Gene

KWMTBOMO12413

Pre Gene Modal

BGIBMGA012446

Annotation

nicotinic_acetylcholine_receptor_alpha_1_subunit_[Bombyx_mori]

Location

Bomo_Chr21(+):2841969-2877656      View in EpiBrowser

Full name

Acetylcholine receptor subunit alpha-like 1      

Alternative Name

Nicotinic acetylcholine receptor alpha 1

Location in the cell

PlasmaMembrane   Reliability : 2.873

CDS

ATGACAACGAACGTGTGGGTAGAACAGGAATGGAATGATTACAAGCTGAAATGGAACCCTGACGACTACGGTGGTGTGGACACGTTGCATGTGCCTTCAGAACACATATGGCTGCCAGATATCGTGCTTTACAACAACGCTGATGGCAACTACGAAGTGACGATAATGACGAAGGCGATCCTCCACCACGACGGCAAAGTGGTCTGGAAGCCGCCCGCCATTTACAAGTCCTTCTGCGAGATCGACGTTGAGTATTTTCCGTTCGACGAGCAAACCTGCTTCATGAAGTTCGGATCTTGGAGCTACGACGGGTACATGGTCGATCTGAGGCATTTAAAACAGTCGCCCGACTCGGACCACATTGGAATGGGAATAGATTTGTCAGAATATTACATCTCAGTTGAATGGGACATCATGCGGGTCCCAGCAACGAGAAACGAAAAGTTTTACTCTTGCTGTGAAGAACCATACCCGGATATTATCTTTAATATCACGCTCAGACGAAAAACTCTGTTCTACACAGTCAATCTTATTATTCCCTGCGTTGGAATTTCCTTCTTATCGGTTCTAGTATTCTATTTGCCTTCTGATTCAGGAGAGAAGATTTCACTTTGTATTTCAATCCTCCTATCTCTCACTGTGTTCTTCTTGCTGTTAGCAGAAATTATACCACCCACGTCACTTACGGTTCCGTTGCTTGGAAAATATTTGTTGTTCACAATGATGCTAGTTACGCTATCGGTAGTTGTCACTATCGTCGTACTCAACATAAATTTTAGGTCGCCCGTAACCCACAATATGGCCCCATGGGTGAGGAAAGTCTTTATAGATTTTTTACCCAAAATATTATTCATACAAAGGCCTGAAAAACCACCTGATGACGACGATGATAACGATAAACCCAGCGAGATACTCACGGATGTTTTTGGCCCAGACGATATGGATGGGAAATTCAAGGAGTGGGGTTGCGAGGAATACGATTTACCGGGGATGCCCCCTTCACCACCACCTCCTCCAGGAGGGGACGATGAGCTGTTCTCTCCACCTCCAGGATCCCCATGCCGTCTGGACCTTGACGATGGTAGCCCTTCTTTAGAAAAGCCGTACGTCAGAGAAATGGAAAAAACTATCGAAGGTTCTAGGTTTATAGCGCAACATGTCAAAAATAAGGATAAATTTGAAAGCGTTGAAGATGACTGGAAATACGTAGCGATGGTTTTAGACAGGATCTTTCTATTCCTGTTCACGATAGCATGCGTTCTCGGTACGGCGCTCATCATATTTAGAGCACCAACATTCTACGATAATACGAAACCTATCGACATTCTATACTCCAAAATAGCGAAGAAGAAGTTAGAGCTGCTCAAAATGGGCTCAGAAGGAGACCCCGGTCTCTGA

Protein

MTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHDGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWSYDGYMVDLRHLKQSPDSDHIGMGIDLSEYYISVEWDIMRVPATRNEKFYSCCEEPYPDIIFNITLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIVVLNINFRSPVTHNMAPWVRKVFIDFLPKILFIQRPEKPPDDDDDNDKPSEILTDVFGPDDMDGKFKEWGCEEYDLPGMPPSPPPPPGGDDELFSPPPGSPCRLDLDDGSPSLEKPYVREMEKTIEGSRFIAQHVKNKDKFESVEDDWKYVAMVLDRIFLFLFTIACVLGTALIIFRAPTFYDNTKPIDILYSKIAKKKLELLKMGSEGDPGL

Description

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Similarity

Belongs to the ligand-gated ion channel (TC 1.A.9) family.
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.

Keywords

Cell junction   Cell membrane   Complete proteome   Disulfide bond   Glycoprotein   Ion channel   Ion transport   Ligand-gated ion channel   Membrane   Polymorphism   Postsynaptic cell membrane   Receptor   Reference proteome   Signal   Synapse   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Acetylcholine receptor subunit alpha-like 1

Uniprot

A8HTA7   A8CGK1   A0A2A4JXA4   A0A2H1WJZ5   A0A0H4U7T7   A0A212FPK4   + More
A0A194R9X4   A0A194PWH0   A0A0L7LC91   H9JSD5   K7XPY0   B0WJI9   A0A0L0BP41   A0A182J166   A0A182P6P6   A0A182QWG6   W8C3D4   Q17DY3   Q7QD62   A0A182UUJ1   A0A1I8M4H7   A0A1I8P8R8   B4K9X9   B4LXX4   A0A3B0JM77   B4GE91   B4JFZ5   A0A1W4URW6   B5DWV2   A0A0B4KHE6   P09478   A0A0B4KGU3   E0WN28   B4PVU1   A0A1J1J1F2   B4NF15   B4HH23   B3P731   B3N1Q7   A0A0M4F5T1   B4QT66   A0A182WRP2   A0A182FNM7   A0A182HU36   A0A182XWD8   A0A182RN97   A0A1B0GDR4   A0A182KFD2   A0A0T6BCQ9   A0A2P8XKP1   R4I597   A0A1B6HT85   A8DIP3   B5ARH1   A0A1Y1KCU3   D3UA13   A0A067RI44   A0A232F011   E0VDF7   A0A2J7PSA3   A0A182MCM3   A0A348BSV1   A0A195DZA5   D2CVP1   K7IMG0   A0A195EVN3   N6UMS2   E2A4K4   A0A182NDV2   A0A1D8GS59   A0A3L8DMC0   A0A1W4WH52   U4TVN3   A0A182TCU4   A0A1D2MXL1   A0A1B0CSE8   A0A087UJR8   A0A1L4BJZ7   A0A336MI73   A0A1L4BJZ9   V9Z9T0   A0A088BD75   B7PBZ1   A0A1D2MEM2   A0A3B0KCA0   A0A1L4BJY5   A0A1B6CSI7   A0A2A4K147   O96632   O46133   Q8MUR0   W6EAG0   A0A0C9RZ38   A0A0N0U641   A0A0L7R4A8   A0A067RUF6   A0A2A3EKN1  

Pubmed

17868469    22118469    26354079    26227816    19121390    23331538    + More
26108605    24495485    17510324    12364791    14747013    15676276    17210077    25315136    17994087    15632085    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    2840281    17550304    25244985    29403074    17880682    18362917    19820115    19533628    28004739    20087392    24845553    28648823    20566863    20075255    23537049    20798317    30249741    27289101    24291321    9660807    12752659    25701599   

EMBL

EU143792    ABV72683.1    EU082074    ABV45511.1    NWSH01000458    PCG76264.1    + More
ODYU01009147    SOQ53369.1    KP711043    RSAL01000098    AKQ12739.1    RVE47607.1    AGBW02001736    OWR55681.1    KQ460473    KPJ14437.1    KQ459591    KPI97104.1    JTDY01001698    KOB73132.1    BABH01033782    KC134198    AFX68724.1    DS231960    EDS29185.1    JRES01001582    KNC21776.1    AXCN02001585    GAMC01010196    GAMC01010194    GAMC01010192    JAB96359.1    CH477290    EAT44618.1    AY705394    AAAB01008859    AAU12503.1    EAA08125.3    CH933806    EDW15627.2    CH940650    EDW66840.2    OUUW01000007    SPP83335.1    CH479182    EDW33926.1    CH916369    EDV92534.1    CM000070    EDY68186.2    AE014297    AGB96297.1    X07194    AGB96296.1    FR689743    CBX19379.1    CM000160    EDW98940.2    CVRI01000064    CRL05596.1    CH964251    EDW83390.2    CH480815    EDW43499.1    CH954182    EDV53851.1    CH902661    EDV34026.2    CP012526    ALC47300.1    CM000364    EDX14230.1    APCN01000604    CCAG010012008    CCAG010012009    CCAG010012010    CCAG010012011    CCAG010012012    CCAG010012013    CCAG010012014    CCAG010012015    CCAG010012016    CCAG010012017    LJIG01001953    KRT84987.1    PYGN01001836    PSN32586.1    JQ585634    KP725463    AFJ04793.1    AKV94620.1    GECU01029812    JAS77894.1    EF526080    KQ971312    ABS86902.1    EEZ99265.1    EU871527    ACG49260.1    GEZM01089799    JAV57435.1    FJ821429    ACY82683.1    KK852460    KDR23472.1    NNAY01001445    OXU23952.1    DS235075    EEB11413.1    NEVH01021935    PNF19215.1    AXCM01009820    LC389175    BBE49554.1    KQ980050    KYN18047.1    EU879965    ACJ64923.1    KQ981953    KYN32320.1    APGK01016960    KB739995    ENN82001.1    GL436710    EFN71606.1    KU557775    AOT81837.1    QOIP01000006    RLU21521.1    KB631626    ERL84827.1    LJIJ01000414    ODM97750.1    AJWK01025958    AJWK01025959    KK120139    KFM77607.1    KX021840    API81630.1    UFQT01000927    SSX28037.1    KX021828    API81618.1    KF695387    AHE40764.1    KF141793    AGV76068.1    ABJB010351222    DS680203    EEC04113.1    LJIJ01001600    ODM91301.1    SPP83336.1    KX021831    API81621.1    GEDC01020789    JAS16509.1    NWSH01000256    PCG77967.1    AF096879    AAD09809.1    AJ000391    CAA04053.1    AF514804    KJ939595    AAM51823.1    AJE70266.1    KF873589    AHJ11218.1    GBYB01013316    JAG83083.1    KQ435756    KOX75921.1    KQ414658    KOC65659.1    KDR23474.1    KZ288229    PBC31729.1   

Proteomes

UP000218220    UP000283053    UP000007151    UP000053240    UP000053268    UP000037510    + More
UP000005204    UP000002320    UP000037069    UP000075880    UP000075885    UP000075886    UP000008820    UP000007062    UP000075903    UP000095301    UP000095300    UP000009192    UP000008792    UP000268350    UP000008744    UP000001070    UP000192221    UP000001819    UP000000803    UP000002282    UP000183832    UP000007798    UP000001292    UP000008711    UP000007801    UP000092553    UP000000304    UP000076407    UP000069272    UP000075840    UP000076408    UP000075900    UP000092444    UP000075881    UP000245037    UP000007266    UP000027135    UP000215335    UP000009046    UP000235965    UP000075883    UP000078492    UP000002358    UP000078541    UP000019118    UP000000311    UP000075884    UP000279307    UP000192223    UP000030742    UP000075902    UP000094527    UP000092461    UP000054359    UP000001555    UP000053105    UP000053825    UP000242457   

PRIDE

A8HTA7    A8CGK1    H9JSD5    P09478   

Pfam

PF02932   Neur_chan_memb        + More
PF02931   Neur_chan_LBD

Interpro

IPR036719   Neuro-gated_channel_TM_sf        + More
IPR002394   Nicotinic_acetylcholine_rcpt       
IPR036734   Neur_chan_lig-bd_sf       
IPR006202   Neur_chan_lig-bd       
IPR006029   Neurotrans-gated_channel_TM       
IPR006201   Neur_channel       
IPR018000   Neurotransmitter_ion_chnl_CS       
IPR036691   Endo/exonu/phosph_ase_sf       

SUPFAM

SSF63712   SSF63712        + More
SSF90112   SSF90112       
SSF56219   SSF56219       

Gene 3D

2.70.170.10     3.60.10.10    

ProteinModelPortal

A8HTA7   A8CGK1   A0A2A4JXA4   A0A2H1WJZ5   A0A0H4U7T7   A0A212FPK4   + More
A0A194R9X4   A0A194PWH0   A0A0L7LC91   H9JSD5   K7XPY0   B0WJI9   A0A0L0BP41   A0A182J166   A0A182P6P6   A0A182QWG6   W8C3D4   Q17DY3   Q7QD62   A0A182UUJ1   A0A1I8M4H7   A0A1I8P8R8   B4K9X9   B4LXX4   A0A3B0JM77   B4GE91   B4JFZ5   A0A1W4URW6   B5DWV2   A0A0B4KHE6   P09478   A0A0B4KGU3   E0WN28   B4PVU1   A0A1J1J1F2   B4NF15   B4HH23   B3P731   B3N1Q7   A0A0M4F5T1   B4QT66   A0A182WRP2   A0A182FNM7   A0A182HU36   A0A182XWD8   A0A182RN97   A0A1B0GDR4   A0A182KFD2   A0A0T6BCQ9   A0A2P8XKP1   R4I597   A0A1B6HT85   A8DIP3   B5ARH1   A0A1Y1KCU3   D3UA13   A0A067RI44   A0A232F011   E0VDF7   A0A2J7PSA3   A0A182MCM3   A0A348BSV1   A0A195DZA5   D2CVP1   K7IMG0   A0A195EVN3   N6UMS2   E2A4K4   A0A182NDV2   A0A1D8GS59   A0A3L8DMC0   A0A1W4WH52   U4TVN3   A0A182TCU4   A0A1D2MXL1   A0A1B0CSE8   A0A087UJR8   A0A1L4BJZ7   A0A336MI73   A0A1L4BJZ9   V9Z9T0   A0A088BD75   B7PBZ1   A0A1D2MEM2   A0A3B0KCA0   A0A1L4BJY5   A0A1B6CSI7   A0A2A4K147   O96632   O46133   Q8MUR0   W6EAG0   A0A0C9RZ38   A0A0N0U641   A0A0L7R4A8   A0A067RUF6   A0A2A3EKN1  

PDB

6CNK     E-value=1.65677e-76,     Score=728

KEGG

100126153    K05312 nicotinic acetylcholine receptor, invertebrate | (RefSeq) nAChRa1, Achra1; nicotinic acetylch

GO

GO:0045211   GO:0030054   GO:0022848   GO:0004888   GO:0016021   GO:0005230   GO:0042391   GO:0007165   GO:0050877   GO:0034220   GO:0007268   GO:0045202   GO:0005887   GO:0043005   GO:0005892   GO:0017085   GO:0007271   GO:0098655   GO:0006811   GO:0016020   GO:0006810   GO:0004889   GO:0005216   GO:0005975   GO:0004553  

PANTHER

PTHR18945  

Subcellular location

Cell junction  
Synapse  
Postsynaptic cell membrane  
Cell membrane  

Length:

465

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

88.28762

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01571

outside

1  -  171

TMhelix

172  -  194

inside

195  -  200

TMhelix

201  -  223

outside

224  -  237

TMhelix

238  -  257

inside

258  -  410

TMhelix

411  -  433

outside

434  -  465

 

 

Pi

182.386847

Theta

152.372474

Tajima's D

0.507941

CLR

0.668578

CSRT

0.517474126293685

Interpretation

Uncertain