Gene

KWMTBOMO12389  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012437

Annotation

coatomer_protein_complex_subunit_epsilon_[Bombyx_mori]

Location

Bomo_Chr21(+):2015687-2020184      View in EpiBrowser

Full name

Coatomer subunit epsilon      

Alternative Name

Epsilon-coat protein

Location in the cell

Golgi   Reliability : 1.647

CDS

ATGGCACGTCATCAGCAAGATGTTGATGAACTTTTCGATGTAAAAAATGCATTTTATGTTGGAAATTATCAGCAAGCTATTAATGAGGCACAAAGCGTTAGCCCTTCTACACCCCTGGTAGCACTCCAACGCGATGCATTCCTATATCGTTCCTACATTGCCCAGGGTAACTACAGGATAGTGCAACAAGAACTAAAGACTGCAGATCCTATGCTACAGCCATTGAAGAGTTTGGTAGATTACTTACTACCTGATGCCAATAAATCTGCCATTGTTGCTGATATTGATGCTCGAGTAGCTAAAGGTACGGAACTGTCCAATGAAATATTCTTGATTGTGGCTGCAACAATTTACTATCATGAAGATAATTATGAAGCTGCATTAAAAATCCTTCATAATGCTGAATCGCTGGAACTAAGAGCGTTCACACTCCAGTGCCTATTGGCTATGAATAGACCAGACCTTGCACGCAAACAACTGAAGTTGCTGCAGGACATTGAAGATGACGGCACTTTGACGCAGCTAGCACAAGCATGGCTGAATCTAATTCAGGGCGGCCCTGGTATCCAAGACGCACACTACAGCGTGATGGAGTTATCTGAACGCCTCGGTTCACTGGGACCTGGTCCGGCCTCTCTCGGTGCTGGGGCTGCAGCTGCCAGAGGTATGTGGGAAGAGGCTGAACAGCAACTGACAGACGCAGCGTCCCGCGCCCCACAGCACGCCGACCTGCTGCTCGGCCTTGCGCTCACCGCGGCGCATCTCGGGAAACCACCGGAGGTGTCGGCCCGATACCTGGCCCAGTTGCTCGACAGCCACCCCCAGCATCCCTTCGTGAAGGAATACAAGGCCAAGACGGACGAGTTCCAACGTCTGGCCGCGCAGTACCAACCCTCAGTGGCTAGTTAA

Protein

MARHQQDVDELFDVKNAFYVGNYQQAINEAQSVSPSTPLVALQRDAFLYRSYIAQGNYRIVQQELKTADPMLQPLKSLVDYLLPDANKSAIVADIDARVAKGTELSNEIFLIVAATIYYHEDNYEAALKILHNAESLELRAFTLQCLLAMNRPDLARKQLKLLQDIEDDGTLTQLAQAWLNLIQGGPGIQDAHYSVMELSERLGSLGPGPASLGAGAAAARGMWEEAEQQLTDAASRAPQHADLLLGLALTAAHLGKPPEVSARYLAQLLDSHPQHPFVKEYKAKTDEFQRLAAQYQPSVAS

Description

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).

Subunit

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

Similarity

Belongs to the COPE family.

Keywords

Complete proteome   Cytoplasm   Cytoplasmic vesicle   ER-Golgi transport   Golgi apparatus   Membrane   Protein transport   Reference proteome   Transport  

Feature

chain  Coatomer subunit epsilon

Uniprot

H9JSC6   D2Y4R6   A0A2A4JU60   A0A2W1BUK7   A0A194R9Z9   S4PI86   + More
A0A194Q115   A0A212EU14   A0A3S2NUA7   I4DNK6   E2B3T3   E2B137   A0A026WNY1   H2TXY5   A0A2I4AKT7   A0A3B5QY69   A0A3Q1I2E1   A0A315VCH4   A0A3B3Z5F8   A0A087XY58   A0A3Q3H3A7   A0A3Q3L0L1   A0A3Q2NYP2   I3J0B6   C1BZK7   A0A3Q2G5P0   A0A3B3BZ76   A0A3B3TI45   A0A3P8QRI5   A0A3P9B2S1   A0A3Q1GFV4   A0A3B4XWU7   A0A3B4FJN5   Q4T9R0   A0A3Q2WP58   W5M8V8   A0A3B3HKV6   A0A3P9J3X6   A0A3B4T6F3   A0A3P8RRV1   C3KGT8   G3P8S5   A0A1S3T4X9   A0A3Q3JYR4   A0A0C9QSP8   A0A3Q3EDI8   A0A3Q2YUS2   C1BG73   A0A1A8RSN6   A0A1A8L604   A0A1A8EAN9   A0A1A8V1S5   A0A1A8FZ89   A0A3P8W6C7   A0A1A8KKV7   A0A088A207   A0A0M9A7Y4   E3TBQ2   A0A2D0RDY8   H3CBU4   A0A1S3MNK2   F7EVS6   A8E5W5   A0A3Q7RL26   A0A411G7Y7   A0A1A7WN54   A0A1A7Z147   A0A3B3R2S7   G1MZN3   Q6GR46   G3WB38   A0A1L8HXP4   F1S7E0   A0A3B4E7Q5   Q5ZIK9   A0A2J7Q4T7   M3WC23   M3YVL5   A0A1V4KQI5   A0A452IS91   A0A2Y9J849   A0A2U3W8W9   A0A3P4LWH6   A0A2A3ELL9   G3SRE1   F4WP22   S7N8E6   Q5U3E8   A0A3Q7WQ77   A0A195EU09   A0A151WMH5   F1R7S1   E2RAT6   A0A3Q7RHZ5   D2GV44   A0A226P182   F6UHV7   A0A3B1KDD1   A0A195B949  

Pubmed

19121390    20967265    28756777    26354079    23622113    22118469    + More
22651552    20798317    24508170    21551351    23542700    29703783    25186727    20433749    25069045    29451363    15496914    17554307    24755649    24487278    20634964    17495919    29240929    20838655    21709235    27762356    30723633    15642098    17975172    28562605    21719571    23594743    16341006    20010809    24621616    20431018    25329095   

EMBL

BABH01033689    BABH01033690    GU322819    ADB66738.1    NWSH01000666    PCG74932.1    + More
KZ149932    PZC77314.1    KQ460473    KPJ14457.1    GAIX01005490    JAA87070.1    KQ459591    KPI97090.1    AGBW02012497    OWR44978.1    RSAL01000188    RVE44749.1    AK402984    BAM19496.1    GL445407    EFN89602.1    GL444771    EFN60610.1    KK107139    EZA57767.1    NHOQ01001926    PWA20926.1    AYCK01005047    AERX01004038    BT080036    ACO14460.1    CAAE01007507    CAF90372.1    AHAT01011148    BT082153    ACQ57860.1    GBYB01006754    JAG76521.1    BT073602    FR904494    ACO08026.1    CDQ65088.1    HAEI01000419    HAEH01018884    SBS08383.1    HAEF01002863    HAEG01012203    SBR40245.1    HADZ01000381    HAEA01014146    SBQ42626.1    HADY01020997    HAEJ01013828    SBS54285.1    HAEB01017760    HAEC01002928    SBQ64287.1    HAED01003724    HAEE01012972    SBR33022.1    KQ435716    KOX79067.1    GU587777    ADO27738.1    BC153743    AAI53744.1    MH366156    QBB01965.1    HADW01005636    SBP07036.1    HADX01013906    SBP36138.1    BC071087    BC106260    AAH71087.1    AAI06261.1    AEFK01069734    AEFK01069735    AEFK01069736    AEFK01069737    CM004466    OCU00886.1    AEMK02000010    DQIR01097111    DQIR01219415    DQIR01250300    HDA52587.1    AJ720775    NEVH01018377    PNF23597.1    AANG04000016    AEYP01051394    AEYP01051395    LSYS01002182    OPJ86679.1    CYRY02002532    VCW67241.1    KZ288215    PBC32600.1    GL888243    EGI63953.1    KE163515    EPQ12440.1    BC085575    BC164066    AAH85575.1    AAI64066.1    KQ981965    KYN31735.1    KQ982944    KYQ48905.1    CU929379    FP074883    AAEX03012274    ACTA01128571    ACTA01136571    GL192348    EFB19133.1    AWGT02000231    OXB73139.1    AAMC01106010    KQ976542    KYM81061.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000283053    + More
UP000008237    UP000000311    UP000053097    UP000005226    UP000192220    UP000002852    UP000265040    UP000261480    UP000028760    UP000264800    UP000261640    UP000265000    UP000005207    UP000265140    UP000265020    UP000261560    UP000261500    UP000265100    UP000265160    UP000257200    UP000261360    UP000261460    UP000264840    UP000018468    UP000001038    UP000265200    UP000261420    UP000265080    UP000007635    UP000087266    UP000261600    UP000261660    UP000264820    UP000193380    UP000265120    UP000005203    UP000053105    UP000221080    UP000007303    UP000002280    UP000286641    UP000261540    UP000001645    UP000007648    UP000186698    UP000008227    UP000261440    UP000000539    UP000235965    UP000011712    UP000000715    UP000190648    UP000291020    UP000248482    UP000245340    UP000242457    UP000007646    UP000007755    UP000286642    UP000078541    UP000075809    UP000000437    UP000002254    UP000286640    UP000008912    UP000198419    UP000008143    UP000018467    UP000078540   

PRIDE

H9JSC6    D2Y4R6    F1S7E0    Q5ZIK9    F1R7S1    E2RAT6    + More

Interpro

IPR011990   TPR-like_helical_dom_sf        + More
IPR006822   Coatomer_esu       
IPR019734   TPR_repeat       

SUPFAM

SSF48452   SSF48452       

Gene 3D

1.25.40.10    

ProteinModelPortal

H9JSC6   D2Y4R6   A0A2A4JU60   A0A2W1BUK7   A0A194R9Z9   S4PI86   + More
A0A194Q115   A0A212EU14   A0A3S2NUA7   I4DNK6   E2B3T3   E2B137   A0A026WNY1   H2TXY5   A0A2I4AKT7   A0A3B5QY69   A0A3Q1I2E1   A0A315VCH4   A0A3B3Z5F8   A0A087XY58   A0A3Q3H3A7   A0A3Q3L0L1   A0A3Q2NYP2   I3J0B6   C1BZK7   A0A3Q2G5P0   A0A3B3BZ76   A0A3B3TI45   A0A3P8QRI5   A0A3P9B2S1   A0A3Q1GFV4   A0A3B4XWU7   A0A3B4FJN5   Q4T9R0   A0A3Q2WP58   W5M8V8   A0A3B3HKV6   A0A3P9J3X6   A0A3B4T6F3   A0A3P8RRV1   C3KGT8   G3P8S5   A0A1S3T4X9   A0A3Q3JYR4   A0A0C9QSP8   A0A3Q3EDI8   A0A3Q2YUS2   C1BG73   A0A1A8RSN6   A0A1A8L604   A0A1A8EAN9   A0A1A8V1S5   A0A1A8FZ89   A0A3P8W6C7   A0A1A8KKV7   A0A088A207   A0A0M9A7Y4   E3TBQ2   A0A2D0RDY8   H3CBU4   A0A1S3MNK2   F7EVS6   A8E5W5   A0A3Q7RL26   A0A411G7Y7   A0A1A7WN54   A0A1A7Z147   A0A3B3R2S7   G1MZN3   Q6GR46   G3WB38   A0A1L8HXP4   F1S7E0   A0A3B4E7Q5   Q5ZIK9   A0A2J7Q4T7   M3WC23   M3YVL5   A0A1V4KQI5   A0A452IS91   A0A2Y9J849   A0A2U3W8W9   A0A3P4LWH6   A0A2A3ELL9   G3SRE1   F4WP22   S7N8E6   Q5U3E8   A0A3Q7WQ77   A0A195EU09   A0A151WMH5   F1R7S1   E2RAT6   A0A3Q7RHZ5   D2GV44   A0A226P182   F6UHV7   A0A3B1KDD1   A0A195B949  

PDB

5NZV     E-value=1.08445e-60,     Score=590

KEGG

100379190    K17268 coatomer subunit epsilon | (RefSeq) COPE; coatomer protein complex subunit epsilon

GO

GO:0005198   GO:0031410   GO:0000139   GO:0006890   GO:0015031   GO:0006891   GO:0006888   GO:0030126   GO:0005654   GO:0030137   GO:0005794   GO:0005515   GO:0003676   GO:0006281   GO:0043140   GO:0006310   GO:0000049   GO:0005975   GO:0004553  

PANTHER

PTHR10805  

Subcellular location

Cytoplasm  
Golgi apparatus membrane   The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.   With evidence from 1 publications.
Cytoplasmic vesicle   The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.   With evidence from 1 publications.
COPI-coated vesicle membrane   The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.   With evidence from 1 publications.

Length:

302

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0183

Exp number, first 60 AAs:

0.00058

Total prob of N-in:

0.08130

outside

1  -  302

 

 

Pi

203.492779

Theta

161.786684

Tajima's D

0.922441

CLR

0.039825

CSRT

0.63916804159792

Interpretation

Uncertain