Gene

KWMTBOMO12174

Pre Gene Modal

BGIBMGA004222

Annotation

PREDICTED:_extracellular_signal-regulated_kinase_2_[Bombyx_mori]

Location

Bomo_Chr20(-):8789281-8798139      View in EpiBrowser

Full name

Mitogen-activated protein kinase      

Location in the cell

Cytoplasmic   Reliability : 1.744 Nuclear   Reliability : 1.684

CDS

ATGAATCAGAACCAGAAAAGAGATGACAAGAAGAAGGACGGACATAAGCATCAACAGAAAAAGAGCTCGGAAAAAAATATGTCCGAAATAGACGAGCACATATTAAAGAGATTCGAAATTAAAAAGAGATTGGGCAAAGGGGCCTACGGGATTGTTTGGAAGGCTGTCGACAAGAAAACCAAAGACGTGGTCGCAATAAAAAAGATATTTGACGCGTTCAGAAACCAGACCGACGCTCAGAGGACGTTCCGGGAGATTATATTCTTGCAATCGTTCAGAAATCACCCGAACATTGTTAAACTACACAGCATACATAGAGCTCTGAACAACAACGACATATATCTGGGATTCGAATACATGGAAACGGACCTGCATAACGTCATCAAACGCGGCAACATACTGAAAGACATCCACAAACGGTACATAATGTATCAAATGCTTAAAGCGACGAAGTACATACACTCTGGGAACGTGATACATCGCGATCAAAAGCCCAGTAACGTGTTAATAGACAGCGCTTGTAGAGTGAAGTTGGCAGATTTCGGTCTGGCTCGCTCAGTCTCTAGTGTGTACTCTGGCGGAGAAGATGGCGCAGATCCTTGTCTGACTGATTACGTCGCCACGCGCTGGTACCGAGCCCCGGAGATACTTATAGCTAGCAAGAATTACACAAAAGGAATCGACATGTGGTCCCTTGGTTGTATCCTGGCTGAGATGCTGGTTGGGGAGCCTCTGTTTCCCGGGACATCGACCGTCAATCAAATTGAGAGGATCATGGCGACACTCCCGAGGCCATCGAACGAAGGTGAGCAACAGAATTTTAAATTTTTTATTGCTTAA

Protein

MNQNQKRDDKKKDGHKHQQKKSSEKNMSEIDEHILKRFEIKKRLGKGAYGIVWKAVDKKTKDVVAIKKIFDAFRNQTDAQRTFREIIFLQSFRNHPNIVKLHSIHRALNNNDIYLGFEYMETDLHNVIKRGNILKDIHKRYIMYQMLKATKYIHSGNVIHRDQKPSNVLIDSACRVKLADFGLARSVSSVYSGGEDGADPCLTDYVATRWYRAPEILIASKNYTKGIDMWSLGCILAEMLVGEPLFPGTSTVNQIERIMATLPRPSNEGEQQNFKFFIA

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Cofactor

Mg(2+)

Similarity

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

Feature

chain  Mitogen-activated protein kinase

Uniprot

H9J3Y3   A0A3S2TNB7   A0A194QQF2   A0A194QFD7   A0A2A4J1G8   A0A212F7P9   + More
A0A1Y1KUB7   A0A0T6BE67   A0A2W1BC41   A0A1W4WSE0   A0A195B782   A0A067RR94   E0VH91   D6WRF3   A0A1B6JV20   E9FW56   A0A267GKN5   K7J0J0   A0A1B6K2A3   A0A0N8DX77   C3YL59   A0A1I8IET1   A0A3L8D757   A0A1I8FX20   V3ZBB1   A0A1I8G9P2   A0A0P5B6P5   A0A0P5B5D1   A0A0C9PSH0   A0A1B6L5P6   A0A0P4ZJK7   A0A1B6FR54   A0A151IMN8   A0A0P4XMK0   A0A151IS01   A0A0P5BC95   A0A0P5BG15   A0A0P5EXJ4   E2A9I8   A0A158NHA2   A0A0P5FUV4   A0A0P5G8C0   A0A267DXK0   A0A0P5QP46   A0A0P5TUJ7   A0A267EB49   A0A0P6I8K5   A0A2J7QYA8   A0A0P5TG99   A0A2J7QY94   C3ZCU0   A0A0R4IIR5   Q503Q2   A0A1S3JU08   A0A0P6AYG3   R7UWR1   A0A2J7QYA0   A0A0K8UX06   A0A1B6DKB0   A0A210PNM3   A0A3Q0RUQ4   A0A1I8P293   A0A3B5AQG8   A0A1I8P2E0   A0A1I8IFA0   A0A2C9JR00   A0A3B3QHF8   G3NNS3   A0A3B3QGG0   A0A0M8ZZY4   A0A3M6UF61   A0A2D0PYT4   A0A1W4ZQQ6   A0A154PS86   A0A2B4SJ31   I3J2P3   A0A0P7ZGZ3   A0A1S3Q1T8   A0A3Q2WL22   A0A3Q3E9N2   A0A3P9B7J6   A0A3P8Q727   A0A0L0BXI8   A0A1W4ZZV0   A0A3Q3S8C4   A0A3B4XX16   A0A3P8WN64   A0A3B4D0J0   A0A087ZZ64   W5MPZ7   A0A3B1JNL5   A0A2A3EH65   A0A3P9KA90   A0A345DKR8   A0A1S3Q1U6   A0A3Q1IFL4   A0A1I8JIJ6   A0A0L8FSR6   A0A1I8I6G0   A0A288W1R9  

EC Number

2.7.11.24

Pubmed

19121390    26354079    22118469    28004739    28756777    24845553    + More
20566863    18362917    19820115    21292972    20075255    18563158    26392545    30249741    23254933    20798317    21347285    23594743    28812685    15562597    29240929    30382153    25186727    26108605    24487278    25329095    17554307   

EMBL

BABH01040234    RSAL01000042    RVE50768.1    KQ461181    KPJ07738.1    KQ459053    + More
KPJ04197.1    NWSH01003771    PCG65831.1    AGBW02009842    OWR49765.1    GEZM01077409    JAV63315.1    LJIG01001733    KRT85207.1    KZ150433    PZC70887.1    KQ976574    KYM80115.1    KK852513    KDR22274.1    DS235165    EEB12747.1    KQ971351    EFA06559.2    GECU01004648    JAT03059.1    GL732525    EFX88665.1    NIVC01000272    PAA86593.1    GECU01002413    JAT05294.1    GDIQ01083052    JAN11685.1    GG666525    EEN59050.1    QOIP01000012    RLU16305.1    KB202719    ESO88318.1    GDIP01189375    JAJ34027.1    GDIP01189374    JAJ34028.1    GBYB01004273    JAG74040.1    GEBQ01020960    JAT19017.1    GDIP01213382    JAJ10020.1    GECZ01017077    JAS52692.1    KQ977035    KYN06191.1    GDIP01240780    LRGB01000024    JAI82621.1    KZS21579.1    KQ981098    KYN09495.1    GDIP01191821    JAJ31581.1    GDIP01189376    JAJ34026.1    GDIQ01266364    JAJ85360.1    GL437917    EFN69878.1    ADTU01015417    GDIQ01251238    JAK00487.1    GDIQ01248087    JAK03638.1    NIVC01003101    PAA53347.1    GDIQ01117735    JAL33991.1    GDIP01126629    JAL77085.1    NIVC01002421    PAA58029.1    GDIQ01008015    JAN86722.1    NEVH01009118    PNF33559.1    GDIP01128072    JAL75642.1    PNF33560.1    GG666610    EEN49593.1    CU633987    BC095227    BC165603    AAH95227.1    AAI65603.1    GDIP01022915    JAM80800.1    AMQN01005968    KB297235    ELU10754.1    PNF33558.1    GDHF01023633    GDHF01021193    GDHF01014970    JAI28681.1    JAI31121.1    JAI37344.1    GEDC01011165    JAS26133.1    NEDP02005573    OWF38077.1    KQ435804    KOX73063.1    RCHS01001704    RMX52058.1    KQ435037    KZC14128.1    LSMT01000082    PFX28482.1    AERX01011176    JARO02000009    KPP80295.1    JRES01001179    KNC24768.1    AHAT01020214    KZ288262    PBC30351.1    MF802853    AXF94777.1    KQ426816    KOF67724.1    KX424625    ARJ54258.1   

Proteomes

UP000005204    UP000283053    UP000053240    UP000053268    UP000218220    UP000007151    + More
UP000192223    UP000078540    UP000027135    UP000009046    UP000007266    UP000000305    UP000215902    UP000002358    UP000001554    UP000095280    UP000279307    UP000030746    UP000078542    UP000076858    UP000078492    UP000000311    UP000005205    UP000235965    UP000000437    UP000085678    UP000014760    UP000242188    UP000261340    UP000095300    UP000261400    UP000076420    UP000261540    UP000007635    UP000053105    UP000275408    UP000221080    UP000192224    UP000076502    UP000225706    UP000005207    UP000034805    UP000087266    UP000264840    UP000261660    UP000265160    UP000265100    UP000037069    UP000261640    UP000261360    UP000265120    UP000261440    UP000005203    UP000018468    UP000018467    UP000242457    UP000265180    UP000265040    UP000053454   

PRIDE

H9J3Y3   

Pfam

PF00069   Pkinase        + More
PF07714   Pkinase_Tyr

Interpro

IPR000719   Prot_kinase_dom        + More
IPR008350   MAPK_ERK3/4       
IPR003527   MAP_kinase_CS       
IPR017441   Protein_kinase_ATP_BS       
IPR011009   Kinase-like_dom_sf       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR008271   Ser/Thr_kinase_AS       

SUPFAM

SSF56112   SSF56112       

ProteinModelPortal

H9J3Y3   A0A3S2TNB7   A0A194QQF2   A0A194QFD7   A0A2A4J1G8   A0A212F7P9   + More
A0A1Y1KUB7   A0A0T6BE67   A0A2W1BC41   A0A1W4WSE0   A0A195B782   A0A067RR94   E0VH91   D6WRF3   A0A1B6JV20   E9FW56   A0A267GKN5   K7J0J0   A0A1B6K2A3   A0A0N8DX77   C3YL59   A0A1I8IET1   A0A3L8D757   A0A1I8FX20   V3ZBB1   A0A1I8G9P2   A0A0P5B6P5   A0A0P5B5D1   A0A0C9PSH0   A0A1B6L5P6   A0A0P4ZJK7   A0A1B6FR54   A0A151IMN8   A0A0P4XMK0   A0A151IS01   A0A0P5BC95   A0A0P5BG15   A0A0P5EXJ4   E2A9I8   A0A158NHA2   A0A0P5FUV4   A0A0P5G8C0   A0A267DXK0   A0A0P5QP46   A0A0P5TUJ7   A0A267EB49   A0A0P6I8K5   A0A2J7QYA8   A0A0P5TG99   A0A2J7QY94   C3ZCU0   A0A0R4IIR5   Q503Q2   A0A1S3JU08   A0A0P6AYG3   R7UWR1   A0A2J7QYA0   A0A0K8UX06   A0A1B6DKB0   A0A210PNM3   A0A3Q0RUQ4   A0A1I8P293   A0A3B5AQG8   A0A1I8P2E0   A0A1I8IFA0   A0A2C9JR00   A0A3B3QHF8   G3NNS3   A0A3B3QGG0   A0A0M8ZZY4   A0A3M6UF61   A0A2D0PYT4   A0A1W4ZQQ6   A0A154PS86   A0A2B4SJ31   I3J2P3   A0A0P7ZGZ3   A0A1S3Q1T8   A0A3Q2WL22   A0A3Q3E9N2   A0A3P9B7J6   A0A3P8Q727   A0A0L0BXI8   A0A1W4ZZV0   A0A3Q3S8C4   A0A3B4XX16   A0A3P8WN64   A0A3B4D0J0   A0A087ZZ64   W5MPZ7   A0A3B1JNL5   A0A2A3EH65   A0A3P9KA90   A0A345DKR8   A0A1S3Q1U6   A0A3Q1IFL4   A0A1I8JIJ6   A0A0L8FSR6   A0A1I8I6G0   A0A288W1R9  

PDB

3OZ6     E-value=6.03975e-77,     Score=730

KEGG

101741529    K19603 mitogen-activated protein kinase 15 [EC:2.7.11.24] | (RefSeq) extracellular signal-regulated

GO

GO:0004707   GO:0005524   GO:0004672   GO:0010468   GO:0035556   GO:0005634   GO:0005737   GO:0006468   GO:0019012   GO:0007165   GO:0005525   GO:0008033   GO:0003676   GO:0016787  

Length:

279

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.31387

Exp number, first 60 AAs:

0

Total prob of N-in:

0.39648

outside

1  -  279

 

 

Pi

302.651714

Theta

160.254354

Tajima's D

2.010877

CLR

0.271487

CSRT

0.88155592220389

Interpretation

Uncertain