Gene

KWMTBOMO12284

Pre Gene Modal

BGIBMGA009154

Annotation

uridine_5'-monophosphate_synthase_[Danaus_plexippus]

Location

Bomo_Chr20(+):11437035-11439250      View in EpiBrowser

Full name

Orotate phosphoribosyltransferase      

Location in the cell

Cytoplasmic   Reliability : 2.275

CDS

ATGACGTCCACTCTACAGGATCTGGCAGTGCAGTTATTCGACGCAGGAGCAGTTCGACTTGAAGACATAGAGGCGAAGGTCGGCAGGCGAACCCCCATCTACTTCGACCTACGAGTCATCGTTTCGCACCCTAAGCTGATGGTAGCAGTGTCACATCAATTGGAGAAACTCATTAAAGACGTTCATCACGATATGATATGTGGAGTTCCATACGCTGCACTGCCTCTTGCAGTAGTCATCTCCATCAACACGGACAGACCAATGATCATGAAGAGAAAAGAAACAAAATTATATGCCACAAAGAAATTACTGGAGGGCGTGTATCAAAAAAATCAGACGTGCCTTGTTGTTGAAGATGTAGTGACATCTGGCGGCAGCTTGCTAGAAACAGTTGAAACTTTACGCAAAGAAGGTTTGATAGTTACACATGCCGTAATAGTACTCGAGCGGGAACAAGGTGGCGCTAGTGTACTCGAAGCGAATGGTATTACAGTGAAATCACTTTTCACATTAACTAATTTAGTGAGAATGCTTCATAAAGCGGGTAGAATTGACAATGACACAGTCGAATTAATATTTGATCATATAAAGGAATGCCAATTTGGAACGAAAGATAATTTGGAGTAG

Protein

MTSTLQDLAVQLFDAGAVRLEDIEAKVGRRTPIYFDLRVIVSHPKLMVAVSHQLEKLIKDVHHDMICGVPYAALPLAVVISINTDRPMIMKRKETKLYATKKLLEGVYQKNQTCLVVEDVVTSGGSLLETVETLRKEGLIVTHAVIVLEREQGGASVLEANGITVKSLFTLTNLVRMLHKAGRIDNDTVELIFDHIKECQFGTKDNLE

Description

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).

Catalytic Activity

diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate

Cofactor

Mg(2+)

Subunit

Homodimer.

Similarity

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.

Uniprot

H9JI06   A0A212FK36   A0A2H1X1H1   A0A2A4IZA9   A0A0N0PB06   A0A2W1BI85   + More
A0A3S2NKS2   A0A194QBV5   A0A0L7LEW0   A0A2H1V5H1   A0A2A4JS88   A0A1B6DH00   E2AMC4   S4NGX6   A0A182SJA8   A0A2M3Z341   H9J7Y6   T1DQ66   A0A1B6KY40   Q2F642   W5JU62   A0A2M4BL31   A0A2M4BL32   A0A2M4AG61   A0A336KMV5   A0A1B6K1V9   A0A1I8QBG3   K7IX88   A0A232FC27   A0A182IR66   A0A026VYJ3   B0W331   A0A182YGP3   E9IMV3   A0A023F7U3   A0A1B6EQX9   A0A1B6G5N9   A0A182QCX4   A0A3B3R2R5   A0A023ES01   A0A195D1G3   U5EU74   A0A151XDF2   F4X083   A0A0L0CLW6   A0A1Q3F1P9   A0A182FSD4   A0A182JTD1   A0A0L7LET4   Q16QF3   A0A182UWE0   A0A1S4FSU7   A0A182U319   Q7QB57   A0A194QGS7   A0A158NHC2   A0A0D2V1M4   A0A195AZK8   B4JSX4   A0A0G1VN04   A0A182HBI2   A0A224XP35   A0A182RYP4   N6ST75   A0A182LTP8   A0A232EWX5   E9J1A5   A0A0D2U139   A0A1U8J468   A0A0V0GAW1   A0A1L8DY49   A0A182P6S0   A0A182NLC8   R7U604   A0A340TBA6   Q7ZVR7   A0A0P4VL83   R4FNI1   B4M4V8   A0A0M8ZX99   A0A182XJ45   A0A182I7R6   A0A154PPC3   A0A397YLM6   A0A1F6LJI1   A0A182L7A8   A0A146P8A5   A0A0C9QBM4   B4KE16   A0A1U8NVE8   A0A061F815   A0A061F719   A0A146MP24   B4NH48   A0A0B0MB88   A0A2J6JYY7   A0A3P6BSA4   A0A084VDC6   A0A1I8ND48   T1PCL7  

EC Number

2.4.2.10

Pubmed

19121390    22118469    26354079    28756777    26227816    20798317    + More
23622113    20920257    23761445    20075255    28648823    24508170    30249741    25244985    21282665    25474469    29240929    24945155    21719571    26108605    17510324    12364791    14747013    17210077    21347285    23257886    17994087    26483478    23537049    25893780    23254933    27129103    27774985    20966253    23731509    28401891    24438588    25315136   

EMBL

BABH01035357    AGBW02008171    OWR54069.1    ODYU01012659    SOQ59088.1    NWSH01004290    + More
PCG65267.1    KQ461072    KPJ09818.1    KZ150040    PZC74568.1    RSAL01000012    RVE53451.1    KQ459193    KPJ03038.1    JTDY01001409    KOB73940.1    ODYU01000778    SOQ36083.1    NWSH01000703    PCG74689.1    GEDC01012344    JAS24954.1    GL440811    EFN65415.1    GAIX01014549    JAA78011.1    GGFM01002107    MBW22858.1    BABH01020166    GAMD01002719    JAA98871.1    GEBQ01023656    JAT16321.1    DQ311230    ABD36175.1    ADMH02000361    ETN66833.1    GGFJ01004639    MBW53780.1    GGFJ01004638    MBW53779.1    GGFK01006452    MBW39773.1    UFQS01000645    UFQT01000410    UFQT01000645    SSX05697.1    SSX24054.1    GECU01002298    JAT05409.1    AAZX01000583    NNAY01000465    OXU28182.1    KK107566    QOIP01000006    EZA48873.1    RLU21950.1    DS231830    EDS30739.1    GL764255    EFZ18097.1    GBBI01001433    JAC17279.1    GECZ01029408    JAS40361.1    GECZ01012037    JAS57732.1    AXCN02000121    GAPW01001603    JAC11995.1    KQ976973    KYN06707.1    GANO01001613    JAB58258.1    KQ982294    KYQ58387.1    GL888493    EGI60148.1    JRES01000211    KNC33256.1    GFDL01013586    JAV21459.1    JTDY01001365    KOB74068.1    CH477750    EAT36623.1    AAAB01008880    EAA08525.3    KQ459232    KPJ02651.1    ADTU01015566    CM001748    KJB62735.1    KQ976698    KYM77470.1    CH916373    EDV94864.1    LCPZ01000022    KKW07853.1    JXUM01032039    JXUM01032040    KQ560942    KXJ80255.1    GFTR01006503    JAW09923.1    APGK01057391    KB741280    KB631604    ENN70894.1    ERL84613.1    AXCM01003761    NNAY01001812    OXU22847.1    GL767586    EFZ13419.1    KJB62734.1    GECL01000923    JAP05201.1    GFDF01002899    JAV11185.1    AMQN01001733    KB305005    ELU01511.1    BC045440    BC055000    BC164016    AAH45440.1    AAH55000.1    AAI64016.1    GDKW01001438    JAI55157.1    ACPB03010572    GAHY01001284    JAA76226.1    CH940652    EDW59669.1    KQ435837    KOX71473.1    APCN01002549    KQ435010    KZC13745.1    CM010634    RID54301.1    MFPS01000007    OGH59499.1    GCES01146131    JAQ40191.1    GBYB01011813    JAG81580.1    CH933806    EDW16037.1    CM001885    EOY12847.1    EOY12846.1    GCES01165942    JAQ20380.1    CH964272    EDW84545.1    JRRC01025018    KHF98024.1    NBSK01009389    PLY68034.1    LR031574    VDC99181.1    ATLV01011254    KE524659    KFB35970.1    KA645885    AFP60514.1   

Proteomes

UP000005204    UP000007151    UP000218220    UP000053240    UP000283053    UP000053268    + More
UP000037510    UP000000311    UP000075901    UP000000673    UP000095300    UP000002358    UP000215335    UP000075880    UP000053097    UP000279307    UP000002320    UP000076408    UP000075886    UP000261540    UP000078542    UP000075809    UP000007755    UP000037069    UP000069272    UP000075881    UP000008820    UP000075903    UP000075902    UP000007062    UP000005205    UP000032304    UP000078540    UP000001070    UP000069940    UP000249989    UP000075900    UP000019118    UP000030742    UP000075883    UP000189702    UP000075885    UP000075884    UP000014760    UP000075920    UP000015103    UP000008792    UP000053105    UP000076407    UP000075840    UP000076502    UP000075882    UP000009192    UP000026915    UP000007798    UP000235145    UP000030765    UP000095301   

PRIDE

H9JI06    H9J7Y6    Q2F642   

Pfam

PF00156   Pribosyltran        + More
PF00215   OMPdecase
PF06479   Ribonuc_2-5A
PF00069   Pkinase
PF02138   Beach
PF00400   WD40
PF01728   FtsJ

Interpro

IPR000836   PRibTrfase_dom        + More
IPR029057   PRTase-like       
IPR004467   Or_phspho_trans_dom       
IPR023031   OPRT       
IPR018089   OMPdecase_AS       
IPR001754   OMPdeCOase_dom       
IPR013785   Aldolase_TIM       
IPR011060   RibuloseP-bd_barrel       
IPR014732   OMPdecase       
IPR033523   IRE2       
IPR011009   Kinase-like_dom_sf       
IPR008271   Ser/Thr_kinase_AS       
IPR010513   KEN_dom       
IPR018997   PUB_domain       
IPR018391   PQQ_beta_propeller_repeat       
IPR038357   KEN_sf       
IPR011047   Quinoprotein_ADH-like_supfam       
IPR000719   Prot_kinase_dom       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR036372   BEACH_dom_sf       
IPR001680   WD40_repeat       
IPR017986   WD40_repeat_dom       
IPR036322   WD40_repeat_dom_sf       
IPR000409   BEACH_dom       
IPR002877   rRNA_MeTrfase_FtsJ_dom       
IPR015507   rRNA-MeTfrase_E       
IPR029063   SAM-dependent_MTases       
IPR017441   Protein_kinase_ATP_BS       

SUPFAM

SSF53271   SSF53271        + More
SSF51366   SSF51366       
SSF56112   SSF56112       
SSF50998   SSF50998       
SSF50978   SSF50978       
SSF81837   SSF81837       
SSF53335   SSF53335       

Gene 3D

3.20.20.70     1.20.1440.180     2.130.10.10     1.10.1540.10    

CDD

cd06223  PRTases_typeI

ProteinModelPortal

H9JI06   A0A212FK36   A0A2H1X1H1   A0A2A4IZA9   A0A0N0PB06   A0A2W1BI85   + More
A0A3S2NKS2   A0A194QBV5   A0A0L7LEW0   A0A2H1V5H1   A0A2A4JS88   A0A1B6DH00   E2AMC4   S4NGX6   A0A182SJA8   A0A2M3Z341   H9J7Y6   T1DQ66   A0A1B6KY40   Q2F642   W5JU62   A0A2M4BL31   A0A2M4BL32   A0A2M4AG61   A0A336KMV5   A0A1B6K1V9   A0A1I8QBG3   K7IX88   A0A232FC27   A0A182IR66   A0A026VYJ3   B0W331   A0A182YGP3   E9IMV3   A0A023F7U3   A0A1B6EQX9   A0A1B6G5N9   A0A182QCX4   A0A3B3R2R5   A0A023ES01   A0A195D1G3   U5EU74   A0A151XDF2   F4X083   A0A0L0CLW6   A0A1Q3F1P9   A0A182FSD4   A0A182JTD1   A0A0L7LET4   Q16QF3   A0A182UWE0   A0A1S4FSU7   A0A182U319   Q7QB57   A0A194QGS7   A0A158NHC2   A0A0D2V1M4   A0A195AZK8   B4JSX4   A0A0G1VN04   A0A182HBI2   A0A224XP35   A0A182RYP4   N6ST75   A0A182LTP8   A0A232EWX5   E9J1A5   A0A0D2U139   A0A1U8J468   A0A0V0GAW1   A0A1L8DY49   A0A182P6S0   A0A182NLC8   R7U604   A0A340TBA6   Q7ZVR7   A0A0P4VL83   R4FNI1   B4M4V8   A0A0M8ZX99   A0A182XJ45   A0A182I7R6   A0A154PPC3   A0A397YLM6   A0A1F6LJI1   A0A182L7A8   A0A146P8A5   A0A0C9QBM4   B4KE16   A0A1U8NVE8   A0A061F815   A0A061F719   A0A146MP24   B4NH48   A0A0B0MB88   A0A2J6JYY7   A0A3P6BSA4   A0A084VDC6   A0A1I8ND48   T1PCL7  

PDB

2WNS     E-value=4.30504e-41,     Score=419

KEGG

101738973    K13421 uridine monophosphate synthetase [EC:2.4.2.10 4.1.1.23] | (RefSeq) uridine 5'-monophosphate s

PATHWAY

00240    Pyrimidine metabolism - Bombyx mori (domestic silkworm)
00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006221   GO:0009116   GO:0004588   GO:0004590   GO:0006207   GO:0044205   GO:0005524   GO:0004540   GO:0006397   GO:0004672   GO:0016021   GO:0019856   GO:0006222   GO:0000287   GO:0008168   GO:0001510   GO:0005525   GO:0005200   GO:0019538   GO:0030145   GO:0000049   GO:0005975   GO:0004553  

PANTHER

PTHR13954:SF15  

Length:

208

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

11.5397

Exp number, first 60 AAs:

0.05361

Total prob of N-in:

0.07582

outside

1  -  208

 

 

Pi

24.06874

Theta

20.758053

Tajima's D

0.438025

CLR

1.458758

CSRT

0.500224988750562

Interpretation

Uncertain