Gene

KWMTBOMO12280

Pre Gene Modal

BGIBMGA009134

Annotation

PREDICTED:_activin_receptor_type-1_[Amyelois_transitella]

Location

Bomo_Chr20(-):11353911-11364964      View in EpiBrowser

Full name

Receptor protein serine/threonine kinase      

Location in the cell

Nuclear   Reliability : 2.021

CDS

ATGGCGGACTCTGTCATATTTGGATATCTGTTCATATTTCTGTTGATAAAGCCTAACTATGCAAGTCTCCCCAATTTGGATGCATTGGTCCAAGATGGACAGGGCAGGGTCCTACAGCAATTGGAAGATCCGATCACACTCGAAAAGATGATGGTACACCCCCCAAAATACAAATGTCACCTCTGCGAGCCCCCTGACTGCGAATCTGGTGTCCAGAACATATGCGTCGACGCCCTATATTGCTTCAAGTCCTCGGTGAGGGAGTCCAATGGAGAGCTGCAGCACTCAAGGGGTTGCTCCGATAAGAACGATCACTACCAGTTCATATGTCGCTCAAGTACGAGGCAAGGGGTCCACAAGCGTCACGCCGGTCAGCTGAACGTGACGTGCTGCACGGGGGACATGTGCAACTCGGGCGAGTTCCCGGCGCTGTGGGAGGCGGCGCGGGCGGGGCGCGCGGCCTGGGAGCCGTGGGCGGGCGGCGCCGCGGCCGTGCTGCTGCTGGCGGCGCTGCTGACGGGCCTGCTGCTGCTGCTGCAACGAGCCCACAGGCTGCGCGTGTCGCGGACTGCCCTGGACAAACTCCGCTCCGAGGCGAAGTACTTCTCATTTAACGTCTACAACCAGCACATGAACAACGCTTATTACGAAGGTGCGGAGGGCTCACAGCCGGGCTGCGTGGCGGTGGCGGCCGGGGACTCCACGCTGCGCGAGTACCTGGAGGGCTCCCTGAGCTCGGGCTCCGGCTCGGGCCTGCCGCTGATGGTGCAGCGCACGCTCGCCAAGCAGGTCACGCTGTACGACTGCGTCGGCAAGGGCCGCTACGGCGAGGTGTGGCGCGGCTCGTGGTACGGGGACAGCGTGGCGGTCAAGATCTTCTTCTCGCGAGACGAGGCCAGCTGGAAGCGCGAGACCGAGGTGTACAGCACCGTGCTGCTGCGCCACCAGAACATCCTGGCCTACGTGGGCAGCGACATGACCAGCCGCGGCAGCTGCACGCAGCTGTGGCTGATCACGCAGTACCACCCGCTGGGCTCGCTGCACGAGCACCTGCAGCGCGGCACGCTCTCCCGCCAGCAGCTCGCCGCGCTCAGCCTGTCCGCCGCCAGCGGCCTGCTGCACCTGCACACGCAGATACACGGCACCCAGGGTAAACCTGCGATAGCACACCGGGACATCAAGTCCAAGAACATCCTGGTCAAGGTGAATGGGGAGTGTTGCATCGGAGACCTCGGGCTCGCCCTCACCGCGCAGCACATCGAGCAGGGCCAGCAGCTGCACAACCCTCGCCAGGGGACCAAGAGGTATATGAGCCCCGAGATGCTGGACCACACCATGCAGACGGACTGCCTGGACGCGTACCTGCGCTGCGACGTGTACGCGCTGGGGCTGGTGCTGTGGGAGCTGTGCCGCCGCGTGCCCCCCGCGCGCCCGCCCGCGCCCCCCTACCACCACCGCGCGCCGCCCGACCCCTCCTACGAGGACATGCGCAAGATCGTCTGCGTGGACCGGGACCGACCCGAGCCGCTGGACTACCACGATCATCCGACAATGGTCTCAATGTGGAAACTGATCCAAGAGTGCTGGCACCACAACCCGTCGGCGCGCCTCTCCGCGCTGCGCGTCAGGAAGACCTTACTGAAGATTGCAGCAGCGGACGAGTCCATACACCTCAACGAGGACAACGAGGTGTCCCTGTAG

Protein

MADSVIFGYLFIFLLIKPNYASLPNLDALVQDGQGRVLQQLEDPITLEKMMVHPPKYKCHLCEPPDCESGVQNICVDALYCFKSSVRESNGELQHSRGCSDKNDHYQFICRSSTRQGVHKRHAGQLNVTCCTGDMCNSGEFPALWEAARAGRAAWEPWAGGAAAVLLLAALLTGLLLLLQRAHRLRVSRTALDKLRSEAKYFSFNVYNQHMNNAYYEGAEGSQPGCVAVAAGDSTLREYLEGSLSSGSGSGLPLMVQRTLAKQVTLYDCVGKGRYGEVWRGSWYGDSVAVKIFFSRDEASWKRETEVYSTVLLRHQNILAYVGSDMTSRGSCTQLWLITQYHPLGSLHEHLQRGTLSRQQLAALSLSAASGLLHLHTQIHGTQGKPAIAHRDIKSKNILVKVNGECCIGDLGLALTAQHIEQGQQLHNPRQGTKRYMSPEMLDHTMQTDCLDAYLRCDVYALGLVLWELCRRVPPARPPAPPYHHRAPPDPSYEDMRKIVCVDRDRPEPLDYHDHPTMVSMWKLIQECWHHNPSARLSALRVRKTLLKIAAADESIHLNEDNEVSL

Catalytic Activity

[receptor-protein]-L-serine + ATP = [receptor-protein]-O-phospho-L-serine + ADP + H(+)
[receptor-protein]-L-threonine + ATP = [receptor-protein]-O-phospho-L-threonine + ADP + H(+)

Similarity

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Belongs to the protein kinase superfamily.

Feature

chain  Receptor protein serine/threonine kinase

Uniprot

H9JHY6   A0A2W1BPA6   A0A2H1WBV9   A0A0N0PB92   A0A194QDJ8   A0A212F8J5   + More
E0W0F7   A0A1Y1KSQ7   C9QP22   Q7JQ36   H5V885   Q7JPM7   Q7JPN8   A0A0J9R7Q9   B4HR79   A0A0T6AVB4   B3N9E3   Q7JQ39   B4QES9   A0A0J9R7H5   A0A1Q3FX50   A0A3B0JM54   A0A1Q3FX39   Q95U21   B4GDK4   Q292G4   D5SHT1   A0A0B4K7J3   B4P239   B4NS66   A0A084VF32   A0A0J9R8S8   A0A182V796   A0A0R3NL31   B4MYH3   A0A1W4WBG3   A0A1B6BYG4   A0A182GZD7   A0A1W4VZ96   Q7QJY6   Q16MX6   B4J4Y1   B3MG92   A0A1W4VZ93   A0A0M4E498   A0A0N8P0G2   B4LMK2   A0A1S4FVA0   A0A023EU41   A0A182NH98   A0A182QAU5   A0A182JN48   A0A182JT42   B4KSY4   A0A0Q9WFH1   A0A1I8Q056   A0A0Q9XIJ8   A0A1I8Q057   A0A0P5KBW8   E9HSW3   A0A0P6DRD4   A0A0P6E301   A0A182LGT8   A0A0F7ZBD9   A0A3Q3DJJ0  

EC Number

2.7.11.30

Pubmed

19121390    28756777    26354079    22118469    20566863    28004739    + More
8044838    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    8044839    8134837    22936249    17994087    15632085    17550304    24438588    26483478    12364791    14747013    17210077    17510324    24945155    21292972    20966253   

EMBL

BABH01035348    KZ150040    PZC74570.1    ODYU01007605    SOQ50527.1    KQ461072    + More
KPJ09816.1    KQ459193    KPJ03040.1    AGBW02009721    OWR50038.1    DS235858    EEB19113.1    GEZM01074879    JAV64423.1    BT099904    ACX32975.1    L33790    AE013599    AAA61946.1    AAF59189.1    BT133186    AFA28427.1    U11441    AAA53242.1    U05209    AAA18208.1    CM002911    KMY92098.1    CH480816    EDW46822.1    LJIG01022730    KRT79009.1    CH954177    EDV59630.1    L33476    AAA28878.1    CM000362    EDX06075.1    KMY92097.1    GFDL01002886    JAV32159.1    OUUW01000001    SPP74356.1    GFDL01003023    JAV32022.1    AY058363    AAL13592.1    AAM68863.1    CH479181    EDW31661.1    CM000071    EAL24898.1    BT124882    ADG46050.1    AFH07948.1    CM000157    EDW89240.1    CH981919    EDX15444.1    ATLV01012360    KE524785    KFB36576.1    KMY92099.1    KRT01656.1    CH963894    EDW77162.1    GEDC01030985    JAS06313.1    JXUM01099363    KQ564486    KXJ72211.1    AAAB01008807    EAA04704.4    CH477846    EAT35698.1    CH916367    EDW01687.1    CH902619    EDV37795.1    CP012524    ALC40816.1    KPU77036.1    CH940648    EDW59989.2    GAPW01000705    JAC12893.1    AXCN02000894    CH933808    EDW08481.2    KRF79184.1    KRG04145.1    GDIQ01212295    JAK39430.1    GL732759    EFX65169.1    GDIQ01073497    JAN21240.1    GDIQ01073498    JAN21239.1    GBEX01000080    JAI14480.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000007151    UP000009046    UP000000803    + More
UP000001292    UP000008711    UP000000304    UP000268350    UP000008744    UP000001819    UP000002282    UP000030765    UP000075903    UP000007798    UP000192221    UP000069940    UP000249989    UP000007062    UP000008820    UP000001070    UP000007801    UP000092553    UP000008792    UP000075884    UP000075886    UP000075880    UP000075881    UP000009192    UP000095300    UP000000305    UP000075882    UP000264820   

PRIDE

H9JHY6    Q7JQ36    H5V885    Q7JPM7    Q7JPN8    Q7JQ39    + More
Q95U21    D5SHT1   

Pfam

PF01064   Activin_recp        + More
PF08515   TGF_beta_GS
PF00069   Pkinase
PF07714   Pkinase_Tyr

Interpro

IPR011009   Kinase-like_dom_sf        + More
IPR008271   Ser/Thr_kinase_AS       
IPR000719   Prot_kinase_dom       
IPR003605   GS_dom       
IPR000333   TGFB_receptor       
IPR017441   Protein_kinase_ATP_BS       
IPR000472   Activin_recp       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR017194   Transform_growth_fac-b_typ-2       

SUPFAM

SSF56112   SSF56112       

ProteinModelPortal

H9JHY6   A0A2W1BPA6   A0A2H1WBV9   A0A0N0PB92   A0A194QDJ8   A0A212F8J5   + More
E0W0F7   A0A1Y1KSQ7   C9QP22   Q7JQ36   H5V885   Q7JPM7   Q7JPN8   A0A0J9R7Q9   B4HR79   A0A0T6AVB4   B3N9E3   Q7JQ39   B4QES9   A0A0J9R7H5   A0A1Q3FX50   A0A3B0JM54   A0A1Q3FX39   Q95U21   B4GDK4   Q292G4   D5SHT1   A0A0B4K7J3   B4P239   B4NS66   A0A084VF32   A0A0J9R8S8   A0A182V796   A0A0R3NL31   B4MYH3   A0A1W4WBG3   A0A1B6BYG4   A0A182GZD7   A0A1W4VZ96   Q7QJY6   Q16MX6   B4J4Y1   B3MG92   A0A1W4VZ93   A0A0M4E498   A0A0N8P0G2   B4LMK2   A0A1S4FVA0   A0A023EU41   A0A182NH98   A0A182QAU5   A0A182JN48   A0A182JT42   B4KSY4   A0A0Q9WFH1   A0A1I8Q056   A0A0Q9XIJ8   A0A1I8Q057   A0A0P5KBW8   E9HSW3   A0A0P6DRD4   A0A0P6E301   A0A182LGT8   A0A0F7ZBD9   A0A3Q3DJJ0  

PDB

4C02     E-value=7.2129e-97,     Score=905

KEGG

101738704    K04675 activin receptor type-1 [EC:2.7.11.30] | (RefSeq) activin receptor type-1

PATHWAY

04350    TGF-beta signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0016021   GO:0004675   GO:0007300   GO:0007179   GO:0007448   GO:0001745   GO:0035222   GO:0030512   GO:0006468   GO:0004672   GO:0045887   GO:0007476   GO:0005025   GO:0030718   GO:0045824   GO:0042078   GO:0050829   GO:0030707   GO:0030514   GO:0008358   GO:0070724   GO:0009953   GO:0036122   GO:0098821   GO:0043235   GO:0046872   GO:0007389   GO:0048179   GO:0005886   GO:0030509   GO:0046332   GO:0005887   GO:0019838   GO:0048185   GO:0005024   GO:0032924   GO:0004674   GO:0016020   GO:0019538   GO:0030145   GO:0000049   GO:0005975   GO:0004553  

PANTHER

PTHR23255  

SignalP

Position:   1 - 21,         Likelihood:  0.741449

 

 

Length:

566

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

36.7722500000001

Exp number, first 60 AAs:

14.41585

Total prob of N-in:

0.25219

POSSIBLE N-term signal

sequence

outside

1  -  156

TMhelix

157  -  179

inside

180  -  566

 

 

Pi

23.951466

Theta

26.682717

Tajima's D

-0.401143

CLR

1.297532

CSRT

0.268286585670716

Interpretation

Uncertain