Gene

KWMTBOMO12375

Annotation

PREDICTED:_sorbitol_dehydrogenase_[Bombyx_mori]

Location

Bomo_Chr21(+):1695127-1699208      View in EpiBrowser

Full name

Sorbitol dehydrogenase      

Alternative Name

L-iditol 2-dehydrogenase
Polyol dehydrogenase
Xylitol dehydrogenase

Location in the cell

Cytoplasmic   Reliability : 1.719

CDS

ATGGAGGAAGGGGCAGCGGTCCAACCGCTAGCCATCGCGATCCACGCCTGCAACCGCGCCAAGATAACTCTCGGATCTAAGATCGTTATCCTTGGAGCCGGACCTATTGGCATCTTGTGTGCTATGGCGGCCAAAGCAATGGGAGCTAGCAAAATTATTTTAACAGACGTAGTTCAGTCACGTTTAGACGCGGCACTGGAGCTGGGAGCGGATAACGTCCTCCTCGTCCGTCGGGAGTACACTGACGAAGAGGTTGTAGAAAAAATTGTGAAGTTGCTCGGTGACCGCCCGGATGTGTCAATCGATGCCTGCGGGTACGGGTCGGCGCAGAGAGTCGCTCTACTGGTGACCAAGACAGCGGGCTTGGTACTGGTGGTCGGCATAGCTGACAAAACGGTGGAGCTGCCGCTCTCACAAGCGCTGCTCAGAGAAGTTGATGTTGTAGGGTCCTTTCGTATTATGAACACGTACCAGCCCGCCCTGGCCGCGGTGTCCTCCGGGGCCATCCCCTTGGACCAGTTCATCACTCATCGCTTCCCATTGAACAAGACCAAAGAAGCACTGGATTTAGCCAAATCCGGTGCCGCCATGAAAATACTCATACACGTGCAAAATTAA

Protein

MEEGAAVQPLAIAIHACNRAKITLGSKIVILGAGPIGILCAMAAKAMGASKIILTDVVQSRLDAALELGADNVLLVRREYTDEEVVEKIVKLLGDRPDVSIDACGYGSAQRVALLVTKTAGLVLVVGIADKTVELPLSQALLREVDVVGSFRIMNTYQPALAAVSSGAIPLDQFITHRFPLNKTKEALDLAKSGAAMKILIHVQN

Description

Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with xylitol, L-iditol and D-sorbitol (D-glucitol) as substrates, leading to the C2-oxidized products D-xylulose, L-sorbose and D-fructose, respectively (By similarity). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism (By similarity).

Catalytic Activity

NAD(+) + xylitol = D-xylulose + H(+) + NADH
L-iditol + NAD(+) = H(+) + L-sorbose + NADH
D-fructose + H(+) + NADH = D-sorbitol + NAD(+)

Cofactor

Zn(2+)

Subunit

Homotetramer.

Similarity

Belongs to the zinc-containing alcohol dehydrogenase family.

Keywords

Complete proteome   Metal-binding   NAD   Oxidoreductase   Reference proteome   Stress response   Zinc  

Feature

chain  Sorbitol dehydrogenase

Uniprot

Q02912   A0A2A4K6E5   A0A2W1BUJ7   A0A2H1WTR0   A0A194RA16   A0A194PUS8   + More
A0A3S2M1Z7   A0A2A4K6T3   A0A0F6Q4H2   A0A2A4K6D8   A0A2W1BUG8   A0A3S8V4J4   A0A194R9F4   A0A1A9X1Z6   B4IVL3   A0A194PUJ4   A0A2H1WTM9   B3P2R4   B4QYY8   B4I4M2   A0A1I8P4I0   W8BR06   A0A1L8E909   A0A1A9UCP4   A0A0K8VFI9   W5JLL7   A0A0A1XLQ9   D3TNZ6   B4PSH4   A0A2M4BS11   V9IJE5   A0A1L8EFN3   A0A0K8V7I9   A0A2A3EH03   A0A1B0ACC0   O97479   Q960H1   A0A2M3Z3I5   A0A2M3ZGL7   A0A1I8NHK1   A0A1W4UU45   A0A1B0GBZ8   A0A0K8VPS5   A0A2M4BS13   H9JS89   A0A0L0BYI5   B4JV28   A0A034W7N1   B4LZX1   Q16R03   A0A2M4AK18   A0A1B6DM11   A0A0N0BII8   E9ID57   A0A2M4AJS6   A0A023ERP5   A0A1B0BKS6   A0A182H933   A0A1A9YJX5   Q1HPK9   J9WRA8   A0A0L7QMW7   Q1ET59   U5EW35   A0A2M4AIE4   A0A151XIX6   O96299   E3WI98   A0A1W4V511   B3NZK8   A0A154P6T2   A0A026VTD9   A0A1D2NEP6   B4QUM4   B4K5T2   B4PLF2   A0A3B0JSY0   A0A212EGR3   B4HIN0   F4WVG1   A0A195EP07   A0A3B0KEM2   A0A087ZU72   A0A0A1XBV0   A0A0J7L8H1   A0A195BV33   B3M0P4   A0A158NEH9   A0A3B0K615   B4NAA9   A0A1Q3FZP2   A0A0C9PQ28   A0A336K7W2   A0A1Q3FZP1   A0A437BGC5   A0A1L8E4L6   A0A1B0GIA5   A0A0P7V8S5   A0A3B0JPY2   B3LZG5  

EC Number

1.1.1.-

Pubmed

8504807    8933178    28756777    26354079    7573945    17994087    + More
17550304    24495485    20920257    23761445    25830018    20353571    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    25315136    19121390    26108605    25348373    17510324    21282665    24945155    26483478    22972362    16546206    21377527    24508170    30249741    27289101    22118469    21719571    21347285   

EMBL

D13371    D66906    NWSH01000093    PCG79639.1    KZ149932    PZC77304.1    + More
ODYU01010939    SOQ56356.1    KQ460473    KPJ14472.1    KQ459591    KPI97077.1    RSAL01000066    RVE49388.1    PCG79628.1    KP237870    AKD01723.1    PCG79629.1    PZC77305.1    MH101955    AZL95671.1    KPJ14473.1    CH893144    EDX00549.1    KPI97076.1    SOQ56357.1    CH954181    EDV48086.1    CM000364    EDX11928.1    CH480821    EDW55165.1    GAMC01007282    GAMC01007281    JAB99273.1    GFDG01003562    JAV15237.1    GDHF01015029    JAI37285.1    ADMH02001070    ETN64198.1    GBXI01002415    JAD11877.1    EZ423148    ADD19424.1    CM000160    EDW96434.1    GGFJ01006724    MBW55865.1    JR050353    AEY61248.1    GFDG01001288    JAV17511.1    GDHF01017405    JAI34909.1    KZ288260    PBC30436.1    AF002212    AE001572    AE014297    BT044539    AAD00902.1    AAD19792.1    AAF54080.1    ACI03575.1    AHN57202.1    AY052067    AAK93491.1    GGFM01002326    MBW23077.1    GGFM01006921    MBW27672.1    CCAG010018956    GDHF01011471    JAI40843.1    GGFJ01006725    MBW55866.1    BABH01033167    JRES01001243    KNC24329.1    CH916374    EDV91348.1    GAKP01008803    GAKP01008802    JAC50150.1    CH940650    EDW67199.1    CH477727    EAT36817.1    EJY57902.1    EJY57903.1    GGFK01007800    MBW41121.1    GEDC01010583    JAS26715.1    KQ435728    KOX77804.1    GL762454    EFZ21422.1    GGFK01007547    MBW40868.1    GAPW01002237    JAC11361.1    JXJN01016005    JXUM01119833    KQ566329    KXJ70230.1    DQ443393    ABF51482.1    JX462662    AFS17318.1    KQ414868    KOC59965.1    AB164059    BAE95831.1    GANO01001600    JAB58271.1    GGFK01007230    MBW40551.1    KQ982080    KYQ60366.1    AF002213    AY058731    AAD00903.1    AAF54573.1    AAL13960.1    BABH01033168    AB604175    BAJ41475.1    EDV49581.1    KQ434814    KZC06840.1    KK107965    QOIP01000001    EZA47058.1    RLU26937.1    LJIJ01000065    ODN03731.1    EDX13431.1    CH933806    EDW15144.1    EDW96859.1    OUUW01000007    SPP83502.1    AGBW02015042    OWR40677.1    CH480815    EDW42677.1    GL888387    EGI61782.1    KQ978625    KYN29637.1    SPP83501.1    GBXI01005866    JAD08426.1    LBMM01000250    KMR02966.1    KQ976401    KYM92442.1    CH902617    EDV42059.2    ADTU01013344    ADTU01013345    ADTU01013346    SPP83500.1    CH964232    EDW81796.1    GFDL01002006    JAV33039.1    GBYB01003308    JAG73075.1    UFQS01000115    UFQS01001832    UFQT01000115    UFQT01001832    SSW99902.1    SSX12489.1    SSX20282.1    GFDL01002017    JAV33028.1    RVE49385.1    GFDF01000404    JAV13680.1    AJWK01013619    JARO02000416    KPP78637.1    OUUW01000008    SPP84185.1    EDV44144.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000283053    UP000091820    + More
UP000002282    UP000008711    UP000000304    UP000001292    UP000095300    UP000078200    UP000000673    UP000242457    UP000092445    UP000000803    UP000095301    UP000192221    UP000092444    UP000037069    UP000001070    UP000008792    UP000008820    UP000053105    UP000092460    UP000069940    UP000249989    UP000092443    UP000053825    UP000075809    UP000076502    UP000053097    UP000279307    UP000094527    UP000009192    UP000268350    UP000007151    UP000007755    UP000078492    UP000005203    UP000036403    UP000078540    UP000007801    UP000005205    UP000007798    UP000092461    UP000034805   

PRIDE

Q02912    O97479    Q960H1    H9JS89    Q1HPK9    Q1ET59    + More
O96299    E3WI98   

Pfam

PF08240   ADH_N        + More
PF00107   ADH_zinc_N

Interpro

IPR013149   ADH_C        + More
IPR013154   ADH_N       
IPR011032   GroES-like_sf       
IPR020843   PKS_ER       
IPR002328   ADH_Zn_CS       
IPR036291   NAD(P)-bd_dom_sf       

SUPFAM

SSF50129   SSF50129        + More
SSF51735   SSF51735       

ProteinModelPortal

Q02912   A0A2A4K6E5   A0A2W1BUJ7   A0A2H1WTR0   A0A194RA16   A0A194PUS8   + More
A0A3S2M1Z7   A0A2A4K6T3   A0A0F6Q4H2   A0A2A4K6D8   A0A2W1BUG8   A0A3S8V4J4   A0A194R9F4   A0A1A9X1Z6   B4IVL3   A0A194PUJ4   A0A2H1WTM9   B3P2R4   B4QYY8   B4I4M2   A0A1I8P4I0   W8BR06   A0A1L8E909   A0A1A9UCP4   A0A0K8VFI9   W5JLL7   A0A0A1XLQ9   D3TNZ6   B4PSH4   A0A2M4BS11   V9IJE5   A0A1L8EFN3   A0A0K8V7I9   A0A2A3EH03   A0A1B0ACC0   O97479   Q960H1   A0A2M3Z3I5   A0A2M3ZGL7   A0A1I8NHK1   A0A1W4UU45   A0A1B0GBZ8   A0A0K8VPS5   A0A2M4BS13   H9JS89   A0A0L0BYI5   B4JV28   A0A034W7N1   B4LZX1   Q16R03   A0A2M4AK18   A0A1B6DM11   A0A0N0BII8   E9ID57   A0A2M4AJS6   A0A023ERP5   A0A1B0BKS6   A0A182H933   A0A1A9YJX5   Q1HPK9   J9WRA8   A0A0L7QMW7   Q1ET59   U5EW35   A0A2M4AIE4   A0A151XIX6   O96299   E3WI98   A0A1W4V511   B3NZK8   A0A154P6T2   A0A026VTD9   A0A1D2NEP6   B4QUM4   B4K5T2   B4PLF2   A0A3B0JSY0   A0A212EGR3   B4HIN0   F4WVG1   A0A195EP07   A0A3B0KEM2   A0A087ZU72   A0A0A1XBV0   A0A0J7L8H1   A0A195BV33   B3M0P4   A0A158NEH9   A0A3B0K615   B4NAA9   A0A1Q3FZP2   A0A0C9PQ28   A0A336K7W2   A0A1Q3FZP1   A0A437BGC5   A0A1L8E4L6   A0A1B0GIA5   A0A0P7V8S5   A0A3B0JPY2   B3LZG5  

PDB

3QE3     E-value=1.01997e-43,     Score=441

KEGG

101738079    K00008 L-iditol 2-dehydrogenase [EC:1.1.1.14] | (RefSeq) sorbitol dehydrogenase

PATHWAY

00040    Pentose and glucuronate interconversions - Bombyx mori (domestic silkworm)
00051    Fructose and mannose metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0008270   GO:0003939   GO:0016021   GO:0016491   GO:0046872   GO:0055114  

Length:

205

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

15.54771

Exp number, first 60 AAs:

14.66855

Total prob of N-in:

0.50135

POSSIBLE N-term signal

sequence

outside

1  -  205

 

 

Pi

181.301799

Theta

135.096184

Tajima's D

0.824477

CLR

0.358717

CSRT

0.614269286535673

Interpretation

Uncertain