Silkworm Genome Informatics Database

Gene

KWMTBOMO12377

Pre Gene Modal

BGIBMGA012404

Annotation

PREDICTED:_Bloom_syndrome_protein_homolog_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr21(-):1703096-1730116 View in EpiBrowser

Full name

ATP-dependent DNA helicase

Location in the cell

Nuclear Reliability : 3.779

CDS

ATGACTCCTGAGAAGATTAAATCTGACTTAAGTAATAGATTTAAGTTAAAAAACTTTATTCTGAAGAGTGACACAGGAACTCTCGATAATAAAACCAGTAAAACGAACAACAACAAAACAAAAAAGAAATTTTCTTATATAGATCCAAAAACAGCAAACAAAACATGGACACCACCATTCAAGACATTGGAGATTGTCAGTTCAGTTAAAGACGAAAACTCTCCGAAAATTCCAGAAAGATACGAAACCGGAGTCAATAGTCCTGAAAGAAGTATAGTGGTTGACATACCAACCCCACCTAAAAACGTAGACATGGACAGCTCGAGTAAAAGGAGCCGTTTGGCTATGTCTGATGACCTTAATGATGTAGATTTACGAATGAATGCCTCATTTGTACCTCTACTAGATCGAATAACAGCACATGTTGCTGTAAAGGAAACGAAACAGAAACAAAATCATCCCGAATTTCTGGATCGGCAAAGTGAAAGAATGTACGTCGAATTGTTAGAAACAATAAGTGACACGTTTGATAGAATTCCAAAGAATTTGCTAGAAATAATTCCTGGTTATGATAGTAAAATACACGACAAGATGAAACGGAGCAGAATAGAAATAAAAAAATATTGCAATAATTTTGAGAATAAATCTAGTTGCTCCATAGATAAATTACATACAACAGAGAAGGATCATAGTAATAGTTTGATACAGAATTCAACCCCGCCTTTAGAACAAAACCCTGGGACCAGTAATATGATACATTCAGATGTTAAAAAAGTCACCACTTCAAATGAATCACCGTCTGTTATGTCTGTAACCAATGATTCGACGATGGATAAAAGCTTAGATCAATCAGACACGAATGTCAAGAAGAAAGGAAAATTTGTATACAAATCCCCATTAAATCATAGCTCGCCGGATTGTATAGCTTCGTCGAGTACAGCGGAGAGACTTAAAAGCATCATGGAGACTCTGAAGCGCGTCCCACCTAAGGTTGCGTCCAATCCAACGCCGCAAGCGAATAATAGTTCAGTAGAATTCCAGCCGCCTCCGCTTGACCGAAGCGCGTTCTTGAACACGGAACGTCCGTCAACATCGGCGACACCAGCATCTGTGACTGATGTCGCCGAAAATGAATACGAACACTTGTTTGACGCCAGTGACGGCTTCGAAGAGAACATTGACCTGATTAGTGAAAATGACGTCAGCGTCGAAGAGTTTCAGAACGGTAAGAACATAAGCGTCGACGATGACGGATGGCCGGAGTACAGAATGGGGGACTTCGCGGACGACGTGGAAGTCGTTAATGCCGTCGAGATGGTGGAAATGAACTTGAACCATACGATGACGTCGAATGTCGTGAATACGAAGTACGAAGGGATCGGGCAATTCGAAGGTGATATCCAGAACGATGGAACCACAGGTGAGTTCGACGGCCTGAACTACCCTCACTCGGCTCCGATGCTGGAGATATTCCGCGAGACGTTCGGCCTGACGAAGTTCCGGCCCAACCAGCTGCAGGCCATCAACGCGGCGCTGCTCGGCCACGACTGCTTCGTCCTCATGCCGACCGGCGGCGGTAAGTCGTTGTGTTACCAGCTGCCCGCTGTACTGTCGCCCGGCGTCACCATCGTCATATCGCCGTTGAAGTCCCTTATCATGGACCAGGTCCGGAAGCTGCAGACGCTCGGCGTCCCGGCCGCCGACTTGTCCGGCAACACGTCGCTCGCAGAGACTGACGAGATCTACCACAAGCTGTCCATGAAGGAGCCGCCCATCAAGCTGCTGTACGTCACCCCCGAGAAGATCGTCGGCAGCGATCGGTTCCAGTCCGTCCTCGACTCGCTCGACGCCAGAGGGAAGTTCGCGAGGTTCGTGATAGACGAGGCGCACTGCGTGTCTCAGTGGGGGCACGAGTTCCGCCCCGACTACACGGCGCTGCGGCTGGTGCGCGCGCGCTGGCCCGCGCCCCGCGCCGTGCTGCTGACGGCCACGGCCACGCCGCGCGTGCGCCGCGACGTGCTGCTGCAGCTGCACGTGCAGCCCGCCGCCTGCCGCTGGTTCCTGTGCAGCTTCGACCGCCCCAACCTGCGCTACCGCTTCCACAAGAAACCGAAGAACATTAACCAGGAGATCGCCAAGCTCATAAAGAACGAATTTTTCGGGGAATCTGGCATAATATACTGCTTATCGTGCAAAGACTGCGAAGTGTTGGCGGGCGACCTCCACAAGACGGGGGTGCAGGCCGCCCCCTACCACGCCAGGCTCGCGGACTCCAAGCGGCAGAGCGTGCAGTCGGCCTGGATCGCCGACGAGATTAAAGTGATCTGTGCGACCATAGCGTTTGGAATGGGCATAGACAAGGCGGACGTCCGCTACGTCATGCACCACAGCATGCCCAAGTCCATAGAAGGATACTACCAAGAGTCAGGTCGCGCTGGGAGGGACGGGCAACTGGCCACCTGCATCCTGTACTACTCCTACCAGGACATGATCAGACATCGAAAATTAAACATGAGGTCGGAAATGAGGACAGAAGCGCGCAATGTCCAAGAGGAGAACCTGCGACGTATGGTGGAGCTCTGCGAGAGTGTCACTGAGTGTCGCCGCGCCTTCATCCTGGCCTACCTCGGGGAGACGCTGCCGCGCTGCAACCCTGCCCACCCTGCCGCCTGCGACAACTGTCTGCGGACACAACGCACAGAGCCGGTGGACGTGACGGAGCACTGCAAGAAGATCGTGCAGGCGGTGAGGGACGCCGGCACCCGGTCGCGGAACGGCTTCACGCTGCTGCACCTCGCGGCCGCCCTGCGCGGCTCCAAGCTGCAGCGCCTCGCCGCGCTGCACGACTCGCCCGTGCACGCACTTTGCAAGTCGTGGGACCGGAGCGACGCCCAGCGCCTGCTGCGGCTGCTGGTGGTTCGAGGGGTTCTGTACGAGAAGATCGTCGTCAACAACGACTTCGCCAGCGGATATATCGACCTGGGACCGAACGCGGACAAACTCATGAAAAATCGCATCCGCATAGTGTTCCCCATGTCGAAGACAACCGACAAGAACAGTTTAACGACAGCTCCCGCAGAGGCCCGGCCCGCGCCCCCCGCCAGCGACCTGGACTCCACGCTGGCCAAGCTCGAGCTCAGGTGCTATGCTGACCTGGTGGAAGTGTGTCGGTAA

Protein

MTPEKIKSDLSNRFKLKNFILKSDTGTLDNKTSKTNNNKTKKKFSYIDPKTANKTWTPPFKTLEIVSSVKDENSPKIPERYETGVNSPERSIVVDIPTPPKNVDMDSSSKRSRLAMSDDLNDVDLRMNASFVPLLDRITAHVAVKETKQKQNHPEFLDRQSERMYVELLETISDTFDRIPKNLLEIIPGYDSKIHDKMKRSRIEIKKYCNNFENKSSCSIDKLHTTEKDHSNSLIQNSTPPLEQNPGTSNMIHSDVKKVTTSNESPSVMSVTNDSTMDKSLDQSDTNVKKKGKFVYKSPLNHSSPDCIASSSTAERLKSIMETLKRVPPKVASNPTPQANNSSVEFQPPPLDRSAFLNTERPSTSATPASVTDVAENEYEHLFDASDGFEENIDLISENDVSVEEFQNGKNISVDDDGWPEYRMGDFADDVEVVNAVEMVEMNLNHTMTSNVVNTKYEGIGQFEGDIQNDGTTGEFDGLNYPHSAPMLEIFRETFGLTKFRPNQLQAINAALLGHDCFVLMPTGGGKSLCYQLPAVLSPGVTIVISPLKSLIMDQVRKLQTLGVPAADLSGNTSLAETDEIYHKLSMKEPPIKLLYVTPEKIVGSDRFQSVLDSLDARGKFARFVIDEAHCVSQWGHEFRPDYTALRLVRARWPAPRAVLLTATATPRVRRDVLLQLHVQPAACRWFLCSFDRPNLRYRFHKKPKNINQEIAKLIKNEFFGESGIIYCLSCKDCEVLAGDLHKTGVQAAPYHARLADSKRQSVQSAWIADEIKVICATIAFGMGIDKADVRYVMHHSMPKSIEGYYQESGRAGRDGQLATCILYYSYQDMIRHRKLNMRSEMRTEARNVQEENLRRMVELCESVTECRRAFILAYLGETLPRCNPAHPAACDNCLRTQRTEPVDVTEHCKKIVQAVRDAGTRSRNGFTLLHLAAALRGSKLQRLAALHDSPVHALCKSWDRSDAQRLLRLLVVRGVLYEKIVVNNDFASGYIDLGPNADKLMKNRIRIVFPMSKTTDKNSLTTAPAEARPAPPASDLDSTLAKLELRCYADLVEVCR

Catalytic Activity

ATP + H2O = ADP + H(+) + phosphate

Similarity

Belongs to the helicase family. RecQ subfamily.

Uniprot

H9JS94 A0A3S2NUZ3 A0A194PVQ9 A0A2H1WS08 A0A2A4K5Y0 B0WJH9 + More
Q17DX5 A0A2W1BZP8 A0A0K8TKJ6 A0A0J7L5Z4

EC Number

3.6.4.12

Pubmed

19121390 26354079 17510324 28756777 26369729

EMBL

BABH01041305 BABH01041306 BABH01041307 BABH01041308 BABH01041309 BABH01041310 + More
BABH01041311 RSAL01000066 RVE49389.1 KQ459591 KPI97078.1 ODYU01010613 SOQ55843.1 NWSH01000093 PCG79641.1 DS231960 EDS29175.1 CH477290 EAT44626.1 KZ149932 PZC77303.1 GDAI01002721 JAI14882.1 LBMM01000423 KMQ98397.1

Proteomes

UP000005204 UP000283053 UP000053268 UP000218220 UP000002320 UP000008820 + More
UP000036403

PRIDE

H9JS94

Pfam

PF00271   Helicase_C        + More
PF09382   RQC
PF16124   RecQ_Zn_bind
PF00270   DEAD
PF00570   HRDC

Interpro

IPR032284   RecQ_Zn-bd        + More
IPR027417   P-loop_NTPase
IPR011545   DEAD/DEAH_box_helicase_dom
IPR002464   DNA/RNA_helicase_DEAH_CS
IPR001650   Helicase_C
IPR036390   WH_DNA-bd_sf
IPR004589   DNA_helicase_ATP-dep_RecQ
IPR014001   Helicase_ATP-bd
IPR018982   RQC_domain
IPR036388   WH-like_DNA-bd_sf
IPR010997   HRDC-like_sf
IPR002121   HRDC_dom

SUPFAM

SSF46785   SSF46785        + More
SSF52540   SSF52540
SSF47819   SSF47819

Gene 3D

1.10.10.10

CDD

cd00079 HELICc

ProteinModelPortal

H9JS94 A0A3S2NUZ3 A0A194PVQ9 A0A2H1WS08 A0A2A4K5Y0 B0WJH9 + More
Q17DX5 A0A2W1BZP8 A0A0K8TKJ6 A0A0J7L5Z4

PDB

4O3M E-value=7.19036e-135, Score=1235

KEGG

101738851 K10901 bloom syndrome protein [EC:3.6.4.12] | (RefSeq) Bloom syndrome protein homolog

PATHWAY

03440 Homologous recombination - Bombyx mori (domestic silkworm)
03460 Fanconi anemia pathway - Bombyx mori (domestic silkworm)

GO

GO:0043140 GO:0003676 GO:0006260 GO:0006310 GO:0005524 GO:0005634 GO:0006281 GO:0008026 GO:0000049 GO:0005975 GO:0004553

Subcellular location

Nucleus

Length:

1057

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00958

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00002

outside

1 - 1057

Pi

181.252673

Theta

141.244067

Tajima's D

0.604071

CLR

0.668976

CSRT

0.547522623868807

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics