Gene

KWMTBOMO12409

Pre Gene Modal

BGIBMGA012422

Annotation

nicotinic_acetylcholine_receptor_subunit_alpha_2_precursor_[Bombyx_mori]

Location

Bomo_Chr21(-):2486194-2507806      View in EpiBrowser

Full name

Acetylcholine receptor subunit alpha-like 2       + More
Acetylcholine receptor subunit alpha-L1      

Alternative Name

Nicotinic acetylcholine receptor alpha 2

Location in the cell

PlasmaMembrane   Reliability : 4.46

CDS

ATGTCTAAAGCTATTTTTGTCGTGTTTTTTTGTAGTTTTACTGTATGTTACGCGAATCCTGACGCGAAGAGGCTTTATGATGACTTACTGAGTAACTACAATAGACTGATTCGACCTGTTGATAAAAATAACAACACCGTACTAGTGAAGCTTGGGCTACGTCTATCCCAGTTGATTGATCTGAATTTGAAAGATCAAATATTAACGACTAACGTATGGTTGGAGCACGAATGGGAAGACCATAAGTTCAAATGGGATCCCTTGGAGTATGGTGGTGTAAGGGAGCTCTATGTGCCATCTGAACATATCTGGCTGCCAGATATAGTGCTTTATAACAATGCCGATGGTGAGTATGTTGTGACGACTATGACGAAAGCTGTGCTGCACCACAATGGAAAAGTGCTTTGGACTCCACCGGCCATCTTCAAGTCCTCCTGCGAGATCGACGTTCGATACTTCCCGTTCGATCAACAGACTTGCTTCTTGAAATTCGGATCTTGGAGCTATGATGGTGATCAGATCGACTTAAAACATATCAACCAAAAAAAGGGGGACATGGTCGAAGTTGGTATCGACCTTCGCGAGTACTACCCGTCAGTGGAATGGGATATTCTCGGAGTACCGGCTGAGAGACACGAGAGGTATTACCCCTGCTGTCAGGAACCGTATCCGGATATCTTCTTTAACATCACACTACGTAGGAAAACCTTATTCTATACTGTCAACCTAATCGTACCGTGTGTGGGGATTTCGTATCTGTCAGTTTTAGTATTTTATCTGCCCGCTGATTCCGGTGAAAAGATAGCCCTCAGCATTTCCATTCTTCTCTCACAAACTATGTTTTTTCTGCTCATTTCCGAAATTATTCCCTCGACTTCTCTAGCTTTACCTTTATTAGGAAAATATTTGCTATTCACCATGCTGCTCGTTGGTTTATCTGTTGTTATAACTATAATAATACTGAATGTACATTATCGAAAGCCTAGTACCCACAAAATGGCTCCATGGGTCAGAAAGTTCTTTATAACAAAACTTCCAAAGTTGCTGCTGATGAGAGTGCCGAAAGATTTGTTGAGAGATTTGGCCGCGCAGAAGATTGCCGGTAGGAGTATGAAGAACAAGAATAAATTCAAAGATGCGCTAGCGGCTGCCGATCAGACTCATTCTAATGCTTCAAGTCCAGACTCGCTCAGACATCACATGCCTGGAGGATGTAATGGACTGCATACTACAACAGCGACAAACAGATTTAGCGGTCTCGTTGGAGCATTAGGAAGCCTCGGTGCTGGATATAATGGTCTACCTTCCGTGATGTCAGGCCTCGATGATTCCTTGAGCGATGTGGTTCCGAGGAAGAAGTATCCGTTTGAATTAGAGAAAGCTATCCACAACGTCATGTTTATACAGCATCACATGCAGCGCCAAGATGAGTTTAATGCGGAAGATCAAGACTGGGGATTTGTGGCTATGGTATTGGATCGTCTGTTCCTGTGGATCTTCACCATAGCTTCCATAGTTGGTACTTTCGCAATCCTATGCGAAGCCCCGTCTTTGTACGACGACACGAAGCCGATTGACATGATGCTGTCTTCTGTGGCCCAGCAGCAATATCTACCTGTCGACAGTGGGGATTCATAA

Protein

MSKAIFVVFFCSFTVCYANPDAKRLYDDLLSNYNRLIRPVDKNNNTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWEDHKFKWDPLEYGGVRELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAVLHHNGKVLWTPPAIFKSSCEIDVRYFPFDQQTCFLKFGSWSYDGDQIDLKHINQKKGDMVEVGIDLREYYPSVEWDILGVPAERHERYYPCCQEPYPDIFFNITLRRKTLFYTVNLIVPCVGISYLSVLVFYLPADSGEKIALSISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNVHYRKPSTHKMAPWVRKFFITKLPKLLLMRVPKDLLRDLAAQKIAGRSMKNKNKFKDALAAADQTHSNASSPDSLRHHMPGGCNGLHTTTATNRFSGLVGALGSLGAGYNGLPSVMSGLDDSLSDVVPRKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVLDRLFLWIFTIASIVGTFAILCEAPSLYDDTKPIDMMLSSVAQQQYLPVDSGDS

Description

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Similarity

Belongs to the ligand-gated ion channel (TC 1.A.9) family.
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
Belongs to the peptidase S1 family.

Keywords

Cell junction   Cell membrane   Complete proteome   Disulfide bond   Glycoprotein   Ion channel   Ion transport   Ligand-gated ion channel   Membrane   Postsynaptic cell membrane   Receptor   Reference proteome   Signal   Synapse   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Acetylcholine receptor subunit alpha-like 2

Uniprot

A8CGK2   A8HTB1   H9JSB1   O96631   A0A0H4TQB9   A0A0A7RQ69   + More
A0A2H1W920   E0WN31   A0A154P4P0   A0A1A9ZCG6   A0A1A9X9A2   A0A1B0GDR8   A0A1A9VTK4   A0A0A1X0E1   Q17DY2   A0A195DYU8   F4WCW3   A0A2A3ESS5   B3N1R0   Q6QHT2   A0A0L7LL34   B4NF14   B4K9Y0   B4JFZ7   B4QT69   Q297D9   B4HH26   P17644   B4LXX5   B4PVT7   A0A195EVM9   B3P729   E2A4K9   A0A3B0KHZ9   A0A3L8DNB1   A0A182WQJ9   A0A2C9GPP7   Q7QD60   A0A034WMC6   A0A0M4EQK7   A1XI34   A0A0K8U8U8   A0A1I8NW57   A1XI33   A0A0L0BP06   K7WZZ6   A0A0C9QEW5   A0A1B0D962   A0A1J1J2B7   A0A310SK04   A0A2Z4N601   A0A348BSV2   A0A1W4V5Q5   A0A0K1U4H6   R4I3V1   A0A151IPU9   E9IZX9   D2CVN9   W6E9A5   E2C6B3   K7IMF9   A0A336M5I2   D3UA14   C3TS22   A8DIQ7   A0A067RKC1   C3TS21   C3TS18   P23414   E0VDF5   A0A1W4XPT8   A0A212EPA7   A0A1D8GS57   A0A026X1G6   A0A194R9Y0   A0A158NB31   A0A0N1PHV8   W8BLF1   A0A194PUL8   N6SS15   A0A0M8ZWT0   A0A0L7RAC4   A0A1B0BF23   A0A1B0CSE7   A0A084VZB4   A0A0U2GQV3   A0A2H8TRZ9   P91765   A0A224ANR7   B4GE90   A0A151I1N3   A0A1S3DA73   A2TM48   A0A3B0KB55   A0A226EXE3   A0A0J7KUP1   A0A2J7PSA1   A0A2P8XCL7   E9G087   A0A1D2MXT5  

Pubmed

17868469    19121390    25504620    25830018    17510324    21719571    + More
17994087    18057021    15656979    26227816    15632085    2117557    1697262    2114015    10731132    12537572    12537569    17550304    20798317    30249741    12364791    14747013    15676276    17210077    25348373    17167752    25315136    26108605    23331538    21282665    25701599    20075255    20087392    19320762    17880682    18362917    19820115    24845553    1702381    20566863    22118469    24508170    26354079    21347285    24495485    23537049    24438588    29403074    21292972    27289101   

EMBL

EU082075    ABV45512.1    EU143793    ABV72684.1    BABH01033749    BABH01033750    + More
BABH01033751    AF096878    NWSH01000941    AAD09808.1    PCG73442.1    KP711044    RSAL01000098    AKQ12740.1    RVE47610.1    KP101241    AJA39817.1    ODYU01006800    SOQ48984.1    FR689746    CBX19382.1    KQ434804    KZC06080.1    CCAG010012019    GBXI01009513    JAD04779.1    CH477290    EAT44619.1    KQ980050    KYN18043.1    GL888074    EGI67944.1    KZ288193    PBC34179.1    CH902661    EDV34029.1    KPU74901.1    AY540846    KJ939589    AAS48080.1    AJE70260.1    JTDY01000730    KOB76074.1    CH964251    EDW83389.1    CH933806    EDW15628.1    CH916369    EDV92536.1    CM000364    EDX14233.1    CM000070    EAL28267.2    CH480815    EDW43502.1    X52274    X53583    AE014297    AY058446    CH940650    EDW66841.1    CM000160    EDW98936.1    KQ981953    KYN32315.1    CH954182    EDV53849.1    GL436710    EFN71611.1    OUUW01000007    SPP83338.1    QOIP01000006    RLU21713.1    APCN01000604    AY705395    AAAB01008859    AAU12504.1    EAA08142.3    GAKP01004009    JAC54943.1    CP012526    ALC47301.1    DQ372063    ABD37618.1    GDHF01029569    GDHF01021142    GDHF01017588    GDHF01014388    JAI22745.1    JAI31172.1    JAI34726.1    JAI37926.1    DQ372062    ABD37617.1    JRES01001582    KNC21741.1    KC134201    AFX68727.1    GBYB01001869    JAG71636.1    AJVK01004243    AJVK01004244    CVRI01000064    CRL05582.1    KQ762207    OAD56063.1    MF612144    AWX65632.1    LC389176    BBE49555.1    KP725464    AKV94621.1    JQ585635    AFJ04794.1    KQ976812    KYN08175.1    GL767291    EFZ13791.1    EU879963    ACJ64921.1    KF873580    AHJ11209.1    GL453058    EFN76512.1    UFQT01000425    SSX24213.1    FJ821430    ACY82684.1    EU930052    EU930053    EU930054    ACM09847.1    EF526081    KQ971372    ABS86903.1    EFA10793.1    KK852460    KDR23473.1    EU930051    ACM09846.1    EU926748    ACL00341.1    X55439    DS235075    EEB11411.1    AGBW02013495    OWR43335.1    KU557776    AOT81838.1    KK107039    EZA61861.1    KQ460473    KPJ14442.1    ADTU01010787    LADI01003211    KPJ20580.1    GAMC01008708    GAMC01008707    JAB97848.1    KQ459591    KPI97101.1    APGK01059131    APGK01059132    KB741292    ENN70434.1    KQ435845    KOX71203.1    KQ414618    KOC67810.1    JXJN01013271    JXJN01013272    AJWK01025954    AJWK01025955    ATLV01018685    ATLV01018686    ATLV01018687    ATLV01018688    ATLV01018689    ATLV01018690    ATLV01018691    ATLV01018692    ATLV01018693    KE525245    KFB43308.1    KT328067    ALB27745.1    GFXV01004846    MBW16651.1    X81887    CAA57476.1    LC215866    BBA21161.1    CH479182    EDW33925.1    KQ976572    KYM80413.1    EF363700    ABM97499.1    SPP83339.1    LNIX01000001    OXA61860.1    LBMM01003055    KMQ94021.1    NEVH01021935    PNF19212.1    PYGN01003029    PSN29730.1    GL732528    EFX86859.1    LJIJ01000414    ODM97751.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000076502    UP000092445    UP000092443    + More
UP000092444    UP000078200    UP000008820    UP000078492    UP000007755    UP000242457    UP000007801    UP000005203    UP000037510    UP000007798    UP000009192    UP000001070    UP000000304    UP000001819    UP000001292    UP000000803    UP000008792    UP000002282    UP000078541    UP000008711    UP000000311    UP000268350    UP000279307    UP000075920    UP000075840    UP000007062    UP000092553    UP000095301    UP000095300    UP000037069    UP000092462    UP000183832    UP000192221    UP000078542    UP000008237    UP000002358    UP000007266    UP000027135    UP000009046    UP000192223    UP000007151    UP000053097    UP000053240    UP000005205    UP000053268    UP000019118    UP000053105    UP000053825    UP000092460    UP000092461    UP000030765    UP000008744    UP000078540    UP000079169    UP000198287    UP000036403    UP000235965    UP000245037    UP000000305    UP000094527   

PRIDE

A8CGK2    A8HTB1    H9JSB1    P17644   

Pfam

PF02932   Neur_chan_memb        + More
PF02931   Neur_chan_LBD
PF00089   Trypsin
PF16087   DUF4817

Interpro

IPR006202   Neur_chan_lig-bd        + More
IPR006029   Neurotrans-gated_channel_TM       
IPR036734   Neur_chan_lig-bd_sf       
IPR002394   Nicotinic_acetylcholine_rcpt       
IPR036719   Neuro-gated_channel_TM_sf       
IPR018000   Neurotransmitter_ion_chnl_CS       
IPR006201   Neur_channel       
IPR033116   TRYPSIN_SER       
IPR001254   Trypsin_dom       
IPR018114   TRYPSIN_HIS       
IPR009003   Peptidase_S1_PA       
IPR001314   Peptidase_S1A       
IPR032135   DUF4817       

SUPFAM

SSF63712   SSF63712        + More
SSF90112   SSF90112       
SSF50494   SSF50494       

Gene 3D

2.70.170.10    

CDD

cd00190  Tryp_SPc

ProteinModelPortal

A8CGK2   A8HTB1   H9JSB1   O96631   A0A0H4TQB9   A0A0A7RQ69   + More
A0A2H1W920   E0WN31   A0A154P4P0   A0A1A9ZCG6   A0A1A9X9A2   A0A1B0GDR8   A0A1A9VTK4   A0A0A1X0E1   Q17DY2   A0A195DYU8   F4WCW3   A0A2A3ESS5   B3N1R0   Q6QHT2   A0A0L7LL34   B4NF14   B4K9Y0   B4JFZ7   B4QT69   Q297D9   B4HH26   P17644   B4LXX5   B4PVT7   A0A195EVM9   B3P729   E2A4K9   A0A3B0KHZ9   A0A3L8DNB1   A0A182WQJ9   A0A2C9GPP7   Q7QD60   A0A034WMC6   A0A0M4EQK7   A1XI34   A0A0K8U8U8   A0A1I8NW57   A1XI33   A0A0L0BP06   K7WZZ6   A0A0C9QEW5   A0A1B0D962   A0A1J1J2B7   A0A310SK04   A0A2Z4N601   A0A348BSV2   A0A1W4V5Q5   A0A0K1U4H6   R4I3V1   A0A151IPU9   E9IZX9   D2CVN9   W6E9A5   E2C6B3   K7IMF9   A0A336M5I2   D3UA14   C3TS22   A8DIQ7   A0A067RKC1   C3TS21   C3TS18   P23414   E0VDF5   A0A1W4XPT8   A0A212EPA7   A0A1D8GS57   A0A026X1G6   A0A194R9Y0   A0A158NB31   A0A0N1PHV8   W8BLF1   A0A194PUL8   N6SS15   A0A0M8ZWT0   A0A0L7RAC4   A0A1B0BF23   A0A1B0CSE7   A0A084VZB4   A0A0U2GQV3   A0A2H8TRZ9   P91765   A0A224ANR7   B4GE90   A0A151I1N3   A0A1S3DA73   A2TM48   A0A3B0KB55   A0A226EXE3   A0A0J7KUP1   A0A2J7PSA1   A0A2P8XCL7   E9G087   A0A1D2MXT5  

PDB

6CNK     E-value=1.38397e-102,     Score=954

KEGG

100126167    K05312 nicotinic acetylcholine receptor, invertebrate | (RefSeq) nAChRa2, Achra2; nicotinic acetylch

GO

GO:0004888   GO:0016021   GO:0022848   GO:0030054   GO:0045211   GO:0015464   GO:0007271   GO:0005892   GO:0098655   GO:0006811   GO:0007268   GO:0034220   GO:0050877   GO:0042391   GO:0007165   GO:0043005   GO:0005887   GO:0045202   GO:0005230   GO:0004252   GO:0016020   GO:0006810   GO:0004889   GO:0005216   GO:0005975   GO:0004553  

PANTHER

PTHR18945  

Subcellular location

Cell junction  
Synapse  
Postsynaptic cell membrane  
Cell membrane  

SignalP

Position:   1 - 18,         Likelihood:  0.991388

 

 

Length:

545

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

102.47751

Exp number, first 60 AAs:

0.29327

Total prob of N-in:

0.02452

outside

1  -  237

TMhelix

238  -  260

inside

261  -  266

TMhelix

267  -  289

outside

290  -  301

TMhelix

302  -  324

inside

325  -  495

TMhelix

496  -  518

outside

519  -  545

 

 

Pi

181.728587

Theta

158.081395

Tajima's D

0.387371

CLR

0.173877

CSRT

0.48297585120744

Interpretation

Uncertain