Gene

KWMTBOMO12208  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007770

Annotation

PREDICTED:_phosphatidylinositide_phosphatase_SAC1_[Bombyx_mori]

Location

Bomo_Chr20(+):9414400-9427364      View in EpiBrowser

Full name

Phosphatidylinositide phosphatase SAC1      

Alternative Name

Suppressor of actin mutations 1-like protein

Location in the cell

PlasmaMembrane   Reliability : 2.207

CDS

ATGGCAGACCAATTGCTAATTCATGATGATATTAAACTATATACGACATCTGATAAATTTTATTTTGAGCCGACAATCAACCCTACAGAGATTATGGTCATAGACAGAGTCACAGGAGAAGCCAGTGTTAAAGATATAAATTCAGTAAGGATCCCAATACCGGCAAATGCCTACAAACCAGTATGTGGGTTCTTAGGCTCCATAAAACTTATTTCCGGATTGTATTTGGTTGTCGCTAAGTACAGGATACTGGTTGGAAAAATTAATGGGCATGAAATATACCAGCTTGCCGGCACAGACATCATTCCGTATACCAGATCGACTTCACATCTTACTACTCAGCAGATTGCTGACAACAACACGTACGAGCGCATGATCCGGGCTGCACTAGAAACACCGGGAATTTACTTCTCTTACAGCTATGATCTAACTCACACATTGCAGAGACTGCATGCTGTAACACCTGATTTCCATAAGATGTCGCTAGCGAACCGTGCGGACACAAGGTTCCTGTGGAACAGACATCTTCTAAGGGATTACTCCCACGACCAGTTTTCAAGATTCGCTCTGCCCATTATTCAAGGATTTGTGTCGATAAACTATGTGAATATAAACGGGCACGACATGACCTGGGCGCTAGTGTCGCGACGCTGCGCGGATAGAGCCGGCACCAGACTCTTCATGAGGGGCGTCGACGCGCAGGGCAACGTGGCCAATTTTGTAGAAACCGAACAGATAGTTGAGCGCGGCGGCGAGAAGTCTTCGTACGTGCAGACCCGGGGCTCGATCCCGCTGTTCTGGAGCCAGTACCCGGACATTCGGTACAAGCCGCCGATGACGCTGGCCCACGAGGACCACGTCGCGGCCTACACCAAGCACCTCCGCGACCAGATACAACGGTACGGGAACCAGGTGCTGGTTAACTTGATCGACCAGCGTGGGCGCGAGGAGGCGCTGGAGCGTGGGTACCGCGCGGCGGCGGCGGCGGCGGCGCTGCCCGGCGTGCGCTACGAGCCCTTCGACTTCCACGCGGAGTGCCGCGCCATGCGCTACCACCGCCTCGCCGTGCTCACCGACAGGATCGCGCACGAGCAGACGGAATTCGGCTACTTCCTGAGTCGGGGCGGCTCCGTGCTGCTGCGGCAGAGCGGCGTGTTCCGCACCAACTGCGTGGACTGCCTGGACCGGACCAACGTGGTGCAGAGCCTGCTCGCCAAGCTGCATCTGACGGCGCTCTTCAAGCTCCTCAACGTCTCCAGCTCCGACCAACTGGAGACCAACTTCGAACATCTGTTCAATAACGTGTGGGCGGATCACGCGGACGCCATCTCCACGCAGTACTCCGGGACGGGCGCCCTGAAGACGGACTACACGCGCACCGGCAAGCGCACGCACGTCGGTCTGTTGCGCGACGGCATCAACTCCCTCACGCGATACTACAAGAACAACTTCAGCGACGGCTTCAGACAGGACTCAATAGATCTGTTCCTGGGTAAGTACGTGGTCGCTGAGGGCGAGGGTCTGGCCGCCCCGAGCCCTCTGAGGAGAGGACACGACTGGAAATATATCACGCTCCCTTCCGTGCTGCTGGTTGCCATGTCAATGTTCTGCGCCCAAGCGGTGCTGCCGGCGCGCTACTCCAGCGAAGTGCTGCTCTACCTCATGTTCTGGGGGGCGGCTGCTGGAGCGACGCTCTCCTACATCGTCAGGCACGGCGCGGAGTTCGTGGACTGGCCGAGTCTGGACGCCGGGGGCCTGGCGTCGGCGCGCGCCCTCGCCGCCCAGCAGTCTTTATGA

Protein

MADQLLIHDDIKLYTTSDKFYFEPTINPTEIMVIDRVTGEASVKDINSVRIPIPANAYKPVCGFLGSIKLISGLYLVVAKYRILVGKINGHEIYQLAGTDIIPYTRSTSHLTTQQIADNNTYERMIRAALETPGIYFSYSYDLTHTLQRLHAVTPDFHKMSLANRADTRFLWNRHLLRDYSHDQFSRFALPIIQGFVSINYVNINGHDMTWALVSRRCADRAGTRLFMRGVDAQGNVANFVETEQIVERGGEKSSYVQTRGSIPLFWSQYPDIRYKPPMTLAHEDHVAAYTKHLRDQIQRYGNQVLVNLIDQRGREEALERGYRAAAAAAALPGVRYEPFDFHAECRAMRYHRLAVLTDRIAHEQTEFGYFLSRGGSVLLRQSGVFRTNCVDCLDRTNVVQSLLAKLHLTALFKLLNVSSSDQLETNFEHLFNNVWADHADAISTQYSGTGALKTDYTRTGKRTHVGLLRDGINSLTRYYKNNFSDGFRQDSIDLFLGKYVVAEGEGLAAPSPLRRGHDWKYITLPSVLLVAMSMFCAQAVLPARYSSEVLLYLMFWGAAAGATLSYIVRHGAEFVDWPSLDAGGLASARALAAQQSL

Description

Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2 (By similarity).

Keywords

Complete proteome   Endoplasmic reticulum   Hydrolase   Membrane   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Phosphatidylinositide phosphatase SAC1

Uniprot

A0A2A4JDW7   A0A3S2NLM3   A0A212F1U3   A0A194QLA8   A0A067RL58   A0A1L8DUN9   + More
A0A1J1IV69   Q171G2   A0A182G0U6   U5EZ16   A0A2J7QJM1   A0A023EX49   A0A1Q3FCU8   B0WWS3   W8BM43   N6T361   A0A0K8TMQ9   A0A336KBA1   A0A0T6AZ35   D6WSC5   A0A034V7X3   A0A1Y1L0D0   A0A0A1WJC3   A0A0K8UI62   F4WW49   A0A026WZI0   A0A195E655   E9J3E8   A0A195EYY9   E2BMY0   E2AHY8   A0A1B6DBF0   A0A232F776   K7J697   E0VIK7   A0A195CTA0   A0A158NLK1   A0A1B6KAC0   A0A1B6FDT6   E9GCU9   A0A151I126   A0A1B6CC19   A0A1W4WWB0   A0A0L7RGZ3   A0A087ZZ41   A0A2A3EDT3   A0A2P6K9U4   A0A0P6GJG1   A0A087UT65   A0A310SN86   A0A0P4XTN5   A0A0P6CS75   A0A1I8QB92   A0A154PQY3   T1PA60   R7T3T3   A0A0M9A1F3   A0A0L0C227   K1QAG7   A0A0M4EZQ6   W4Y1R6   A0A0K8RAH6   T1KBK4   A0A2P2I606   A0A2S2Q599   B4J2F5   A0A1E1XAC6   B4MXY9   B4HVQ3   A0A3B3CKY1   A0A0J9UBU9   Q29EV1   A0A0R3P8H8   A0A0R3P5P7   T1EGD7   A0A1W4W7V0   A0A1W4VV89   A0A0J9RMY4   A0A1S3DPV1   B4LG85   A0A131XC04   H2LED3   A0A224Z3G2   A0A0P4WGI8   M9MRM4   T1GKC4   Q9W0I6   B4QLY6   A0A3Q0JJ97   A0A3B1K197   A0A2H8TWH0   A0A3B0JRL3   A0A3B0KGA3   A0A2R5LM26   A0A0L8G743   A0A3B0JRK2   A0A3P9J976   G3MLV2   A0A131Z7L7  

EC Number

3.1.3.-

Pubmed

22118469    26354079    24845553    17510324    26483478    24945155    + More
24495485    23537049    26369729    18362917    19820115    25348373    28004739    25830018    21719571    24508170    30249741    21282665    20798317    28648823    20075255    20566863    21347285    21292972    25315136    23254933    26108605    22992520    17994087    28503490    29451363    22936249    15632085    28049606    17554307    28797301    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    12537569    25329095    22216098    26830274   

EMBL

NWSH01001737    PCG70275.1    RSAL01000042    RVE50800.1    AGBW02010795    OWR47702.1    + More
KQ459053    KPJ04226.1    KK852611    KDR20269.1    GFDF01003935    JAV10149.1    CVRI01000061    CRL04071.1    CH477456    EAT40629.1    JXUM01135349    KQ568258    KXJ69075.1    GANO01001604    JAB58267.1    NEVH01013550    PNF28791.1    GAPW01000649    JAC12949.1    GFDL01009727    JAV25318.1    DS232152    EDS36184.1    GAMC01015816    JAB90739.1    APGK01054085    KB741247    KB632281    ENN71993.1    ERL91330.1    GDAI01001979    JAI15624.1    UFQS01000171    UFQT01000171    SSX00705.1    SSX21085.1    LJIG01022479    KRT80353.1    KQ971352    EFA06386.1    GAKP01019546    JAC39406.1    GEZM01068176    JAV67113.1    GBXI01015677    JAC98614.1    GDHF01026093    JAI26221.1    GL888404    EGI61638.1    KK107063    QOIP01000005    EZA61121.1    RLU22282.1    KQ979579    KYN20680.1    GL768063    EFZ12654.1    KQ981914    KYN33122.1    GL449382    EFN82884.1    GL439602    EFN66978.1    GEDC01014300    JAS22998.1    NNAY01000798    OXU26452.1    DS235200    EEB13213.1    KQ977349    KYN03364.1    ADTU01019612    GEBQ01031586    JAT08391.1    GECZ01021383    JAS48386.1    GL732539    EFX82800.1    KQ976605    KYM79347.1    GEDC01026453    JAS10845.1    KQ414596    KOC70103.1    KZ288269    PBC29887.1    MWRG01019084    PRD23069.1    GDIQ01044762    JAN49975.1    KK121473    KFM80554.1    KQ759820    OAD62735.1    GDIP01240936    JAI82465.1    GDIQ01088091    JAN06646.1    KQ435037    KZC14157.1    KA645622    AFP60251.1    AMQN01003652    KB312379    ELT87336.1    KQ435765    KOX75375.1    JRES01000987    KNC26398.1    JH823241    EKC33652.1    CP012525    ALC44237.1    AAGJ04101869    AAGJ04101870    GADI01005935    JAA67873.1    CAEY01001951    IACF01003849    LAB69457.1    GGMS01003706    MBY72909.1    CH916366    EDV96014.1    GFAC01002965    JAT96223.1    CH963876    EDW76978.1    CH480817    EDW50018.1    CM002912    KMY96775.1    CH379070    EAL29959.2    KRT08517.1    KRT08516.1    AMQM01007866    KB097680    ESN91957.1    KMY96774.1    CH940647    EDW69393.1    GEFH01004102    JAP64479.1    GFPF01009466    MAA20612.1    GDRN01057498    JAI65685.1    AE014296    ADV37453.1    CAQQ02394138    AY047571    CM000363    EDX08772.1    GFXV01006830    MBW18635.1    OUUW01000009    SPP84765.1    SPP84766.1    GGLE01006460    MBY10586.1    KQ423675    KOF72420.1    SPP84764.1    JO842853    AEO34470.1    GEDV01002396    JAP86161.1   

Proteomes

UP000218220    UP000283053    UP000007151    UP000053268    UP000027135    UP000183832    + More
UP000008820    UP000069940    UP000249989    UP000235965    UP000002320    UP000019118    UP000030742    UP000007266    UP000007755    UP000053097    UP000279307    UP000078492    UP000078541    UP000008237    UP000000311    UP000215335    UP000002358    UP000009046    UP000078542    UP000005205    UP000000305    UP000078540    UP000192223    UP000053825    UP000005203    UP000242457    UP000054359    UP000095300    UP000076502    UP000095301    UP000014760    UP000053105    UP000037069    UP000005408    UP000092553    UP000007110    UP000015104    UP000001070    UP000007798    UP000001292    UP000261560    UP000001819    UP000015101    UP000192221    UP000079169    UP000008792    UP000001038    UP000000803    UP000015102    UP000000304    UP000018467    UP000268350    UP000053454    UP000265200   

PRIDE

M9MRM4    Q9W0I6   

Pfam

PF02383   Syja_N

Interpro

IPR002013   SAC_dom       

ProteinModelPortal

A0A2A4JDW7   A0A3S2NLM3   A0A212F1U3   A0A194QLA8   A0A067RL58   A0A1L8DUN9   + More
A0A1J1IV69   Q171G2   A0A182G0U6   U5EZ16   A0A2J7QJM1   A0A023EX49   A0A1Q3FCU8   B0WWS3   W8BM43   N6T361   A0A0K8TMQ9   A0A336KBA1   A0A0T6AZ35   D6WSC5   A0A034V7X3   A0A1Y1L0D0   A0A0A1WJC3   A0A0K8UI62   F4WW49   A0A026WZI0   A0A195E655   E9J3E8   A0A195EYY9   E2BMY0   E2AHY8   A0A1B6DBF0   A0A232F776   K7J697   E0VIK7   A0A195CTA0   A0A158NLK1   A0A1B6KAC0   A0A1B6FDT6   E9GCU9   A0A151I126   A0A1B6CC19   A0A1W4WWB0   A0A0L7RGZ3   A0A087ZZ41   A0A2A3EDT3   A0A2P6K9U4   A0A0P6GJG1   A0A087UT65   A0A310SN86   A0A0P4XTN5   A0A0P6CS75   A0A1I8QB92   A0A154PQY3   T1PA60   R7T3T3   A0A0M9A1F3   A0A0L0C227   K1QAG7   A0A0M4EZQ6   W4Y1R6   A0A0K8RAH6   T1KBK4   A0A2P2I606   A0A2S2Q599   B4J2F5   A0A1E1XAC6   B4MXY9   B4HVQ3   A0A3B3CKY1   A0A0J9UBU9   Q29EV1   A0A0R3P8H8   A0A0R3P5P7   T1EGD7   A0A1W4W7V0   A0A1W4VV89   A0A0J9RMY4   A0A1S3DPV1   B4LG85   A0A131XC04   H2LED3   A0A224Z3G2   A0A0P4WGI8   M9MRM4   T1GKC4   Q9W0I6   B4QLY6   A0A3Q0JJ97   A0A3B1K197   A0A2H8TWH0   A0A3B0JRL3   A0A3B0KGA3   A0A2R5LM26   A0A0L8G743   A0A3B0JRK2   A0A3P9J976   G3MLV2   A0A131Z7L7  

PDB

4TU3     E-value=5.31061e-90,     Score=846

KEGG

101739169    K21797 phosphatidylinositol 4-phosphatase [EC:3.1.3.-] | (RefSeq) phosphatidylinositide phosphatase

PATHWAY

00562    Inositol phosphate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04070    Phosphatidylinositol signaling system - Bombyx mori (domestic silkworm)

GO

GO:0042578   GO:0016021   GO:0046856   GO:0005783   GO:0043812   GO:0008088   GO:0060074   GO:0046488   GO:0031122   GO:0046329   GO:0030424   GO:0052866   GO:0016199   GO:0043025   GO:0046664   GO:0071683   GO:0005789   GO:0012505   GO:0016791   GO:0035149   GO:0005524   GO:0005515   GO:0003676   GO:0016788   GO:0007165   GO:0005525   GO:0008033   GO:0016787  

Subcellular location

Endoplasmic reticulum membrane  

Length:

598

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

43.49419

Exp number, first 60 AAs:

0.17079

Total prob of N-in:

0.07477

outside

1  -  521

TMhelix

522  -  544

inside

545  -  550

TMhelix

551  -  573

outside

574  -  598

 

 

Pi

5.664844

Theta

170.206929

Tajima's D

-1.850507

CLR

287.787904

CSRT

0.024298785060747

Interpretation

Possibly Positive selection