Gene

KWMTBOMO12425

Pre Gene Modal

BGIBMGA012416

Annotation

nicotinic_acetylcholine_receptor_alpha_8_subunit_[Bombyx_mori]

Location

Bomo_Chr21(-):3044124-3090081      View in EpiBrowser

Full name

Acetylcholine receptor subunit beta-like 2      

Alternative Name

Nicotinic acetylcholine receptor beta 2

Location in the cell

PlasmaMembrane   Reliability : 4.175

CDS

ATGGTGCAGGAGAAAGTAATAATCGTCCGGAGGGTTCCCAACACTTTCTACTATCCGTACAGCTTGTGGCCTATGCCCAAGTTTCAAATCAAAGCTGTTAAACTACTCGAAGCGAATCCTGATGTAAAACGCCTTTACGATGATCTACTTAGCAACTACAATCGGTTGATTCGACCCGTCACTAATGTCAGTGACATATTGACAGTGAGGCTTGGGCTGAAGCTTTCGCAGCTGATGGAGGTTAACCTGAAAAATCAGGTCATGACTACTAACCTTTGGGTGGAGCAGAAATGGTTTGACTATAAATTGCAATGGAACCCAGACGACTACGGAGGAGTGGAAATGCTGTACGTACCGTCGGAGCACATTTGGTTGCCCGACATCGTGCTCTACAACAACTGGGATGGTAATTATGAAGTAACTTTAATGACCAAAGCAACCTTGAAGTACACCGGCGAAGTGAACTGGAAGCCGCCAGCGATCTACAAATCCTCCTGCGAGATCAACGTCGAATACTTTCCATTTGATGAACAAACATGCTTCATGAAGTTTGGTTCTTGGACCTATAATGGAGCTCAGGTTGACCTTAAACATATGGACCAGTCTTCCGGAAGCAGTCTAGTTCACGTCGGTATTGATCTAAGCGAGTTTTATTTGTCAGTCGAGTGGGATATACTTGAAGTACCGGCTACGAGGAACGAAGAGTACTACCCTTGTTGCCCCGAGCCTTTTTCTGACATAACATTCAAACTGACGATGCGCAGAAAAACATTGTTCTATACCGTCAACCTGATTATACCCTGTGTGGGTTTGACGTTTTTGACCGTCTTAGTTTTCTATCTACCCTCGGATTCGGGTGAGAAGATTTCGCTCTGCATCTCCATCCTGGTGTCCCTCACTGTGTTCTTCCTCGGTTTGGCCGAGATCATCCCGCCAACATCCCTGGCAATCCCATTGCTCGGGAAATATCTTCTATTCACCATGATACTCGTCTCGCTCAGCGTATTGGTCACTGTGTGCATAGTAAACGTGCATTTCAGGTCTCCGTCAACGCACACAATGTCGCCGTGGATGAAGAAGTTATTCCTTCAGCTGATGCCCAAACTCTTGATGATGAGGAGGACGAAGTACTCGCTTCCAGACTACGATGACACGTTCGTATCTAATGGATACACCAACGAATTGGAAATGAGTCGAGATAGTTTGACTGACGCTTTCGGAGATTCGAAATGTGACAACGGAGATTACCGCAAGTCTCCTGCTCCTGAAGACGACATGATGGGAGCCAGCGCACACCAGAGACCTTCAGTAACCGAATCTGAGAATATGCTGCCTCGCCATTTGTCGCCTGAAGTCGCTGCTGCCCTGAAGAGTGTCAGATTCATCGCTCAACACATTAAAGATGCTGACAAGGATAATGAGGTCATCGAAGATTGGAAGTTCATGTCAATGGTGCTGGACCGCTTCTTTCTCTGGCTGTTCACCATAGCTTGTTTTGTGGGAACTTTTGGGATAATCTTCCAATCCCCGTCTCTATACGACACCAGAGTCCCTGTCGATCAGCAAATATCATCTATACCGATGAAGAAAAACAACTTTTTCTATCCTAAAGACATTGAAACTATTGGAATTATTAGTTGA

Protein

MVQEKVIIVRRVPNTFYYPYSLWPMPKFQIKAVKLLEANPDVKRLYDDLLSNYNRLIRPVTNVSDILTVRLGLKLSQLMEVNLKNQVMTTNLWVEQKWFDYKLQWNPDDYGGVEMLYVPSEHIWLPDIVLYNNWDGNYEVTLMTKATLKYTGEVNWKPPAIYKSSCEINVEYFPFDEQTCFMKFGSWTYNGAQVDLKHMDQSSGSSLVHVGIDLSEFYLSVEWDILEVPATRNEEYYPCCPEPFSDITFKLTMRRKTLFYTVNLIIPCVGLTFLTVLVFYLPSDSGEKISLCISILVSLTVFFLGLAEIIPPTSLAIPLLGKYLLFTMILVSLSVLVTVCIVNVHFRSPSTHTMSPWMKKLFLQLMPKLLMMRRTKYSLPDYDDTFVSNGYTNELEMSRDSLTDAFGDSKCDNGDYRKSPAPEDDMMGASAHQRPSVTESENMLPRHLSPEVAAALKSVRFIAQHIKDADKDNEVIEDWKFMSMVLDRFFLWLFTIACFVGTFGIIFQSPSLYDTRVPVDQQISSIPMKKNNFFYPKDIETIGIIS

Description

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Similarity

Belongs to the ligand-gated ion channel (TC 1.A.9) family.
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.

Keywords

Alternative splicing   Cell junction   Cell membrane   Complete proteome   Disulfide bond   Glycoprotein   Ion channel   Ion transport   Ligand-gated ion channel   Membrane   Postsynaptic cell membrane   Receptor   Reference proteome   RNA editing   Signal   Synapse   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Acetylcholine receptor subunit beta-like 2
splice variant  In isoform B.

Uniprot

A8HTD0   A8CGN2   A8CGM9   B5LVL4   A0A2A4K147   O96632   + More
A0A0H4TM43   Q8WRS1   A0A0H4TME7   A0A0A7RWN6   A0A194PWH7   H9JSA5   A0A1B0DGT5   A0A182XWD4   A0A1Y9HEI1   Q7PQY4   A0A1W7R7Y4   A0A1S4G816   A0A1B0D5D3   A0A0R3NNI9   A0A1Q3FVK1   Q297E0   B4GE89   A0A3B0K5L7   B4NF13   A0A1W4V4C7   B4QT71   B4PVT5   B3N1R1   B3P727   P25162   W8C655   B4HH28   A0A0A1WKB2   A0A0K8UFQ9   B4JFZ8   A0A0M4ENR1   B4K9Y1   A0A034WMD6   A0A0Q9X0L2   A0A1B6CSI7   B4LXX6   A0A1B6LB43   H6TY12   A0A0K1U4G4   W6E9B6   A0A1A9X9A0   W6EAG0   B7UDC9   K7IUV1   A0A1I8P470   O46133   A0A348BSW5   A0A232F686   A0A1I8MQQ8   A0A2Z4N5Q9   Q8MUR0   D3UA20   D2CVP0   A0A0L0BP39   T1PH14   F4WAV6   A0A1I8P432   A0A2A3EKN1   A0A158P3L7   W6EL46   W6E971   A0A0N0U641   A8DIV5   D6WB25   C3TS66   A0A075W270   A0A195F170   C3TS54   A0A139WNS9   A0A154P3T9   A0A0L7R4A8   A0A139WNI5   A8DIU4   C3TS55   B5ARH0   A0A195CSV5   A0A026WYS6   A0A1Y1LP14   T2HNV7   A0A1W4XG06   E0VDF4   Q5F2K5   Q1NZ58   Q4ZHN1   Q4ZHN0   A0A1D2MEM2   A0A067RUF6   A0A2H1WTV6   A0A151JA70   A0A2S2R818   A0A182P6N9   A0A182HU27   A0A182VYJ2   A0A182NDW0  

Pubmed

17868469    25504620    26354079    19121390    25244985    12364791    + More
14747013    15676276    17210077    15632085    17994087    17550304    2121539    9109505    10731132    12537572    12537569    12907802    24495485    25830018    25348373    25701599    20075255    9660807    28648823    25315136    29136191    12752659    20087392    26108605    21719571    21347285    17880682    18362917    19820115    19320762    19533628    24508170    28004739    20566863    27289101    24845553   

EMBL

EU143799    ABV72690.1    EU082086    ABV45522.1    EU082085    ABV45521.1    + More
EU914853    ACG76113.1    NWSH01000256    PCG77967.1    AF096879    AAD09809.1    KP711057    RSAL01000243    AKQ12753.1    RVE43612.1    AF418987    AAL40742.1    KP711050    AKQ12746.1    KP101247    AJA39823.1    KQ459591    KPI97114.1    BABH01033800    BABH01033801    BABH01033802    BABH01033803    AJVK01060318    AY705403    AAAB01008859    AAU12512.1    EAA08126.4    GEHC01000367    JAV47278.1    AJVK01025143    CM000070    KRT00611.1    GFDL01003573    JAV31472.1    EAL28266.3    CH479182    EDW33924.1    OUUW01000007    SPP83340.1    CH964251    EDW83388.1    CM000364    EDX14235.1    CM000160    EDW98934.1    CH902661    EDV34030.2    CH954182    EDV53847.1    X55676    Y14678    AE014297    AY089498    GAMC01008706    JAB97849.1    CH480815    EDW43504.1    GBXI01015322    JAC98969.1    GDHF01026898    GDHF01003421    JAI25416.1    JAI48893.1    CH916369    EDV92537.1    CP012526    ALC47302.1    CH933806    EDW15629.1    GAKP01003143    JAC55809.1    KRG01648.1    GEDC01020789    JAS16509.1    CH940650    EDW66842.1    GEBQ01019064    JAT20913.1    JN390947    AFA28130.1    KP725466    AKV94623.1    KF873590    AHJ11219.1    KF873589    AHJ11218.1    FJ481979    ACK75719.1    AAZX01002653    AJ000391    CAA04053.1    LC389189    BBE49568.1    NNAY01000907    OXU25983.1    MF612139    QKKF02026599    AWX65627.1    RZF36327.1    AF514804    KJ939595    AAM51823.1    AJE70266.1    FJ821439    ACY82693.1    EU879964    ACJ64922.1    JRES01001582    KNC21743.1    KA648102    AFP62731.1    GL888053    EGI68712.1    KZ288229    PBC31729.1    ADTU01008200    KF873592    AHJ11221.1    KF873591    AHJ11220.1    KQ435756    KOX75921.1    EF526093    ABS86915.1    KQ971311    EEZ99341.2    EU937809    ACP31314.1    KJ747359    AIG92772.1    KQ981880    KYN33917.1    EU937797    EU937799    EU937800    EU937801    ACP31302.1    KYB29425.1    KQ434809    KZC06609.1    KQ414658    KOC65659.1    KYB29426.1    EF526090    ABS86912.1    EU937798    ACP31303.1    EU871526    ACG49259.1    KQ977304    KYN03783.1    KK107064    EZA60916.1    GEZM01051844    JAV74671.1    AB748924    BAN81842.1    DS235075    EEB11410.1    AJ880082    CAI54099.1    DQ480159    ABE67099.1    DQ009491    AAY28924.1    DQ009492    AAY28925.1    LJIJ01001600    ODM91301.1    KK852460    KDR23474.1    ODYU01010968    SOQ56406.1    KQ979321    KYN21946.1    GGMS01016915    MBY86118.1    APCN01000602    APCN01000603   

Proteomes

UP000218220    UP000283053    UP000053268    UP000005204    UP000092462    UP000076408    + More
UP000075900    UP000007062    UP000001819    UP000008744    UP000268350    UP000007798    UP000192221    UP000000304    UP000002282    UP000007801    UP000008711    UP000000803    UP000001292    UP000001070    UP000092553    UP000009192    UP000008792    UP000092443    UP000002358    UP000095300    UP000215335    UP000095301    UP000291343    UP000037069    UP000007755    UP000242457    UP000005205    UP000053105    UP000007266    UP000078541    UP000076502    UP000053825    UP000078542    UP000053097    UP000192223    UP000009046    UP000094527    UP000027135    UP000078492    UP000075885    UP000075840    UP000075920    UP000075884   

PRIDE

A8HTD0    A8CGN2    A8CGM9    H9JSA5    P25162   

Pfam

PF02931   Neur_chan_LBD        + More
PF02932   Neur_chan_memb

Interpro

IPR036719   Neuro-gated_channel_TM_sf        + More
IPR002394   Nicotinic_acetylcholine_rcpt       
IPR036734   Neur_chan_lig-bd_sf       
IPR006029   Neurotrans-gated_channel_TM       
IPR006202   Neur_chan_lig-bd       
IPR006201   Neur_channel       
IPR018000   Neurotransmitter_ion_chnl_CS       

SUPFAM

SSF63712   SSF63712        + More
SSF90112   SSF90112       

Gene 3D

2.70.170.10    

ProteinModelPortal

A8HTD0   A8CGN2   A8CGM9   B5LVL4   A0A2A4K147   O96632   + More
A0A0H4TM43   Q8WRS1   A0A0H4TME7   A0A0A7RWN6   A0A194PWH7   H9JSA5   A0A1B0DGT5   A0A182XWD4   A0A1Y9HEI1   Q7PQY4   A0A1W7R7Y4   A0A1S4G816   A0A1B0D5D3   A0A0R3NNI9   A0A1Q3FVK1   Q297E0   B4GE89   A0A3B0K5L7   B4NF13   A0A1W4V4C7   B4QT71   B4PVT5   B3N1R1   B3P727   P25162   W8C655   B4HH28   A0A0A1WKB2   A0A0K8UFQ9   B4JFZ8   A0A0M4ENR1   B4K9Y1   A0A034WMD6   A0A0Q9X0L2   A0A1B6CSI7   B4LXX6   A0A1B6LB43   H6TY12   A0A0K1U4G4   W6E9B6   A0A1A9X9A0   W6EAG0   B7UDC9   K7IUV1   A0A1I8P470   O46133   A0A348BSW5   A0A232F686   A0A1I8MQQ8   A0A2Z4N5Q9   Q8MUR0   D3UA20   D2CVP0   A0A0L0BP39   T1PH14   F4WAV6   A0A1I8P432   A0A2A3EKN1   A0A158P3L7   W6EL46   W6E971   A0A0N0U641   A8DIV5   D6WB25   C3TS66   A0A075W270   A0A195F170   C3TS54   A0A139WNS9   A0A154P3T9   A0A0L7R4A8   A0A139WNI5   A8DIU4   C3TS55   B5ARH0   A0A195CSV5   A0A026WYS6   A0A1Y1LP14   T2HNV7   A0A1W4XG06   E0VDF4   Q5F2K5   Q1NZ58   Q4ZHN1   Q4ZHN0   A0A1D2MEM2   A0A067RUF6   A0A2H1WTV6   A0A151JA70   A0A2S2R818   A0A182P6N9   A0A182HU27   A0A182VYJ2   A0A182NDW0  

PDB

6CNK     E-value=6.12191e-104,     Score=966

KEGG

100126155    K05312 nicotinic acetylcholine receptor, invertebrate | (RefSeq) nAChRa8, Achra8; nicotinic acetylch

GO

GO:0045211   GO:0030054   GO:0022848   GO:0004888   GO:0016021   GO:0005230   GO:0034220   GO:0007268   GO:0050877   GO:0042391   GO:0007165   GO:0043005   GO:0005887   GO:0045202   GO:0017085   GO:0007271   GO:0005892   GO:0006810   GO:0016020   GO:0006811   GO:0004889   GO:0005216   GO:0005975   GO:0004553  

PANTHER

PTHR18945  

Subcellular location

Cell junction  
Synapse  
Postsynaptic cell membrane  
Cell membrane  

Length:

546

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

87.71248

Exp number, first 60 AAs:

0.23342

Total prob of N-in:

0.04852

outside

1  -  259

TMhelix

260  -  282

inside

283  -  288

TMhelix

289  -  311

outside

312  -  323

TMhelix

324  -  346

inside

347  -  488

TMhelix

489  -  508

outside

509  -  546

 

 

Pi

195.118359

Theta

177.934567

Tajima's D

0.297407

CLR

0.468408

CSRT

0.447927603619819

Interpretation

Uncertain