Gene

KWMTBOMO12435

Pre Gene Modal

BGIBMGA012449

Annotation

PREDICTED:_protein_groucho-like_isoform_X3_[Bombyx_mori]

Location

Bomo_Chr21(+):3334951-3343600      View in EpiBrowser

Full name

Protein groucho      

Alternative Name

Enhancer of split m9/10 protein

Location in the cell

Extracellular   Reliability : 3.67

CDS

ATGCACCGGACCGCGTACTCGTACCACTCGTGCGGCGGCGGGGGGCTGCAGGCGGTGGGGTTCCCGGCGGACGCGCTGTCGGCGGCGGGCGTGCCGCGGGGCGCGCGCGCGGTGGCGGCGCTGGCGCACGGCGAGGTGGTGTGCGCGGTGGCGCTGTCGCTGGGCGGCGGCGCGCGCCACGCCTACACGGGCGGCAAGGGCTGCGTCAAGCTGTGGGACATCACCAACCCCGGCTCGCCGGCCACGCTCGAGCCGCTGTCGCAGTTGGACTGCTTGCAAAGAGACAACTACATACGCTCCGTGAAACTCTTGCCCGACGGCCGCACCCTCATCGTGGGAGGGGAAGCATCGACACTGTCAATATGGGACCTCGGCTCCGGCACTCCGCGGATGAGGGCCGAGCTCACCTCGTGCGCGCCCGCGTGTTACGCGTTAGCCATTAGTCCGGATTCTAAGGTTTGCTTTAGTTGCTGTTCAGATGGCAACATAGCTGTATGGGACCTACAAAATCAAACACTAGTTAGACAATTTCAAGGGCACACGGACGGCGCCTCGTGCATAGACATCAGCGGCGACGGCACGCGGCTGTGGACGGGCGGCCTCGACAACACGGTGCGCTCGTGGGACCTGCGGGAAGGCAGGCAACTACACCAACACGACTTCTCGAGTCAAATATTCTCGCTGGGATATTGTTCAACAGGATCCTGGCTGGCGGTGGGCATGGAGAATTCGCACGTCGAAGTACTACATTCAGGGAAGCCGGACAGGTATCAGCTGTTGCTGCACGAGTCTTGCGTTTTGTCGTTAAAATTCGCAACGTGCGGGAAATGGTTCGTCTCTACAGGGAAAGATAATTTGTTGAACGCATGGCGTACGCCTTACGGAGCTAGTATATTTCAGTCTAAAGAATCATCATCGGTGCTCAGTTGTGATATATCAACGGACGATAAGTTCATAGTGACGGGATCGGGCGACAAAAAGGCAACAGTTTATGAAGTCGTTTATTAA

Protein

MHRTAYSYHSCGGGGLQAVGFPADALSAAGVPRGARAVAALAHGEVVCAVALSLGGGARHAYTGGKGCVKLWDITNPGSPATLEPLSQLDCLQRDNYIRSVKLLPDGRTLIVGGEASTLSIWDLGSGTPRMRAELTSCAPACYALAISPDSKVCFSCCSDGNIAVWDLQNQTLVRQFQGHTDGASCIDISGDGTRLWTGGLDNTVRSWDLREGRQLHQHDFSSQIFSLGYCSTGSWLAVGMENSHVEVLHSGKPDRYQLLLHESCVLSLKFATCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISTDDKFIVTGSGDKKATVYEVVY

Description

Transcriptional corepressor that regulates transcription when recruited to specific target DNA by hairy-related bHLH proteins. Maternally required for neurogenesis; in the segregation of the neuroectoderm. Directly or indirectly interacts with Notch and Delta.

Subunit

Forms a complex with the hairy/Enhancer of split/deadpan family of basic helix-loop-helix proteins in order to repress transcription. Its activity in regulating transcription depends on other proteins as it lacks a DNA-binding motif.

Similarity

Belongs to the WD repeat Groucho/TLE family.

Keywords

Alternative splicing   Complete proteome   Developmental protein   Differentiation   Neurogenesis   Nucleus   Phosphoprotein   Reference proteome   Repeat   Repressor   Transcription   Transcription regulation   Ubl conjugation   WD repeat   Wnt signaling pathway  

Feature

chain  Protein groucho
splice variant  In isoform A.

Uniprot

H9JSD8   A0A2H1VML5   A0A3S2NC38   A0A212EPW9   S4PTI1   A0A0N1IAX6   + More
A0A2A4JF60   A0A2A4JGR0   A0A2A4JFW2   A0A2A4JGT2   A0A2A4JFK7   A0A2A4JGQ6   A0A194Q013   A0A1J1J8D2   A0A1Q3FTJ8   A0A1Q3FTN3   A0A0L0BNT4   B4K6D4   A0A139WM63   A0A0M4EPG5   A0A1I8Q0W1   A0A1I8Q0W6   B4JGJ3   A0A1S4FQJ2   A0A0Q9WEH9   A0A1I8Q0Y2   B4LYS6   A0A1Q3EWU8   K7IVW5   A0A1I8Q0T3   A0A1I8JSJ7   A0A2M4BFG3   A0A1L8DX89   A0A1L8DXQ3   A0A1Q3EWV7   B4NK36   A0A1L8DX54   W8APR0   A0A3B0KUR7   A0A0P4VM37   A0A0B4JDF1   W8B181   B0WQA4   P16371-2   A0A1W4VKI4   A0A1W4V8D4   A0A1L8DX46   A0A1Q3FTQ9   A0A1Q3EWS8   A0A0B4JD02   A0A0B4LHP1   A0A0R1EAK7   B4ICI5   B3P6A6   A0A0A1WRL4   B4PSX2   P16371   A0A1W4VL66   B4QW19   A0A0B4KH09   A0A034VJ87   A0A1W4VLW7   A0A0K8UN71   A0A0A1WN86   Q296Z2   B3LY32   T1P812   A0A034VH93   A0A034VIA5   A0A1I8NA79   A0A1I8NA76   A0A1I8NA77   A0A1I8NA75   A0A0R3NI67   I5AP77   A0A0B4K6L6   A0A182YE04   A0A2M4CJD8   A0A195FLN6   A0A0P9C9B7   A0A0P8YMB5   A0A1B6JW44   W5JMS7   A0A084W6R3   Q16T04   B4GEG0   A0A0K8SNJ1   R4WDS2   A0A1B6KKI2   A0A1B6DHC3   A0A1B6I5Z0   A0A1B6KTK3   T1PMF4   A0A0A9YUC4   A0A182RWZ8   A0A0K8SNT9   T1IFT0   A0A182W845   A0A151XIP0   Q7PMQ2  

Pubmed

19121390    22118469    23622113    26354079    26108605    17994087    + More
18362917    19820115    17510324    18057021    20075255    24495485    27129103    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    3142687    10731138    8001118    18327897    22304967    17550304    25830018    25348373    15632085    23185243    25315136    25244985    20920257    23761445    24438588    23691247    25401762    12364791    14747013    17210077   

EMBL

BABH01033822    BABH01033823    BABH01033824    ODYU01003365    SOQ42036.1    RSAL01000243    + More
RVE43618.1    AGBW02013352    OWR43545.1    GAIX01011998    JAA80562.1    KQ460234    KPJ16412.1    NWSH01001640    PCG70601.1    PCG70603.1    PCG70598.1    PCG70602.1    PCG70599.1    PCG70600.1    KQ459585    KPI98334.1    CVRI01000070    CRL07169.1    GFDL01004116    JAV30929.1    GFDL01004118    JAV30927.1    JRES01001582    KNC21750.1    CH933806    EDW15207.2    KQ971317    KYB28976.1    CP012526    ALC46738.1    CH916369    EDV93690.1    CH940650    KRF83052.1    EDW67003.2    KRF83050.1    KRF83051.1    KRF83053.1    GFDL01015289    JAV19756.1    GGFJ01002417    MBW51558.1    GFDF01003048    JAV11036.1    GFDF01003049    JAV11035.1    GFDL01015246    JAV19799.1    CH964272    EDW85078.2    GFDF01003047    JAV11037.1    GAMC01015780    JAB90775.1    OUUW01000023    SPP89576.1    GDKW01001008    JAI55587.1    AE014297    ADV37384.1    GAMC01015779    GAMC01015777    GAMC01015775    JAB90778.1    DS232037    EDS32767.1    M20571    AF145695    GFDF01003100    JAV10984.1    GFDL01004117    JAV30928.1    GFDL01015295    JAV19750.1    ADV37383.1    AHN57538.1    CM000160    KRK04418.1    CH480828    EDW45081.1    CH954182    EDV53576.1    GBXI01012593    JAD01699.1    EDW98659.2    KRK04415.1    CM000364    EDX14518.1    AGB96361.1    GAKP01017082    JAC41870.1    GDHF01024182    GDHF01023943    JAI28132.1    JAI28371.1    GBXI01014322    GBXI01003326    JAC99969.1    JAD10966.1    CM000070    EAL28314.2    KRT00643.1    KRT00645.1    KRT00646.1    CH902617    EDV42888.1    KPU79971.1    KA644679    AFP59308.1    GAKP01017083    GAKP01017079    JAC41869.1    GAKP01017085    GAKP01017084    GAKP01017078    GAKP01017077    JAC41867.1    KRT00644.1    EIM52762.1    AFH06626.1    GGFL01001245    MBW65423.1    KQ981490    KYN41246.1    KPU79970.1    KPU79969.1    GECU01004292    JAT03415.1    ADMH02000601    ETN65687.1    ATLV01020916    ATLV01020917    ATLV01020918    ATLV01020919    ATLV01020920    ATLV01020921    KE525310    KFB45907.1    CH477662    EAT37586.1    CH479182    EDW33995.1    GBRD01010922    JAG54902.1    AK417794    BAN21009.1    GEBQ01028024    JAT11953.1    GEDC01012283    JAS25015.1    GECU01025367    JAS82339.1    GEBQ01025229    GEBQ01025131    JAT14748.1    JAT14846.1    KA649098    AFP63727.1    GBHO01029781    GBHO01008901    GBHO01008900    GBHO01008898    GBHO01008896    GBHO01008895    JAG13823.1    JAG34703.1    JAG34704.1    JAG34706.1    JAG34708.1    JAG34709.1    GBRD01010921    JAG54903.1    ACPB03007090    ACPB03007091    ACPB03007092    ACPB03007093    KQ982080    KYQ60274.1    AAAB01008972    EAA13394.5   

Proteomes

UP000005204    UP000283053    UP000007151    UP000053240    UP000218220    UP000053268    + More
UP000183832    UP000037069    UP000009192    UP000007266    UP000092553    UP000095300    UP000001070    UP000008792    UP000002358    UP000069272    UP000007798    UP000268350    UP000000803    UP000002320    UP000192221    UP000002282    UP000001292    UP000008711    UP000000304    UP000001819    UP000007801    UP000095301    UP000076408    UP000078541    UP000000673    UP000030765    UP000008820    UP000008744    UP000075900    UP000015103    UP000075920    UP000075809    UP000007062   

PRIDE

H9JSD8    P16371   

Pfam

PF03920   TLE_N        + More
PF00400   WD40

Interpro

IPR036322   WD40_repeat_dom_sf        + More
IPR019775   WD40_repeat_CS       
IPR005617   Groucho/TLE_N       
IPR001680   WD40_repeat       
IPR017986   WD40_repeat_dom       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR009146   Groucho_enhance       

SUPFAM

SSF50978   SSF50978       

Gene 3D

2.130.10.10    

ProteinModelPortal

H9JSD8   A0A2H1VML5   A0A3S2NC38   A0A212EPW9   S4PTI1   A0A0N1IAX6   + More
A0A2A4JF60   A0A2A4JGR0   A0A2A4JFW2   A0A2A4JGT2   A0A2A4JFK7   A0A2A4JGQ6   A0A194Q013   A0A1J1J8D2   A0A1Q3FTJ8   A0A1Q3FTN3   A0A0L0BNT4   B4K6D4   A0A139WM63   A0A0M4EPG5   A0A1I8Q0W1   A0A1I8Q0W6   B4JGJ3   A0A1S4FQJ2   A0A0Q9WEH9   A0A1I8Q0Y2   B4LYS6   A0A1Q3EWU8   K7IVW5   A0A1I8Q0T3   A0A1I8JSJ7   A0A2M4BFG3   A0A1L8DX89   A0A1L8DXQ3   A0A1Q3EWV7   B4NK36   A0A1L8DX54   W8APR0   A0A3B0KUR7   A0A0P4VM37   A0A0B4JDF1   W8B181   B0WQA4   P16371-2   A0A1W4VKI4   A0A1W4V8D4   A0A1L8DX46   A0A1Q3FTQ9   A0A1Q3EWS8   A0A0B4JD02   A0A0B4LHP1   A0A0R1EAK7   B4ICI5   B3P6A6   A0A0A1WRL4   B4PSX2   P16371   A0A1W4VL66   B4QW19   A0A0B4KH09   A0A034VJ87   A0A1W4VLW7   A0A0K8UN71   A0A0A1WN86   Q296Z2   B3LY32   T1P812   A0A034VH93   A0A034VIA5   A0A1I8NA79   A0A1I8NA76   A0A1I8NA77   A0A1I8NA75   A0A0R3NI67   I5AP77   A0A0B4K6L6   A0A182YE04   A0A2M4CJD8   A0A195FLN6   A0A0P9C9B7   A0A0P8YMB5   A0A1B6JW44   W5JMS7   A0A084W6R3   Q16T04   B4GEG0   A0A0K8SNJ1   R4WDS2   A0A1B6KKI2   A0A1B6DHC3   A0A1B6I5Z0   A0A1B6KTK3   T1PMF4   A0A0A9YUC4   A0A182RWZ8   A0A0K8SNT9   T1IFT0   A0A182W845   A0A151XIP0   Q7PMQ2  

PDB

5MWJ     E-value=5.96531e-150,     Score=1360

KEGG

101743676    K04497 groucho | (RefSeq) protein groucho-like

PATHWAY

04013    MAPK signaling pathway - fly - Bombyx mori (domestic silkworm)
04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)
04330    Notch signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0005634   GO:0006355   GO:0032991   GO:0045751   GO:0007173   GO:0008543   GO:0070491   GO:0071906   GO:0007399   GO:0003714   GO:0008293   GO:0000122   GO:0071837   GO:0090090   GO:0005667   GO:0016055   GO:0007541   GO:0045892   GO:0005654   GO:0030154   GO:0008134   GO:0005515   GO:0005622   GO:0015934   GO:0005216   GO:0016021   GO:0045211   GO:0005975   GO:0004553  

PANTHER

PTHR10814  

Subcellular location

Nucleus  

Length:

335

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.05111

Exp number, first 60 AAs:

0.99756

Total prob of N-in:

0.10278

outside

1  -  335

 

 

Pi

157.553825

Theta

152.242032

Tajima's D

-0.378198

CLR

0.228593

CSRT

0.272936353182341

Interpretation

Uncertain