Silkworm Genome Informatics Database

Gene

KWMTBOMO12403 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012444

Annotation

PREDICTED:_importin-11_[Bombyx_mori]

Location

Bomo_Chr21(+):2275087-2285261 View in EpiBrowser

Full name

Importin-11

Alternative Name

Ran-binding protein 11

Location in the cell

Cytoplasmic Reliability : 1.363 PlasmaMembrane Reliability : 1.581

CDS

ATGGATCCGAATATCTATGCACTAGTATTGGATACCCTAAACAAGGCCACCAGCCAAGACACAGAAGTTTTAAAACCAGCTGAGAAAAAACTGCAGGAATGGGAGATAGAACCAGGATATTATTCTGTCTTATTGAATGTGCTCACTAACCACTCAATCGATGTGAATGTAAGATGGCTTGCTGTCATGTGCTTCAAGAATGGAGTGGACAGGTACTGGAGGAGGAATGCTCCTAATGCCATTTCAGAGGAAGAAAAACAGAAACTAAAACAGGGCTTGCTAACAACAAGTATTTTAAGTGAACCTGTCTCCCAGATAGCAACACAACAAGCAGTTTTGATATCAAAAATCGCTAGGTTTGACTGTCCAGCTAACTGGCCAGATTTAGTTCCAGAGCTAATGGGTGCCATGAAAACTACACAACCTTTGATCCAGCACAGATCTTTGTTAATCTTCCATCATGTAGTCAAGGCTTTGGCTTCTAAAAGATTAGTTGGTGACAGGAAGACATTTCAGGAATTAACCAACTCAGTGTATTCATTCATATTAAGTCTATGGCACGAGAACACGGAGATATTCTTACGTCAGATCCAAGAAGGGGCCGCCACCGAAATAATTACCGAACATCTAGAGAAGGCCCTCCTGTGTCTTAGGATATTGCGAAAGTTGACAGTGTTCGGTTTCAAAAAGGCGCACGAAAGCCAAGACGCTGTTGCTTTTTTAAACGTAGTATTCGATCGGGCTAAGTCCAGCTTGGAATGTCGTAAACTTCTAAAGGGTCGTGGGATCTACTTATTAGAGTTATGCGAAAAATTCATAATACATTTAACCAAAGTAGCGTTAGGAGTATTATTTTTCCACCCGTTTTCCTATGTGCCTTTGATCCGACCGTCTTTAGAATTCGCTTTGTATTATTGCTTCACCGAGCCTGGAATGGCTCTCATATACGAAAGATTCACGATACAGTGTCTTAATATAGTAAAAGGTATATTGCAGTGCATCGAATATAAAGTGCCAAAGGGAACGGAACAGATCAAGGAACCTATGACGTTACAAGCGCATCAAACAAAGATGGAAGTGTTGGACGCTAACACCCTCTGTCACATGTGTAGGCACTTAGTGACTCACTATTTCCTGCTCAGTAGCGACGATTTAGCTTTATGGGACGCCGAACCTGAGAGCTTCGCTATCGATGAAGCCGGTGAATCCTGGAAATACAGTCTGAGGCCGTGCACCGAAGCATTATTCATGGAGCTGTTTCAATTCCGCGAGGTGCTGTCGCCGGAGCTGGTGCGGCTGCTGGCGTCGCTGCAGCACCGGCAGGTGTCGCCCGACGACCTGCCCGCCATACTCAACAAGGACGCCATCTACAACGCTGTCAGGTTGGCCGCCTTCGACTTGTACGATGATGTCGATTTCGATGAGTGGTTCACGAACGTTTTAAGTCAAGAATTGAAAATCAAAGATAATAATTTCAGAATAATAAGAAGGCGGGTCTGTCAGCTCATAGGTCAGTGGTGCGGCGTGCGCGCGTCCCAGTGCCTGCGGCCCGCGATGTACGAGGCGCTGCTGGCGCCGCTCGCGAGCCGCGACGAGGACGCCGCCGTCAAGCTCGCCGCGGCCGAGGCCCTCCGGAGCACCATAGACGACTTCAACTTTGACGTGGAGCAGTTCGCGCCCTACGCGCCCCACGCTATTGCCGCGCTTTACGAGCTCCTGGTGGAGTCGGAGGAGTGCGACACCAAGATGCACGTGCTGCACGTGGTGTCGTGCGTGACGGAGCGCTGCGGGGCGGGCGTGGCGCGGGGCGGGGGCGCGGGGTCGCTCACCGCCTACCTGCCGCAGCTGTGGCACCACGCCGCCGCGCACCAGCACAACATGCTGCGGGCCGCCGCACTGTCCGCCCTCGTGCACCTGCTCAAGGCGCTGGGCGATTGCACACTGACCATTAGACCGTGGATCCTGAGCGTCGTCAACGAGTCCACGCGGCTGTCGGAGCCGGCGCACGTGTACTTGTTGGAGGACGCCCTGGAACTGTGGCTCGCCGTGCTGGAGACGTCCACCAGCGCCGACCCCGCCACGATACAGCTCGCCGAGAACTTGTACCCCATCATAGAGCAATCGACGGAGCACCACCGCATCGTGGTGTACATAATGCAGGCGTACTCGCTGCTGTGCCCCGAGGAGTTCCTGCTGGGCGCCGGCGGCCGCTGCCTGTCGCTGCTGGACGACATGATGGCCGACATGAGGTCCGACGGCGTGCTCTCCGTGCTCAAGATGGCCGAGATATGCCTCAGCGTCACGCTACCGGAGAGGAACACGTTCCTCGGGGTCAAGGTCGTCTGGCCCATACTCATCAGAGTCATTCAGTGA

Protein

MDPNIYALVLDTLNKATSQDTEVLKPAEKKLQEWEIEPGYYSVLLNVLTNHSIDVNVRWLAVMCFKNGVDRYWRRNAPNAISEEEKQKLKQGLLTTSILSEPVSQIATQQAVLISKIARFDCPANWPDLVPELMGAMKTTQPLIQHRSLLIFHHVVKALASKRLVGDRKTFQELTNSVYSFILSLWHENTEIFLRQIQEGAATEIITEHLEKALLCLRILRKLTVFGFKKAHESQDAVAFLNVVFDRAKSSLECRKLLKGRGIYLLELCEKFIIHLTKVALGVLFFHPFSYVPLIRPSLEFALYYCFTEPGMALIYERFTIQCLNIVKGILQCIEYKVPKGTEQIKEPMTLQAHQTKMEVLDANTLCHMCRHLVTHYFLLSSDDLALWDAEPESFAIDEAGESWKYSLRPCTEALFMELFQFREVLSPELVRLLASLQHRQVSPDDLPAILNKDAIYNAVRLAAFDLYDDVDFDEWFTNVLSQELKIKDNNFRIIRRRVCQLIGQWCGVRASQCLRPAMYEALLAPLASRDEDAAVKLAAAEALRSTIDDFNFDVEQFAPYAPHAIAALYELLVESEECDTKMHVLHVVSCVTERCGAGVARGGGAGSLTAYLPQLWHHAAAHQHNMLRAAALSALVHLLKALGDCTLTIRPWILSVVNESTRLSEPAHVYLLEDALELWLAVLETSTSADPATIQLAENLYPIIEQSTEHHRIVVYIMQAYSLLCPEEFLLGAGGRCLSLLDDMMADMRSDGVLSVLKMAEICLSVTLPERNTFLGVKVVWPILIRVIQ

Description

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).

Subunit

Interacts with UBE2E3 and RPL12.

Similarity

Belongs to the importin beta family.

Keywords

Acetylation Alternative splicing Complete proteome Cytoplasm Nucleus Phosphoprotein Polymorphism Protein transport Reference proteome Repeat Transport

Feature

chain  Importin-11
splice variant  In isoform 2.
sequence variant  In dbSNP:rs35107530.

Uniprot

H9JSD3 A0A2A4JLK7 A0A437BB68 A0A2H1WAT9 A0A194PVS7 A0A194R9Y7 + More
A0A067QZY0 A0A2J7QZ00 A0A1Y1NEM3 D6WCP8 A0A088AFX0 A0A2A3EGJ7 A0A310SR03 A0A1B6L138 A0A0M9A5W7 A0A195BUY7 A0A158NEJ4 A0A195FML6 A0A224X6D6 E2AYU4 A0A0P4WDI7 A0A069DWW7 A0A0V0G648 A0A195BYN6 A0A3R7Q146 U4U535 E2BG20 A0A195ENY3 A0A287A273 A0A2Y9I1L1 A0A287B6E0 F7D3G9 A0A3Q7TZ65 G1PJ15 A0A3Q7TZ88 A0A287ACP5 A0A3Q7TCS9 F1PTU2 M3VZZ6 A0A2Y9KL05 A0A1W5APR6 A0A3Q7V089 A0A1W5AGK4 A0A384C3Z0 A0A2Y9KIV4 A0A3Q7VR32 A0A3Q7R0U8 I3M798 A0A384C433 U6DJM8 A0A3Q7S3V8 A0A2Y9KR99 A0A3Q7V094 A0A3Q7QR63 E1BEW3 A0A2R5LKD7 U3K964 A0A093JYM8 A0A3Q0GK68 A0A3Q0GJD8 N6U702 A0A3Q0GK72 A0A3Q0GNR2 A0A1U7RT83 A0A2K6BXQ7 A0A2K6BXQ8 A0A2I2Z3D4 A0A218V9D0 A0A3Q0GNP9 A0A2K5VA88 G3QL52 A0A2I3LV90 A0A2K6QXQ5 A0A2K5NAK4 A0A293N054 A0A026WXS8 L5L242 A0A2K5VA86 G1QSI3 A0A2K5XJB3 A0A096NBN1 F6Y6Y1 A0A2K6QXU1 A0A2K5NAK0 A0A2J8RL73 F6VU09 A0A2I3TTE3 G1LBR6 A0A341D298 A0A2K5XJC7 A0A2U4AX57 A0A2R9CB67 A0A2Y9FTS5 A0A2K5QEF1 H2R5K5 A0A2Y9QAH1 Q9UI26-2 A0A2I0M569 A0A341D581 A0A452EFT8

Pubmed

19121390 26354079 24845553 28004739 18362917 19820115 + More
21347285 20798317 26334808 23537049 19892987 21993624 16341006 17975172 19393038 22398555 25362486 24508170 23258410 17495919 17431167 16136131 20010809 22722832 14702039 15372022 15489334 17974005 11032817 19413330 21269460 23186163 23371554

EMBL

BABH01033726 BABH01033727 BABH01033728 BABH01033729 NWSH01001088 PCG72699.1 + More
RSAL01000098 RVE47622.1 ODYU01007422 SOQ50178.1 KQ459591 KPI97098.1 KQ460473 KPJ14447.1 KK852844 KDR15146.1 NEVH01009080 PNF33813.1 GEZM01007628 GEZM01007627 JAV95035.1 KQ971317 EEZ97802.1 KZ288254 PBC30847.1 KQ761108 OAD58205.1 GEBQ01026406 GEBQ01022564 GEBQ01004526 GEBQ01001237 JAT13571.1 JAT17413.1 JAT35451.1 JAT38740.1 KQ435735 KOX77116.1 KQ976401 KYM92397.1 ADTU01013467 ADTU01013468 KQ981490 KYN41184.1 GFTR01008391 JAW08035.1 GL444002 EFN61389.1 GDRN01071375 JAI63698.1 GBGD01000321 JAC88568.1 GECL01002655 JAP03469.1 KQ978501 KYM93425.1 QCYY01000710 ROT83251.1 KB631950 ERL87428.1 GL448096 EFN85422.1 KQ978625 KYN29604.1 AEMK02000102 AAPE02000842 AAPE02000843 AAPE02000844 AAEX03001466 AANG04002524 AGTP01014081 HAAF01010488 CCP82312.1 GGLE01005867 MBY09993.1 AGTO01021315 KL206556 KFV83534.1 APGK01047013 APGK01047014 APGK01047015 APGK01047016 APGK01047017 APGK01047018 APGK01047019 APGK01047020 APGK01047021 KB741074 ENN74367.1 CABD030104655 CABD030104656 CABD030104657 CABD030104658 CABD030104659 CABD030104660 CABD030104661 CABD030104662 CABD030104663 CABD030104664 MUZQ01000025 OWK62559.1 AQIA01058993 AQIA01058994 AQIA01058995 AHZZ02029215 GFWV01020232 MAA44960.1 KK107064 EZA60875.1 KB030401 ELK17707.1 ADFV01030953 ADFV01030954 ADFV01030955 ADFV01030956 ADFV01030957 ADFV01030958 ADFV01030959 ADFV01030960 ADFV01030961 ADFV01030962 NDHI03003674 PNJ09273.1 JSUE03036065 JSUE03036066 JSUE03036067 JSUE03036068 AACZ04069332 AACZ04069333 NBAG03000320 PNI41080.1 ACTA01105058 ACTA01113058 ACTA01121058 ACTA01129058 ACTA01137058 ACTA01145057 ACTA01153056 ACTA01161055 ACTA01169053 ACTA01177051 AJFE02096465 AJFE02096466 AJFE02096467 AJFE02096468 AJFE02096469 AJFE02096470 AJFE02096471 AJFE02096472 AJFE02096473 AJFE02096474 PNI41078.1 AF111109 AK302781 AK001696 AC008859 CH471137 BC031694 BC033776 AL162083 AKCR02000038 PKK24813.1 LWLT01000017

Proteomes

UP000005204 UP000218220 UP000283053 UP000053268 UP000053240 UP000027135 + More
UP000235965 UP000007266 UP000005203 UP000242457 UP000053105 UP000078540 UP000005205 UP000078541 UP000000311 UP000078542 UP000283509 UP000030742 UP000008237 UP000078492 UP000008227 UP000248481 UP000002281 UP000286640 UP000001074 UP000002254 UP000011712 UP000248482 UP000192224 UP000286642 UP000261680 UP000286641 UP000005215 UP000009136 UP000016665 UP000053584 UP000189705 UP000019118 UP000233120 UP000001519 UP000197619 UP000233100 UP000028761 UP000233200 UP000233060 UP000053097 UP000010552 UP000001073 UP000233140 UP000002280 UP000006718 UP000002277 UP000008912 UP000252040 UP000245320 UP000240080 UP000248484 UP000233040 UP000248483 UP000005640 UP000053872 UP000291000

PRIDE

H9JSD3 Q9UI26

Pfam

PF03810 IBN_N + More
PF08389 Xpo1

Interpro

IPR001494   Importin-beta_N        + More
IPR016024   ARM-type_fold
IPR011989   ARM-like
IPR013598   Exportin-1/Importin-b-like

SUPFAM

SSF48371 SSF48371

Gene 3D

1.25.10.10

ProteinModelPortal

H9JSD3 A0A2A4JLK7 A0A437BB68 A0A2H1WAT9 A0A194PVS7 A0A194R9Y7 + More
A0A067QZY0 A0A2J7QZ00 A0A1Y1NEM3 D6WCP8 A0A088AFX0 A0A2A3EGJ7 A0A310SR03 A0A1B6L138 A0A0M9A5W7 A0A195BUY7 A0A158NEJ4 A0A195FML6 A0A224X6D6 E2AYU4 A0A0P4WDI7 A0A069DWW7 A0A0V0G648 A0A195BYN6 A0A3R7Q146 U4U535 E2BG20 A0A195ENY3 A0A287A273 A0A2Y9I1L1 A0A287B6E0 F7D3G9 A0A3Q7TZ65 G1PJ15 A0A3Q7TZ88 A0A287ACP5 A0A3Q7TCS9 F1PTU2 M3VZZ6 A0A2Y9KL05 A0A1W5APR6 A0A3Q7V089 A0A1W5AGK4 A0A384C3Z0 A0A2Y9KIV4 A0A3Q7VR32 A0A3Q7R0U8 I3M798 A0A384C433 U6DJM8 A0A3Q7S3V8 A0A2Y9KR99 A0A3Q7V094 A0A3Q7QR63 E1BEW3 A0A2R5LKD7 U3K964 A0A093JYM8 A0A3Q0GK68 A0A3Q0GJD8 N6U702 A0A3Q0GK72 A0A3Q0GNR2 A0A1U7RT83 A0A2K6BXQ7 A0A2K6BXQ8 A0A2I2Z3D4 A0A218V9D0 A0A3Q0GNP9 A0A2K5VA88 G3QL52 A0A2I3LV90 A0A2K6QXQ5 A0A2K5NAK4 A0A293N054 A0A026WXS8 L5L242 A0A2K5VA86 G1QSI3 A0A2K5XJB3 A0A096NBN1 F6Y6Y1 A0A2K6QXU1 A0A2K5NAK0 A0A2J8RL73 F6VU09 A0A2I3TTE3 G1LBR6 A0A341D298 A0A2K5XJC7 A0A2U4AX57 A0A2R9CB67 A0A2Y9FTS5 A0A2K5QEF1 H2R5K5 A0A2Y9QAH1 Q9UI26-2 A0A2I0M569 A0A341D581 A0A452EFT8

PDB

1Z3H E-value=2.36168e-05, Score=117

KEGG

101744982 no KO assigned | (RefSeq) importin-11

GO

GO:0008536 GO:0005634 GO:0006886 GO:0005829 GO:0006606 GO:0005635 GO:0006610 GO:0001650 GO:0061608 GO:0005623 GO:0005488 GO:0003676 GO:0006281 GO:0043140 GO:0006310 GO:0000049 GO:0005975 GO:0004553

Subcellular location

Nucleus
Cytoplasm

Length:

790

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.37598

Exp number, first 60 AAs:

0.00614

Total prob of N-in:

0.00628

outside

1 - 790

Pi

169.998345

Theta

171.368015

Tajima's D

-1.062432

CLR

0.462907

CSRT

0.125693715314234

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics