Gene

KWMTBOMO12171  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004224

Annotation

PREDICTED:_GMP_reductase_1-like_[Papilio_polytes]

Location

Bomo_Chr20(-):8740015-8755499      View in EpiBrowser

Full name

GMP reductase       + More
GMP reductase 1      

Alternative Name

Guanosine 5'-monophosphate oxidoreductase
Guanosine 5'-monophosphate oxidoreductase 1

Location in the cell

Cytoplasmic   Reliability : 2.265

CDS

ATGCCTAACATTATAAATGAAGTTAAATTGGATTTCAAGGACGTCCTTTTGCGACCCAAACGGAGCACGTTAAAAAGCAGAAATGACGTCGATTTGTACCGGGAGATCACGTTCAAGAATTCAGGGCAGACGTACCGAGGTGTCCCGGTAATGGCGAGCAACATGGACACCGTCGGCACCTTCGAAATGGCGCAGGAGTTATCGAAGCACGGACTCTTCACTTGCATACACAAGTACTACTCGGCCGAGGACTGGAAGAAGTTTTCTGATGCGCATCCAGAATGCTTGGAGCAAATGGCCGCGAGCTCTGGAACCGCGGAGGCTGACTTCGAGCGTCTCACGGAGATCCTGAAGACGGTCGCCGACATCAAGTTCATCTGTCTGGACGTGGCGAATGGGTATTCTCAGCACTTCGTCGAGTACGTCCGGAGGGTTCGGGCTGCCTTCCCGAAGCACACTATCATTGCAGGTAACGTGGTGACCGGTGAAATGGTCGAGGAGTTGATTCTATCCGGAGCTGATATCATCAAGGTTGGTATCGGCCCGGGATCAGTCTGTACGACCCGTATCAAGACCGGCGTGGGGTATCCGCAGCTATCAGCCGTCATCGAATGCGCTGACGCTGCCCACGGCCTCAAAGGACATATTATATCGGACGGGGGCTGCACCTGTCCTGGGGATGTGGCGAAGGCGTTCGGAGCGGGGGCCGACTTCGTGATGGCTGGCGGCATGTTCGCGGGCCACGACCAGTGCGGGGGCGACGTCGTCACGCATCCCGACGGGAGGAAGGTCAAGCTTTTCTACGGGATGTCGTCCTCCACCGCCATGCTGAAGCATTCCGGAGGGGTCGCTGACTACAGGTCCTCCGAAGGTAAAACCGTTGAAGTGGAATACCGGGGTGACGTTGCGATAACGGTCAAGGATATTCTGGGTGGTCTCAGGTCGGCCTGCACTTACGTGGGAGCGGCAAGGCTCAGGGAATTACCCCGTAGAGCCACCTTCATCCGGTGCTGCAGACAGGTCAACGACACCTTCTCTTAA

Protein

MPNIINEVKLDFKDVLLRPKRSTLKSRNDVDLYREITFKNSGQTYRGVPVMASNMDTVGTFEMAQELSKHGLFTCIHKYYSAEDWKKFSDAHPECLEQMAASSGTAEADFERLTEILKTVADIKFICLDVANGYSQHFVEYVRRVRAAFPKHTIIAGNVVTGEMVEELILSGADIIKVGIGPGSVCTTRIKTGVGYPQLSAVIECADAAHGLKGHIISDGGCTCPGDVAKAFGAGADFVMAGGMFAGHDQCGGDVVTHPDGRKVKLFYGMSSSTAMLKHSGGVADYRSSEGKTVEVEYRGDVAITVKDILGGLRSACTYVGAARLRELPRRATFIRCCRQVNDTFS

Description

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.

Catalytic Activity

IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH

Subunit

Homotetramer.

Similarity

Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.

Keywords

3D-structure   Complete proteome   Metal-binding   NADP   Oxidoreductase   Polymorphism   Potassium   Purine metabolism   Reference proteome  

Feature

chain  GMP reductase 1
sequence variant  In dbSNP:rs760571328.

Uniprot

A0A194QVZ4   A0A2H1WGX5   A0A2W1BDW7   A0A2J7RGM2   A0A232FK85   K7IWB2   + More
A0A1B6K6Q4   A0A1B6LHH5   A0A1B6FBG5   A0A026WM14   A0A067RNR4   A0A154PIN5   A0A0L7QUN6   A0A158NXK9   A0A195ECT7   D6WQX7   J3JUE9   A0A1B6DSF6   E2B9Y1   A0A195FG41   A0A151WKS8   A0A151IM51   A0A195BME9   A0A2P8XUU9   A0A1Y1JTS6   A0A087ZPR9   A0A310S5E2   A0A194QGY0   A0A2A3EJA7   A0A2H1W6U6   A0A0J7L133   H3AAS2   A0A1U7S9G1   A0A091G9F3   A0A1V4JWY3   V9KMB0   A0A0Q3W2V1   A0A0A0ADM2   A0A093GEX8   A0A3B5BHR0   A0A226PY05   W5M4Y6   A0A2K6EE90   A0A091I7M8   R4GLI2   A0A3Q1FEY0   A0A3Q3BK73   A0A3Q4MR02   V9L1T4   A0A3P8Q050   A0A3P9B3U6   A9JRK1   A0A2K6KYI3   A0A2K6R144   A0A3Q1BG06   A0A3P8SW03   G3QNH0   G1QJZ0   A0A2K5Z147   Q5RCX6   H2QSC0   E9GCV2   A0A087QRC5   A0A2K6DKX7   A0A2K5W3H2   A0A0D9R5G2   A0A096NL36   A0A2K5LI68   G7MQS5   A0A2A4J468   A0A0P5ZSV4   A0A3Q3MDJ4   A0A1W4Y388   A0A3B4XN13   A0A3B4G113   A0A099ZAN5   A0A218UVA4   A0A1S3Q185   H0Z6I8   A0A1U7QHT1   P36959   A0A3Q2EKA7   A0A3N0XZ93   Q5ZJA6   A0A1U7SJF9   J3SEG5   A0A164XSN8   A0A1L8FY48   H0WTF3   A0A1S3AR67   U3FFQ5   A0A087Y8Y9   A0A1S3GD02   A0A250XYY4   A0A2K5JAW0   A0A3Q1IH16   A0A3Q3GLL9   A0A0B8RSK6   I3M4S5   A0A0B8RRI8  

EC Number

1.7.1.7

Pubmed

26354079    28756777    28648823    20075255    24508170    30249741    + More
24845553    21347285    18362917    19820115    22516182    23537049    20798317    29403074    28004739    9215903    24402279    24621616    15592404    25186727    25362486    16136131    21292972    17431167    22002653    25319552    20360741    2758468    1661705    14574404    15489334    2570640    1694726    21269460    1757097    15642098    23025625    27762356    25243066    28087693    25727380    25476704   

EMBL

KQ461181    KPJ07736.1    ODYU01008278    SOQ51724.1    KZ150228    PZC72035.1    + More
NEVH01003767    PNF39973.1    NNAY01000110    OXU30878.1    GECU01002113    GECU01000576    JAT05594.1    JAT07131.1    GEBQ01016832    JAT23145.1    GECZ01022516    JAS47253.1    KK107168    QOIP01000001    EZA56124.1    RLU26881.1    KK852513    KDR22245.1    KQ434910    KZC11344.1    KQ414731    KOC62362.1    ADTU01003136    ADTU01003137    KQ979074    KYN22926.1    KQ971351    EFA06520.1    APGK01035338    APGK01035339    BT126862    KB740923    AEE61824.1    ENN78280.1    GEDC01008687    JAS28611.1    GL446610    EFN87499.1    KQ981610    KYN39331.1    KQ983001    KYQ48446.1    KQ977063    KYN05960.1    KQ976441    KYM86425.1    PYGN01001311    PSN35783.1    GEZM01103141    JAV51528.1    KQ769958    OAD52714.1    KQ459053    KPJ04195.1    KZ288227    PBC31778.1    ODYU01006714    SOQ48809.1    LBMM01001331    KMQ96497.1    AFYH01135824    AFYH01135825    AFYH01135826    AFYH01135827    AFYH01135828    AFYH01135829    AFYH01135830    AFYH01135831    AFYH01135832    AFYH01135833    KL447914    KFO78588.1    LSYS01005643    OPJ76651.1    JW866745    AFO99262.1    LMAW01000519    KQL36181.1    KL871647    KGL92604.1    KL215560    KFV65482.1    AWGT02000003    OXB84534.1    AHAT01012206    KL218247    KFP03458.1    AADN05000024    JW872687    AFP05205.1    BC155691    BC171050    BC171052    AAI55692.1    AAI71050.1    CABD030043462    CABD030043463    CABD030043464    CABD030043465    ADFV01015818    ADFV01015819    ADFV01015820    ADFV01015821    ABGA01379736    ABGA01379737    ABGA01379738    ABGA01379739    ABGA01379740    ABGA01379741    ABGA01379742    ABGA01379743    ABGA01379744    ABGA01379745    CR858142    NDHI03003384    CAH90381.1    PNJ71228.1    AACZ04065895    AACZ04065896    GABC01003589    GABF01009872    GABD01006765    GABE01008195    NBAG03000244    JAA07749.1    JAA12273.1    JAA26335.1    JAA36544.1    PNI62755.1    GL732539    EFX82619.1    KL225831    KFM03779.1    AQIA01052657    AQIB01159418    AQIB01159419    AQIB01159420    AHZZ02024189    JSUE03030326    JSUE03030327    JU334057    JV046791    CM001256    AFE77812.1    AFI36862.1    EHH17971.1    NWSH01003461    PCG66240.1    GDIP01043217    GDIP01010134    GDIQ01053583    JAM60498.1    JAN41154.1    KL891474    KGL78836.1    MUZQ01000118    OWK57734.1    ABQF01024106    ABQF01024107    L35304    M27941    M24470    AL009031    AL138883    BC008281    RJVU01057109    ROK35794.1    AJ720528    CAG32187.1    JU174680    GBEX01001401    AFJ50206.1    JAI13159.1    LRGB01000944    KZS14533.1    CM004476    OCT76499.1    AAQR03055864    GAMT01008484    GAMS01000699    GAMR01003206    GAMQ01001915    GAMP01009791    JAB03377.1    JAB22437.1    JAB30726.1    JAB39936.1    JAB42964.1    AYCK01002783    GFFV01003367    JAV36578.1    GBKC01001555    GBKD01000941    JAG46677.1    AGTP01056379    AGTP01056380    AGTP01056381    GBSH01001185    JAG67840.1   

Proteomes

UP000053240    UP000235965    UP000215335    UP000002358    UP000053097    UP000279307    + More
UP000027135    UP000076502    UP000053825    UP000005205    UP000078492    UP000007266    UP000019118    UP000008237    UP000078541    UP000075809    UP000078542    UP000078540    UP000245037    UP000005203    UP000053268    UP000242457    UP000036403    UP000008672    UP000189705    UP000053760    UP000190648    UP000051836    UP000053858    UP000053875    UP000261400    UP000198419    UP000018468    UP000233160    UP000054308    UP000000539    UP000257200    UP000264840    UP000261580    UP000265100    UP000265160    UP000233180    UP000233200    UP000257160    UP000265080    UP000001519    UP000001073    UP000233140    UP000001595    UP000002277    UP000000305    UP000053286    UP000233120    UP000233100    UP000029965    UP000028761    UP000233060    UP000006718    UP000218220    UP000261640    UP000192224    UP000261360    UP000261460    UP000053641    UP000197619    UP000087266    UP000007754    UP000189706    UP000005640    UP000265020    UP000076858    UP000186698    UP000005225    UP000079721    UP000008225    UP000028760    UP000081671    UP000233080    UP000265040    UP000261660    UP000005215   

PRIDE

A0A087ZPR9    P36959   

Pfam

PF00478   IMPDH

Interpro

IPR013785   Aldolase_TIM        + More
IPR015875   IMP_DH/GMP_Rdtase_CS       
IPR001093   IMP_DH_GMPRt       
IPR005993   GMPR       

Gene 3D

3.20.20.70    

CDD

cd00381  IMPDH

ProteinModelPortal

A0A194QVZ4   A0A2H1WGX5   A0A2W1BDW7   A0A2J7RGM2   A0A232FK85   K7IWB2   + More
A0A1B6K6Q4   A0A1B6LHH5   A0A1B6FBG5   A0A026WM14   A0A067RNR4   A0A154PIN5   A0A0L7QUN6   A0A158NXK9   A0A195ECT7   D6WQX7   J3JUE9   A0A1B6DSF6   E2B9Y1   A0A195FG41   A0A151WKS8   A0A151IM51   A0A195BME9   A0A2P8XUU9   A0A1Y1JTS6   A0A087ZPR9   A0A310S5E2   A0A194QGY0   A0A2A3EJA7   A0A2H1W6U6   A0A0J7L133   H3AAS2   A0A1U7S9G1   A0A091G9F3   A0A1V4JWY3   V9KMB0   A0A0Q3W2V1   A0A0A0ADM2   A0A093GEX8   A0A3B5BHR0   A0A226PY05   W5M4Y6   A0A2K6EE90   A0A091I7M8   R4GLI2   A0A3Q1FEY0   A0A3Q3BK73   A0A3Q4MR02   V9L1T4   A0A3P8Q050   A0A3P9B3U6   A9JRK1   A0A2K6KYI3   A0A2K6R144   A0A3Q1BG06   A0A3P8SW03   G3QNH0   G1QJZ0   A0A2K5Z147   Q5RCX6   H2QSC0   E9GCV2   A0A087QRC5   A0A2K6DKX7   A0A2K5W3H2   A0A0D9R5G2   A0A096NL36   A0A2K5LI68   G7MQS5   A0A2A4J468   A0A0P5ZSV4   A0A3Q3MDJ4   A0A1W4Y388   A0A3B4XN13   A0A3B4G113   A0A099ZAN5   A0A218UVA4   A0A1S3Q185   H0Z6I8   A0A1U7QHT1   P36959   A0A3Q2EKA7   A0A3N0XZ93   Q5ZJA6   A0A1U7SJF9   J3SEG5   A0A164XSN8   A0A1L8FY48   H0WTF3   A0A1S3AR67   U3FFQ5   A0A087Y8Y9   A0A1S3GD02   A0A250XYY4   A0A2K5JAW0   A0A3Q1IH16   A0A3Q3GLL9   A0A0B8RSK6   I3M4S5   A0A0B8RRI8  

PDB

2BWG     E-value=1.96092e-151,     Score=1373

KEGG

101741248    K00364 GMP reductase [EC:1.7.1.7] | (RefSeq) GMP reductase 1-like

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0046872   GO:0006163   GO:1902560   GO:0006144   GO:0003920   GO:0009117   GO:0015951   GO:0043101   GO:0005829   GO:0009409   GO:0003824   GO:0016491   GO:0019012   GO:0007165   GO:0005525   GO:0008033   GO:0003676   GO:0016787   GO:0055114  

Length:

346

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00521000000000001

Exp number, first 60 AAs:

0.0005

Total prob of N-in:

0.01153

outside

1  -  346

 

 

Pi

333.635506

Theta

152.815764

Tajima's D

1.492224

CLR

0.647204

CSRT

0.785310734463277

Interpretation

Uncertain