Gene

KWMTBOMO12238  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA014193

Annotation

hypothetical_protein_KGM_04110_[Danaus_plexippus]

Location

Bomo_Chr20(+):10259060-10260924      View in EpiBrowser

Full name

Histone-arginine methyltransferase CARMER      

Alternative Name

Coactivator-associated arginine methyltransferase 1

Location in the cell

PlasmaMembrane   Reliability : 1.617

CDS

ATGGCGAACACGTTTCGCGGCGTGACGGTGTCGACCGTCAACAGCGATGGCGTTCTGACGCCTCGATTCAATTTCCCGACGAACGTAAACGTGGACTACGACCCGCAAGGGCTGAGTGTGAAAGTGATACGTGCTGATCCTGTGCTCGCGCAGGAGGTGCTGGAGTTTCCTGTTCATAGCCAGAGTGAGTGTTCCCGCGTGGCCGGACAGTCATACATATTTACGATAGACAATGAAACGCTATTTTTCAAACTGGCATCCGACGCAGACTGCCAGAGTTTCCATCTGCTCGTCAGCAAAGTCAAGGCGGGCAGGTCGTCCTCAGTTTTCACGGTCAGGACCGAAGACTCGTCGGCAATGCAGTACTTCCAGTTTTATGGTTACCTGAGTCAGCAACAGAACATGATGCAGGACTATGTTAGAACGAGTACATATCAGCGCGCCATATTGTCTAATGTGAACGATTTCAAAAACAAAGTGGTCTTGGATGTTGGGGCAGGCTCCGGGATACTTTCATTTTTCGCGGCCCAGGCAGGTGCTCGGAAGGTTTACGCAGTAGAAGCCAGCAACATGGCGCACCACGCACAGGCCCTAGTCAGAGCGAACAGTTTACATGATCGTATCACAGTCATAGCGGGTAAAATTGAAGAAATTGAATTACCAGAAAGTGTTGATATAATTATCTCTGAACCGATGGGTTACATGTTGTACAATGAACGTATGTTAGAGACATATTTACATGCGAAGAAATGGCTAAAACCGAATGGTAATATGTACCCAACGAGAGGTGATCTCCATATAGCACCATTCACTGATGATGCATTATTCATGGAACAATATAATAAGGCTAATTTTTGGTATCAAGTGTGCTTCCACGGGGTAGACCTGAGTGCATTACGCACAGCTGCTATGAAAGAGTACTTTAGACAGCCTATAGTTGACACATTTGATGTACGCATATGCATGTCTCGGTCTGTTAGACACGTTGTTGACTTCTTAAATGCTCATGAAACTGACTTACATCGTATAGAGGTACCCTTTAGATTTGAACTAACCCAGTCTGGTACTTGTCACGGATTAGCTTTCTGGTTTGATGTTTTATTTGCTGGGGGAACACAGCACATATGGTTATCGACTGCACCAACGGAACCTTTAACGCATTGGTATCAAGTGCGGTGTTTGCTTGAGACACCTATATTTGCTAAACAAGGTCAAGCTCTTACAGGTCGAGTGCTTTTGTTGGCAAACAAGCGCCAGAGCTATGATGTGACAATGGAAGTGAACTTAGAAGGTACAAATATATCTTCATCAAACACATTGGATTTGAAGAATCCTTACTTTAGGTACACAGGTGCTCCAGCAGCACCTCCGCCCGGAGTCAATAGCACATCCCCAAGTGAAAACTACTGGAACTCTATTGACACAACAACATCTATCAGCAACGGTCAGGTTATCCTAACAGATGGCACCCAACAATACTGTTCGACTCCAGATCAAACTCTTTCATATGGAGCCCATCCGAATATGATCAAAACAGTGATGCTTCAAGAAGAATTCATCAAGAGAATCGGGATCAGTCAGAACGGGGACATATAA

Protein

MANTFRGVTVSTVNSDGVLTPRFNFPTNVNVDYDPQGLSVKVIRADPVLAQEVLEFPVHSQSECSRVAGQSYIFTIDNETLFFKLASDADCQSFHLLVSKVKAGRSSSVFTVRTEDSSAMQYFQFYGYLSQQQNMMQDYVRTSTYQRAILSNVNDFKNKVVLDVGAGSGILSFFAAQAGARKVYAVEASNMAHHAQALVRANSLHDRITVIAGKIEEIELPESVDIIISEPMGYMLYNERMLETYLHAKKWLKPNGNMYPTRGDLHIAPFTDDALFMEQYNKANFWYQVCFHGVDLSALRTAAMKEYFRQPIVDTFDVRICMSRSVRHVVDFLNAHETDLHRIEVPFRFELTQSGTCHGLAFWFDVLFAGGTQHIWLSTAPTEPLTHWYQVRCLLETPIFAKQGQALTGRVLLLANKRQSYDVTMEVNLEGTNISSSNTLDLKNPYFRYTGAPAAPPPGVNSTSPSENYWNSIDTTTSISNGQVILTDGTQQYCSTPDQTLSYGAHPNMIKTVMLQEEFIKRIGISQNGDI

Description

Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in proteins. May methylate histone H3 at 'Arg-17' and activate transcription via chromatin remodeling.

Catalytic Activity

L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine

Subunit

Homodimer.

Similarity

Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.

Keywords

Chromatin regulator   Complete proteome   Cytoplasm   Methylation   Methyltransferase   Nucleus   Reference proteome   S-adenosyl-L-methionine   Transcription   Transcription regulation   Transferase  

Feature

chain  Histone-arginine methyltransferase CARMER

Uniprot

H9JXC8   A0A212FIJ9   A0A2H1V0N7   A0A194QH32   A0A0N1IDG5   A0A2A4J4E0   + More
A0A2W1BGJ0   A0A0L7L4Y8   A0A2Z5UIV8   E9IBS2   E2C9V5   A0A2J7QPK7   A0A151IJX2   A0A088A147   A0A2A3EN87   A0A0L7QUF6   A0A151WT68   A0A195EHH5   A0A154PTY3   A0A026X243   A0A3L8D981   A0A158NKE4   A0A195B027   A0A195FAS8   A0A0C9R5M2   F4W8P4   D6W859   A0A1Y1MGF4   A0A0J7KPE1   A0A0A9XU93   A0A0A9XM57   A0A1B6CGN0   A0A1B6J5W5   A0A1W4WKL8   A0A1W4W9E6   A0A1W4W9J4   A0A1B6LGF4   A0A1B6KX09   A0A067REI8   A0A0N0BGK3   A0A1Y1MGJ8   A0A0P5RZ21   A0A2R7WRH2   A0A0P5RYS3   A0A1L8DXB2   A0A0P5KC64   A0A0P5FLL1   A0A162NGK6   A0A0P5D140   A0A0N8BNT6   A0A0P5LWW6   A0A0P5CG42   A0A0P6C650   A0A0P5KF96   A0A0N8A020   A0A0P5LX32   A0A0P5PSD5   A0A0P5KWM7   A0A0P5GFL7   A0A0P5ZSJ4   A0A0P5FXT3   A0A0P5QH80   A0A0P5G191   A0A0P5DR51   E9G5N3   A0A1B6KLB0   A0A0P5HBQ7   A0A1B6KZB4   A0A0P5QNK1   A0A0P5PYM3   R4WQE9   A0A0N8AEK0   A0A2P8XTU8   A0A182MBB8   A0A0P5UID3   A0A182RY78   A0A182VQF0   A0A0P5C2Y3   A0A0P5D060   U4UM39   A0A182UYL3   A0A182XGZ9   A0A1J1J3V1   A0A182I8F2   A0A182K657   Q7Q2B7   A0A182TNG8   A0A182S649   A0A0P4WTQ4   A0A182XXK1   A0A182N6U2   A0A182KMW8   A0A182PK48   B0W3L6   A0A0P5V5H7   A0A0P5V9U0   Q174R2   A0A182HB13   A0A1Q3EWA7   A0A2K7P6A7  

EC Number

2.1.1.319

Pubmed

19121390    22118469    26354079    28756777    26227816    21282665    + More
20798317    24508170    30249741    21347285    21719571    18362917    19820115    28004739    25401762    26823975    24845553    21292972    23691247    29403074    23537049    12364791    19472346    25244985    20966253    17510324    26483478   

EMBL

BABH01035842    AGBW02008371    OWR53559.1    ODYU01000126    SOQ34379.1    KQ459053    + More
KPJ04245.1    KQ461157    KPJ08088.1    NWSH01003436    PCG66310.1    KZ150152    PZC72825.1    JTDY01002999    KOB70339.1    AP017506    BBB06812.1    GL762137    EFZ21951.1    GL453902    EFN75292.1    NEVH01012088    PNF30518.1    KQ977294    KYN03923.1    KZ288215    PBC32666.1    KQ414735    KOC62194.1    KQ982762    KYQ51044.1    KQ978881    KYN27723.1    KQ435127    KZC14818.1    KK107021    EZA62362.1    QOIP01000011    RLU16692.1    ADTU01018790    KQ976692    KYM77811.1    KQ981693    KYN37725.1    GBYB01003230    JAG72997.1    GL887908    EGI69535.1    KQ971307    EFA10996.1    GEZM01032195    GEZM01032193    JAV84784.1    LBMM01004620    KMQ92233.1    GBHO01022884    GBRD01017168    GDHC01013735    JAG20720.1    JAG48659.1    JAQ04894.1    GBHO01022883    JAG20721.1    GEDC01024684    JAS12614.1    GECU01013159    JAS94547.1    GEBQ01017237    JAT22740.1    GEBQ01024012    JAT15965.1    KK852519    KDR22157.1    KQ435776    KOX74904.1    GEZM01032196    GEZM01032194    JAV84783.1    GDIQ01094537    JAL57189.1    KK855358    PTY22163.1    GDIQ01094538    JAL57188.1    GFDF01003001    JAV11083.1    GDIQ01186204    JAK65521.1    GDIQ01256069    JAJ95655.1    LRGB01000568    KZS17959.1    GDIP01162644    JAJ60758.1    GDIQ01159571    JAK92154.1    GDIQ01164023    JAK87702.1    GDIP01186693    JAJ36709.1    GDIP01020416    JAM83299.1    GDIQ01186205    JAK65520.1    GDIP01195777    JAJ27625.1    GDIQ01164024    JAK87701.1    GDIQ01123977    JAL27749.1    GDIQ01186206    JAK65519.1    GDIQ01241591    JAK10134.1    GDIP01040604    JAM63111.1    GDIQ01248887    JAK02838.1    GDIQ01123976    JAL27750.1    GDIQ01248886    JAK02839.1    GDIP01152587    JAJ70815.1    GL732532    EFX85598.1    GEBQ01027740    JAT12237.1    GDIQ01229892    JAK21833.1    GEBQ01023181    JAT16796.1    GDIQ01121626    JAL30100.1    GDIQ01121628    JAL30098.1    AK417916    BAN21131.1    GDIP01155137    JAJ68265.1    PYGN01001358    PSN35433.1    AXCM01002014    GDIP01113900    JAL89814.1    GDIP01181038    JAJ42364.1    GDIP01179086    JAJ44316.1    KB632382    ERL94182.1    CVRI01000070    CRL07080.1    APCN01002742    AAAB01008978    FJ391182    ACJ24894.1    GDIP01252331    JAI71070.1    DS231832    EDS31802.1    GDIP01105090    JAL98624.1    GDIP01105089    JAL98625.1    CH477406    EAT41589.1    JXUM01123884    JXUM01123885    KQ566765    KXJ69845.1    GFDL01015489    JAV19556.1   

Proteomes

UP000005204    UP000007151    UP000053268    UP000053240    UP000218220    UP000037510    + More
UP000008237    UP000235965    UP000078542    UP000005203    UP000242457    UP000053825    UP000075809    UP000078492    UP000076502    UP000053097    UP000279307    UP000005205    UP000078540    UP000078541    UP000007755    UP000007266    UP000036403    UP000192223    UP000027135    UP000053105    UP000076858    UP000000305    UP000245037    UP000075883    UP000075900    UP000075920    UP000030742    UP000075903    UP000076407    UP000183832    UP000075840    UP000075881    UP000007062    UP000075902    UP000075901    UP000076408    UP000075884    UP000075882    UP000075885    UP000002320    UP000008820    UP000069940    UP000249989   

PRIDE

H9JXC8   

Pfam

PF11531   CARM1        + More
PF13649   Methyltransf_25

Interpro

IPR011993   PH-like_dom_sf        + More
IPR020989   Histone-Arg_MeTrfase_N       
IPR029063   SAM-dependent_MTases       
IPR025799   Arg_MeTrfase       
IPR041698   Methyltransf_25       

SUPFAM

SSF53335   SSF53335       

Gene 3D

2.30.29.30    

ProteinModelPortal

H9JXC8   A0A212FIJ9   A0A2H1V0N7   A0A194QH32   A0A0N1IDG5   A0A2A4J4E0   + More
A0A2W1BGJ0   A0A0L7L4Y8   A0A2Z5UIV8   E9IBS2   E2C9V5   A0A2J7QPK7   A0A151IJX2   A0A088A147   A0A2A3EN87   A0A0L7QUF6   A0A151WT68   A0A195EHH5   A0A154PTY3   A0A026X243   A0A3L8D981   A0A158NKE4   A0A195B027   A0A195FAS8   A0A0C9R5M2   F4W8P4   D6W859   A0A1Y1MGF4   A0A0J7KPE1   A0A0A9XU93   A0A0A9XM57   A0A1B6CGN0   A0A1B6J5W5   A0A1W4WKL8   A0A1W4W9E6   A0A1W4W9J4   A0A1B6LGF4   A0A1B6KX09   A0A067REI8   A0A0N0BGK3   A0A1Y1MGJ8   A0A0P5RZ21   A0A2R7WRH2   A0A0P5RYS3   A0A1L8DXB2   A0A0P5KC64   A0A0P5FLL1   A0A162NGK6   A0A0P5D140   A0A0N8BNT6   A0A0P5LWW6   A0A0P5CG42   A0A0P6C650   A0A0P5KF96   A0A0N8A020   A0A0P5LX32   A0A0P5PSD5   A0A0P5KWM7   A0A0P5GFL7   A0A0P5ZSJ4   A0A0P5FXT3   A0A0P5QH80   A0A0P5G191   A0A0P5DR51   E9G5N3   A0A1B6KLB0   A0A0P5HBQ7   A0A1B6KZB4   A0A0P5QNK1   A0A0P5PYM3   R4WQE9   A0A0N8AEK0   A0A2P8XTU8   A0A182MBB8   A0A0P5UID3   A0A182RY78   A0A182VQF0   A0A0P5C2Y3   A0A0P5D060   U4UM39   A0A182UYL3   A0A182XGZ9   A0A1J1J3V1   A0A182I8F2   A0A182K657   Q7Q2B7   A0A182TNG8   A0A182S649   A0A0P4WTQ4   A0A182XXK1   A0A182N6U2   A0A182KMW8   A0A182PK48   B0W3L6   A0A0P5V5H7   A0A0P5V9U0   Q174R2   A0A182HB13   A0A1Q3EWA7   A0A2K7P6A7  

PDB

3B3J     E-value=9.02233e-170,     Score=1533

KEGG

101737538    K05931 type I protein arginine methyltransferase [EC:2.1.1.319] | (RefSeq) histone-arginine methyltr

GO

GO:0006479   GO:0008168   GO:0008469   GO:0019919   GO:0034969   GO:0035242   GO:0005829   GO:0006355   GO:0042054   GO:0035241   GO:0005634   GO:0005737   GO:0006338   GO:0004822   GO:0005524   GO:0006428   GO:0004812   GO:0000049   GO:0005975   GO:0004553  

Subcellular location

Cytoplasm  
Nucleus  

Length:

531

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.11197

Exp number, first 60 AAs:

0.00055

Total prob of N-in:

0.00775

outside

1  -  531

 

 

Pi

53.959951

Theta

123.208389

Tajima's D

-1.779499

CLR

1129.859178

CSRT

0.0311984400779961

Interpretation

Uncertain