Gene

KWMTBOMO12266

Pre Gene Modal

BGIBMGA009136

Annotation

PREDICTED:_lipase_member_H-B-like_[Bombyx_mori]

Location

Bomo_Chr20(-):11014187-11022204      View in EpiBrowser

Full name

Lipase member H-B       + More
Pancreatic lipase-related protein 2      
Triacylglycerol lipase      
Lipase member H-A      

Alternative Name

GPL
Galactolipase
Pancreatic lipase

Location in the cell

PlasmaMembrane   Reliability : 1.955

CDS

ATGGATCCGAGGAGTGAGACTGGATATCCTACGGGAATGATGTCTGTTTGTCCCGGCTCCACGAAGCCTGCAATCATACCGAAGAGCCAGCTGAAGTACCTGTCCTTCGTGGTGCAGGGGAACGGGAGAAGCCGGCGCAAGTACTCATATTGGAACGCTAGGAATATAGCCAAGGATCCGAGAATCAATTTTAAAAGGAAAACTCTCCTCCTGGCCATAGGGTATCTCGACAGCCCCAGTTTCCCCATTTCAATGATGTTCGCGAACGAGTACGAAGCTCTGGGGTACAATGTCATAATTATTGACAACCAGAGGTTTTCGACTGTGCATTACCATTTAGCAAGCCGCCTCATGAGACCAGTGGGTAAGCTTGTAGCCGAAGTCCTAGTCCAGCTAACTGACTACGGCCTAGACCCTTCCAGGCTAGAATTATTAGGGTTTAGTCTGGGCGCCCAAACGGTCAGCTACATAGCCAAAAACTTCCAGACCATAACAGGAAGGAACGTATCGTCTATCGTCGCTCTAGAGCCTTCCGGCCCGTGTTTTAGGACATTAGTTTCGGACGACAGACTCAACCCGTCAGACGCTGGCTTCGTGCAGGTCGTGCACACGAACATAGACGGGTACGGTATGGCCAACAGAATGGGCCACGTCGACTTCTACGTCAACGGCGGGGAGTACCAACCCTCAGACATCAACCTTTACCCTTGTACGACAACTTGCAGCCATTTCAGGGTGCTCGCGCTTTGGGTTGCCGCCTTAAAGAATCCCGGTAAATTTATAGGTATGAAGTGTGATAGTGTGCAGCAAGCGAGGGACGCTCAGTGCTATAACAACAAGCCTCTCGTCACTAATACAATGGGTTTGAGTCCTGACAAGAGTAAGCTGGGCATATTTTATTTATCGACTAGTAAGGGGTATCCTTACTTCTTGGGGGCAAAAGGACTGATAGAGGCCAATGTTTACTGGCGGACGATTACTGAAATCAATAATGGTGACGATATTTTAGTGTACACTTAA

Protein

MDPRSETGYPTGMMSVCPGSTKPAIIPKSQLKYLSFVVQGNGRSRRKYSYWNARNIAKDPRINFKRKTLLLAIGYLDSPSFPISMMFANEYEALGYNVIIIDNQRFSTVHYHLASRLMRPVGKLVAEVLVQLTDYGLDPSRLELLGFSLGAQTVSYIAKNFQTITGRNVSSIVALEPSGPCFRTLVSDDRLNPSDAGFVQVVHTNIDGYGMANRMGHVDFYVNGGEYQPSDINLYPCTTTCSHFRVLALWVAALKNPGKFIGMKCDSVQQARDAQCYNNKPLVTNTMGLSPDKSKLGIFYLSTSKGYPYFLGAKGLIEANVYWRTITEINNGDDILVYT

Description

Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA).
Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis (By similarity).

Catalytic Activity

a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)
a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+)

Similarity

Belongs to the AB hydrolase superfamily. Lipase family.

Keywords

Disulfide bond   Glycoprotein   Hydrolase   Lipid degradation   Lipid metabolism   Membrane   Secreted   Signal   3D-structure   Calcium   Complete proteome   Direct protein sequencing   Metal-binding   Reference proteome  

Feature

chain  Lipase member H-B

Uniprot

H9JHY8   A0A2H1WL24   A0A2W1BNT7   A0A194QBX2   A0A194QUH6   A0A212FPW6   + More
A0A0L7L1G4   A0A194Q1D6   A0A0N1II42   A0A2W1B572   A0A212FBR8   H9JQ12   A0A2H1WK50   H9JQQ8   A0A2A4JBH9   A0A191XQW7   A0A3S2LBT4   A0A2H1VJ13   A0A0L7LHY6   A0A194QBZ0   A0A0N1IGL3   A0A3S2PK48   A0A2A4JXD4   A0A2W1BL36   A0A194PEP3   A0A3S2P6E3   A0A194QZ66   A0A2H1VGU5   A0A212EY15   A0A212EJL3   A0A2W1BWG2   A0A2A4JGD9   A0A2H1X3Q9   A0A3S2NZZ7   H9JWY8   A0A3S2L3L9   A0A2W1BV63   A0A2H1W795   A0A0L7KP71   I6TFN4   A0A2W1BXY3   A0A220K8L9   A0A2H1W7F1   A0A0L7L8R4   A0A194PCA8   A0A2H1WNR8   A0A194QNS4   A0A2H1WL84   A0A2A4IT83   A0A2A4J1M9   A0A210QK37   A0A1B6MCF6   A0A212FKA5   A0A1B6L5N2   A0A194QC74   Q641F6   A0A210PSA1   A0A1L8H505   P81139   A0A2H1W9L5   H0V008   T1H7M9   A0A224XHR8   A0A1B0G9P9   A0A2B4RJ44   A0A3B3ZZW1   Q6PA23   A0A2W1BTP2   A0A1B0AP02   A0A1L8HCT6   A0A3Q3WX63   A0A2W1B7Q2   D6W6G8   A0A0L7LP71   A0A1W4WIH6   K7GJB0  

EC Number

3.1.1.-
3.1.1.3

Pubmed

19121390    28756777    26354079    22118469    26227816    23171126    + More
28630352    28812685    27762356    8490016    21993624    25463417    18362917    19820115    17381049   

EMBL

BABH01035306    ODYU01009344    SOQ53707.1    KZ149947    PZC76719.1    KQ459193    + More
KPJ03053.1    KQ461154    KPJ08630.1    AGBW02000859    OWR55743.1    JTDY01003560    KOB69343.1    KQ459590    KPI97210.1    KQ460391    KPJ15413.1    KZ150534    PZC70591.1    AGBW02009288    OWR51181.1    BABH01012334    ODYU01009136    SOQ53346.1    NWSH01002209    PCG68904.1    KU360126    ANJ42864.1    RSAL01000052    RVE50204.1    ODYU01002823    SOQ40786.1    JTDY01001036    KOB75067.1    KPJ03068.1    KQ460781    KPJ12226.1    RSAL01000010    RVE53725.1    NWSH01000400    PCG76675.1    KZ149983    PZC75749.1    KQ459606    KPI91164.1    RSAL01000291    RVE42897.1    KQ460947    KPJ10569.1    ODYU01002500    SOQ40069.1    AGBW02011630    OWR46389.1    AGBW02014435    OWR41693.1    KZ149926    PZC77547.1    NWSH01001670    PCG70462.1    ODYU01013233    SOQ59929.1    RSAL01000012    RVE53468.1    BABH01041781    RSAL01000184    RVE44850.1    PZC77545.1    ODYU01006796    SOQ48975.1    JTDY01007594    KOB65092.1    JQ814807    AFM73623.1    PZC77546.1    MF319718    ASJ26432.1    SOQ48977.1    JTDY01002277    KOB71750.1    KPI90911.1    ODYU01009953    SOQ54715.1    KQ461196    KPJ06625.1    ODYU01009427    SOQ53845.1    NWSH01007523    PCG62931.1    NWSH01003717    PCG65891.1    NEDP02003256    OWF49099.1    GEBQ01006364    JAT33613.1    AGBW02008082    OWR54177.1    GEBQ01020948    JAT19029.1    KPJ03024.1    BC082381    NEDP02005531    OWF39326.1    CM004469    OCT91179.1    ODYU01007212    SOQ49795.1    AAKN02003095    ACPB03000883    GFTR01007078    JAW09348.1    CCAG010003515    LSMT01000515    PFX16839.1    BC060482    KZ149921    PZC77721.1    JXJN01001096    CM004468    OCT93917.1    KZ150304    PZC71518.1    KQ971307    EFA11062.1    JTDY01000429    KOB77220.1    AGCU01091550    AGCU01091551    AGCU01091552   

Proteomes

UP000005204    UP000053268    UP000053240    UP000007151    UP000037510    UP000218220    + More
UP000283053    UP000242188    UP000186698    UP000005447    UP000015103    UP000092444    UP000225706    UP000261520    UP000092460    UP000261620    UP000007266    UP000192223    UP000007267   

PRIDE

H9JHY8    H9JQ12    H9JQQ8    H9JWY8    Q641F6    P81139    + More
Q6PA23   

Pfam

PF00151   Lipase        + More
PF01477   PLAT

Interpro

IPR013818   Lipase/vitellogenin        + More
IPR029058   AB_hydrolase       
IPR000734   TAG_lipase       
IPR033906   Lipase_N       
IPR036392   PLAT/LH2_dom_sf       
IPR001024   PLAT/LH2_dom       
IPR016272   Lipase_LIPH       
IPR002331   Lipase_panc       
IPR002334   Allerg_PlipaseA1       

SUPFAM

SSF53474   SSF53474        + More
SSF49723   SSF49723       

Gene 3D

3.40.50.1820    

CDD

cd00707  Pancreat_lipase_like

ProteinModelPortal

H9JHY8   A0A2H1WL24   A0A2W1BNT7   A0A194QBX2   A0A194QUH6   A0A212FPW6   + More
A0A0L7L1G4   A0A194Q1D6   A0A0N1II42   A0A2W1B572   A0A212FBR8   H9JQ12   A0A2H1WK50   H9JQQ8   A0A2A4JBH9   A0A191XQW7   A0A3S2LBT4   A0A2H1VJ13   A0A0L7LHY6   A0A194QBZ0   A0A0N1IGL3   A0A3S2PK48   A0A2A4JXD4   A0A2W1BL36   A0A194PEP3   A0A3S2P6E3   A0A194QZ66   A0A2H1VGU5   A0A212EY15   A0A212EJL3   A0A2W1BWG2   A0A2A4JGD9   A0A2H1X3Q9   A0A3S2NZZ7   H9JWY8   A0A3S2L3L9   A0A2W1BV63   A0A2H1W795   A0A0L7KP71   I6TFN4   A0A2W1BXY3   A0A220K8L9   A0A2H1W7F1   A0A0L7L8R4   A0A194PCA8   A0A2H1WNR8   A0A194QNS4   A0A2H1WL84   A0A2A4IT83   A0A2A4J1M9   A0A210QK37   A0A1B6MCF6   A0A212FKA5   A0A1B6L5N2   A0A194QC74   Q641F6   A0A210PSA1   A0A1L8H505   P81139   A0A2H1W9L5   H0V008   T1H7M9   A0A224XHR8   A0A1B0G9P9   A0A2B4RJ44   A0A3B3ZZW1   Q6PA23   A0A2W1BTP2   A0A1B0AP02   A0A1L8HCT6   A0A3Q3WX63   A0A2W1B7Q2   D6W6G8   A0A0L7LP71   A0A1W4WIH6   K7GJB0  

PDB

1GPL     E-value=1.15682e-26,     Score=297

KEGG

101741295    K19404 phosphatidic acid-selective phospholipase A1 [EC:3.1.1.-] | (RefSeq) lipase member H-B-like

GO

GO:0005576   GO:0052689   GO:0016021   GO:0006629   GO:0046872   GO:0016020   GO:0016042   GO:0004806   GO:0005509   GO:0005615   GO:0047372   GO:0019376   GO:0009395   GO:0004620   GO:0102549   GO:0047714   GO:0009617   GO:0006968   GO:0044258   GO:0008970   GO:0016298   GO:0008201   GO:0005886  

PANTHER

PTHR11610  

Subcellular location

Secreted  
Membrane  

Length:

339

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.616369999999999

Exp number, first 60 AAs:

0.00574

Total prob of N-in:

0.03781

outside

1  -  339

 

 

Pi

25.522971

Theta

23.597362

Tajima's D

0.298018

CLR

1.494872

CSRT

0.462926853657317

Interpretation

Uncertain