Gene

KWMTBOMO12328  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009181

Annotation

PREDICTED:_DNA_ligase_1_[Amyelois_transitella]

Location

Bomo_Chr20(+):12224610-12234391      View in EpiBrowser

Full name

DNA ligase       + More
DNA ligase 1      

Alternative Name

DNA ligase I
Polydeoxyribonucleotide synthase [ATP] 1

Location in the cell

Nuclear   Reliability : 2.928

CDS

ATGGCTCAAAGGAGTATCACGTCATTCTTCAAGAAAACTCCATTTACACCTATGGAAATAAAAAGTAATGGTGGATCCAAAGTAAGCCATGTAAATGGGGACACATCACCCATATCCGACGAAAAAGACAAGCCTTCTGAAAGACAACAATCCAACAGCATAGATAATGACGGTGACTCCCAAGATTCTTTGAAACCGAAAAATAAAGCTAAACGACAACGTGTGATAAGCTCTAGTAGTGAATCAGAATCTCCAGTTAAAGTGAAAAAGGAAGACCTTTCAGACAATGATGACTCTATAACTTTAAACAAGAGCGTAAACAAAACTTATGACTCACCAAAAAATAAAAAAGCTAAAATAAAAAAAGAAATCAAAAGCCCATCACCTAAAAAGGGTGCAAAGAGTTTGTCTCGTGATGAGGTAAAAGAAAACAGCTTAAAATTGAAGATTGTTGGATCAAAGGAAAAAGACAATATTGTGAAAAATACCGAGCATATTGATAATATTGAAAATGAGAGTGAAGAAATACAGAAAGTAGCAGAAAATGCATACAATCCATCAAAATCAAAATACCACCCTATAAAAGATGCTTGCTGGTCTAAAGGCGACCCAGTGCCGTATCTTGCATTAGCTAAGACTTTGGATCTTATAGAAGGAACATCAGCTCGACTGAAGATAATAGAAATATTAAGTAATTTTTATAGGTCTGTAATGGTGTTGACTTCAGAAGACTTGTTGCCTTGTATTTACTTGTGCTTAAATCAACTAGCACCAGCATACCACAGTTTGGAGCTTGGCATAGCAGAAACGTACCTAATGAAAGCCATAGGCCAGTGTACAGGCCGTACCCTAGCACAAGTGAAGTCTGCAGTACAGAAGTGTGGGGATATGGGAAGAGTGGCAGAACAGGCTCGAGCCGCACAAAAGACAATGTTTGCGGCCCCTAAACTTCAGATAAGAAAGGTTTTTGCTGCACTAAAAGAAATTGCTCACATGACTGGTCAAGCATCAGTGAATAAGAAAATAAATAAAATCCAGTCCTTGTATGTCGCCTGCAGAGATTGTGAAGCACGATTCCTAATAAGGTCCCTGGAGGGGAAGCTGCGCATCGGCCTGGCGGAGCAGTCGGTGCTGCACGCGCTGGCGCTGGCCGTCGCCACCACGCCGCCCGGACCCAACCTGCAGCTCGACGCGGCGCAGCACATGTCCGCCGACAAGTTCAAGGCGCTGGTGGAGCAGCACGTGGCGGTGGTGCGGCGCACGTACTGCGAGTGTCCCGACTGGGCCGAGCTGCTGCACGAGCTGCTGCGCGGCGGCGTGGCGGCGCTGGCCTCCCGCTGCAGCATGCGCGTCGGCGTGCCGCTGCGCCCCATGCTCGCGCACCCCACCCGCGCCGTGCGCGACGTGCTCGCCAGGTTTGAGAATGAAGAGTTCACCTGCGAGTACAAGTACGACGGCGAGCGTGCCCAGATCCACGTGCCCGCCGCGCCCGACGACAAGCCGGACTTCGCCAACGCTGCCATATTCAGCAGGAACCAAGAAAATAATACCGCCAAGTACCCGGACGTGCTGAGTCGCCTGCCCACGCTGCTCAAGGAGGGCGTGTCCAGCTGCGTGCTGGACTGCGAGGCCGTCGCCTTCGACGCCGCCAACGGCAAGCTGCTGCCCTTCCAGGTGCTGTCGAGCCGCAAGCGTGCGTGCGCGAGTGCGGAGGACGTGCGCGTGCCGGTCTGCGTGTTCGTGTTCGACCTGCTGTACCTCAACGGCGCCCCGCTGGTGGGCAGCACGCTGGCGCACCGCCGCAAGCTGCTGCGGGAACACTTCCGCACCCAGCCCGGTACATGGCAGTTCGCCACGTCCAAAGACTGCAGCACTATCGAGGAAGTGCAGCTGTTCCTTGAAGAAGCTGTGAAAGAAAGCTGCGAGGGACTCATGGTGAAGATGCTCACTGGTGACAATTCGAAATATGATATAGCTAGGAGGTCACACAATTGGCTAAAGTTGAAGAAAGACTACTTGGAAGGCGTCGGAGACACGGTGGACGCTGTCATTATCGGAGCCTACCGCGGCAAGGGCAAGCGCGCCGGCGTCTACGGAGGGTTCCTGGTCGCGTGCTACGACCCCGAGTCCGAGCAGTTCCAGTCGCTGTGCAAGCTGGGGACCGGCTTCTCCGATGAGGACCTGCAGGCCTTGTCCGACATGCTGAAGGAACACATTATTGATTCTCCGAGAAACTACTACAACTACGACAGCTCCCACTCCGCCGACGTATGGACCAGCGCCGCCGTGGTGGTGGAGGTGCGCTGCGCAGACCTGTCCCTCTCGCCCGCGCACCGCGCCGCCATCGCGCGCCTGCACCCGCACAAGGGCGTGTCACTCCGCTTCCCCAGGTTCGTGCGGGTGCGGGAGGACAAGGCGGCGGAGCAGGCCACCACGGCGGCGCAGGTGGCGCAGCTCTACCTGGCGCAGGACCAGATCAAGAACCAAGTCAAACAACCTGACGCCGCTCACGAAGACGACTTCTACTGA

Protein

MAQRSITSFFKKTPFTPMEIKSNGGSKVSHVNGDTSPISDEKDKPSERQQSNSIDNDGDSQDSLKPKNKAKRQRVISSSSESESPVKVKKEDLSDNDDSITLNKSVNKTYDSPKNKKAKIKKEIKSPSPKKGAKSLSRDEVKENSLKLKIVGSKEKDNIVKNTEHIDNIENESEEIQKVAENAYNPSKSKYHPIKDACWSKGDPVPYLALAKTLDLIEGTSARLKIIEILSNFYRSVMVLTSEDLLPCIYLCLNQLAPAYHSLELGIAETYLMKAIGQCTGRTLAQVKSAVQKCGDMGRVAEQARAAQKTMFAAPKLQIRKVFAALKEIAHMTGQASVNKKINKIQSLYVACRDCEARFLIRSLEGKLRIGLAEQSVLHALALAVATTPPGPNLQLDAAQHMSADKFKALVEQHVAVVRRTYCECPDWAELLHELLRGGVAALASRCSMRVGVPLRPMLAHPTRAVRDVLARFENEEFTCEYKYDGERAQIHVPAAPDDKPDFANAAIFSRNQENNTAKYPDVLSRLPTLLKEGVSSCVLDCEAVAFDAANGKLLPFQVLSSRKRACASAEDVRVPVCVFVFDLLYLNGAPLVGSTLAHRRKLLREHFRTQPGTWQFATSKDCSTIEEVQLFLEEAVKESCEGLMVKMLTGDNSKYDIARRSHNWLKLKKDYLEGVGDTVDAVIIGAYRGKGKRAGVYGGFLVACYDPESEQFQSLCKLGTGFSDEDLQALSDMLKEHIIDSPRNYYNYDSSHSADVWTSAAVVVEVRCADLSLSPAHRAAIARLHPHKGVSLRFPRFVRVREDKAAEQATTAAQVAQLYLAQDQIKNQVKQPDAAHEDDFY

Catalytic Activity

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.

Cofactor

Mg(2+)

Similarity

Belongs to the ATP-dependent DNA ligase family.
Belongs to the ubiquitin-activating E1 family.
Belongs to the ETS family.

Keywords

ATP-binding   Cell cycle   Cell division   DNA damage   DNA recombination   DNA repair   DNA replication   Ligase   Magnesium   Metal-binding   Nucleotide-binding   Nucleus  

Feature

chain  DNA ligase 1

Uniprot

A0A2W1BRB8   A0A0N1IDS8   A0A194QBR1   A0A310SSJ1   A0A3L8E1A5   A0A0J7L6A6   + More
A0A0L7RIX0   A0A026WD56   A0A0C9R7A2   A0A1B0GKD1   A0A088AVT0   E9IA98   E2A154   A0A0P4VZ05   A0A1B6DEE5   A0A0M8ZRH0   A0A1Y1N860   A0A1Y1N567   A0A069DZK5   T1HIR0   E2B772   A0A2J7QBH5   A0A158NEQ8   A0A023F491   A0A067RJ93   A0A2J7QBF6   A0A2J7QBF7   A0A224X8E2   A0A2J7QBF5   A0A195E099   F4WRN8   A0A2J7QBG1   A0A195FMY6   A0A0V0G787   A0A2A3EPL3   A0A195AVS3   A0A232F4R4   A0A1W4WY29   A0A1W4WNC1   K7IZI0   A0A1B0D270   A0A195CRA6   A0A151XIL7   A0A1L8FMV1   A0A210PFJ6   D6WF20   V9I8Y1   A0A2H8TVL3   A0A2R7VVH4   P51892   A0A2R8Q0Q5   B0S533   A0A154PPG8   F6WCY3   U5EV64   J9K4X4   A0A087U1W4   A0A3R7MMP4   A0A182IU67   A0A098LZ92   A0A084W4E8   J9HJ51   A0A182N7T5   H9GHC9   A0A1S4G6J7   W5JIY5   A0A2Y9D1S0   A0A444U0M2   A0A402FQ34   A0A1Q3FW15   A0A3B4CXZ5   A0A2S2NAI6   A0A182RG56   A0A182WHA2   K7FZW6   A0A182PAL8   A0A182XKU0   A0A3N0XH30   A0A1S4H0H7   K7FZX9   A0A452GH34   A0A182I5A2   A0A182H3P9   A0A1S3JWW3   W5M103   A0A3B4EXX9   A0A3P8NLU6   A0A3P9DCC4   Q7PVP5   A0A336MB82   A0A3Q2V7J0   A0A3P8NLY1   A0A2A4J2H1   A0A293LP81   I3KD07   A0A1A7Y584   A0A3B3T509   I3KD06   A0A3Q3GHB0  

EC Number

6.5.1.1

Pubmed

28756777    26354079    30249741    24508170    21282665    20798317    + More
27129103    28004739    26334808    21347285    25474469    24845553    21719571    28648823    20075255    27762356    28812685    18362917    19820115    8682316    23594743    20431018    24438588    17510324    21881562    20920257    23761445    17381049    12364791    28562605    26483478    25186727    29240929   

EMBL

KZ149926    PZC77588.1    KQ461072    KPJ09864.1    KQ459193    KPJ02993.1    + More
KQ759817    OAD62767.1    QOIP01000001    RLU26447.1    LBMM01000509    KMQ98186.1    KQ414582    KOC70892.1    KK107260    EZA54005.1    GBYB01003825    GBYB01011856    JAG73592.1    JAG81623.1    AJWK01028672    GL761997    EFZ22486.1    GL435707    EFN72821.1    GDKW01000754    JAI55841.1    GEDC01013234    JAS24064.1    KQ435922    KOX68476.1    GEZM01012247    GEZM01012246    GEZM01012243    GEZM01012242    JAV93070.1    GEZM01012249    GEZM01012248    GEZM01012245    GEZM01012244    JAV93051.1    GBGD01000480    JAC88409.1    ACPB03007889    GL446149    EFN88433.1    NEVH01016298    PNF25919.1    ADTU01013610    ADTU01013611    GBBI01002760    JAC15952.1    KK852601    KDR20511.1    PNF25917.1    PNF25918.1    GFTR01007810    JAW08616.1    PNF25915.1    KQ979999    KYN18304.1    GL888292    EGI63045.1    PNF25920.1    KQ981490    KYN41274.1    GECL01002548    JAP03576.1    KZ288198    PBC33657.1    KQ976736    KYM76125.1    NNAY01000947    OXU25784.1    AJVK01010498    KQ977381    KYN03170.1    KQ982080    KYQ60246.1    CM004478    OCT72895.1    NEDP02076736    OWF35231.1    KQ971326    EFA01343.2    JR035926    JR035932    AEY56794.1    AEY56799.1    GFXV01006036    MBW17841.1    KK854113    PTY11497.1    L43496    BX005264    BX294126    BX005060    KQ434998    KZC13334.1    AAMC01120211    GANO01003548    JAB56323.1    ABLF02020542    KK117759    KFM71353.1    QCYY01003062    ROT65649.1    GBSI01000743    JAC95753.1    ATLV01020328    KE525298    KFB45092.1    CH477719    EJY57894.1    AAWZ02022076    ADMH02001277    ETN63253.1    SCEB01215590    RXM28714.1    BDOT01000435    GCF58589.1    GFDL01003403    JAV31642.1    GGMR01001540    MBY14159.1    AGCU01152702    AGCU01152703    RJVU01073245    ROI24873.1    AAAB01008984    APCN01003840    JXUM01107754    JXUM01107755    KQ565171    KXJ71253.1    AHAT01038862    AHAT01038863    AHAT01038864    AHAT01038865    AHAT01038866    EAA15024.3    UFQT01000690    SSX26591.1    NWSH01003682    PCG65936.1    GFWV01003920    MAA28650.1    AERX01017771    AERX01017772    HADW01014232    HADX01003209    SBP25441.1   

Proteomes

UP000053240    UP000053268    UP000279307    UP000036403    UP000053825    UP000053097    + More
UP000092461    UP000005203    UP000000311    UP000053105    UP000015103    UP000008237    UP000235965    UP000005205    UP000027135    UP000078492    UP000007755    UP000078541    UP000242457    UP000078540    UP000215335    UP000192223    UP000002358    UP000092462    UP000078542    UP000075809    UP000186698    UP000242188    UP000007266    UP000000437    UP000076502    UP000008143    UP000007819    UP000054359    UP000283509    UP000075880    UP000030765    UP000008820    UP000075884    UP000001646    UP000000673    UP000075900    UP000288954    UP000261440    UP000075920    UP000007267    UP000075885    UP000076407    UP000291020    UP000075840    UP000069940    UP000249989    UP000085678    UP000018468    UP000261460    UP000265100    UP000265160    UP000007062    UP000264840    UP000218220    UP000005207    UP000261540    UP000264800   

PRIDE

P51892    B0S533   

Pfam

PF04675   DNA_ligase_A_N        + More
PF04679   DNA_ligase_A_C
PF01068   DNA_ligase_A_M
PF16191   E1_4HB
PF09358   E1_UFD
PF00899   ThiF
PF10585   UBA_e1_thiolCys
PF16190   E1_FCCH
PF01926   MMR_HSR1
PF06441   EHN
PF03911   Sec61_beta
PF00178   Ets

Interpro

IPR016059   DNA_ligase_ATP-dep_CS        + More
IPR012340   NA-bd_OB-fold       
IPR012310   DNA_ligase_ATP-dep_cent       
IPR012308   DNA_ligase_ATP-dep_N       
IPR000977   DNA_ligase_ATP-dep       
IPR012309   DNA_ligase_ATP-dep_C       
IPR036599   DNA_ligase_N_sf       
IPR032420   E1_4HB       
IPR042063   Ubi_acti_E1_SCCH       
IPR018074   UBQ-activ_enz_E1_CS       
IPR042302   E1_FCCH_sf       
IPR032418   E1_FCCH       
IPR033127   UBQ-activ_enz_E1_Cys_AS       
IPR018965   Ub-activating_enz_E1_C       
IPR000011   UBQ/SUMO-activ_enz_E1-like       
IPR019572   UBA_E1_Cys       
IPR000594   ThiF_NAD_FAD-bd       
IPR038252   UBA_E1_C_sf       
IPR035985   Ubiquitin-activating_enz       
IPR018075   UBQ-activ_enz_E1       
IPR006073   GTP_binding_domain       
IPR027417   P-loop_NTPase       
IPR030388   G_ERA_dom       
IPR005225   Small_GTP-bd_dom       
IPR010497   Epoxide_hydro_N       
IPR029058   AB_hydrolase       
IPR000639   Epox_hydrolase-like       
IPR016482   SecG/Sec61-beta/Sbh       
IPR036390   WH_DNA-bd_sf       
IPR036388   WH-like_DNA-bd_sf       
IPR000418   Ets_dom       

SUPFAM

SSF117018   SSF117018        + More
SSF50249   SSF50249       
SSF69572   SSF69572       
SSF52540   SSF52540       
SSF53474   SSF53474       
SSF46785   SSF46785       

Gene 3D

1.10.3260.10     1.10.10.2660     2.40.30.180     3.10.290.60     1.10.10.10    

CDD

cd04163  Era

ProteinModelPortal

A0A2W1BRB8   A0A0N1IDS8   A0A194QBR1   A0A310SSJ1   A0A3L8E1A5   A0A0J7L6A6   + More
A0A0L7RIX0   A0A026WD56   A0A0C9R7A2   A0A1B0GKD1   A0A088AVT0   E9IA98   E2A154   A0A0P4VZ05   A0A1B6DEE5   A0A0M8ZRH0   A0A1Y1N860   A0A1Y1N567   A0A069DZK5   T1HIR0   E2B772   A0A2J7QBH5   A0A158NEQ8   A0A023F491   A0A067RJ93   A0A2J7QBF6   A0A2J7QBF7   A0A224X8E2   A0A2J7QBF5   A0A195E099   F4WRN8   A0A2J7QBG1   A0A195FMY6   A0A0V0G787   A0A2A3EPL3   A0A195AVS3   A0A232F4R4   A0A1W4WY29   A0A1W4WNC1   K7IZI0   A0A1B0D270   A0A195CRA6   A0A151XIL7   A0A1L8FMV1   A0A210PFJ6   D6WF20   V9I8Y1   A0A2H8TVL3   A0A2R7VVH4   P51892   A0A2R8Q0Q5   B0S533   A0A154PPG8   F6WCY3   U5EV64   J9K4X4   A0A087U1W4   A0A3R7MMP4   A0A182IU67   A0A098LZ92   A0A084W4E8   J9HJ51   A0A182N7T5   H9GHC9   A0A1S4G6J7   W5JIY5   A0A2Y9D1S0   A0A444U0M2   A0A402FQ34   A0A1Q3FW15   A0A3B4CXZ5   A0A2S2NAI6   A0A182RG56   A0A182WHA2   K7FZW6   A0A182PAL8   A0A182XKU0   A0A3N0XH30   A0A1S4H0H7   K7FZX9   A0A452GH34   A0A182I5A2   A0A182H3P9   A0A1S3JWW3   W5M103   A0A3B4EXX9   A0A3P8NLU6   A0A3P9DCC4   Q7PVP5   A0A336MB82   A0A3Q2V7J0   A0A3P8NLY1   A0A2A4J2H1   A0A293LP81   I3KD07   A0A1A7Y584   A0A3B3T509   I3KD06   A0A3Q3GHB0  

PDB

1X9N     E-value=0,     Score=1656

KEGG

101739080    K10747 DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] | (RefSeq) DNA ligase 1

PATHWAY

03030    DNA replication - Bombyx mori (domestic silkworm)
03410    Base excision repair - Bombyx mori (domestic silkworm)
03420    Nucleotide excision repair - Bombyx mori (domestic silkworm)
03430    Mismatch repair - Bombyx mori (domestic silkworm)

GO

GO:0006310   GO:0051103   GO:0003677   GO:0071897   GO:0003910   GO:0005524   GO:0006260   GO:0006281   GO:0008641   GO:0006464   GO:0005525   GO:0016021   GO:0005739   GO:0005737   GO:0006273   GO:1903461   GO:0005634   GO:0046872   GO:0051301   GO:0007049   GO:0006284   GO:0005654   GO:0003909   GO:0000049   GO:0005975   GO:0004553  

Subcellular location

Nucleus  

Length:

842

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.05324

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00037

outside

1  -  842

 

 

Pi

18.139182

Theta

15.785421

Tajima's D

0.05359

CLR

1.202012

CSRT

0.390080495975201

Interpretation

Uncertain