Gene

KWMTBOMO12412

Annotation

reverse_transcriptase_[Bombyx_mori]

Location

Bomo_Chr21(-):2743654-2747658      View in EpiBrowser

Full name

RNA-directed DNA polymerase from mobile element jockey       + More
Probable RNA-directed DNA polymerase from transposon BS      

Alternative Name

Reverse transcriptase

Location in the cell

Nuclear   Reliability : 2.906

CDS

ATGATACTCGTGGCGTTAGAACCCACCCCGGAGGCCAAAAAGAAGATCGCATGTCTCACGACAATTTGCGGCCTATCCGGGATATCGATCGAAGCCCCCCATAAGCGTGGCACTCCCGGGCAGTGCTACAGGTGCCAACTCTATGGCCACTCGGCGCGTAATTGCCACGCGCGCCCCCGCTGCGTGAAATGCCTCGGCGATCACGCTACGTTAGATTGCGTTAGAGATAGGGAAACCGCGACCGAACCTCCCAGCTGTGTCCTATGCCTTAAGCAAGGGCACCCCGCGAACTACCGTGGATGTCCCAGGGCTCCGCGAAAACGCCCAACCCACCCAGCTCCGCGAACCGTCGGCCCAAAGACTTCGGCACCCTCAGTGCCGAAACCTGCCTTCGTGCCGGCTGCAGTTCCCACGGTTTCAGCGTGGAAAAAGCCGCTGCCGTATACGAAGGCGGGAACGCAAACCGCACCCCCGCCCCCGCTCGCGACACGCCCCGCGCCTCAGCCCCTGCTCGCACCTCGCCCCGCGCCCGCGTTCCGTCCCCCGCAACCCTCTGCCGCCAACGACTTCGCGCTCGTGCGCGACTTCGTCACCGCGGTGAACTTCGACCGTCTGCGATCGTTCGCTGACGCTATCCGTAGGTCGACAACCCCCGAACAGCGGCTCGCGGCCGCGTTCGATCACATGGACGTTTATGAGTCCGTGTCGCCATTCTACAATGCTAACGGAATCGCGCGGCAACGCGATCAAATTTTCGAATTCCTCCGCGATAATCTTGTAGATATTCTATTAGTGCAGGAAACCTGTCTGAAGCCCCCGCGTCGCGACCCGAAAGTCGCGAATTACGTCATGGTTAGGAATGACAGACTCACCGCCTCCAAAGGCGGGACTGCCATTTACTATAGGCGGGCCCTGCACGTTGTCCCTCTCGATACTCCCTCGCTCTCACATATCGAGGCGTCAGTGTGCCGTATCTCGCTGACGGGACACCAGCCGATCGTCATCGCATCCGTTTATCTCCCCCCGGACAAGCCCCTTCTGAGCAGTGACATCGAGTCACTGTTCGGCATGGGAGACTCCGTCATCCTGGCAGGCGATTTAAATTGCCACCACACTAGGTGGAACTGCCATCGTACTAACGTTAACGGTAGGCGTCTCGACGCGTTTATAGACGACCTCACCTTTGAAATAGTCGGTCCCCCAACTCCAACATGTTATCCGTATAACATCGCGCTCCGTCCGAGCACTATAGACCTGGCATTGCTTAGGAACGTAACTCTGCGCTTGCGTTCCATCGAAGCAATGTCAGAGCTCGACTCAGACCACCGACCTGTCGTTATGCAGCTCGGTCGCCCCCACAACCCAGTCACTGTTACGAGGACCATGGTGGATTGGAATAAGCTGGGCACGTGCCTAGCCGACACCGCTCCGCCAATCCTCCCTTACGGCCCGGATTCGAATCTATCCCCCGAGGACACCGTCGAATCCATAAACATCATTACCGATCACATATCTTCCGCGATCATTAGATCTTCTAAAGAAGTCGATGTGGAGGACAGCTTCCACCGCATCAGACTGTCCCCCGATCTTAGGAATCTCTTAAGAGTTAGGAACGCGGCAATCCGGGCCTACGATCGTCTTCCCACGCATTCAAACCGGATTCGGATGCGTCGTCTACAACGCGAAGTCCACTCCCGCTTAAGCGACGCGCGTAACGATAATTGGCATAGTTATTTAGAACAACTCGCGCCCTCCCACCAAGCATACTGGCGACTAGCTAGGACTCTCAAATCCGAAACTACCGCTACTATGCCTCCCCTCGTACGCCCTTCAGGCCAACCACCGGCATTCGATGACGATGACAAGGCTGAGCTGCTGGCCGATGCACTGCAAGAGCAGTGCACCACCAGCACTCAACACGCGGACCCCGAACACACCGAGTTAGTCGACAGGGAGGTCGAGCGCAGAGCTTCCCTGCCGCCCTCGGACGCGTTACCCCCCATTACCACTGACGAAGTTAGAGACGCGATCCACAACCTACAACCTAGGAAGGCACCCGGCTCCGACGGCATCCACAACCGCGCGCTTAAACTCTTGCCAGTCCAACTGATAGCAATGTTGGCTACAATTTTAAATGCCGCTATGACGCACTGCATCTTTCCCGCGGTGTGGAAAGAAGCGGACGTTATCGGTATACATAAGCCGGGCAAACCGACAAACGAAACTTCTAGTTACCGTCCGATTAGTCTCCTCTCGACGATAGGAAAAATTTACGAACGGCTCCTTAGGAAACGCCTCTGGGATTTTGTTACCGCGAACAAAATTCTCATAGACGAACAGTTCGGATTCCGCTCAAAACACTCGTGCGTACAACAAGTGCACCGCCTCACGGAGCACATTCTGATAGGACTAAATAGGCGTAAACAAATCCCGACCGGCGCCCTCTTCTTCGACATCGCGAAGGCGTTCGACAAAGTCTGGCACAACGGTTTAATTTATAAACTGTACAACATGGGAGTGCCAGACAGACTCGTGCTCATCATACGAGACTTCTTGTCGAACCGTTCGTTTCGATATCGAGTAGAGGGAACTCGTTCTCGTCCCCGTCAACTGACCGCCGGAGTCCCGCAAGGCTCCGCGCTCTCCCCGTTATTATTTAGTTTGTATATCAATGATATACCCCGGTCTCCGGAGACCCATCTAGCGCTCTTCGCCGATGACACGGCTATCTACTACTCGTGTAGGAAGATGTCGCTGCTTCATCGGCGACTCCAGATCGCAGTAGCCACCCTGGGACAGTGGTTCCGGAAGTGGCGAATAGACATCAACCCCACGAAAAGCGCAGCGGTGCTCTTCAAAAGGGGTCGCCCTCCGAACATCACTTCGAGCATCCCACTCCGTAGTAGGCGCGCAAACACCTCCGCCGTTAGTCCCATCACTCTCTTTGGCCAGCCCATTCCGTGGGTCTCGAAGGTCAAATATCTAGGCGTCACCCTCGACAGAGGGATGACATTCCGTCCCCATATAAAAACGGTACGCGACCGCGCCGCGTTTATTCTAGGACGACTCTATCCAATGCTTTGTAGTCGAAGCAAACTGTCCCTCCGTAATAAGGTAACTCTCTACAAAACTTGTATACGCCCCGTCATGACGTATGCAAGCGTAGTGTTCGCTCACGCAGCCCGCACCAACTTGAAATCCCTTCAGGTTATTCAATCACGATTCTGCAGGATAGCCGTCCGAGCGCCTTGGTTCCTTAGGAATGTGGATCTCCACGACGACCTGGAGCTCGACTCCTTTAGTAAGTATCTACAGTCGGCTTCGCTGCGCCATTTTGAGAAGGCGGCACGACATGAGAACCCTCTCATCGTAGCCGCTGGAAATTACATACCCGACCCAGTAGACCGAATGGTAAACCGTCGACGTCGCCCAAAGCACGTCATTACGGATCCTCCTGATCCATTAACGGTGCTTTTAGGCACCACAAGCACCGGTCACCGTCCTCGTCGAACCCGTCGCTTGCGACGAAGGGCTCGACGAGCGAACTAA

Protein

MILVALEPTPEAKKKIACLTTICGLSGISIEAPHKRGTPGQCYRCQLYGHSARNCHARPRCVKCLGDHATLDCVRDRETATEPPSCVLCLKQGHPANYRGCPRAPRKRPTHPAPRTVGPKTSAPSVPKPAFVPAAVPTVSAWKKPLPYTKAGTQTAPPPPLATRPAPQPLLAPRPAPAFRPPQPSAANDFALVRDFVTAVNFDRLRSFADAIRRSTTPEQRLAAAFDHMDVYESVSPFYNANGIARQRDQIFEFLRDNLVDILLVQETCLKPPRRDPKVANYVMVRNDRLTASKGGTAIYYRRALHVVPLDTPSLSHIEASVCRISLTGHQPIVIASVYLPPDKPLLSSDIESLFGMGDSVILAGDLNCHHTRWNCHRTNVNGRRLDAFIDDLTFEIVGPPTPTCYPYNIALRPSTIDLALLRNVTLRLRSIEAMSELDSDHRPVVMQLGRPHNPVTVTRTMVDWNKLGTCLADTAPPILPYGPDSNLSPEDTVESINIITDHISSAIIRSSKEVDVEDSFHRIRLSPDLRNLLRVRNAAIRAYDRLPTHSNRIRMRRLQREVHSRLSDARNDNWHSYLEQLAPSHQAYWRLARTLKSETTATMPPLVRPSGQPPAFDDDDKAELLADALQEQCTTSTQHADPEHTELVDREVERRASLPPSDALPPITTDEVRDAIHNLQPRKAPGSDGIHNRALKLLPVQLIAMLATILNAAMTHCIFPAVWKEADVIGIHKPGKPTNETSSYRPISLLSTIGKIYERLLRKRLWDFVTANKILIDEQFGFRSKHSCVQQVHRLTEHILIGLNRRKQIPTGALFFDIAKAFDKVWHNGLIYKLYNMGVPDRLVLIIRDFLSNRSFRYRVEGTRSRPRQLTAGVPQGSALSPLLFSLYINDIPRSPETHLALFADDTAIYYSCRKMSLLHRRLQIAVATLGQWFRKWRIDINPTKSAAVLFKRGRPPNITSSIPLRSRRANTSAVSPITLFGQPIPWVSKVKYLGVTLDRGMTFRPHIKTVRDRAAFILGRLYPMLCSRSKLSLRNKVTLYKTCIRPVMTYASVVFAHAARTNLKSLQVIQSRFCRIAVRAPWFLRNVDLHDDLELDSFSKYLQSASLRHFEKAARHENPLIVAAGNYIPDPVDRMVNRRRRPKHVITDPPDPLTVLLGTTSTGHRPRRTRRLRRRARRAN

Catalytic Activity

a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)

Cofactor

Mg(2+)
Mn(2+)

Miscellaneous

Prefers poly(rC) and poly(rA) as template and activated DNA is not effective.

Keywords

Nucleotidyltransferase   RNA-directed DNA polymerase   Transferase   Transposable element  

Feature

chain  RNA-directed DNA polymerase from mobile element jockey

Uniprot

Q9XXW0   Q93137   Q9BPQ0   A0A0N1PFV1   O96546   A0A1Y1NA23   + More
A0A139W8G9   A0A139WA11   V5GNJ2   V5GNF3   A0A023EYS8   A0A2S2PPK8   A0A023EZE6   X1WLB2   A0A2S2Q383   Q07995   A0A3N5Z7I3   A0A2S2QEE0   A0A2M4CV42   A0A2J7QR37   A0A2M4BD66   A0A2M4BDA5   A0A2M4BD62   A0A087UGF5   A0A2M4CV52   A0A2J7PU96   A0A2J7PBY3   A0A224X6Q4   A0A2J7QY69   X1WNI2   A0A2M4BD67   A0A2M4BDV6   A0A2J7R7D0   J9LC21   J9LFC9   A0A2S2NGV8   X1WQI9   A0A2J7Q6J2   A0A2S2N814   A0A224X6T4   X1WZH0   A0A224X6S1   A0A069DZL8   A0A224XB44   A0A2H8TF37   A0A224XI99   A0A2J7PDM0   A0A224X6U5   A0A224X746   A0A224X6R6   A0A1Y1KFR3   A0A2S2R9D4   A0A0A9YJ00   A0A0A9YU04   A0A2S2P698   A0A069DX78   A0A1B6EGD8   K7IN67   A0A2J7QB68   P21328   A0A2A4IUM2   Q8I7P8   A0A224XJI0   Q95SX7   A0A142LX26   A0A2J7PVX3   A0A2S2NPG3   A0A224XHW8   A0A0V0G5B6   P21329   A0A2S2PJG2   A0A2M4CVF1   A0A2M4CVK2   A0A224X6W2   A0A2S2N6Q7   A0A2J7RD70   A0A2S2NH02   A0A352X8G4   A0A2J7Q0S7   A0A2H8TKI9   Q8T9X4  

EC Number

2.7.7.49

Pubmed

10333566    26354079    10380107    28004739    18362917    19820115    + More
25474469    8387152    30086797    26334808    25401762    20075255    2463954    3040362    1714378    7753626    12537569    25527032    1701254    30148503   

EMBL

AB018558    BAA76304.1    U07847    AAA17752.1    AB055391    BAB21761.1    + More
KQ459265    KPJ02064.1    AF081103    AAC72921.1    GEZM01008457    JAV94772.1    KQ973342    KXZ75569.1    KQ971729    KYB24751.1    GALX01005299    JAB63167.1    GALX01005359    JAB63107.1    GBBI01004395    JAC14317.1    GGMR01018716    MBY31335.1    GBBI01004571    JAC14141.1    ABLF02042518    ABLF02057746    GGMS01002992    MBY72195.1    S59870    AAB26437.2    RPOV01000134    RPJ78669.1    GGMS01006359    MBY75562.1    GGFL01005012    MBW69190.1    NEVH01011985    PNF31054.1    GGFJ01001844    MBW50985.1    GGFJ01001842    MBW50983.1    GGFJ01001843    MBW50984.1    KK119692    KFM76444.1    GGFL01004957    MBW69135.1    NEVH01021205    PNF19912.1    NEVH01027074    PNF13841.1    GFTR01008279    JAW08147.1    NEVH01009134    PNF33528.1    ABLF02008153    ABLF02008462    ABLF02008464    GGFJ01001858    MBW50999.1    GGFJ01001857    MBW50998.1    NEVH01006736    PNF36716.1    ABLF02036316    ABLF02036319    ABLF02048663    ABLF02066977    ABLF02023911    GGMR01003407    MBY16026.1    ABLF02022418    NEVH01017470    PNF24199.1    GGMR01000676    MBY13295.1    GFTR01008261    JAW08165.1    ABLF02034467    GFTR01008271    JAW08155.1    GBGD01000415    JAC88474.1    GFTR01008262    JAW08164.1    GFXV01000908    MBW12713.1    GFTR01008256    JAW08170.1    NEVH01026386    PNF14434.1    GFTR01008251    JAW08175.1    GFTR01008151    JAW08275.1    GFTR01008269    JAW08157.1    GEZM01084969    JAV60363.1    GGMS01017365    MBY86568.1    GBHO01010547    GBHO01010546    JAG33057.1    JAG33058.1    GBHO01021814    GBHO01010549    JAG21790.1    JAG33055.1    GGMR01012305    MBY24924.1    GBGD01000389    JAC88500.1    GEDC01000337    JAS36961.1    NEVH01016302    PNF25823.1    M22874    M38643    NWSH01007753    PCG62823.1    AY180919    AAN87272.1    GFTR01008257    JAW08169.1    AY060438    AAL25477.1    KU543673    AMS38352.1    NEVH01020940    PNF20481.1    GGMR01006408    MBY19027.1    GFTR01008254    JAW08172.1    GECL01003538    JAP02586.1    M38437    GGMR01016905    MBY29524.1    GGFL01005122    MBW69300.1    GGFL01005121    MBW69299.1    GFTR01008260    JAW08166.1    GGMR01000226    MBY12845.1    NEVH01005295    PNF38784.1    GGMR01003864    MBY16483.1    DNOY01000259    HBE18313.1    NEVH01019963    PNF22185.1    GFXV01002840    MBW14645.1    AF456125    AAL57609.1   

Proteomes

UP000053268    UP000007266    UP000007819    UP000235965    UP000054359    UP000002358    + More
UP000218220   

PRIDE

Q9XXW0    Q93137    Q9BPQ0    P21328    Q8I7P8    Q95SX7    + More
P21329    Q8T9X4   

Pfam

PF14529   Exo_endo_phos_2        + More
PF00078   RVT_1
PF07530   PRE_C2HC
PF03372   Exo_endo_phos

Interpro

IPR000477   RT_dom        + More
IPR005135   Endo/exonuclease/phosphatase       
IPR036691   Endo/exonu/phosph_ase_sf       
IPR006579   Pre_C2HC_dom       

SUPFAM

SSF56219   SSF56219       

Gene 3D

3.60.10.10    

ProteinModelPortal

Q9XXW0   Q93137   Q9BPQ0   A0A0N1PFV1   O96546   A0A1Y1NA23   + More
A0A139W8G9   A0A139WA11   V5GNJ2   V5GNF3   A0A023EYS8   A0A2S2PPK8   A0A023EZE6   X1WLB2   A0A2S2Q383   Q07995   A0A3N5Z7I3   A0A2S2QEE0   A0A2M4CV42   A0A2J7QR37   A0A2M4BD66   A0A2M4BDA5   A0A2M4BD62   A0A087UGF5   A0A2M4CV52   A0A2J7PU96   A0A2J7PBY3   A0A224X6Q4   A0A2J7QY69   X1WNI2   A0A2M4BD67   A0A2M4BDV6   A0A2J7R7D0   J9LC21   J9LFC9   A0A2S2NGV8   X1WQI9   A0A2J7Q6J2   A0A2S2N814   A0A224X6T4   X1WZH0   A0A224X6S1   A0A069DZL8   A0A224XB44   A0A2H8TF37   A0A224XI99   A0A2J7PDM0   A0A224X6U5   A0A224X746   A0A224X6R6   A0A1Y1KFR3   A0A2S2R9D4   A0A0A9YJ00   A0A0A9YU04   A0A2S2P698   A0A069DX78   A0A1B6EGD8   K7IN67   A0A2J7QB68   P21328   A0A2A4IUM2   Q8I7P8   A0A224XJI0   Q95SX7   A0A142LX26   A0A2J7PVX3   A0A2S2NPG3   A0A224XHW8   A0A0V0G5B6   P21329   A0A2S2PJG2   A0A2M4CVF1   A0A2M4CVK2   A0A224X6W2   A0A2S2N6Q7   A0A2J7RD70   A0A2S2NH02   A0A352X8G4   A0A2J7Q0S7   A0A2H8TKI9   Q8T9X4  

PDB

6AR3     E-value=0.000226426,     Score=110

KEGG

105842121    no KO assigned | (RefSeq) uncharacterized LOC105842121

GO

GO:0003964   GO:0004519   GO:0006313   GO:0003676   GO:0008270   GO:0016021   GO:0005230   GO:0006810   GO:0004889   GO:0005216   GO:0045211   GO:0005975   GO:0004553  

Length:

1182

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.446130000000001

Exp number, first 60 AAs:

0.00368

Total prob of N-in:

0.00022

outside

1  -  1182

 

 

Pi

0

Theta

0

Tajima's D

0

CLR

0.000052

CSRT

0

Interpretation

Uncertain