Gene

KWMTBOMO12180  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004218

Annotation

PREDICTED:_dolichyl-phosphate_mannosyltransferase_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr20(-):8852207-8856129      View in EpiBrowser

Full name

Dolichol-phosphate mannosyltransferase subunit 1      

Alternative Name

Dolichol-phosphate mannose synthase subunit 1
Dolichyl-phosphate beta-D-mannosyltransferase subunit 1
Mannose-P-dolichol synthase subunit 1

Location in the cell

Cytoplasmic   Reliability : 1.018 PlasmaMembrane   Reliability : 1.525

CDS

ATGGAGGTGGATTCGGGATTGATAAAAAGAGATAAATACTCAATTTTACTACCAACTTACAATGAACGAGAAAACCTCCCTATAATAATATGGCTAATAATTAAATATTTAGACGAAAGCGGTGTCGATTACGAAGTGATCATAATAGATGATGGAAGTCCTGATGGGACTTCAGAAGTGGCGCGTCAGCTGCAGAAGCTCTATGGCTCCTCTAAAATAGTGCTTCGACCTCGCGAGATGAAGCTTGGTCTCGGAACTGCCTACATTCATGGGATACAGCAAGCTTCTGGAAATTTTATTATTATAATGGATGCGGATTTGAGCCATCATCCAAAGTTCATTCCAGAGTTCATCAAACTCCAATTAAAATATGATTACGATATTGTCTCTGGTACTCGTTACAAGGGGAGTGGTGGAGTCTACGGCTGGGACTTCAAGCGTAAGCTCATATCTAGGGGAGCTAACTTTTTGACTCAGTTAATGCTGAGACCTGGAGTTTCAGATCTGACTGGCTCATTTAGATTGTACAAAAAGGAAGTTCTCGAGAAGCTTATTCTAAGCTGCGTTTCTAAAGGATATGTCTTCCAAATGGAAATGATTATCAGAGCGAGGCAATTTGATTATTCAATTGGAGAGGTGCCTATCTCATTTGTGGATCGTGTCTACGGAGAGTCTAAACTCGGTGGTTCGGAAATAGTACAATTCGCAAAAGCCCTACTTTATCTATTTGCCACAACATAA

Protein

MEVDSGLIKRDKYSILLPTYNERENLPIIIWLIIKYLDESGVDYEVIIIDDGSPDGTSEVARQLQKLYGSSKIVLRPREMKLGLGTAYIHGIQQASGNFIIIMDADLSHHPKFIPEFIKLQLKYDYDIVSGTRYKGSGGVYGWDFKRKLISRGANFLTQLMLRPGVSDLTGSFRLYKKEVLEKLILSCVSKGYVFQMEMIIRARQFDYSIGEVPISFVDRVYGESKLGGSEIVQFAKALLYLFATT

Description

Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.

Catalytic Activity

dolichyl phosphate + GDP-alpha-D-mannose = dolichyl beta-D-mannosyl phosphate + GDP

Subunit

Component of the dolichol-phosphate mannose (DPM) synthase complex.
Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex interacts directly with DPM3.

Similarity

Belongs to the glycosyltransferase 2 family.

Keywords

Acetylation   Complete proteome   Congenital disorder of glycosylation   Congenital muscular dystrophy   Disease mutation   Dystroglycanopathy   Endoplasmic reticulum   Glycosyltransferase   Phosphoprotein   Reference proteome   Transferase  

Feature

chain  Dolichol-phosphate mannosyltransferase subunit 1
sequence variant  In CDG1E; dbSNP:rs121908583.

Uniprot

Q1HPN8   H9J3X9   A0A194QF83   A0A194QW04   A0A212EXP8   A0A2A4JAG0   + More
A0A2W1BDH5   A0A2H1V4Q7   D6WPH7   A0A1B6DY92   K7JAA4   A0A182Q9N6   A0A182PFI6   A0A182RHF6   A0A087ZYS0   A0A182M2V4   A0A182YDM0   Q1HR12   A0A1B6FA00   A0A154PQH2   U5EZ22   A0A182NUK2   A0A084W219   A0A182HRL4   A0A067RTV5   A0A1W4X9X5   A0A1W4XKC6   A0A182H4F8   A0A3S2MZF2   A0A182KTP6   A0A2M3Z2T1   A0A182K721   Q7Q1B7   A0A3B3DF72   A0A023EKR8   A0A1A7XDL1   W5J999   A0A2K5IC50   A0A315WAM6   A0A226F3Z6   A0A182UQE5   A0A182U246   A0A182F6A1   A0A1A8EU67   A0A286X9A8   A0A310SWQ5   A0A2K5YCV2   H9F662   A0A2K6CEJ3   A0A2K5W3B5   I0FW34   A0A2K6K3X4   A0A2K6Q8Y9   A0A2K5NX69   A0A2M4AFC4   A0A1Y1KJJ3   J9NZX5   F6RQC7   A0A3Q1H120   A0A0L7RH18   A0A1Q3FBS5   A0A3Q7TYS9   A0A2K5DXH7   A0A3P9LHR4   H2L910   A0A182JKR3   A0A3P9I4S5   M3WC50   A0A0K8TP84   A0A3P4NM98   A0A2M4BYD1   A0A1S3DTB4   I3MNC2   A0A2M4BYD0   W8BXV1   A0A1U7TG39   A0A1S3JV08   A0A3Q7MPY8   A0A1A8J8X9   A0A1A8D3D3   A0A2U3WT56   H2P2A8   A0A0S2Z4Y5   O60762   A0A2K6V131   A0A384CN11   A0A3Q7WD07   F4WW36   V9L673   A0A3Q2QPG4   A0A2K6EVD4   H3AP13   A0A1A8UCE9   A0A1U7QWB3   A0A3B4B8Y2   I3IZJ1   H0WRY7   M3ZW98   A0A2R9CPW5   H2QKK7  

EC Number

2.4.1.83

Pubmed

19121390    26354079    22118469    28756777    18362917    19820115    + More
20075255    25244985    17204158    17510324    24438588    24845553    26483478    20966253    12364791    29451363    24945155    20920257    23761445    29703783    21993624    25319552    25362486    28004739    16341006    17554307    17975172    26369729    24495485    26871637    9535917    14702039    11780052    15489334    9223280    10835346    17081983    16280320    18691976    20068231    21269460    21406692    22814378    23186163    24275569    25944712    10642597    10642602    15669674    23856421    24813606    21719571    24402279    9215903    25463417    25186727    23542700    22722832    16136131   

EMBL

DQ443364    ABF51453.1    BABH01040240    BABH01040241    KQ459053    KPJ04203.1    + More
KQ461181    KPJ07746.1    AGBW02011714    OWR46241.1    NWSH01002285    PCG68678.1    KZ150117    PZC73262.1    ODYU01000663    SOQ35830.1    KQ971354    EFA06224.2    GEDC01006673    JAS30625.1    AAZX01002420    AXCN02002063    AXCM01008671    DQ440282    CH477649    ABF18315.1    EAT37808.1    GECZ01022825    JAS46944.1    KQ435037    KZC14151.1    GANO01001573    JAB58298.1    ATLV01019473    KE525272    KFB44263.1    APCN01001719    KK852423    KDR24245.1    JXUM01025283    KQ560717    KXJ81162.1    CM012443    RVE70278.1    GGFM01002073    MBW22824.1    AAAB01008980    EAA14417.2    GAPW01003838    JAC09760.1    HADW01014757    HADX01002782    SBP16157.1    ADMH02002020    ETN59968.1    NHOQ01000110    PWA32891.1    LNIX01000001    OXA64154.1    HAEB01002872    HAEC01014381    SBQ49399.1    AAKN02050435    KQ759820    OAD62723.1    JU326365    AFE70121.1    AQIA01009143    JV048589    AFI38660.1    GGFK01006142    MBW39463.1    GEZM01081549    JAV61602.1    AAEX03014002    KQ414596    KOC70109.1    GFDL01010019    JAV25026.1    AANG04000928    GDAI01001635    JAI15968.1    CYRY02026032    VCW98605.1    GGFJ01008881    MBW58022.1    AGTP01038186    GGFJ01008882    MBW58023.1    GAMC01000325    JAC06231.1    HAED01019496    HAEE01003284    SBR05961.1    HADZ01021430    HAEA01002389    SBP85371.1    ABGA01105891    ABGA01105892    ABGA01105893    NDHI03003576    PNJ19454.1    KU178444    ALQ33902.1    D86198    D86202    CR456926    AK289569    AL034553    BC007073    BC008466    BC016322    AF007875    GL888404    EGI61625.1    JW874667    AFP07184.1    AFYH01129601    HADY01003686    HAEJ01005323    SBS45780.1    AERX01043460    AAQR03050455    AJFE02050471    AJFE02050472    AJFE02050473    AJFE02050474    AACZ04052869    GABE01011456    NBAG03000253    JAA33283.1    PNI59605.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000007151    UP000218220    UP000007266    + More
UP000002358    UP000075886    UP000075885    UP000075900    UP000005203    UP000075883    UP000076408    UP000008820    UP000076502    UP000075884    UP000030765    UP000075840    UP000027135    UP000192223    UP000069940    UP000249989    UP000075882    UP000075881    UP000007062    UP000261560    UP000000673    UP000233080    UP000198287    UP000075903    UP000075902    UP000069272    UP000005447    UP000233140    UP000233120    UP000233100    UP000233180    UP000233200    UP000233060    UP000002254    UP000008225    UP000265040    UP000053825    UP000286640    UP000233020    UP000265180    UP000001038    UP000075880    UP000265200    UP000011712    UP000079169    UP000005215    UP000189704    UP000085678    UP000286641    UP000245340    UP000001595    UP000005640    UP000233220    UP000261680    UP000291021    UP000286642    UP000007755    UP000265000    UP000233160    UP000008672    UP000189706    UP000261520    UP000005207    UP000005225    UP000002852    UP000240080    UP000002277   

PRIDE

Q1HPN8    H9J3X9    A0A0S2Z4Y5    O60762   

Pfam

PF00535   Glycos_transf_2

Interpro

IPR039528   DPM1-like        + More
IPR029044   Nucleotide-diphossugar_trans       
IPR001173   Glyco_trans_2-like       

SUPFAM

SSF53448   SSF53448       

Gene 3D

3.90.550.10    

CDD

cd06442  DPM1_like

ProteinModelPortal

Q1HPN8   H9J3X9   A0A194QF83   A0A194QW04   A0A212EXP8   A0A2A4JAG0   + More
A0A2W1BDH5   A0A2H1V4Q7   D6WPH7   A0A1B6DY92   K7JAA4   A0A182Q9N6   A0A182PFI6   A0A182RHF6   A0A087ZYS0   A0A182M2V4   A0A182YDM0   Q1HR12   A0A1B6FA00   A0A154PQH2   U5EZ22   A0A182NUK2   A0A084W219   A0A182HRL4   A0A067RTV5   A0A1W4X9X5   A0A1W4XKC6   A0A182H4F8   A0A3S2MZF2   A0A182KTP6   A0A2M3Z2T1   A0A182K721   Q7Q1B7   A0A3B3DF72   A0A023EKR8   A0A1A7XDL1   W5J999   A0A2K5IC50   A0A315WAM6   A0A226F3Z6   A0A182UQE5   A0A182U246   A0A182F6A1   A0A1A8EU67   A0A286X9A8   A0A310SWQ5   A0A2K5YCV2   H9F662   A0A2K6CEJ3   A0A2K5W3B5   I0FW34   A0A2K6K3X4   A0A2K6Q8Y9   A0A2K5NX69   A0A2M4AFC4   A0A1Y1KJJ3   J9NZX5   F6RQC7   A0A3Q1H120   A0A0L7RH18   A0A1Q3FBS5   A0A3Q7TYS9   A0A2K5DXH7   A0A3P9LHR4   H2L910   A0A182JKR3   A0A3P9I4S5   M3WC50   A0A0K8TP84   A0A3P4NM98   A0A2M4BYD1   A0A1S3DTB4   I3MNC2   A0A2M4BYD0   W8BXV1   A0A1U7TG39   A0A1S3JV08   A0A3Q7MPY8   A0A1A8J8X9   A0A1A8D3D3   A0A2U3WT56   H2P2A8   A0A0S2Z4Y5   O60762   A0A2K6V131   A0A384CN11   A0A3Q7WD07   F4WW36   V9L673   A0A3Q2QPG4   A0A2K6EVD4   H3AP13   A0A1A8UCE9   A0A1U7QWB3   A0A3B4B8Y2   I3IZJ1   H0WRY7   M3ZW98   A0A2R9CPW5   H2QKK7  

PDB

5MM1     E-value=5.58814e-33,     Score=350

KEGG

733008    K00721 dolichol-phosphate mannosyltransferase [EC:2.4.1.83] | (RefSeq) dolichyl-phosphate mannosyltr

PATHWAY

00510    N-Glycan biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0005783   GO:0006486   GO:0004582   GO:0005789   GO:0019348   GO:0035269   GO:0006506   GO:0061061   GO:0016020   GO:0018279   GO:0005634   GO:0004169   GO:0035268   GO:0033185   GO:0016740  

PANTHER

PTHR43398  

Subcellular location

Endoplasmic reticulum  

Length:

246

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.10063

Exp number, first 60 AAs:

0.00259

Total prob of N-in:

0.05205

outside

1  -  246

 

 

Pi

164.934983

Theta

143.378512

Tajima's D

0.672446

CLR

0.303504

CSRT

0.563421828908555

Interpretation

Uncertain