Gene

KWMTBOMO12123  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004241

Annotation

PREDICTED:_exportin-2_[Papilio_xuthus]

Location

Bomo_Chr20(-):8009848-8021966      View in EpiBrowser

Full name

Exportin-2      

Alternative Name

Chromosome segregation 1-like protein
Importin-alpha re-exporter

Location in the cell

PlasmaMembrane   Reliability : 1.733

CDS

ATGCTGGAGAAGTACAGCGCGTCTGGCGGCGCGGAGTGGCGCGGCAAGGACGCGGCCGTGTACCTGGTGACGTCACTGGCGTCGCGCGGCGCCACGCTGGCGGCCGGCGTGACGCGCGCCTCCCCGCTCGTGGACCTGGGACAGTTCGCCGCCAACCACGCGCTGCCCGAGCTGCAGCGGCCCAACCTGAACGAGCTGCCGGTTCTGAAGGCGGACGCCATCAAGTTCCTGATGACGTTCAGGTCGCTTCTGCCCAACGAGCTACTGCTGACCGCTTTCCCATTGCTGGTGGAGCACATCCGCGGCGCGGGCGTGGTGTGCACGTACGCGGCGTGCTGCGCGGAGAAGCTGGTGGCGGGCGGCATGGTGCGGCGCGCCGAGCTGGCCCCGCACGCCGCCGCGCTGCTCGCCGCGCTGTTCGCCGCGCTGCCCGACCACTGCACGCCCGAGCAGCACAACGAATACGTCATGAAGGCTATATTAAGGACCCTGGCGTGCCTGCAAGAGGAGGCTCTGCCGTACCTCGGCGAGGCGCTGCCGAAACTCGCCAGGATGCTGTCCGTGGTCGCCAAGAATCCTTGCAAACCTCATTTCAACCACTACCTATTCGAGACACTGTCTCTGGCTGTGTCGTTGGTGACGAAATCGAATCCAAACGCCATAGCTGCCTTCGAGGACGCCCTGTTCCCGATATTCCAAGAAATATTGCAGAACGATATACAGGAGTTCATGCCGTACGTGTTCCAAATGCTGTCGCTGCTGCTGGAGCTGCGGGGCGGGGCGGGGGGCGGCGCGGGCGAGGCGTACAGCGCGCTGCTGCCGTGCGCGGTGGCGCCCGCGCTGTGGGAGCGCGCCGCCAACGTGCGCCCGCTCGTGCGCCTGCTGTGCGCGTACGTCGCCGTCGCGCCCAACCTCGTCGTCAACTCCGGGAAACTGAACGCGATACTCGGAGTGTTTCAAAAGTTGATAGCTTCGAAAACAAACGACCATGAAGGCTTCTACTTGATACAGACTATGCTCTACAAGTTTGGACAATCTGTAATGCAGCCGTACACCAAGCAGATAATGACGCTGCTGTTCCAGCGCCTGTCCTCGTCCAAGACGACCAAGTACATCCGGGGACTGATAGCCTTCCTCGGGTTCTACGCGGTGCAGTTTGGCGCAGACCCGCTCATCGACCTCATCGACTCGGTGCAGACGAACATGTTCGCGATGTACGTGGAGCGCGTGCTGGTGTCGGAGCTGCAGCGCGTGACCGGCACGCACGAGCGCCGCGCCGCCGCCGCCGGCTGCACGCGCCTGCTCTGCACCTCCGCGCACCTGCGGGACGGCAGCCTCGCGCATCTGTGGGCGCCGCTCATGCAGGCCCTGATCCAGTTGTTCGAGCTGCCCCCGGACGAGTCCTCGCTGCCGGACGACCACTTCGTCGAGGTGGACGACGCGCCCGGCTACCAGGCGCACTACGCGCAGCTCGCCTGCGCCAAGGGACTCCTCGACGACCCGCTAGCAAAGATAGAGGATCCGAAGCGCGACCTGGTGGAGAGCTTGGAGCGCATGTCGCGCGCGCACCCCGGCGTGCTGCCCCCCCGCCTCGCCGCGCTCTCCGCCCCGCACCGCGCCGCGCTCGCCGCGTACCTCGCCGCGCACAACGTGCACCTGTCCTAA

Protein

MLEKYSASGGAEWRGKDAAVYLVTSLASRGATLAAGVTRASPLVDLGQFAANHALPELQRPNLNELPVLKADAIKFLMTFRSLLPNELLLTAFPLLVEHIRGAGVVCTYAACCAEKLVAGGMVRRAELAPHAAALLAALFAALPDHCTPEQHNEYVMKAILRTLACLQEEALPYLGEALPKLARMLSVVAKNPCKPHFNHYLFETLSLAVSLVTKSNPNAIAAFEDALFPIFQEILQNDIQEFMPYVFQMLSLLLELRGGAGGGAGEAYSALLPCAVAPALWERAANVRPLVRLLCAYVAVAPNLVVNSGKLNAILGVFQKLIASKTNDHEGFYLIQTMLYKFGQSVMQPYTKQIMTLLFQRLSSSKTTKYIRGLIAFLGFYAVQFGADPLIDLIDSVQTNMFAMYVERVLVSELQRVTGTHERRAAAAGCTRLLCTSAHLRDGSLAHLWAPLMQALIQLFELPPDESSLPDDHFVEVDDAPGYQAHYAQLACAKGLLDDPLAKIEDPKRDLVESLERMSRAHPGVLPPRLAALSAPHRAALAAYLAAHNVHLS

Description

Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity). Negatively regulates fluid secretion and plays a role in fluid homeostasis by downregulating cftr activity (PubMed:20933420).

Subunit

Interacts with cftr (PubMed:20933420).

Similarity

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Belongs to the XPO2/CSE1 family.

Keywords

Cell membrane   Complete proteome   Cytoplasm   Membrane   Nucleus   Protein transport   Reference proteome   Transport  

Feature

chain  Exportin-2

Uniprot

H9J402   A0A212F558   A0A194QFC7   A0A2H1W216   A0A2D1QUE9   A0A2J7RI16   + More
A0A1B6CNE8   A0A1B6GBG3   A0A067REG1   A0A1B6IER0   D6WTV7   W8BRV6   U4U9R7   N6U7H0   A0A2J7RI15   A0A034W6I8   A0A1Y1KAV5   A0A1S4FK97   A0A182H483   A0A0A1XDD7   A0A0K8V1J2   A0A0J7K700   Q16XY2   T1GR31   A0A195B0R1   A0A158NKK0   B0WXZ4   A0A195FBK4   A0A1Q3F0Q1   A0A151JBE9   A0A336KZ79   A0A336M2M8   F4WWC9   A0A151WRQ7   A0A0P6EQZ7   A0A084WNJ8   A0A0L0BSZ8   A0A182FVF8   W5JFU2   A0A182QT46   A0A182N2M9   A0A0P5U8H2   E2BZ56   A0A182J0K5   T1PBI4   A0A1I8NSS0   E9IFD4   K7IQA9   A0A232EYL1   A0A182WE55   A0A151IJS9   A0A0C9R0E6   A0A0P5B0W0   A0A1A9W5E5   A0A182K3X1   A0A2A3E9T1   A0A088A291   A0A0L7R791   A0A0P5ZVT1   A0A0P5U809   A0A1A9XVX2   A0A0P5PI72   A0A182PM17   A0A1J1J244   A0A0P5ZL41   A0A310SPL4   A0A1A9VIB6   A0A182U6G5   A0A182WXX2   Q7QE09   A0A182I5Z3   A0A182M1Y2   A0A182KV25   A0A182V1L9   A0A0N7ZEU1   E9HY45   A0A1B0A4R0   A0A1S3I3Z4   A0A1L8DKS7   A0A182RW86   A0A0P4Y7H2   A0A2U9BFP7   A0A182Y9N4   A0A182SBW8   A0A0K2UVJ0   Q7SZC2   A0A1B0G9Q1   B7QNR8   A0A1B0CYT2   A0A0P5ZFL7   A0A162QWR0   A0A026WED2   A0A1E1XAG0   G1KRY7   A0A023GFX0   A0A147BS71   A0A131Y3V5   A0A3N0YQG9   W5M5L4   A0A224YY17  

Pubmed

19121390    22118469    26354079    24845553    18362917    19820115    + More
24495485    23537049    25348373    28004739    26483478    25830018    17510324    21347285    21719571    24438588    26108605    20920257    23761445    20798317    25315136    21282665    20075255    28648823    12364791    14747013    17210077    20966253    21292972    25244985    23594743    20933420    24508170    28503490    29652888    28797301   

EMBL

BABH01040156    BABH01040157    BABH01040158    BABH01040159    BABH01040160    AGBW02010240    + More
OWR48872.1    KQ459053    KPJ04187.1    ODYU01005806    SOQ47063.1    KY285054    ATP16157.1    NEVH01003506    PNF40478.1    GEDC01022433    JAS14865.1    GECZ01010007    JAS59762.1    KK852686    KDR18464.1    GECU01022326    JAS85380.1    KQ971352    EFA07339.1    GAMC01010569    JAB95986.1    KB632188    ERL89802.1    APGK01045816    KB741039    ENN74537.1    PNF40477.1    GAKP01009554    JAC49398.1    GEZM01087742    GEZM01087741    JAV58514.1    JXUM01108986    KQ565280    KXJ71133.1    GBXI01007135    GBXI01005322    JAD07157.1    JAD08970.1    GDHF01019545    JAI32769.1    LBMM01012834    KMQ85966.1    CH477530    EAT39461.1    CAQQ02190525    CAQQ02190526    KQ976692    KYM77882.1    ADTU01018869    DS232177    EDS36804.1    KQ981693    KYN37793.1    GFDL01013936    JAV21109.1    KQ979182    KYN22319.1    UFQS01001404    UFQT01001404    SSX10714.1    SSX30396.1    UFQS01000450    UFQT01000450    SSX04129.1    SSX24494.1    GL888406    EGI61471.1    KQ982805    KYQ50487.1    GDIQ01059088    JAN35649.1    ATLV01024618    KE525353    KFB51792.1    JRES01001418    KNC23108.1    ADMH02001630    ETN61689.1    AXCN02001080    GDIP01118333    JAL85381.1    GL451563    EFN79025.1    KA646122    AFP60751.1    GL762838    EFZ20732.1    NNAY01001630    OXU23377.1    KQ977294    KYN03892.1    GBYB01001470    JAG71237.1    GDIP01191317    JAJ32085.1    KZ288311    PBC28487.1    KQ414645    KOC66626.1    GDIP01038690    JAM65025.1    GDIP01118334    JAL85380.1    GDIQ01149612    JAL02114.1    CVRI01000064    CRL05526.1    GDIP01042832    JAM60883.1    KQ761976    OAD56402.1    AAAB01008848    EAA07074.1    APCN01003537    AXCM01007239    GDIP01252409    JAI70992.1    GL733109    EFX63333.1    GFDF01007018    JAV07066.1    GDIP01233710    JAI89691.1    CP026248    AWP02868.1    HACA01024355    CDW41716.1    CR559931    BC052479    BC066737    CCAG010003515    ABJB010852356    ABJB011137628    DS979863    EEC20490.1    AJVK01009334    AJVK01009335    AJVK01009336    GDIP01047185    JAM56530.1    LRGB01000248    KZS20019.1    KK107249    EZA54460.1    GFAC01002943    JAT96245.1    GBBM01003540    JAC31878.1    GEGO01001795    JAR93609.1    GEFM01002746    JAP73050.1    RJVU01031169    ROL48230.1    AHAT01025290    GFPF01007718    MAA18864.1   

Proteomes

UP000005204    UP000007151    UP000053268    UP000235965    UP000027135    UP000007266    + More
UP000030742    UP000019118    UP000069940    UP000249989    UP000036403    UP000008820    UP000015102    UP000078540    UP000005205    UP000002320    UP000078541    UP000078492    UP000007755    UP000075809    UP000030765    UP000037069    UP000069272    UP000000673    UP000075886    UP000075884    UP000008237    UP000075880    UP000095301    UP000095300    UP000002358    UP000215335    UP000075920    UP000078542    UP000091820    UP000075881    UP000242457    UP000005203    UP000053825    UP000092443    UP000075885    UP000183832    UP000078200    UP000075902    UP000076407    UP000007062    UP000075840    UP000075883    UP000075882    UP000075903    UP000000305    UP000092445    UP000085678    UP000075900    UP000246464    UP000076408    UP000075901    UP000000437    UP000092444    UP000001555    UP000092462    UP000076858    UP000053097    UP000001646    UP000018468   

PRIDE

H9J402    Q7SZC2   

Pfam

PF08506   Cse1        + More
PF03378   CAS_CSE1
PF03810   IBN_N
PF00063   Myosin_head
PF00620   RhoGAP
PF00788   RA
PF00612   IQ

Interpro

IPR011989   ARM-like        + More
IPR013713   XPO2_central       
IPR005043   XPO2_C       
IPR016024   ARM-type_fold       
IPR001494   Importin-beta_N       
IPR029071   Ubiquitin-like_domsf       
IPR027417   P-loop_NTPase       
IPR000159   RA_dom       
IPR002219   PE/DAG-bd       
IPR001609   Myosin_head_motor_dom       
IPR036961   Kinesin_motor_dom_sf       
IPR008936   Rho_GTPase_activation_prot       
IPR000198   RhoGAP_dom       
IPR036023   MYSc_Myo9       
IPR000048   IQ_motif_EF-hand-BS       

SUPFAM

SSF48371   SSF48371        + More
SSF52540   SSF52540       
SSF48350   SSF48350       
SSF54236   SSF54236       

Gene 3D

1.25.10.10     1.10.555.10     3.40.850.10    

CDD

cd00029  C1
cd01385  MYSc_Myo9

ProteinModelPortal

H9J402   A0A212F558   A0A194QFC7   A0A2H1W216   A0A2D1QUE9   A0A2J7RI16   + More
A0A1B6CNE8   A0A1B6GBG3   A0A067REG1   A0A1B6IER0   D6WTV7   W8BRV6   U4U9R7   N6U7H0   A0A2J7RI15   A0A034W6I8   A0A1Y1KAV5   A0A1S4FK97   A0A182H483   A0A0A1XDD7   A0A0K8V1J2   A0A0J7K700   Q16XY2   T1GR31   A0A195B0R1   A0A158NKK0   B0WXZ4   A0A195FBK4   A0A1Q3F0Q1   A0A151JBE9   A0A336KZ79   A0A336M2M8   F4WWC9   A0A151WRQ7   A0A0P6EQZ7   A0A084WNJ8   A0A0L0BSZ8   A0A182FVF8   W5JFU2   A0A182QT46   A0A182N2M9   A0A0P5U8H2   E2BZ56   A0A182J0K5   T1PBI4   A0A1I8NSS0   E9IFD4   K7IQA9   A0A232EYL1   A0A182WE55   A0A151IJS9   A0A0C9R0E6   A0A0P5B0W0   A0A1A9W5E5   A0A182K3X1   A0A2A3E9T1   A0A088A291   A0A0L7R791   A0A0P5ZVT1   A0A0P5U809   A0A1A9XVX2   A0A0P5PI72   A0A182PM17   A0A1J1J244   A0A0P5ZL41   A0A310SPL4   A0A1A9VIB6   A0A182U6G5   A0A182WXX2   Q7QE09   A0A182I5Z3   A0A182M1Y2   A0A182KV25   A0A182V1L9   A0A0N7ZEU1   E9HY45   A0A1B0A4R0   A0A1S3I3Z4   A0A1L8DKS7   A0A182RW86   A0A0P4Y7H2   A0A2U9BFP7   A0A182Y9N4   A0A182SBW8   A0A0K2UVJ0   Q7SZC2   A0A1B0G9Q1   B7QNR8   A0A1B0CYT2   A0A0P5ZFL7   A0A162QWR0   A0A026WED2   A0A1E1XAG0   G1KRY7   A0A023GFX0   A0A147BS71   A0A131Y3V5   A0A3N0YQG9   W5M5L4   A0A224YY17  

PDB

1Z3H     E-value=1.87266e-51,     Score=513

KEGG

101739596    K18423 exportin-2 (importin alpha re-exporter) | (RefSeq) exportin-2

GO

GO:0008536   GO:0005634   GO:0006886   GO:0005623   GO:0005635   GO:0006606   GO:0006611   GO:0005829   GO:0005049   GO:0003779   GO:0046872   GO:0035556   GO:0003774   GO:0005524   GO:0016459   GO:0009925   GO:0007589   GO:0016328   GO:0016324   GO:0016021   GO:0005654   GO:0005488   GO:0005515   GO:0019001   GO:0031683   GO:0007165   GO:0005525   GO:0008033   GO:0003676   GO:0016787  

Subcellular location

Nucleus  
Cytoplasm   Shuttles between the nucleus and the cytoplasm.   With evidence from 1 publications.
Apical cell membrane   Shuttles between the nucleus and the cytoplasm.   With evidence from 1 publications.
Basal cell membrane   Shuttles between the nucleus and the cytoplasm.   With evidence from 1 publications.
Lateral cell membrane   Shuttles between the nucleus and the cytoplasm.   With evidence from 1 publications.

Length:

554

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.35078

Exp number, first 60 AAs:

0.18384

Total prob of N-in:

0.01846

outside

1  -  554

 

 

Pi

181.305315

Theta

161.068498

Tajima's D

0.159213

CLR

0.221982

CSRT

0.415079246037698

Interpretation

Uncertain