATTTTTTTACGGTACCGCTGTCTCCCCCATACGGCTACGAAATAAAGACTATATGAACTCGAAAAATTCGTACCACGAAGAAAAAACATATCACATTAATGACGTATACGATGCATCTGAATACTCTCAGTTTTTAAACGAAATTGAACTAGGTATTTCAGACAGGCGTAGCTACGAGAAAAACATTCCATCGGCTCAAAGAAAGAATGTTTTAGCGGATGCTAATGATAAGCAAGTGCAGAGACTATGCGATCCGGAATGTGATTCGCAGGGCTGCTACGGCAAAGGCCCAACGCAGTGTGTCGCTTGTAAACATTACCGTTTGGATAATTCATGTGTTTCAAAATGCCCCCCCAGGAGTTTTGTTAATCAAGGCGGAGTCTGCTGGCCATGTCACGAGTCTTGTGAAACGTGTGCCGGAGCCGGACAAGATTCATGTTTGACTTGCGCGCCGGCACATTTACTGGTCGTGGATTTGGCTGTCTGCCTGCAGCAGTGCCCAGATGGTTACTATGAAGACCCAGATGCCAACGCATGTTTTCCATGCGCCGAACATTGTGATACATGCACAGAGAAAGCAGACTTGTGTTCTTCTTGTGCCCACAGTTATGTTTTGTACAATGGATCTTGTTTAGCGGCCTGTCCACCAAGTACTTATCAAAAAGACTACTATGGCTGTATGCCATGTCACGAATCTTGTGACTCTTGTTACGGACCGAGCCAAAATTCTTGCGTGTCCTGTAAAATTGGAGACTTTGTCTTCAAGAACCAATGTATTTCGAAGTGTCCTTCAGGCTTCTATGCGGATTCGCAGAAAAGGGAATGCTTAGAGTGTCCGATTGGATGTTTGGTATGCTCTTATGGAGTGTGTTCTTCCTGTAAAGAGGAGTGGACGCTCACTAAGGGAGGAAGTTGCTTTCCCGATGGAAACGAAAAATGTGATACAAATGAATATTACGAGGGAGGTCGATGCAAAAATTGCCATTCAACATGCGAGAAATGTAGCGGACCGAACGAGTGGGATTGCATCTCTTGTTCAAGTCCTCTTCTGTTACAAGGGTCGAGGTGTGTGGCAGAATGTGGACGCGGGTATTATCAAACCGCCGGGTCTGGACCAACAAGTTGTGTTACTTGCGCTCATCCACTTCAATTAGATAGAGTCAACTACAAATGTTTACCTTGCTGCTTAGAAAATATGGCATCTATTTACTTAACAGTCAATGAAACATCAGATTGTTGCCATTGTGATAAGGATATCGGGGGGTGCTTAAATGGTTCATCGGCTGGTAAAAGAAGAATAGCTGAAAATATAAGGACACATATTACTGCATCATATTTCATAGAGGATTCGAAGGATTCTGCAGATACCATCGATTTAAACTATGTTATCATTTGGAGTGCGGCAGCTACTGTTATTGTGATTGTCATAATCGACAGAAATTTATCTGATATTTCATAA

Protein

MRQSSAPSFPDPLFKEQWYLNGGAADGLDMNVGYAWRKGYTGKGVVITILDDGIQPNHPDLSQNYDPAASTDINGNDTDPTPQDNGDNKHGTRCAGEVAAVAYNRYCGVGIAYNASIGGVRMLDGVVNDAVEAQALGFNTHHIDIYSASWGPEDDGKTVDGPGPLARRAFINGVTNGRGGKGSIFIWASGNGGRHTDSCNCDGYANSIFTISISSATQGGYKPWYLEECSSTLASTYSSGTPGRDKSVATVDMDVQLRAEHICTVDHTGTSASAPLAAGICALALEANPLLSWRDMQHLIVMTSRSQPLEKEEGWIVNGVKRKVSHKFGYGLMDAAQMVNLAEQWTNVAPQHICKSQEINEDKSIETSFGYTISVHMDVNGCSGTTNEVRFLEHVQCKISLSFFPRGNLRILLTSPMGTTSTLLFERTHDAISSNFDDWPFLSVHFWGENAEGRWTLQIINAGNTHATQAGVLKKWQLFFYGTAVSPIRLRNKDYMNSKNSYHEEKTYHINDVYDASEYSQFLNEIELGISDRRSYEKNIPSAQRKNVLADANDKQVQRLCDPECDSQGCYGKGPTQCVACKHYRLDNSCVSKCPPRSFVNQGGVCWPCHESCETCAGAGQDSCLTCAPAHLLVVDLAVCLQQCPDGYYEDPDANACFPCAEHCDTCTEKADLCSSCAHSYVLYNGSCLAACPPSTYQKDYYGCMPCHESCDSCYGPSQNSCVSCKIGDFVFKNQCISKCPSGFYADSQKRECLECPIGCLVCSYGVCSSCKEEWTLTKGGSCFPDGNEKCDTNEYYEGGRCKNCHSTCEKCSGPNEWDCISCSSPLLLQGSRCVAECGRGYYQTAGSGPTSCVTCAHPLQLDRVNYKCLPCCLENMASIYLTVNETSDCCHCDKDIGGCLNGSSAGKRRIAENIRTHITASYFIEDSKDSADTIDLNYVIIWSAAATVIVIVIIDRNLSDIS

Description

Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.

Catalytic Activity

Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.

Cofactor

Ca(2+)

Similarity

Belongs to the peptidase S8 family.
Belongs to the peptidase S8 family. Furin subfamily.

Keywords

Alternative splicing   Cleavage on pair of basic residues   Complete proteome   Disulfide bond   Glycoprotein   Hydrolase   Membrane   Protease   Reference proteome   Repeat   Serine protease   Signal   Transmembrane   Transmembrane helix   Zymogen  

Feature

chain  Furin-like protease 2
splice variant  In isoform A.

Uniprot

H9IYM0   A0A194RGR3   A0A2A4JGI8   A0A2H1WK85   A0A437B8F0   A0A212FLJ6   + More
A0A194PZ75   A0A0L7LPQ1   A0A2A4K7Y7   A0A212F4A7   Q26489   A0A437BM12   A0A194RFY5   A0A194PYD1   A0A2H1W496   H9IYN1   A0A0A1XGS4   A0A0K8U8C6   A0A0A1X1M3   A0A0L7LUE0   W8APW3   A0A1Q3FTU0   A0A1Q3FU12   A0A1Q3FTV5   A0A1Q3FUD1   T1P9R1   A0A1I8Q1H9   A0A1I8Q1I4   A0A0L0BQD1   A0A2M4DS50   A0A2M3Z0N1   A0A2M4A589   A0A2M4DS69   A0A2M4A5Q5   A0A2M4A4R7   A0A2M4B9F8   A0A2M4B9B2   A0A2M4CJY4   A0A2M4B9D5   Q5DNW1   A0A023EXA8   W4VRF9   A0A336LJ86   A0A336LIK8   A0A2C9GWR4   A0A195FL77   A0A1B6GHW2   A0A195BWS1   A0A1B6CCM9   A0A158NEY8   A0A1Y1KM81   A0A139WNE9   A0A1J1IF38   A0A0C9QJY7   A0A151IEG1   A0A0C9QQN8   A0A088AL19   A0A336LJV0   E2BLN8   A0A0Q9WMJ9   B4M1S6   A0A3B0K7Y0   A0A0R1EG80   B4L8R4   A0A0R3P5B9   B4PXS5   B3NX47   Q29GI8   A0A0Q5T754   A0A0M4ELX6   A0A2D3FB63   A0A0R1EEA9   A0A0Q9XGD4   B4NCL2   A0A0R3P6H0   E0V9N9   A0A0R1EGT9   A0A0Q9XJA6   E1JJL4   A0A0R3P116   A0A0Q9XRF1   P30432   A0A0Q5T532   B4JKM2   B3N0S2   P30432-2   B4R5T4   A0A0P8ZKG0   F4WVD8   A0A1S4GGJ0   A0A195EN83   A0A2A3EGB8   A0A151XIV9   A0A2H8TUQ2   A0A026X0H0   A0A1W4VTY2   A0A1W4VHD4   A0A084VGH8   X1WJ00   A0A1W4VVH0  

EC Number

3.4.21.75

Pubmed

19121390    26354079    22118469    26227816    25830018    24495485    + More
26108605    24945155    21347285    28004739    18362917    19820115    20798317    17994087    18057021    17550304    15632085    23185243    20566863    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    1512259    7880443    12537569    21719571    12364791    24508170    24438588   

EMBL

BABH01037938    KQ460211    KPJ16515.1    NWSH01001572    PCG70828.1    ODYU01009227    + More
SOQ53495.1    RSAL01000126    RVE46569.1    AGBW02007756    OWR54611.1    KQ459585    KPI98343.1    JTDY01000441    KOB77156.1    NWSH01000051    PCG80179.1    AGBW02010411    OWR48567.1    Z68888    CAA93116.1    RSAL01000033    RVE51494.1    KPJ16512.1    KPI98346.1    ODYU01006244    SOQ47911.1    BABH01037900    GBXI01004172    JAD10120.1    GDHF01029508    JAI22806.1    GBXI01009632    JAD04660.1    JTDY01000105    KOB78841.1    GAMC01018483    JAB88072.1    GFDL01004014    JAV31031.1    GFDL01004017    JAV31028.1    GFDL01004015    JAV31030.1    GFDL01004012    JAV31033.1    KA645434    AFP60063.1    JRES01001522    KNC22262.1    GGFL01016196    MBW80374.1    GGFM01001305    MBW22056.1    GGFK01002655    MBW35976.1    GGFL01016237    MBW80415.1    GGFK01002802    MBW36123.1    GGFK01002391    MBW35712.1    GGFJ01000501    MBW49642.1    GGFJ01000503    MBW49644.1    GGFL01001478    MBW65656.1    GGFJ01000508    MBW49649.1    AY555267    AAT37510.1    GAPW01000047    JAC13551.1    GANO01003419    JAB56452.1    UFQT01000021    SSX17946.1    SSX17944.1    KQ981490    KYN41168.1    GECZ01007763    JAS62006.1    KQ976401    KYM92418.1    GEDC01026106    JAS11192.1    ADTU01013412    ADTU01013413    GEZM01082529    JAV61340.1    KQ971311    KYB29424.1    CVRI01000047    CRK97614.1    GBYB01003844    JAG73611.1    KQ977871    KYM99195.1    GBYB01002977    JAG72744.1    SSX17945.1    GL449036    EFN83372.1    CH940651    KRF82319.1    EDW65630.1    KRF82320.1    OUUW01000015    SPP88772.1    CM000162    KRK06433.1    CH933815    EDW08039.1    CH379064    KRT06943.1    EDX01911.1    CH954180    EDV46876.2    EAL32121.2    KQS30224.1    KQS30225.1    CP012528    ALC48584.1    KY407546    ATU47252.1    KRK06435.1    KRG07562.1    KRG07564.1    KRG07565.1    KRG07567.1    CH964239    EDW82571.2    KRT06944.1    KRT06945.1    DS234995    EEB10108.1    KRK06434.1    KRK06436.1    KRG07561.1    AE014298    ACZ95309.1    KRT06942.1    KRG07566.1    M94375    L33831    BT021414    AY070553    KQS30223.1    CH916370    EDW00125.1    CH902644    EDV34801.1    CM000366    EDX18084.1    KPU75290.1    GL888387    EGI61759.1    AAAB01008859    KQ978625    KYN29621.1    KZ288254    PBC30823.1    KQ982080    KYQ60346.1    GFXV01006180    MBW17985.1    KK107064    EZA60894.1    ATLV01012931    ATLV01012932    ATLV01012933    ATLV01012934    ATLV01012935    ATLV01012936    ATLV01012937    ATLV01012938    KE524827    KFB37072.1    ABLF02040171    ABLF02040188    ABLF02040191   

Proteomes

UP000005204    UP000053240    UP000218220    UP000283053    UP000007151    UP000053268    + More
UP000037510    UP000095300    UP000037069    UP000075900    UP000078541    UP000078540    UP000005205    UP000007266    UP000183832    UP000078542    UP000005203    UP000008237    UP000008792    UP000268350    UP000002282    UP000009192    UP000001819    UP000008711    UP000092553    UP000007798    UP000009046    UP000000803    UP000001070    UP000007801    UP000000304    UP000007755    UP000078492    UP000242457    UP000075809    UP000053097    UP000192221    UP000030765    UP000007819   

PRIDE

H9IYM0    H9IYN1    E1JJL4    P30432   

Pfam

PF01483   P_proprotein        + More
PF14843   GF_recep_IV
PF00082   Peptidase_S8
PF16470   S8_pro-domain
PF15913   Furin-like_2

Interpro

IPR034182   Kexin/furin        + More
IPR023828   Peptidase_S8_Ser-AS       
IPR022398   Peptidase_S8_His-AS       
IPR002884   P_dom       
IPR023827   Peptidase_S8_Asp-AS       
IPR009030   Growth_fac_rcpt_cys_sf       
IPR006212   Furin_repeat       
IPR036852   Peptidase_S8/S53_dom_sf       
IPR008979   Galactose-bd-like_sf       
IPR015500   Peptidase_S8_subtilisin-rel       
IPR000209   Peptidase_S8/S53_dom       
IPR032778   GF_recep_IV       
IPR038466   S8_pro-domain_sf       
IPR032815   S8_pro-domain       
IPR000742   EGF-like_dom       
IPR011031   Multihaem_cyt       

SUPFAM

SSF52743   SSF52743        + More
SSF49785   SSF49785       
SSF57184   SSF57184       

Gene 3D

2.60.120.260     3.40.50.200     3.30.70.850    

CDD

cd00064  FU
cd04059  Peptidases_S8_Protein_converta

ProteinModelPortal

H9IYM0   A0A194RGR3   A0A2A4JGI8   A0A2H1WK85   A0A437B8F0   A0A212FLJ6   + More
A0A194PZ75   A0A0L7LPQ1   A0A2A4K7Y7   A0A212F4A7   Q26489   A0A437BM12   A0A194RFY5   A0A194PYD1   A0A2H1W496   H9IYN1   A0A0A1XGS4   A0A0K8U8C6   A0A0A1X1M3   A0A0L7LUE0   W8APW3   A0A1Q3FTU0   A0A1Q3FU12   A0A1Q3FTV5   A0A1Q3FUD1   T1P9R1   A0A1I8Q1H9   A0A1I8Q1I4   A0A0L0BQD1   A0A2M4DS50   A0A2M3Z0N1   A0A2M4A589   A0A2M4DS69   A0A2M4A5Q5   A0A2M4A4R7   A0A2M4B9F8   A0A2M4B9B2   A0A2M4CJY4   A0A2M4B9D5   Q5DNW1   A0A023EXA8   W4VRF9   A0A336LJ86   A0A336LIK8   A0A2C9GWR4   A0A195FL77   A0A1B6GHW2   A0A195BWS1   A0A1B6CCM9   A0A158NEY8   A0A1Y1KM81   A0A139WNE9   A0A1J1IF38   A0A0C9QJY7   A0A151IEG1   A0A0C9QQN8   A0A088AL19   A0A336LJV0   E2BLN8   A0A0Q9WMJ9   B4M1S6   A0A3B0K7Y0   A0A0R1EG80   B4L8R4   A0A0R3P5B9   B4PXS5   B3NX47   Q29GI8   A0A0Q5T754   A0A0M4ELX6   A0A2D3FB63   A0A0R1EEA9   A0A0Q9XGD4   B4NCL2   A0A0R3P6H0   E0V9N9   A0A0R1EGT9   A0A0Q9XJA6   E1JJL4   A0A0R3P116   A0A0Q9XRF1   P30432   A0A0Q5T532   B4JKM2   B3N0S2   P30432-2   B4R5T4   A0A0P8ZKG0   F4WVD8   A0A1S4GGJ0   A0A195EN83   A0A2A3EGB8   A0A151XIV9   A0A2H8TUQ2   A0A026X0H0   A0A1W4VTY2   A0A1W4VHD4   A0A084VGH8   X1WJ00   A0A1W4VVH0  

PDB

1P8J     E-value=1.3192e-152,     Score=1388

KEGG

101742208    K08654 proprotein convertase subtilisin/kexin type 5 [EC:3.4.21.-] | (RefSeq) furin-like protease 2

GO

GO:0016021   GO:0004252   GO:0030173   GO:0016485   GO:0016020   GO:0005802   GO:0005886   GO:0051048   GO:0006508   GO:0006355   GO:0005622   GO:0015934   GO:0005216   GO:0045211   GO:0005975   GO:0004553  

Subcellular location

Membrane  

Length:

963

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

11.75856

Exp number, first 60 AAs:

0.00019

Total prob of N-in:

0.00118

outside

1  -  963

 

 

Pi

185.508713

Theta

166.357344

Tajima's D

0.06608

CLR

13.924643

CSRT

0.392930353482326

Interpretation

Uncertain