Gene

KWMTBOMO12168  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA014058

Annotation

PREDICTED:_protein_TSSC1_[Papilio_polytes]

Location

Bomo_Chr20(-):8645936-8656066      View in EpiBrowser

Full name

EARP and GARP complex-interacting protein 1      

Alternative Name

Endosome-associated recycling protein-interacting protein
Golgi-associated retrograde protein-interacting protein
Tumor-suppressing STF cDNA 1 protein
Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein

Location in the cell

Nuclear   Reliability : 2.778

CDS

ATGGAGGATGGAAACTCCATCATATACGGACTTGAGCATCAGACTAGATCGTTATCACCACAATATGCTGAAAGTGAGGCAATAAGGTTCTTGATTGGCACACAGAGCCTCAAACCGAACTCGAACCAAGTACATGTTGTTGAGTTAGAGGAAGATACTGGAGCCTTGCATACTAAGGTCTTCAAACATGACATCGGAGAGATATGGCACCTTCGTTGTTCACCACATGATGCTGCTAATCTCGTCACAACTCATAACACCTATGACCCTAATACCTTGCAGTGCACTATGGGGGTATCTATCTTCAAGCTTCCTACATTACAAGTCATTCCCAAGGATCTGGACGAATTAAGCTCATTACAAGGACGTAATGCTGAAGACTTGGAATTACTAGTAACCATTAAACCAGAGAAGGCCGAAGAGGAGATCCGTTGCGCTGAGTGGCATCCTACGGACGCGGGGCGCTTGGGTGTCGTATACGAGTCCAGCGTGAGGGTACACGACGTGAGCTCTGGAGCTGCGGTGTGCAGCATGAAATCTGACGGTCGGACCAGGCTCAAGCTCACCGCCGGCAAGTGGAACCCGCATCAAGGTCACACTCAGTTTGCTGTTCTGCAAGATATGCACATAAAATGCTTCGACACGCGCACTGACTGCTCGAAACCATCTTGGAGCATAGACAACGCGCATAGACAATTAGTTCGGGATCTAGACTTCAATCCGAATCGCCAGTTCCACCTGGCCAGCGCGGGTGATGACGCAGCGCTGAACATATGGGACTATAGGAACGGGAAAGAGCCTATATTCAACAGAACCGATCACTCTCACTGGGTGTGGACGGTAAGATACAACAGCTACCACGAACAGTTACTGTTGACTGGCAGCTCGGATGGTCGGGGCTTGTTGTACGCGGCCGCTAGCATCTGCCGCGACCCGGACGACGATAGCGAAAAGACCGGGAAAATTTTAGAGGACGGCGTGCTGCAGTCCTACGAGCAGCACGAAGACTCCGTGTACTGTAGTGAGTGGAGCACCGTGGAGCCCTGGACCTTCGCCTCTCTCAGCTACGATGCGAGGCTGGTCATCTCGCGAGTCCCTCGACCGTTCAAATACAAACTTCTACTGTGA

Protein

MEDGNSIIYGLEHQTRSLSPQYAESEAIRFLIGTQSLKPNSNQVHVVELEEDTGALHTKVFKHDIGEIWHLRCSPHDAANLVTTHNTYDPNTLQCTMGVSIFKLPTLQVIPKDLDELSSLQGRNAEDLELLVTIKPEKAEEEIRCAEWHPTDAGRLGVVYESSVRVHDVSSGAAVCSMKSDGRTRLKLTAGKWNPHQGHTQFAVLQDMHIKCFDTRTDCSKPSWSIDNAHRQLVRDLDFNPNRQFHLASAGDDAALNIWDYRNGKEPIFNRTDHSHWVWTVRYNSYHEQLLLTGSSDGRGLLYAAASICRDPDDDSEKTGKILEDGVLQSYEQHEDSVYCSEWSTVEPWTFASLSYDARLVISRVPRPFKYKLLL

Description

Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex.

Subunit

Interacts with two multisubunit tethering complexes: EARP composed of VPS50, VPS51, VPS52 and VPS53 subunits and GARP complex composed of VPS51, VPS52, VPS53 and VPS54 subunits (PubMed:27440922, PubMed:27191843). Interacts with SNAP29 (PubMed:27191843).

Similarity

Belongs to the ubiquitin-conjugating enzyme family.
Belongs to the WD repeat EIPR1 family.

Keywords

Acetylation   Complete proteome   Golgi apparatus   Phosphoprotein   Reference proteome   Repeat   WD repeat  

Feature

chain  EARP and GARP complex-interacting protein 1

Uniprot

H9JWZ3   A0A194QQE8   I4DKH7   A0A2A4J2Z8   S4P9T8   A0A212EUR7   + More
A0A067QNQ0   A0A1B6D331   A0A2J7RT27   A0A154PQL2   K7IW93   A0A232EQT6   D6WQQ0   A0A2A3EBC0   A0A1Y1M0C4   B0WT72   A0A023ERW9   A0A195EV22   A0A088AI53   U4UEK7   A0A1B6JMN9   E2A8P6   J3JYF9   A0A1B6EVA5   A0A158NXP2   A0A0L7QVC1   A0A1Q3F9N8   A0A182PL91   A0A182UTC8   A0A182X8L3   A0A182I159   A0A182UJ44   Q7Q5S1   E2BS59   A0A0M4EQ47   Q174Z6   A0A182T6D3   A0A0A1WKG5   A0A0A1WG72   A0A151WPS2   A0A1W4X8K9   A0A1L8DAV6   A0A2M4CN24   A0A182WLS1   A0A034WB22   A0A1I8MEP6   A0A182JSS2   W5JNC9   A0A0K8UHL4   A0A182QJW5   A0A182N945   A0A026WM61   E0W0H0   A0A1V4JNA6   W8C1R1   A0A182J954   A0A182MA13   A0A093GEA9   A0A084VDN9   A0A0L0CCX6   A0A182R8S0   U3JH87   K7F499   B3MB17   F1NN26   A0A091F515   A0A182FHQ9   A0A1I8PWY2   A0A218VD19   A0A1U7S1Z7   A0A195B0K1   A0A0Q3R2H2   A0A2K6ETW8   H2ZZS9   A0A3Q7NZ65   A0A1S3G6M9   A0A3Q7WLH7   W5NKX5   V9KNG9   A0A250YGY2   A0A1U7TTX4   B4L0R4   A0A2Y9QXF5   Q5PPK9   A0A384BPQ2   A0A1W4UUX3   G3N094   G3I3C2   G1KEQ7   A0A1U7QMG8   A0A1S2ZGE2   F7BHT8   M3WAK8   A0A2L2YH41   A0A3B0KNK6   A0A1B0C5B5   A0A0J7KXJ2  

Pubmed

19121390    26354079    22651552    23622113    22118469    24845553    + More
20075255    28648823    18362917    19820115    28004739    24945155    23537049    20798317    22516182    21347285    12364791    14747013    17210077    17510324    25830018    25348373    25315136    20920257    23761445    24508170    30249741    20566863    24495485    24438588    26108605    17381049    17994087    15592404    9215903    24402279    28087693    15489334    27440922    27191843    24813606    19393038    21804562    19892987    17975172    26561354   

EMBL

BABH01041746    BABH01041747    KQ461181    KPJ07733.1    AK401795    KQ459053    + More
BAM18417.1    KPJ04191.1    NWSH01003461    PCG66249.1    GAIX01003584    JAA88976.1    AGBW02012313    OWR45235.1    KK853131    KDR10922.1    GEDC01017197    JAS20101.1    NEVH01000249    PNF43990.1    KQ435043    KZC14191.1    NNAY01002716    OXU20708.1    KQ971354    EFA07641.1    KZ288293    PBC29025.1    GEZM01044862    JAV78080.1    DS232080    EDS34215.1    GAPW01002147    JAC11451.1    KQ981958    KYN32001.1    KB632287    ERL91467.1    GECU01007354    JAT00353.1    GL437663    EFN70125.1    BT128285    AEE63245.1    GECZ01027907    JAS41862.1    ADTU01003272    ADTU01003273    KQ414731    KOC62416.1    GFDL01010789    JAV24256.1    APCN01000031    AAAB01008960    EAA11588.1    GL450151    EFN81451.1    CP012525    ALC44342.1    CH477404    EAT41635.1    GBXI01015267    JAC99024.1    GBXI01016263    JAC98028.1    KQ982851    KYQ49866.1    GFDF01010481    JAV03603.1    GGFL01002120    MBW66298.1    GAKP01007627    JAC51325.1    ADMH02001054    ETN64279.1    GDHF01026132    JAI26182.1    AXCN02000488    KK107168    QOIP01000001    EZA56194.1    RLU26720.1    DS235858    EEB19126.1    LSYS01006902    OPJ73525.1    GAMC01000803    JAC05753.1    AXCM01000856    KL216220    KFV68565.1    ATLV01011632    KE524705    KFB36083.1    JRES01000577    KNC30100.1    AGTO01010631    AGTO01020751    AGCU01012861    AGCU01012862    AGCU01012863    AGCU01012864    AGCU01012865    AGCU01012866    AGCU01012867    AGCU01012868    AGCU01012869    AGCU01012870    CH902618    EDV40283.1    AADN05000003    KK719741    KFO65233.1    MUZQ01000008    OWK63786.1    KQ976692    KYM77729.1    LMAW01002578    KQK79601.1    AFYH01173064    AFYH01173065    AFYH01173066    AFYH01173067    AFYH01173068    AFYH01173069    AFYH01173070    AFYH01173071    AFYH01173072    AFYH01173073    AHAT01032617    AHAT01032618    JW867629    AFP00147.1    GFFW01001881    JAV42907.1    CH933809    EDW18141.1    BC087633    JH001181    EGW10647.1    AANG04003329    IAAA01026590    IAAA01026591    IAAA01026592    IAAA01026593    IAAA01026594    LAA07357.1    OUUW01000012    SPP87436.1    JXJN01025926    LBMM01002304    KMQ95013.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000007151    UP000027135    + More
UP000235965    UP000076502    UP000002358    UP000215335    UP000007266    UP000242457    UP000002320    UP000078541    UP000005203    UP000030742    UP000000311    UP000005205    UP000053825    UP000075885    UP000075903    UP000076407    UP000075840    UP000075902    UP000007062    UP000008237    UP000092553    UP000008820    UP000075901    UP000075809    UP000192223    UP000075920    UP000095301    UP000075881    UP000000673    UP000075886    UP000075884    UP000053097    UP000279307    UP000009046    UP000190648    UP000075880    UP000075883    UP000053875    UP000030765    UP000037069    UP000075900    UP000016665    UP000007267    UP000007801    UP000000539    UP000052976    UP000069272    UP000095300    UP000197619    UP000189705    UP000078540    UP000051836    UP000233160    UP000008672    UP000286641    UP000081671    UP000286642    UP000018468    UP000189704    UP000009192    UP000248480    UP000002494    UP000261680    UP000291021    UP000192221    UP000009136    UP000001075    UP000001646    UP000189706    UP000079721    UP000002281    UP000011712    UP000268350    UP000092460    UP000036403   

PRIDE

H9JWZ3    Q5PPK9    G3I3C2   

Pfam

PF00400   WD40        + More
PF00179   UQ_con

Interpro

IPR001680   WD40_repeat        + More
IPR017986   WD40_repeat_dom       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR036322   WD40_repeat_dom_sf       
IPR040323   EIPR1       
IPR019775   WD40_repeat_CS       
IPR016135   UBQ-conjugating_enzyme/RWD       
IPR000608   UBQ-conjugat_E2       
IPR023313   UBQ-conjugating_AS       

SUPFAM

SSF50978   SSF50978        + More
SSF54495   SSF54495       

Gene 3D

2.130.10.10     3.10.110.10    

CDD

cd00195  UBCc

ProteinModelPortal

H9JWZ3   A0A194QQE8   I4DKH7   A0A2A4J2Z8   S4P9T8   A0A212EUR7   + More
A0A067QNQ0   A0A1B6D331   A0A2J7RT27   A0A154PQL2   K7IW93   A0A232EQT6   D6WQQ0   A0A2A3EBC0   A0A1Y1M0C4   B0WT72   A0A023ERW9   A0A195EV22   A0A088AI53   U4UEK7   A0A1B6JMN9   E2A8P6   J3JYF9   A0A1B6EVA5   A0A158NXP2   A0A0L7QVC1   A0A1Q3F9N8   A0A182PL91   A0A182UTC8   A0A182X8L3   A0A182I159   A0A182UJ44   Q7Q5S1   E2BS59   A0A0M4EQ47   Q174Z6   A0A182T6D3   A0A0A1WKG5   A0A0A1WG72   A0A151WPS2   A0A1W4X8K9   A0A1L8DAV6   A0A2M4CN24   A0A182WLS1   A0A034WB22   A0A1I8MEP6   A0A182JSS2   W5JNC9   A0A0K8UHL4   A0A182QJW5   A0A182N945   A0A026WM61   E0W0H0   A0A1V4JNA6   W8C1R1   A0A182J954   A0A182MA13   A0A093GEA9   A0A084VDN9   A0A0L0CCX6   A0A182R8S0   U3JH87   K7F499   B3MB17   F1NN26   A0A091F515   A0A182FHQ9   A0A1I8PWY2   A0A218VD19   A0A1U7S1Z7   A0A195B0K1   A0A0Q3R2H2   A0A2K6ETW8   H2ZZS9   A0A3Q7NZ65   A0A1S3G6M9   A0A3Q7WLH7   W5NKX5   V9KNG9   A0A250YGY2   A0A1U7TTX4   B4L0R4   A0A2Y9QXF5   Q5PPK9   A0A384BPQ2   A0A1W4UUX3   G3N094   G3I3C2   G1KEQ7   A0A1U7QMG8   A0A1S2ZGE2   F7BHT8   M3WAK8   A0A2L2YH41   A0A3B0KNK6   A0A1B0C5B5   A0A0J7KXJ2  

PDB

5Y1U     E-value=4.45822e-10,     Score=155

KEGG

101745767    K23289 EARP and GARP complex-interacting protein 1 | (RefSeq) protein TSSC1

GO

GO:0016567   GO:0004402   GO:0016740   GO:0005524   GO:0005802   GO:1905281   GO:2001137   GO:0005515   GO:0003676   GO:0006750   GO:0016874   GO:0019012   GO:0007165   GO:0005525   GO:0008033   GO:0016787  

PANTHER

PTHR14205  

Subcellular location

  

Length:

375

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00039

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00745

outside

1  -  375

 

 

Pi

190.420347

Theta

163.853732

Tajima's D

0.814517

CLR

0.013864

CSRT

0.606369681515924

Interpretation

Uncertain