Gene

KWMTBOMO12165  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA014063

Annotation

PREDICTED:_glutathione_synthetase-like_isoform_X2_[Amyelois_transitella]

Location

Bomo_Chr20(+):8601807-8629745      View in EpiBrowser

Full name

Glutathione synthetase      

Location in the cell

Cytoplasmic   Reliability : 2.01

CDS

ATGTCACAAGCAAGATTAGCGCCGTGCCTTCAGTTGCCTTTAGAAAACAAAACGTTAGTGAACGTGATTGAGAAAGCCAAGGACTGGGCCCTCATGCATGGTGTTGGTATGAGGGACAAGAAGCATTTCAACAAAGACGTAATTCAGATTGCACCATTTATACTGTTACCGTCACCTTTTCCAAAGACCGAATTTATGAAGGCGGTTGAACTACAGCCAGTTTTGAATGAACTCATGCATAAGGTCGCCCATGATGATGAATTCTTGGAGCAAACTTTGCAGAATGCTCTACAAGTAGATGAGTTCACAGCAAATTTGTATGACATATGGTTGAAAGTGAAAAACGAGGGCATATCTCAATCGCTCAGCCTTGGATTGTTCCGTTCGGATTATCTGCTGCAACACCCAGACGGGAATGTGTTAAAGCAAGTCGAGTTTAACACGATAGCGTCGAGTTTCGGTGCCATAACGTCGCATCTGCCCAACATGTCTCGTTACATCCTAAGGCAATTAGGTCACGGCGATCTGATTAAGAATATGCCGGAAAACCGGGCATTGTCCGGTTTATGCTCTGGGATCATAGAAGCGTTCGATTTGTTTGGCGTCCTCAACGCAGTGGTGCTGTTTGTTGTCGAGGAAGTGTCCTACAATATATGCGACCAGAGGTTCCACGAGTTCGAGATATCGGAGAAACGGCCCGAGATACAGATTTATAGAAAAACCTTAAACGAAATTTACGAGGAGACCGAACTGAACGACAAGAAGCAACTGATATTGGACGGTCATCCCGTAGCAGTCGTTTACTACAGATCAGGGTACGAGCCGGCTCAGTACCCCACCGCAAGGGAATGGGATGCGAGATTACGCGTCGAAAGATCCACGGCCATAAAATGTCCATCGATCCACTACCAACTGGCGGGAACGAAGAAGGTCCAACAAGCCCTGGCCGGTCCCGGGGTGCTGGAGAAGTTCATGGGCTCCGGGACGAGCACCTCTCGCGTCCGGGATATATTCACGGGACTGTACTCGCTGGACTTCGACGAGAGCGGCGAGAGAGCAGTGGAGATGGCACTGGCCGATGCCGAGAGATTCGTATTGAAGCCTCAAAGGGAAGGTGGCGGGAATAATGTGTACGGTTCGGAAGTGAGGGACGCGTTGACTCGCATGCGACACAGCCGGGAGCGAGCCGCGTACATACTGATGGAGAGGATATTGCCGCCTCTGATAATGTTAAACTGTTACCGCAACTATGAGTTCCTGTCCATCTTAAGAGATAACTCGAGTCTTTTGTATCAGGGTACATGA

Protein

MSQARLAPCLQLPLENKTLVNVIEKAKDWALMHGVGMRDKKHFNKDVIQIAPFILLPSPFPKTEFMKAVELQPVLNELMHKVAHDDEFLEQTLQNALQVDEFTANLYDIWLKVKNEGISQSLSLGLFRSDYLLQHPDGNVLKQVEFNTIASSFGAITSHLPNMSRYILRQLGHGDLIKNMPENRALSGLCSGIIEAFDLFGVLNAVVLFVVEEVSYNICDQRFHEFEISEKRPEIQIYRKTLNEIYEETELNDKKQLILDGHPVAVVYYRSGYEPAQYPTAREWDARLRVERSTAIKCPSIHYQLAGTKKVQQALAGPGVLEKFMGSGTSTSRVRDIFTGLYSLDFDESGERAVEMALADAERFVLKPQREGGGNNVYGSEVRDALTRMRHSRERAAYILMERILPPLIMLNCYRNYEFLSILRDNSSLLYQGT

Catalytic Activity

ATP + glycine + L-gamma-glutamyl-L-cysteine = ADP + glutathione + H(+) + phosphate

Cofactor

Mg(2+)

Similarity

Belongs to the eukaryotic GSH synthase family.

Uniprot

A0A2A4J2G3   A0A194QF66   A0A212F397   A0A2W1BGT3   A0A2A4J415   A0A2J7QQS3   + More
A0A2J7QQR6   A0A067R1Y6   A0A1B6GW61   A0A1B6JW55   A0A1B6KF67   A0A1Y1MFP8   A0A2J7QQS8   E0VGR8   A0A1L8E4J2   A0A1L8E4X9   A0A1B6I2J5   A0A1B6KYF4   A0A1S4FLG0   A0A034VWQ2   A0A0K8W8J6   W8BQV4   A0A0K8WE26   Q0IEN8   A0A0A1WFR1   V5G3N6   D6WQX3   A0A182QKC0   A0A1B6DNJ1   A0A182YQ41   U5ELQ8   A0A182M9J9   A0A2M4CU33   A0A182FK64   A0A2M4CUL3   B4N2I6   A0A2M4BJB9   A0A0Q9XR59   A0A182R9J8   A0A0Q9WDC5   B4Q2L9   A0A2M4BJ18   Q8IQZ1   A0A1Q3FKE7   A0A182GPT4   A0A034VXC9   A0A0K8W5V0   A0A0P8Y7R5   A0A2M3Z7V9   A0A182G4R2   A0A3B0JYS9   W8BQV8   A0A1W4UNP9   A0A1S4FLG8   A0A0P4WD75   A0A1I8MZ23   A0A182NGR7   A0A2M4AG29   A0A2M4AF47   A0A0R3P3X4   T1P8D2   A0A087ZPS0   A0A0A1WJ57   A0A2M4AFW1   A3FP35   Q0IEN7   A0A151WPW9   A0A1B0GKG1   A0A2P8Z572   A0A2J7QQR4   N6T2J5   A0A1I8PQ94   A0A336KCW9   J9K9I3   A0A0N8D3U9   A0A0N8AT51   A0A2S2NDK9   A0A2S2PXG9   A0A195AZS9   A0A026WJF7   A0A158NXN2   A0A195EDS8   D3PGP0   A0A0M9A3K6   A0A0P4WKA9   A0A0K2V7T9   A0A0L7QUS2   A0A1Q3FKM0   A0A1Q3FKG7   A0A1B6DXB3   A0A084VVP0   A0A0P5PBR6   A0A0P6A6U2   B0WSC1   B4JM12   E1ZX19   A0A2A3EKR3  

EC Number

6.3.2.3

Pubmed

26354079    22118469    28756777    24845553    28004739    20566863    + More
25348373    24495485    17510324    25830018    18362917    19820115    25244985    17994087    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    26483478    25315136    15632085    29403074    23537049    24508170    21347285    24438588    20798317   

EMBL

NWSH01003461    PCG66255.1    KQ459053    KPJ04188.1    AGBW02010604    OWR48192.1    + More
KZ150228    PZC72026.1    PCG66254.1    NEVH01012083    PNF30934.1    PNF30929.1    KK853083    KDR11658.1    GECZ01003176    JAS66593.1    GECU01009641    GECU01004255    JAS98065.1    JAT03452.1    GEBQ01029880    JAT10097.1    GEZM01035036    GEZM01035035    JAV83420.1    PNF30932.1    DS235151    EEB12574.1    GFDF01000416    JAV13668.1    GFDF01000415    JAV13669.1    GECU01026548    GECU01008484    JAS81158.1    JAS99222.1    GEBQ01023546    JAT16431.1    GAKP01012421    GAKP01012420    JAC46532.1    GDHF01021447    GDHF01010891    GDHF01004853    JAI30867.1    JAI41423.1    JAI47461.1    GAMC01014651    GAMC01014649    GAMC01014648    GAMC01014647    JAB91904.1    GDHF01002898    JAI49416.1    CH477558    EAT39012.1    GBXI01016453    JAC97838.1    GALX01003831    JAB64635.1    KQ971351    EFA06494.1    AXCN02002156    GEDC01010066    JAS27232.1    GANO01001308    JAB58563.1    AXCM01005498    GGFL01004674    MBW68852.1    GGFL01004673    MBW68851.1    CH963925    EDW78575.1    GGFJ01003910    MBW53051.1    CH933812    KRG07057.1    CH940655    KRF82616.1    CM000162    EDX02660.1    GGFJ01003909    MBW53050.1    AE014298    EF419258    EF419259    EF419260    BT099771    AAN09449.2    ABN58453.1    ABN58454.1    ABN58455.1    ACV88430.1    ACZ95317.1    GFDL01007040    JAV28005.1    JXUM01079107    JXUM01079108    JXUM01079109    KQ563108    KXJ74450.1    GAKP01012422    GAKP01012418    JAC46530.1    GDHF01031183    GDHF01008041    GDHF01005731    JAI21131.1    JAI44273.1    JAI46583.1    CH902630    KPU77477.1    GGFM01003868    MBW24619.1    JXUM01144298    KQ569759    KXJ68522.1    OUUW01000003    SPP78839.1    GAMC01014650    GAMC01014646    JAB91909.1    GDRN01048220    JAI66668.1    GGFK01006419    MBW39740.1    GGFK01006021    MBW39342.1    CH379063    KRT06317.1    KA644887    AFP59516.1    GBXI01015193    JAC99098.1    GGFK01006281    MBW39602.1    EF419256    ABN58451.1    EAT39011.1    KQ982851    KYQ49880.1    AJWK01028824    AJWK01028825    PYGN01000190    PSN51649.1    PNF30928.1    APGK01054727    APGK01054728    KB741253    ENN71773.1    UFQS01000229    UFQT01000229    SSX01702.1    SSX22082.1    ABLF02026510    ABLF02026515    GDIP01071455    JAM32260.1    GDIQ01245451    GDIQ01149883    JAK06274.1    GGMR01002588    MBY15207.1    GGMS01000399    MBY69602.1    KQ976692    KYM77743.1    KK107168    EZA56177.1    ADTU01003246    KQ979074    KYN22999.1    BT120796    ADD24436.1    KQ435746    KOX76540.1    GDRN01048217    JAI66669.1    HACA01029014    CDW46375.1    KQ414731    KOC62360.1    GFDL01007012    JAV28033.1    GFDL01006968    JAV28077.1    GEDC01006980    JAS30318.1    ATLV01017200    KE525157    KFB42034.1    GDIQ01133034    GDIP01049157    LRGB01000872    JAL18692.1    JAM54558.1    KZS15426.1    GDIP01033904    JAM69811.1    DS232068    EDS33759.1    CH916371    EDV91773.1    GL434950    EFN74269.1    KZ288227    PBC31776.1   

Proteomes

UP000218220    UP000053268    UP000007151    UP000235965    UP000027135    UP000009046    + More
UP000008820    UP000007266    UP000075886    UP000076408    UP000075883    UP000069272    UP000007798    UP000009192    UP000075900    UP000008792    UP000002282    UP000000803    UP000069940    UP000249989    UP000007801    UP000268350    UP000192221    UP000095301    UP000075884    UP000001819    UP000005203    UP000075809    UP000092461    UP000245037    UP000019118    UP000095300    UP000007819    UP000078540    UP000053097    UP000005205    UP000078492    UP000053105    UP000053825    UP000030765    UP000076858    UP000002320    UP000001070    UP000000311    UP000242457   

PRIDE

A3FP35   

Pfam

PF03917   GSH_synth_ATP        + More
PF03199   GSH_synthase

Interpro

IPR005615   Glutathione_synthase        + More
IPR014042   Glutathione_synthase_a-hlx       
IPR004887   GSH_synth_subst-bd       
IPR016185   PreATP-grasp_dom_sf       
IPR014709   Glutathione_synthase_C_euk       
IPR037013   GSH-S_sub-bd_sf       
IPR014049   Glutathione_synthase_N_euk       

SUPFAM

SSF52440   SSF52440       

Gene 3D

1.10.1080.10     3.30.1490.50     3.30.1490.80     3.40.50.1760    

ProteinModelPortal

A0A2A4J2G3   A0A194QF66   A0A212F397   A0A2W1BGT3   A0A2A4J415   A0A2J7QQS3   + More
A0A2J7QQR6   A0A067R1Y6   A0A1B6GW61   A0A1B6JW55   A0A1B6KF67   A0A1Y1MFP8   A0A2J7QQS8   E0VGR8   A0A1L8E4J2   A0A1L8E4X9   A0A1B6I2J5   A0A1B6KYF4   A0A1S4FLG0   A0A034VWQ2   A0A0K8W8J6   W8BQV4   A0A0K8WE26   Q0IEN8   A0A0A1WFR1   V5G3N6   D6WQX3   A0A182QKC0   A0A1B6DNJ1   A0A182YQ41   U5ELQ8   A0A182M9J9   A0A2M4CU33   A0A182FK64   A0A2M4CUL3   B4N2I6   A0A2M4BJB9   A0A0Q9XR59   A0A182R9J8   A0A0Q9WDC5   B4Q2L9   A0A2M4BJ18   Q8IQZ1   A0A1Q3FKE7   A0A182GPT4   A0A034VXC9   A0A0K8W5V0   A0A0P8Y7R5   A0A2M3Z7V9   A0A182G4R2   A0A3B0JYS9   W8BQV8   A0A1W4UNP9   A0A1S4FLG8   A0A0P4WD75   A0A1I8MZ23   A0A182NGR7   A0A2M4AG29   A0A2M4AF47   A0A0R3P3X4   T1P8D2   A0A087ZPS0   A0A0A1WJ57   A0A2M4AFW1   A3FP35   Q0IEN7   A0A151WPW9   A0A1B0GKG1   A0A2P8Z572   A0A2J7QQR4   N6T2J5   A0A1I8PQ94   A0A336KCW9   J9K9I3   A0A0N8D3U9   A0A0N8AT51   A0A2S2NDK9   A0A2S2PXG9   A0A195AZS9   A0A026WJF7   A0A158NXN2   A0A195EDS8   D3PGP0   A0A0M9A3K6   A0A0P4WKA9   A0A0K2V7T9   A0A0L7QUS2   A0A1Q3FKM0   A0A1Q3FKG7   A0A1B6DXB3   A0A084VVP0   A0A0P5PBR6   A0A0P6A6U2   B0WSC1   B4JM12   E1ZX19   A0A2A3EKR3  

PDB

2HGS     E-value=2.33129e-84,     Score=796

KEGG

101745237    K21456 glutathione synthase [EC:6.3.2.3] | (RefSeq) glutathione synthetase-like

PATHWAY

00270    Cysteine and methionine metabolism - Bombyx mori (domestic silkworm)
00480    Glutathione metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0042803   GO:0043295   GO:0004363   GO:0000287   GO:0046872   GO:0005829   GO:0006750   GO:0016874   GO:0019012   GO:0007165   GO:0005525   GO:0008033   GO:0003676   GO:0016787  

PANTHER

PTHR11130  

Length:

434

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.35145

Exp number, first 60 AAs:

0.00576

Total prob of N-in:

0.01193

outside

1  -  434

 

 

Pi

237.119342

Theta

178.941865

Tajima's D

1.479685

CLR

0.48445

CSRT

0.783310834458277

Interpretation

Uncertain