Gene

KWMTBOMO12310

Pre Gene Modal

BGIBMGA009118

Annotation

PREDICTED:_ubiquitin-conjugating_enzyme_E2_C_[Amyelois_transitella]

Location

Bomo_Chr20(-):11926542-11929203      View in EpiBrowser

Full name

Ubiquitin-conjugating enzyme E2 C      

Alternative Name

(E3-independent) E2 ubiquitin-conjugating enzyme C
E2 ubiquitin-conjugating enzyme C
Ubiquitin carrier protein C
Ubiquitin carrier protein vihar
Ubiquitin-protein ligase C

Location in the cell

Extracellular   Reliability : 1.072 Mitochondrial   Reliability : 1.205 Nuclear   Reliability : 1.546

CDS

ATGGCTCAAAACATCAATCCACATTACGCGTCGTCTTCGAACCCAGCTAAGCAGAGTGAAGACACGATTAAACTAAAAGACAATCATGCTGTGAGCAAACGACTCCAGAAAGAGCTAATGGAGCTAATGCGGTGCAGTGATAAAGGAATATCAGCATTCCCTGAAAGTGAAAACCTCTTCAAATGGATCGGGACCATCAATGGACCTTTAGAAACTGTATACGCAGGCCACAAATACAAATTATCACTTGAATTTCCAAATTCATACCCGTACGCACCACCTGTTGTCAAATTTATGACTCCGTGTTTTCATCCAAATGTTGACACGTGTGGTTTAATATGTTTAGATATTTTAAAAGATAAGTGGACGGCTTTATATGATGTACGTACAGTATTGTTGTCAATCCAAAGTCTTTTAGCAGAACCAAATACACAAAGCCCTTTAAACCAGCAAGCATCATATCTATGGCCGAACCAAGCTGCCTATAAAAAATATTTAGATGAATTTTACAATAAACATAAAGACTCATAG

Protein

MAQNINPHYASSSNPAKQSEDTIKLKDNHAVSKRLQKELMELMRCSDKGISAFPESENLFKWIGTINGPLETVYAGHKYKLSLEFPNSYPYAPPVVKFMTPCFHPNVDTCGLICLDILKDKWTALYDVRTVLLSIQSLLAEPNTQSPLNQQASYLWPNQAAYKKYLDEFYNKHKDS

Description

Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.

Catalytic Activity

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.

Subunit

Component of the APC/C complex.

Similarity

Belongs to the ubiquitin-conjugating enzyme family.

Keywords

ATP-binding   Complete proteome   Cytoplasm   Cytoskeleton   Nucleotide-binding   Reference proteome   Transferase   Ubl conjugation   Ubl conjugation pathway  

Feature

chain  Ubiquitin-conjugating enzyme E2 C

Uniprot

H9JHX0   S4PH77   A0A212ENI4   A0A2W1BR46   A0A2A4ISQ4   A0A2H1W6X6   + More
A0A1E1WE12   A0A0N1PFT9   A0A0L7L2S5   A0A194QC27   A0A0K8TN60   A0A182JMW9   A0A2M3ZII3   A0A084VDN8   T1E8A4   A0A2M4ASM1   W5JLV0   A0A182LWT6   A0A1Q3F034   B0WXE8   A0A182QKT7   A0A182YKZ3   A0A182SSB0   A0A182R8R9   A0A182UW44   A0A182X8L2   A0A182LLJ6   Q7Q5S2   A0A182I160   A0A182N946   A0A1I8NF86   A0A1I8PH41   A0A182PL92   A0A1A9WRC3   A0A0L0CEZ6   A0A182JSS3   A0A1A9ZG41   Q174Z9   Q2M0M1   A0A0K8VFU2   D3TRP0   B4IX76   W8C8L2   B4LGQ0   B4L0R3   B4GRF8   A0A0A1WQ82   A0A1B0BT35   A0A1Q3F003   A0A3B0JZD1   A0A1A9Y388   B3MB18   A0A0M4EAM9   A0A336M6M5   B4N339   A0A154PB72   A0A1B0CGU3   A0A1W4UUQ9   A0A1A9V2X9   B4PGR9   B3NHB5   Q9VTY6   B4HG25   B4QRN3   A0A1B0DKA7   E9IYR7   U5EWC8   A0A310SQA5   E2AQX4   A0A151JRV3   F4WFQ9   A0A195FTD1   A0A158NYQ6   A0A151X2W7   A0A2A3EG36   A0A087ZYY9   A0A1B6I048   A0A026WN21   A0A1L8DTD9   A0A1B6GBY0   A0A0M8ZYH0   A0A1B6MK18   A0A232EZ54   K7IQP0   A0A182FHQ9   E2BTB1   A0A0C9PI55   A0A0T6AUR6   A0A0P4WII0   A0A0P4VRA2   R4FKB5   A0A1W4WM10   A0A3R7MM33   A0A170XX18   A0A1A9UTT5   A0A3M0J461   A0A224XLI4   A0A069DWR8   A0A226DHK8   A0A0V0G8X5  

EC Number

2.3.2.23

Pubmed

19121390    23622113    22118469    28756777    26354079    26227816    + More
26369729    24438588    20920257    23761445    25244985    20966253    12364791    14747013    17210077    25315136    26108605    17510324    15632085    17994087    20353571    24495485    25830018    17550304    15458643    10731132    12537572    19822757    22936249    21282665    20798317    21719571    21347285    24508170    30249741    28648823    20075255    27129103    26334808   

EMBL

BABH01035414    BABH01035415    GAIX01003367    JAA89193.1    AGBW02013665    OWR43017.1    + More
KZ149926    PZC77569.1    NWSH01007790    PCG62805.1    ODYU01006600    SOQ48582.1    GDQN01005830    JAT85224.1    KQ461072    KPJ09842.1    JTDY01003418    KOB69584.1    KQ459193    KPJ03017.1    GDAI01002037    JAI15566.1    GGFM01007603    MBW28354.1    ATLV01011632    KE524705    KFB36082.1    GAMD01002347    JAA99243.1    GGFK01010448    MBW43769.1    ADMH02001054    GGFL01004311    ETN64278.1    MBW68489.1    AXCM01000856    GFDL01014129    JAV20916.1    DS232163    EDS36478.1    AXCN02000488    AAAB01008960    EAA11580.3    APCN01000031    JRES01000577    KNC30059.1    CH477404    EAT41632.1    CH379069    EAL30909.1    GDHF01014597    JAI37717.1    CCAG010005148    EZ424092    ADD20368.1    CH916366    EDV97408.1    GAMC01002955    GAMC01002954    JAC03602.1    CH940647    EDW70515.1    CH933809    EDW18140.1    CH479188    EDW40343.1    GBXI01013714    JAD00578.1    JXJN01019970    GFDL01014176    JAV20869.1    OUUW01000012    SPP87437.1    CH902618    EDV40284.1    CP012525    ALC44341.1    UFQT01000530    SSX25021.1    CH964062    EDW78778.1    KQ434864    KZC09083.1    AJWK01011591    CM000159    EDW94308.1    CH954178    EDV51572.1    AF410850    AE014296    BT028772    CH480815    EDW41271.1    CM000363    CM002912    EDX10247.1    KMY99244.1    AJVK01006411    GL767043    EFZ14302.1    GANO01001475    JAB58396.1    KQ761768    OAD57073.1    GL441846    EFN64120.1    KQ978566    KYN30103.1    GL888122    EGI66952.1    KQ981276    KYN43713.1    ADTU01004209    KQ982566    KYQ54733.1    KZ288269    PBC29961.1    GECU01027399    JAS80307.1    KK107151    QOIP01000003    EZA57348.1    RLU25024.1    GFDF01004440    JAV09644.1    GECZ01009821    JAS59948.1    KQ435824    KOX72159.1    GEBQ01020327    GEBQ01003667    JAT19650.1    JAT36310.1    NNAY01001539    OXU23651.1    GL450384    EFN81113.1    GBYB01000588    JAG70355.1    LJIG01022767    KRT78824.1    GDRN01056630    JAI65801.1    GDKW01002192    JAI54403.1    ACPB03005095    GAHY01001928    JAA75582.1    QCYY01001113    ROT80503.1    GEMB01003937    JAR99319.1    QRBI01000184    RMB95704.1    GFTR01003099    JAW13327.1    GBGD01003115    JAC85774.1    LNIX01000021    OXA43666.1    GECL01001638    JAP04486.1   

Proteomes

UP000005204    UP000007151    UP000218220    UP000053240    UP000037510    UP000053268    + More
UP000075880    UP000030765    UP000000673    UP000075883    UP000002320    UP000075886    UP000076408    UP000075901    UP000075900    UP000075903    UP000076407    UP000075882    UP000007062    UP000075840    UP000075884    UP000095301    UP000095300    UP000075885    UP000091820    UP000037069    UP000075881    UP000092445    UP000008820    UP000001819    UP000092444    UP000001070    UP000008792    UP000009192    UP000008744    UP000092460    UP000268350    UP000092443    UP000007801    UP000092553    UP000007798    UP000076502    UP000092461    UP000192221    UP000078200    UP000002282    UP000008711    UP000000803    UP000001292    UP000000304    UP000092462    UP000000311    UP000078492    UP000007755    UP000078541    UP000005205    UP000075809    UP000242457    UP000005203    UP000053097    UP000279307    UP000053105    UP000215335    UP000002358    UP000069272    UP000008237    UP000015103    UP000192223    UP000283509    UP000269221    UP000198287   

PRIDE

H9JHX0    Q9VTY6   

Pfam

PF00179   UQ_con        + More
PF00400   WD40

Interpro

IPR016135   UBQ-conjugating_enzyme/RWD        + More
IPR000608   UBQ-conjugat_E2       
IPR023313   UBQ-conjugating_AS       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR017986   WD40_repeat_dom       
IPR001680   WD40_repeat       
IPR040323   EIPR1       
IPR019775   WD40_repeat_CS       
IPR036322   WD40_repeat_dom_sf       

SUPFAM

SSF54495   SSF54495        + More
SSF50978   SSF50978       

Gene 3D

3.10.110.10     2.130.10.10    

CDD

cd00195  UBCc

ProteinModelPortal

H9JHX0   S4PH77   A0A212ENI4   A0A2W1BR46   A0A2A4ISQ4   A0A2H1W6X6   + More
A0A1E1WE12   A0A0N1PFT9   A0A0L7L2S5   A0A194QC27   A0A0K8TN60   A0A182JMW9   A0A2M3ZII3   A0A084VDN8   T1E8A4   A0A2M4ASM1   W5JLV0   A0A182LWT6   A0A1Q3F034   B0WXE8   A0A182QKT7   A0A182YKZ3   A0A182SSB0   A0A182R8R9   A0A182UW44   A0A182X8L2   A0A182LLJ6   Q7Q5S2   A0A182I160   A0A182N946   A0A1I8NF86   A0A1I8PH41   A0A182PL92   A0A1A9WRC3   A0A0L0CEZ6   A0A182JSS3   A0A1A9ZG41   Q174Z9   Q2M0M1   A0A0K8VFU2   D3TRP0   B4IX76   W8C8L2   B4LGQ0   B4L0R3   B4GRF8   A0A0A1WQ82   A0A1B0BT35   A0A1Q3F003   A0A3B0JZD1   A0A1A9Y388   B3MB18   A0A0M4EAM9   A0A336M6M5   B4N339   A0A154PB72   A0A1B0CGU3   A0A1W4UUQ9   A0A1A9V2X9   B4PGR9   B3NHB5   Q9VTY6   B4HG25   B4QRN3   A0A1B0DKA7   E9IYR7   U5EWC8   A0A310SQA5   E2AQX4   A0A151JRV3   F4WFQ9   A0A195FTD1   A0A158NYQ6   A0A151X2W7   A0A2A3EG36   A0A087ZYY9   A0A1B6I048   A0A026WN21   A0A1L8DTD9   A0A1B6GBY0   A0A0M8ZYH0   A0A1B6MK18   A0A232EZ54   K7IQP0   A0A182FHQ9   E2BTB1   A0A0C9PI55   A0A0T6AUR6   A0A0P4WII0   A0A0P4VRA2   R4FKB5   A0A1W4WM10   A0A3R7MM33   A0A170XX18   A0A1A9UTT5   A0A3M0J461   A0A224XLI4   A0A069DWR8   A0A226DHK8   A0A0V0G8X5  

PDB

5KHR     E-value=5.94841e-55,     Score=537

KEGG

101740454    K06688 ubiquitin-conjugating enzyme E2 C [EC:2.3.2.23] | (RefSeq) ubiquitin-conjugating enzyme E2 C

PATHWAY

04120    Ubiquitin mediated proteolysis - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0016740   GO:0061631   GO:0005634   GO:0031145   GO:0031616   GO:0010458   GO:1903364   GO:0000151   GO:0045842   GO:0016874   GO:0005815   GO:0005737  

PANTHER

PTHR14205  

Subcellular location

Cytoplasm  
Cytoskeleton  
Microtubule organizing center  
Centrosome  

Length:

176

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00314

Exp number, first 60 AAs:

0.00019

Total prob of N-in:

0.22435

outside

1  -  176

 

 

Pi

14.818695

Theta

17.395086

Tajima's D

-1.024594

CLR

0.14822

CSRT

0.131443427828609

Interpretation

Uncertain