SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO12286  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA009132
Annotation
beta-tubulin_[Bombyx_mori]
Full name
Tubulin beta chain       + More
Tubulin beta-1 chain      
Alternative Name
Beta-1-tubulin
Location in the cell
Cytoplasmic   Reliability : 3.706
 

Sequence

CDS
ATGAGGGAAATCGTTCATCTACAGGCCGGCCAATGTGGTAACCAGATTGGAGCTAAGTTCTGGGAGATCATCTCCGACGAGCACGGCATCGACCCCACCGGTGCCTACCATGGAGACTCTGACTTGCAGTTGGAGCGCATCAATGTATACTACAATGAAGCCTCCGGCGGCAAGTACGTGCCCCGCGCCATCCTCGTCGACTTGGAGCCCGGCACCATGGACTCTGTCCGCTCCGGACCTTTCGGACAGATCTTCCGTCCGGACAACTTCGTCTTCGGACAGTCCGGCGCCGGCAACAACTGGGCCAAGGGACACTACACAGAGGGTGCTGAGCTCGTTGACTCGGTCCTCGATGTAGTCCGCAAAGAATCAGAATCTTGCGATTGCCTACAGGGCTTCCAACTTACACATTCCCTCGGTGGCGGCACCGGGTCCGGTATGGGCACCCTCCTCATCTCAAAGATCCGTGAAGAGTACCCCGACAGAATCATGAACACATACTCAGTAGTCCCCTCGCCCAAAGTATCAGACACTGTCGTCGAACCATACAATGCGACTCTCTCAGTTCACCAGCTAGTTGAAAACACAGACGAAACATACTGCATCGACAACGAGGCTCTATACGACATCTGCTTCCGCACTCTCAAACTGTCCACACCCACTTACGGTGACCTTAACCACTTAGTTTCCCTCACAATGTCTGGTGTCACCACTTGCCTTAGGTTCCCCGGTCAGTTGAACGCTGATCTCAGAAAATTGGCGGTAAACATGGTTCCCTTCCCGCGTCTCCACTTCTTCATGCCAGGTTTCGCTCCCCTCACATCCCGTGGAAGCAGACAGTACCGTGCCTTGACTGTACCCGAGCTCACGCAACAGATGTTCGACGCCAAGAACATGATGGCTGCCTGCGACCCACGCCACGGCCGCTACCTCACCGTCGCCGCCATCTTCCGCGGCCGCATGTCCATGAAGGAGGTCGACGAACAAATGCTTAACATCCAGAACAAGAACTCCTCCTACTTCGTGGAATGGATCCCGAACAACGTGAAGACCGCCGTGTGCGACATTCCTCCTCGTGGTCTCAAGATGGCCGCCACCTTCATCGGAAACTCCACCGCCATCCAGGAGCTGTTCAAGCGCATCTCGGAACAGTTCACCGCTATGTTCAGGCGCAAGGCTTTCTTGCATTGGTACACCGGCGAGGGCATGGACGAGATGGAGTTCACCGAGGCTGAGAGCAACATGAACGACCTTGTCTCCGAGTACCAACAGTACCAGGAGGCCACCGCCGACGAGGACGCAGAGTTTGACGAAGAGCAGGAGCAGGAGATTGAAGAGCATTAA
Protein
MREIVHLQAGQCGNQIGAKFWEIISDEHGIDPTGAYHGDSDLQLERINVYYNEASGGKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTYSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLSTPTYGDLNHLVSLTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSRQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNIQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMAATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEATADEDAEFDEEQEQEIEEH

Summary

Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
Subunit
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with mgr and Vhl.
Similarity
Belongs to the tubulin family.
Keywords
Cytoplasm   Cytoskeleton   GTP-binding   Microtubule   Nucleotide-binding   Complete proteome   Phosphoprotein   Reference proteome  
Feature
chain  Tubulin beta-1 chain
EMBL
RSAL01000012    RVE53453.1    KZ150040    PZC74567.1    AK402356    BAM18978.1    + More
AB072307    BAB86852.1    KQ459193    KPJ03036.1    GDQN01000168    JAT90886.1    AB003287    BAA19845.1    LC328975    BBA78422.1    AK402544    BAM19166.1    RVE53452.1    GDQN01009594    JAT81460.1    AK401197    BAM17819.1    BABH01035358    AB072308    BAB86853.1    EU234504    ABY47891.1    AGBW02008171    OWR54067.1    JF767013    AEF32528.1    JN029962    AEJ84083.1    NEVH01013629    PNF28355.1    GEZM01080243    JAV62278.1    NEVH01011896    PNF31182.1    AF030547    KU194643    ALP82107.1    KQ435824    KOX72161.1    KQ971352    EFA06663.1    NEVH01024538    PNF16855.1    KK852686    KDR18435.1    KK855763    PTY23825.1    GALX01001232    JAB67234.1    EU373305    ABY66392.1    KX981998    APQ43051.1    GECZ01027490    JAS42279.1    GFXV01002575    MBW14380.1    ABLF02041120    ABLF02041135    AB011069    BAA32102.1    JTDY01001409    KOB73939.1    EU429675    ABZ91904.1    GL888122    EGI66955.1    KQ976681    KYM78155.1    KZ288269    PBC29959.1    JR049240    AEY60906.1    ADTU01004210    ADTU01004211    GL441846    EFN64123.1    ACPB03021733    GAHY01000456    JAA77054.1    KK107151    QOIP01000003    EZA57342.1    RLU24488.1    BT120510    ADD24150.1    HACA01027819    CDW45180.1    GBHO01005781    JAG37823.1    GAPW01001430    JAC12168.1    GALA01001146    JAA93706.1    GFDL01016207    JAV18838.1    GANO01001316    JAB58555.1    GBHO01005780    JAG37824.1    GBHO01028818    JAG14786.1    NEVH01011213    PNF31670.1    GDIQ01047153    GDIQ01002074    JAN47584.1    UFQT01000630    UFQT01000929    SSX25891.1    SSX28043.1    CH477254    EAT45945.1    LNIX01000001    OXA63748.1    DS235222    EEB13502.1    CH940648    EDW61137.1    GAMC01001610    JAC04946.1    EZ423882    ADD20158.1    CH933808    EDW09833.1    KR133399    AKM70869.1    GDHF01016881    JAI35433.1    JXJN01002474    CH674335    EDY71630.1    CH479183    EDW36350.1    CM000158    EDW91493.1    CP012524    ALC42690.1    CH902619    EDV35701.1    CH963850    EDW74799.1    CH480816    EDW48605.1    CH916367    EDW01883.1    CH954179    EDV55213.2    GBXI01014311    JAC99980.1    GFDG01000517    JAV18282.1    GDAI01000029    JAI17574.1    CM000362    CM002911    EDX07818.1    KMY95122.1    JRES01001535    JRES01000890    KNC22195.1    KNC27524.1    KA647387    AFP62016.1    DQ377071    M20419    AE013599    BT003242    HM047134    ADI24738.1    GFDF01000155    JAV13929.1    AK416954    BAN20169.1    GDIQ01040660    GDIQ01003233    JAN91504.1    GFTR01006332    JAW10094.1    GFDF01000126    JAV13958.1    GAMD01003291    JAA98299.1   
Pfam
PF00091   Tubulin        + More
PF03953   Tubulin_C
PF10294   Methyltransf_16
Interpro
IPR023123   Tubulin_C        + More
IPR000217   Tubulin       
IPR018316   Tubulin/FtsZ_2-layer-sand-dom       
IPR036525   Tubulin/FtsZ_GTPase_sf       
IPR017975   Tubulin_CS       
IPR003008   Tubulin_FtsZ_GTPase       
IPR008280   Tub_FtsZ_C       
IPR013838   Beta-tubulin_BS       
IPR002453   Beta_tubulin       
IPR037103   Tubulin/FtsZ_C_sf       
IPR019410   Methyltransf_16       
IPR029063   SAM-dependent_MTases       
SUPFAM
SSF52490   SSF52490        + More
SSF55307   SSF55307       
SSF53335   SSF53335       
PDB
5Z4U     E-value=0,     Score=2174

Ontologies

Topology

Subcellular location
  
Length:
447
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.01066
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00368
outside
1  -  447
 
 

Population Genetic Test Statistics

Pi
23.615503
Theta
22.82971
Tajima's D
0.105176
CLR
0.11307
CSRT
0.401429928503575
Interpretation
Uncertain

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
Peptides ×
Source Sequence Identity Evalue
28556443 FWEIISDEHGIDPTGAYHGDSDLQLER 100.00 1e-14
28556443 FVEWIPNNVK 100.00 1e-14
28556443 FPGQLNADLR 100.00 1e-14
26822097 TAVCDIPPR 100.00 4e-14
26280517 SGNIIVTTSVVDPK 100.00 4e-14
25044914 SGNDIIIR 100.00 4e-14
24402669 SGNIDFEGK 100.00 4e-14
27102218 GHYTEGAEIVDSVIDVVR 100.00 4e-14
28467696 SGNISVNYK 100.00 4e-14
21761556 LHFFMPGFAPLTSR 100.00 4e-14
28556443 SGPFGQIFRPDNFVFGQSGAGNNWAK 100.00 4e-14
28556443 SGPFGQIFRPDNFVFGQSGAGNNWAK 100.00 4e-14
28556443 SGPFGQIFRPDNF 100.00 4e-14
28556443 SGPFGQIFRPDNF 100.00 4e-14
28556443 LSTPTYGDLNHLV 100.00 7e-12
28556443 LHFFMPGFAPLTSR 100.00 7e-12
28556443 QIFRPDNFVFGQSGAGNNWAK 100.00 5e-10
28556443 QIFRPDNFVFGQSGAGNNWAK 100.00 5e-10
28556443 QIFRPDNFVFGQSGAGNNWAK 100.00 5e-10
28556443 QIFRPDNFVFGQSGAGNNWAK 100.00 5e-10
28556443 QIFRPDNFVFGQSGAGNNWAK 100.00 5e-10
28556443 QIFRPDNFVFGQSGAGNNWAK 100.00 5e-10
28556443 NSSYFVEWIPNNVK 100.00 5e-10
28556443 NSSYFVEWIPNNVK 100.00 5e-10
28556443 QLFRPDNFVFGQSGAGNNWAK 95.24 1e-09
28556443 QLFRPDNFVFGQSGAGNNWAK 95.24 1e-09
28556443 QLFRPDNFVFGQSGAGNNWAK 95.24 1e-09
28556443 QLFRPDNFVFGQSGAGNNWAK 95.24 1e-09
28556443 QLFRPDNFVFGQSGAGNNWAK 95.24 1e-09
28556443 QLFRPDNFVFGQSGAGNNWAK 95.24 1e-09
28556443 QLFRPDNFVFGQSGAGNNWAK 95.24 1e-09
28556443 NMMAACDPR 95.24 1e-09
28556443 LAVNMVPFP 100.00 2e-09
27102218 IMNTYSVVPSPK 100.00 1e-07
26822097 MREIVHIQAGQCGNQIGAK 100.00 5e-07
28467696 PDIDNAVIVR 100.00 5e-07
28556443 LHFFMPGFAP 100.00 9e-07
28556443 GHYTEGAELVDSVLDVVR 100.00 3e-06
28556443 GHYTEGAELVDSVLDVVR 100.00 3e-06
28556443 GHYTEGAELVDSVLDVVR 100.00 3e-06
28556443 GHYTEGAELVDSVLDVVR 100.00 3e-06
28556443 GHYTEGAELVDSVLDVVR 100.00 3e-06
28556443 GHYTEGAELVDSVLDVVR 100.00 3e-06
28556443 FWEIISDEHGIDPTGAYHGDSDLQLER 100.00 3e-06
28556443 FWEIISDEHGIDPTGAYHGDSDLQLER 100.00 3e-06
28556443 EIVHLQAGQCGNQIGAK 100.00 3e-06
28556443 EIVHLQAGQCGNQIGAK 100.00 3e-06
28556443 EIVHLQAGQCGNQIGAK 100.00 3e-06
28556443 EIVHLQAGQCGN 100.00 3e-06
28556443 AILLDLEPGTMDAVR 100.00 3e-06
28556443 MAATFIGNSTAIQELFK 100.00 6e-06
28556443 TTCLRFPGQLNADLR 100.00 6e-06
28556443 MPGFAPLTSR 100.00 1e-05
26280517 INTFIIK 100.00 3e-05
27102218 MSMKEVDEQMINIQNK 100.00 3e-05
28556443 VSDTVVEPY 100.00 3e-05
28556443 MAATFIGNSTAIQELFK 100.00 3e-05
28556443 MAATFIGNSTAIQELFK 100.00 3e-05
28556443 MAATFIGNSTAIQELFK 100.00 3e-05
28556443 MAATFIGNSTAIQELFK 100.00 3e-05
28556443 MAATFIGNSTAIQELFK 100.00 3e-05
28556443 MAATFIGNSTAIQELFK 100.00 3e-05
28556443 MAATFIGNSTAIQELFK 100.00 3e-05
28556443 LSTPTYGDLNHLVSLTMSGVTTCLR 100.00 3e-05
28556443 LSTPTYGDLNHLVSLTMSGVTTCLR 100.00 3e-05
28556443 TAVCDIPPK 100.00 4e-05
28556443 TFIGNSTAIQEIFK 100.00 4e-05
28556443 INVYYNEASGGKYVPR 100.00 4e-05
28556443 AATFIGNSTAIQELFK 100.00 6e-05
28556443 VSDTVVEPYNATLSVH 100.00 2e-04
28556443 TAVCDIPPR 100.00 2e-04
28556443 TAVCDIPPR 100.00 2e-04
28556443 LSTPTYGDLNHLVSL 100.00 2e-04
31223520 LHFFMPGFAPLTSR 100.00 2e-04
31223520 AILVDLEPGTMDSVR 100.00 2e-04
21761556 ISEQFTAMFR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTS 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLT 100.00 2e-04
28556443 LAVNMVPFPR 100.00 2e-04
28556443 LSTPTYGDLNHLVSLTM 100.00 3e-04
31223520 ALTVPELTQQMFDAK 100.00 3e-04
26822097 GHYTEGAEIVDSVIDVVRK 100.00 3e-04
26280517 NQITTNPENTVFDAKR 100.00 3e-04
25044914 NSSIDPDIPIIIK 100.00 3e-04
27102218 INVYYNEASGGKYVPR 100.00 3e-04
28467696 NSSPQTISVEAYR 100.00 3e-04
28556443 NSSYFVEWIPNNVK 100.00 3e-04
28556443 NSSYFVEWIPNNVK 100.00 3e-04
28556443 NSSYFVEWIPNNVK 100.00 3e-04
28556443 NSSYFVEWIPNNVK 100.00 3e-04
28556443 NSSYFVEWIPNNVK 100.00 3e-04
28556443 NSSYFVEWIPNNVK 100.00 3e-04
28556443 NSSYFVEWIPNNVK 100.00 3e-04
28556443 NMMAACDPR 100.00 3e-04
28556443 MAATFIGNSTAIQELFK 100.00 3e-04
31223520 EVDEQMLNIQNK 100.00 5e-04
21761556 LAVNMVPFPR 100.00 5e-04
28556443 AILVDLEPGTMDSVR 100.00 5e-04
28556443 AILVDLEPGTMDSVR 100.00 5e-04
28556443 AILVDLEPGTMDSVR 100.00 5e-04
28556443 AILVDLEPGTMDSVR 100.00 5e-04
28556443 ILVDLEPGTMDSVR 100.00 5e-04
28556443 YLQEDLSSEK 100.00 5e-04
31223520 LHFFMPGFAPLTSR 100.00 0.001
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