SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO12393
Pre Gene Modal
BGIBMGA012439
Annotation
PREDICTED:_neuroendocrine_convertase_1-like?_partial_[Amyelois_transitella]
Full name
Neuroendocrine convertase 1      
Alternative Name
Prohormone convertase 1
Proprotein convertase 1
Furin homolog
PC3
Propeptide-processing protease
Location in the cell
Cytoplasmic   Reliability : 0.921
 

Sequence

CDS
ATGTTCTCGGAAGTAATGTTCTTAAATTTAATCGTTTTGGTCGTGTCGTGGTATCCATATGAGCACGGTTTTATTGTACCAGGCGAGCATAGGTATCGTGGAGTTCACGATGGCTCGAAGCACGCGAAGAGCTACCTCAATGAGTGGACGGTCGAAGTGGACGGCGGTGAAGAGGTCGCGCAACTGGTGGCTTTGGAACTTGGATACGTCTATGGTGGCCTGGTACAGGGTTTCCCGAACACATACGTATTTTTGAAATACGAACACGTGAAACAACGCCGTACCCCTGGCTCGCATCACACGTCGACGCTAGTACAAGATCGAAGGGTACGATGGGCCGAACAATTATTTAGTAAGTCTCGTGTTAAAAGGCTCGCTTCACCCGGACCTGATCAAACTCTATTCAGAGTCAAGAGAATTCAAACGAATAACAACAAACTTATGGAGAAGAGAAATGGCCCATATTCATATTCTAAATATGAGTTCAATGACGAACTATGGAGTAATCAGTGGTATTTGCAAGATACCCGCACGTCGTCTAAACTGCCTCGTTTAGATTTAAATGTGTTGCCAGTCTACAAATCGGGATTCAATGGAAAAGGTGTTCGTGTTTCTGTACTTGATGATGGCATTGAACACAATCACACGGATCTCCGAGCCAACTACGATCCAGAAATAAGTTGGGACTGCAATGATAGAGATTCGGACCCTTTCCCGAGGTACCAGAAAGTTATGAAAAATTCTCACGGCACACGTTGCGCTGGCGAAATAGCAATGACCGCGAACAATGTGAAATGTGGAGTGGGCGTGGCGTGGGGGGCGAAAGTGGGCGGTGTACGTATGCTCGATGGAGCTATCACCGACCGGATTGAGGGGGAGGCAATAGGATATGCTGTTGATAAGGTCGATATTTACAGTGCCTCGTGGGGACCTAATGACGACGGAAGAACCGTTGAAGGACCTGGTCATTTGGCGATGGAGGCATTCAAGAGAGGTGTCGAAACGGGTCGAGGCGGCAAAGGCGCCATCTATGTTTGGGCGAACGGTAATGGCGGCGGACATAGCGATAATTGCAACTGCGACGGTTATTCATCCAGTATTTATACCGTATCAATTGGAAGCGCCTCCCAGCACGGACTATTTCCCTGGTACGGGGAGATCTGTTCTTCTACTCTTGCTGCCGCTTATTCGTCTGGTGCATACAAAGATCAGAAAATCGCCACTACGGACACAGGAGACTCATGCACGCTTAGTCACACCGGGACATCCGCAGCTGCGCCTTTAGCGGCTGGTATCATCGCACTCGCCCTAGAAGCTAATCCAAATCTCACGTGGCGAGACGTCCAGCACTTGATAGTCTGGACCTCGGAATATGCACCGTTGTCAGCGAATCCTGGATGGCAATTGAATGGAGTTGGACTTCGTTTTGATATTCGATTTGGATTTGGATTAATGAATGCAGGAGGACTTGTCAAAGCAGCTTTGAATTGGACTAATGTCCCAGAAAAATCGATTTGTCGACTGAAAGCATCTCCTTCGGAGTACGAAAATAAATTGACTACAGGGGAAGGCGTTGATATTTTGTTGGACGTCGAAAATTGCGTTGTTAACTATTTGGAACATGTTGAAGTTATTTCAAATATAAAATATACTCGTCGTGGGGCGTTACAAATTTCATTGATTTCACCGCAAGGAACCAAAATACAGCTTTTGAGCCCACGTCCTCTTGATATATCCAATGATGGTTTTTTCAATTGGCCTCTAATGTCTGTGGGTACTTGGGGCGAAAATCCTAATGGAATTTGGAAAATTGTCATAGAAGATAAGACAAACGAACGTAATTCCGGGGAAATTGGTACATTCAGTTTGATAGTACACGGAACTAATGAAATGCCAGAGCACATGAGAAACGGTCCAAGGAAATACAATAAAGAGTACAACAACAACAGCTACGGGGACGTATTCGAATACTTCGATAGCGTGCGTAACAGCGATTTGAACACGGTTACGGACGATATTGCAGCTGCTGTACCAGGGTCGCATGAGGCCGAGGAGTTTGATGCGAATGAAATCGACCCAGAAGTACTCGCGGCAGTTGAAAAAGAATTACAAAGAATTCATCACCGAAAAAACTATCTGCCTAGTCTCGGACTTTAA
Protein
MFSEVMFLNLIVLVVSWYPYEHGFIVPGEHRYRGVHDGSKHAKSYLNEWTVEVDGGEEVAQLVALELGYVYGGLVQGFPNTYVFLKYEHVKQRRTPGSHHTSTLVQDRRVRWAEQLFSKSRVKRLASPGPDQTLFRVKRIQTNNNKLMEKRNGPYSYSKYEFNDELWSNQWYLQDTRTSSKLPRLDLNVLPVYKSGFNGKGVRVSVLDDGIEHNHTDLRANYDPEISWDCNDRDSDPFPRYQKVMKNSHGTRCAGEIAMTANNVKCGVGVAWGAKVGGVRMLDGAITDRIEGEAIGYAVDKVDIYSASWGPNDDGRTVEGPGHLAMEAFKRGVETGRGGKGAIYVWANGNGGGHSDNCNCDGYSSSIYTVSIGSASQHGLFPWYGEICSSTLAAAYSSGAYKDQKIATTDTGDSCTLSHTGTSAAAPLAAGIIALALEANPNLTWRDVQHLIVWTSEYAPLSANPGWQLNGVGLRFDIRFGFGLMNAGGLVKAALNWTNVPEKSICRLKASPSEYENKLTTGEGVDILLDVENCVVNYLEHVEVISNIKYTRRGALQISLISPQGTKIQLLSPRPLDISNDGFFNWPLMSVGTWGENPNGIWKIVIEDKTNERNSGEIGTFSLIVHGTNEMPEHMRNGPRKYNKEYNNNSYGDVFEYFDSVRNSDLNTVTDDIAAAVPGSHEAEEFDANEIDPEVLAAVEKELQRIHHRKNYLPSLGL

Summary

Description
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
Catalytic Activity
Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.
Cofactor
Ca(2+)
Similarity
Belongs to the peptidase S8 family.
Belongs to the complex I LYR family.
Belongs to the peptidase S8 family. Furin subfamily.
Keywords
Calcium   Cleavage on pair of basic residues   Complete proteome   Cytoplasmic vesicle   Disulfide bond   Glycoprotein   Hydrolase   Protease   Reference proteome   Serine protease   Signal   Zymogen   3D-structure   Direct protein sequencing  
Feature
chain  Neuroendocrine convertase 1
EC Number
3.4.21.93
EMBL
NWSH01000666    PCG74927.1    KZ149932    PZC77316.1    RSAL01000188    RVE44747.1    + More
AGBW02010560    OWR48322.1    KQ459591    KPI97092.1    ODYU01002128    SOQ39227.1    NEVH01019070    PNF23002.1    DS235222    EEB13549.1    GDIQ01007276    JAN87461.1    GDIP01163129    JAJ60273.1    GDIP01163130    JAJ60272.1    LRGB01001005    KZS13965.1    GDIP01245156    JAI78245.1    QOIP01000007    RLU21044.1    GL732527    EFX87650.1    LJIJ01001210    ODM92521.1    KQ981744    KYN36407.1    GDIP01192873    JAJ30529.1    GDIQ01139269    JAL12457.1    GDIP01143071    JAJ80331.1    GDIP01218872    JAJ04530.1    KQ980341    KYN16467.1    KK121786    KFM81220.1    GDIP01047546    JAM56169.1    KQ982173    KYQ59410.1    JH432104    KQ434890    KZC10408.1    KQ976558    KYM80646.1    KQ971382    EEZ97211.2    GFAH01000370    JAV48019.1    APGK01053397    APGK01053398    APGK01053399    KB741223    ENN72376.1    AB105175    BAC98350.1    KB631623    ERL84743.1    AERX01008729    RJVU01035392    ROL47407.1    BX511081    FJ373314    ACJ05352.1    FQ310506    CBN81111.1    JARO02004787    KPP67905.1    GL888498    EGI59984.1    MCFN01000050    OXB66904.1    AHZZ02029533    GCES01014532    JAR71791.1    REGN01008080    RNA04507.1    HADZ01009167    HAEA01010674    SBQ39154.1    CM001281    EHH54415.1    AGTO01001632    AQIA01059675    JSUE03036470    JU334825    AFE78578.1    AC188442    CM001258    EHH26677.1    HAEG01002392    SBR67177.1    HADY01007255    HAEJ01014256    SBP45740.1    AANG04001174    M76705    M83745    AYCK01005655    HAEF01000175    SBR37557.1    AM236095    CAJ84769.1    HAEH01003365    HAEI01004363    SBR88446.1    HAED01019021    HAEE01005190    SBR25210.1    U20545    AAA85577.1    KQ042348    KKF15528.1    HAEC01009875    SBQ78091.1    BC108982    BC108983    CH466563    AAI08984.1    EDL37106.1    M58507    M69196    X57088    M58589    M55668    AF186405   
Pfam
PF00082   Peptidase_S8        + More
PF16470   S8_pro-domain
PF01483   P_proprotein
PF05347   Complex1_LYR
PF00531   Death
PF00023   Ank
PF12796   Ank_2
PF12177   Proho_convert
Interpro
IPR022398   Peptidase_S8_His-AS        + More
IPR002884   P_dom       
IPR023827   Peptidase_S8_Asp-AS       
IPR023828   Peptidase_S8_Ser-AS       
IPR034182   Kexin/furin       
IPR032815   S8_pro-domain       
IPR000209   Peptidase_S8/S53_dom       
IPR015500   Peptidase_S8_subtilisin-rel       
IPR038466   S8_pro-domain_sf       
IPR036852   Peptidase_S8/S53_dom_sf       
IPR008979   Galactose-bd-like_sf       
IPR008011   Complex1_LYR       
IPR020683   Ankyrin_rpt-contain_dom       
IPR036770   Ankyrin_rpt-contain_sf       
IPR011029   DEATH-like_dom_sf       
IPR002110   Ankyrin_rpt       
IPR000488   Death_domain       
IPR022005   Proho_convert       
SUPFAM
SSF49785   SSF49785        + More
SSF52743   SSF52743       
SSF47986   SSF47986       
SSF48403   SSF48403       
PDB
1P8J     E-value=8.3009e-117,     Score=1078

Ontologies

Topology

Subcellular location
  
Length:
718
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
2.26455000000001
Exp number, first 60 AAs:
2.16612
Total prob of N-in:
0.10749
outside
1  -  718
 
 

Population Genetic Test Statistics

Pi
172.703931
Theta
159.472892
Tajima's D
0.0205
CLR
0.618572
CSRT
0.376081195940203
Interpretation
Uncertain
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