SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO12282  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA009132
Annotation
beta-tubulin_[Bombyx_mori]
Location
Bomo_Chr20(-):11375948-11382464      View in EpiBrowser
Full name
Tubulin beta chain       + More
Tubulin beta-3 chain      
Alternative Name
Beta-3-tubulin
Location in the cell
Cytoplasmic   Reliability : 3.44
 

Sequence

CDS
ATGTTCTGGGAGATAATATCGGAAGAGCACGGCATCGACCCTACCGGCGTCTACCGCGGCACCAGCGACCTCCAGCTCGAGAGGATCTCTGTTTACTATAATGAGGCCTCTGTTGCGACGGCGGAGAGCGGCGGGAAGTATGTCCCCCGCGCCATCCTCCTCGACCTCGAGCCCGGCACCATGGACGCCGTGCGCTCCGGCGCCTACGGGCAACTCTTCCGGCCGGACAACTTCGTCTTCGGCCAGTCCGGCGCCGGCAACAACTGGGCCAAGGGACACTACACGGAGGGCGCTGAGCTCGTCGACGCCGTCCTTGATGTAGTACGCAAGGAGTGTGAGAACTGCGATTGCCTCCAGGGTTTCCAACTGACTCATTCCCTCGGCGGCGGCACCGGTTCCGGCATGGGCACCCTCCTCATCTCAAAGATCCGTGAAGAGTACCCCGACAGAATCATGAACACATACTCAGTAGTCCCCTCGCCCAAAGTATCAGACACCGTCGTCGAACCATACAACGCAGTTCTCTCCATCCATCAACTAGTCGAGAATACAGACGAAACTTACTGCATAGACAATGAGGCCCTTTACGATATCTGCTACAGGACTCTCAAGGTACCGAACCCAACGTACGGCGACCTGAACCACCTGGTGTCGCTGACCATGTCCGGCGTGACGACGTGCCTGCGGTTCCCCGGACAGCTGAACGCCGACCTGCGCAAGCTGGCGGTCAACATGGTGCCCTTCCCGCGTCTGCACTTCTTCATGCCCGGCTTCGCGCCGCTGACGTCACGCGGCAGCCAGCAGTACCGCGCGCTCACCGTGCCGGAGCTCACGCAGCAGATGTTCGACGCCAAGAACATGATGGCCGCCTGCGACCCGCGCCACGGCCGCTACCTCACCGTCGCCGCCATCTTCCGCGGCCGCATGTCCATGAAGGAGGTCGACGAGCAGATGCTCTCCATCCAAAACAAGAACAGCAGCTTCTTCGTCGAGTGGATCCCCAACAACGTGAAAACAGCCGTGTGCGACATCCCTCCCAAGGGTCTGAAGATGTCGTCTACGTTTATCGGGAACACGACAGCCATCCAGGAACTATTCAAGAGAATATCCGAGCAGTTCTCTGCCATGTTCAGACGTAAAGCTTTCTTGCACTGGTACACCGGCGAGGGCATGGACGAGATGGAGTTCAACGAAGCAGAGAGCAACGTCAACGATCTGGTGTCTGAGTACCAACAGTACCAGGAGGCCACCGCGGAAGACGACACCGAGTTCGACCAAGAAGACCTGGAGGAGTTGGCGCAGGACGAGCACCATGACTAG
Protein
MFWEIISEEHGIDPTGVYRGTSDLQLERISVYYNEASVATAESGGKYVPRAILLDLEPGTMDAVRSGAYGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVVRKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTYSVVPSPKVSDTVVEPYNAVLSIHQLVENTDETYCIDNEALYDICYRTLKVPNPTYGDLNHLVSLTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLSIQNKNSSFFVEWIPNNVKTAVCDIPPKGLKMSSTFIGNTTAIQELFKRISEQFSAMFRRKAFLHWYTGEGMDEMEFNEAESNVNDLVSEYQQYQEATAEDDTEFDQEDLEELAQDEHHD

Summary

Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Subunit
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
Miscellaneous
Beta-3 is a developmentally regulated isoform.
Similarity
Belongs to the tubulin family.
Keywords
Complete proteome   Cytoplasm   Cytoskeleton   GTP-binding   Microtubule   Nucleotide-binding   Reference proteome  
Feature
chain  Tubulin beta-3 chain
Uniprot
A0A2H1WBT4   A0A2W1BHJ4   Q8T8B1   A0A212F8H2   I4DJ84   A0A0N1INH4   + More
A0A2P8YDV3   A0A182H8I8   A0A1L8E625   A0A1B0C8Q4   A0A182UPL1   A0A182TJQ3   Q17GX8   A0A1S4F2Y4   A0A023EUS0   A0A182QZM6   B0W7F0   A0A182MY89   A0A182MT22   A0A182WUV4   A0A182HYE9   A0A084WAZ5   Q7PPR6   A0A182PJ94   A0A182YF86   A0A182K7P5   A0A182LPX7   A0A182VT65   T1DPP7   A0A182RIT5   A0A182JB51   A0A0L7L7X9   A0A310SK65   A0A1B0G7V4   A0A026WMT3   A0A0L7RDT4   E2BTA8   W8BTX9   A0A1B0ARD4   A0A2A3EE21   A0A087ZYZ2   A0A0A1XA21   A0A3L8DVN8   A0A1A9W8E8   A0A034VGS8   A0A151JRU6   A0A195CWK5   F4WFR3   A0A195B1R8   A0A158NYR2   A0A1A9XF06   A0A195FSZ2   B4MYE2   A0A0L0BRB5   A0A1B0ADB8   A0A0M5J4Z9   E2A682   A0A151X2S9   A0A1W4WCG1   B4PAX3   B4KMI5   B3MDL7   B3NQH8   P08841   B4LK54   A0A0K8V413   Q28WU4   A0A336MV72   E9IYR5   A0A194QC42   A0A0J9RJX0   A0A3B0JQE6   A0A0R3NQ23   A0A336MCC6   A0A232EW68   B4J4T7   K7IQN8   A0A1W4W0T8   A0A0B4LGH1   A0A0R1DTQ0   A0A1I8MHC4   B4IHE6   A0A0J9RKH4   A0A212FK03   N6T1W2   A0A1E1VZL2   A0A1I8NYJ0   A0A139WFK6   A0A224XGD3   A0A0V0G361   A0A170XZW9   A0A069DU54   A0A1Y1KNW8   A0A0P4VUI7   R4G588   A0A0K8SM25   R4WCS2   A0A0N0BEN7   A0A067R7H3   V5GSS5  
Pubmed
28756777    12459208    22118469    22651552    26354079    29403074    + More
26483478    17510324    24945155    24438588    12364791    14747013    17210077    25244985    20966253    26227816    24508170    20798317    24495485    25830018    30249741    25348373    21719571    21347285    17994087    26108605    17550304    3037352    8375576    10731132    12537572    1363225    8485515    15632085    21282665    22936249    28648823    20075255    12537568    12537573    12537574    16110336    17569856    17569867    25315136    23537049    18362917    19820115    26334808    28004739    27129103    23691247    24845553   
EMBL
ODYU01007605    SOQ50528.1    KZ150040    PZC74569.1    AB072309    BAB86854.1    + More
AGBW02009721    OWR50037.1    AK401352    BAM17974.1    KQ461072    KPJ09817.1    PYGN01000673    PSN42437.1    JXUM01029849    JXUM01029850    KQ560866    KXJ80565.1    GFDF01000122    JAV13962.1    AJWK01001243    AJWK01001244    AJWK01001245    CH477254    EAT45946.1    GAPW01001384    JAC12214.1    AXCN02002039    DS231853    EDS37865.1    AXCM01000131    APCN01005900    ATLV01022298    KE525331    KFB47389.1    AAAB01008933    EAA09971.5    GAMD01003164    JAA98426.1    JTDY01002354    KOB71598.1    KQ761768    OAD57076.1    CCAG010021503    KK107151    EZA57340.1    KQ414613    KOC68979.1    GL450384    EFN81110.1    GAMC01009814    JAB96741.1    JXJN01002352    JXJN01002353    JXJN01002354    KZ288269    PBC29958.1    GBXI01006779    JAD07513.1    QOIP01000003    RLU24481.1    GAKP01017640    GAKP01017637    JAC41312.1    KQ978566    KYN30108.1    KQ977220    KYN04917.1    GL888122    EGI66956.1    KQ976681    KYM78154.1    ADTU01004211    ADTU01004212    KQ981276    KYN43710.1    CH963894    EDW77131.1    JRES01001473    KNC22620.1    CP012524    ALC41881.1    GL437116    EFN71062.1    KQ982566    KYQ54735.1    CM000158    EDW92513.1    CH933808    EDW10832.1    CH902619    EDV37480.2    CH954179    EDV56981.1    M22335    M22341    X16825    X16826    AE013599    BT015991    X68393    S60740    CH940648    EDW60643.1    GDHF01018766    JAI33548.1    CM000071    EAL26572.1    UFQS01003065    UFQT01003065    SSX15125.1    SSX34504.1    GL767043    EFZ14304.1    KQ459193    KPJ03037.1    CM002911    KMY96308.1    OUUW01000001    SPP73388.1    KRT03176.1    UFQT01000929    SSX28042.1    NNAY01001910    OXU22587.1    CH916367    EDW00633.1    AHN56630.1    KRK00556.1    CH480838    EDW49170.1    KMY96307.1    AGBW02008171    OWR54068.1    APGK01055462    APGK01055463    APGK01055464    APGK01055465    KB741266    ENN71503.1    GDQN01010891    JAT80163.1    KQ971352    KYB26625.1    GFTR01006332    JAW10094.1    GECL01003583    JAP02541.1    GEMB01003848    JAR99406.1    GBGD01001439    JAC87450.1    GEZM01080243    JAV62278.1    GDKW01000385    JAI56210.1    GAHY01000141    JAA77369.1    GBRD01011969    JAG53855.1    AK416954    BAN20169.1    KQ435824    KOX72161.1    KK852686    KDR18432.1    GALX01001232    JAB67234.1   
Proteomes
UP000007151    UP000053240    UP000245037    UP000069940    UP000249989    UP000092461    + More
UP000075903    UP000075902    UP000008820    UP000075886    UP000002320    UP000075884    UP000075883    UP000076407    UP000075840    UP000030765    UP000007062    UP000075885    UP000076408    UP000075881    UP000075882    UP000075920    UP000075900    UP000075880    UP000037510    UP000092444    UP000053097    UP000053825    UP000008237    UP000092460    UP000242457    UP000005203    UP000279307    UP000091820    UP000078492    UP000078542    UP000007755    UP000078540    UP000005205    UP000092443    UP000078541    UP000007798    UP000037069    UP000092445    UP000092553    UP000000311    UP000075809    UP000192221    UP000002282    UP000009192    UP000007801    UP000008711    UP000000803    UP000008792    UP000001819    UP000053268    UP000268350    UP000215335    UP000001070    UP000002358    UP000095301    UP000001292    UP000019118    UP000095300    UP000007266    UP000053105    UP000027135   
PRIDE
Q8T8B1    A0A087ZYZ2    P08841   
Pfam
PF03953   Tubulin_C        + More
PF00091   Tubulin
Interpro
IPR017975   Tubulin_CS        + More
IPR003008   Tubulin_FtsZ_GTPase       
IPR008280   Tub_FtsZ_C       
IPR002453   Beta_tubulin       
IPR037103   Tubulin/FtsZ_C_sf       
IPR023123   Tubulin_C       
IPR000217   Tubulin       
IPR018316   Tubulin/FtsZ_2-layer-sand-dom       
IPR036525   Tubulin/FtsZ_GTPase_sf       
IPR013838   Beta-tubulin_BS       
SUPFAM
SSF55307   SSF55307        + More
SSF52490   SSF52490       
Gene 3D
1.10.287.600     3.30.1330.20     3.40.50.1440    
ProteinModelPortal
A0A2H1WBT4   A0A2W1BHJ4   Q8T8B1   A0A212F8H2   I4DJ84   A0A0N1INH4   + More
A0A2P8YDV3   A0A182H8I8   A0A1L8E625   A0A1B0C8Q4   A0A182UPL1   A0A182TJQ3   Q17GX8   A0A1S4F2Y4   A0A023EUS0   A0A182QZM6   B0W7F0   A0A182MY89   A0A182MT22   A0A182WUV4   A0A182HYE9   A0A084WAZ5   Q7PPR6   A0A182PJ94   A0A182YF86   A0A182K7P5   A0A182LPX7   A0A182VT65   T1DPP7   A0A182RIT5   A0A182JB51   A0A0L7L7X9   A0A310SK65   A0A1B0G7V4   A0A026WMT3   A0A0L7RDT4   E2BTA8   W8BTX9   A0A1B0ARD4   A0A2A3EE21   A0A087ZYZ2   A0A0A1XA21   A0A3L8DVN8   A0A1A9W8E8   A0A034VGS8   A0A151JRU6   A0A195CWK5   F4WFR3   A0A195B1R8   A0A158NYR2   A0A1A9XF06   A0A195FSZ2   B4MYE2   A0A0L0BRB5   A0A1B0ADB8   A0A0M5J4Z9   E2A682   A0A151X2S9   A0A1W4WCG1   B4PAX3   B4KMI5   B3MDL7   B3NQH8   P08841   B4LK54   A0A0K8V413   Q28WU4   A0A336MV72   E9IYR5   A0A194QC42   A0A0J9RJX0   A0A3B0JQE6   A0A0R3NQ23   A0A336MCC6   A0A232EW68   B4J4T7   K7IQN8   A0A1W4W0T8   A0A0B4LGH1   A0A0R1DTQ0   A0A1I8MHC4   B4IHE6   A0A0J9RKH4   A0A212FK03   N6T1W2   A0A1E1VZL2   A0A1I8NYJ0   A0A139WFK6   A0A224XGD3   A0A0V0G361   A0A170XZW9   A0A069DU54   A0A1Y1KNW8   A0A0P4VUI7   R4G588   A0A0K8SM25   R4WCS2   A0A0N0BEN7   A0A067R7H3   V5GSS5  
PDB
5KMG     E-value=0,     Score=1965

Ontologies

KEGG
692432    K07375 tubulin beta | (RefSeq) Tub3, bmtub3; beta-tubulin
PATHWAY
04145    Phagosome - Bombyx mori (domestic silkworm)
GO
GO:0005525   GO:0005874   GO:0007017   GO:0005200   GO:0003924   GO:0005737   GO:0009416   GO:0007411   GO:0030537   GO:0007507   GO:0007409   GO:0000226   GO:0000278   GO:0019538   GO:0030145   GO:0000049   GO:0005975   GO:0004553  
PANTHER
PTHR11588  

Topology

Subcellular location
  
Length:
439
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00514999999999999
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00180
outside
1  -  439
 
 

Population Genetic Test Statistics

Pi
25.512128
Theta
28.082212
Tajima's D
-0.46058
CLR
0.054919
CSRT
0.250287485625719
Interpretation
Uncertain

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
Peptides ×
Source Sequence Identity Evalue
28556443 SGAYGQLFRPDNFVFGQSGAGNNWAK 100.00 6e-14
28556443 QLTHSLGGGTGSGMGTLLISK 100.00 6e-14
26822097 GTSDIQIER 96.15 1e-13
25044914 SGAYGQIFR 96.15 1e-13
28467696 SGATIIAYSK 96.15 1e-13
28556443 QLFRPDNFVFGQSGAGNNWAK 100.00 4e-10
28556443 QLFRPDNFVFGQSGAGNNWAK 100.00 4e-10
28556443 QLFRPDNFVFGQSGAGNNWAK 100.00 4e-10
28556443 QLFRPDNFVFGQSGAGNNWAK 100.00 4e-10
28556443 QLFRPDNFVFGQSGAGNNWAK 100.00 4e-10
28556443 QLFRPDNFVFGQSGAGNNWAK 100.00 4e-10
28556443 QLFRPDNFVFGQSGAGNNWAK 100.00 4e-10
28556443 NMMAACDPR 100.00 4e-10
28556443 LSTPTYGDLNHLV 100.00 5e-10
28556443 LHFFMPGFAPLTSR 100.00 5e-10
28556443 QIFRPDNFVFGQSGAGNNWAK 95.24 8e-10
28556443 QIFRPDNFVFGQSGAGNNWAK 95.24 8e-10
28556443 QIFRPDNFVFGQSGAGNNWAK 95.24 8e-10
28556443 QIFRPDNFVFGQSGAGNNWAK 95.24 8e-10
28556443 QIFRPDNFVFGQSGAGNNWAK 95.24 8e-10
28556443 QIFRPDNFVFGQSGAGNNWAK 95.24 8e-10
28556443 NSSYFVEWIPNNVK 95.24 8e-10
28556443 NSSYFVEWIPNNVK 95.24 8e-10
28556443 LFRPDNFVFGQSGAGNNWAK 100.00 2e-09
28556443 IREEYPDR 100.00 2e-09
28556443 LAVNMVPFPR 100.00 2e-09
28556443 INVYYNEASSGK 100.00 2e-09
28556443 LSSPSYGDLNHLISLTMSGVTTCLR 100.00 2e-09
25044914 FWEIISDEHGIDPTGAYHGDSDIQIER 100.00 8e-08
28467696 FWEIISDEHGIDPTGAYHGDSDIQIER 100.00 8e-08
27102218 IMNTYSVVPSPK 100.00 1e-07
26822097 MREIVHIQAGQCGNQIGAK 100.00 4e-07
28467696 PDIDNAVIVR 100.00 4e-07
26822097 SGAYGQIFRPDNFVFGQSGAGNNWAK 100.00 3e-05
25044914 ISVYEIAEQVWSPR 100.00 3e-05
28467696 ISVQEIEER 100.00 3e-05
28556443 TAVCDIPPK 100.00 4e-05
28556443 TFIGNSTAIQEIFK 100.00 4e-05
28556443 INVYYNEASGGKYVPR 100.00 4e-05
31223520 LHFFMPGFAPLTSR 100.00 2e-04
31223520 AILVDLEPGTMDSVR 100.00 2e-04
21761556 ISEQFTAMFR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTS 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLT 100.00 2e-04
28556443 LAVNMVPFPR 100.00 2e-04
25044914 NSQASPWIR 100.00 4e-04
28467696 NSQCQIVMGSVPDPIPINYYR 100.00 4e-04
28556443 NTLNDIYFGK 100.00 5e-04
28556443 MPGFAPLTSR 100.00 6e-04
28556443 TTCLRFPGQLNADLR 100.00 0.001
28556443 VDLEPGTMDAVR 100.00 0.001
28556443 NMMAACDPR 100.00 0.001
28556443 LHFFMPGFAPLT 100.00 0.001
28556443 VDLEPGTMDSVR 100.00 0.001
31223520 LHFFMPGFAPLTSR 100.00 0.002
28556443 ALTVPELTQQMFDAK 100.00 0.002
28556443 ALTVPELTQQMFDAK 100.00 0.002
28556443 ALTVPELTQQMFDAK 100.00 0.002
28556443 ALTVPELTQQMFDAK 100.00 0.002
28556443 ALTVPELTQQMFDAK 100.00 0.002
28556443 ALTVPELTQQMFDAK 100.00 0.002
28556443 ALTVPELTQQMFDAK 100.00 0.002
28556443 AFLHWY 100.00 0.002
28556443 ALTVPELTQQMFDAK 100.00 0.002
28556443 ALTVPELTQQMFDAK 100.00 0.002
28556443 ALTVPELTQQMFDAK 100.00 0.002
28556443 ALTVPELTQQMFDAK 100.00 0.002
28556443 ALTVPELTQQMFDAK 100.00 0.002
28556443 ALTVPELTQQMFDAK 100.00 0.002
28556443 AILVDLEPGTMDSVR 100.00 0.002
28556443 AILVDLEPGTMDSVR 100.00 0.002
28556443 GGGTGSGMGTLLISK 100.00 0.002
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