Gene

KWMTBOMO12118  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004249

Annotation

PREDICTED:_acyl-CoA_synthetase_family_member_3?_mitochondrial_[Bombyx_mori]

Location

Bomo_Chr20(+):7902237-7915595      View in EpiBrowser

Full name

Acyl-CoA synthetase family member 3, mitochondrial      

Location in the cell

Mitochondrial   Reliability : 2.233

CDS

ATGGAAATAACTTTTCGTTCGTGTCGTTTGATCAACCGGCTTTTGAGAAAACCCCTCGCTTTAACAAGTTACAGAAGTGTAGTTAATGTCGCGGCCAAAGATGAAGTGAATACCGAGCTACTGACGAGTTTCAATAAAGATATTCAAGATGGAGGTGCAGTGCCGGTGTTCCGTCGCGCTCTGCTGTTCCCGACCCGGGTCGCCTTGCAAGACGAAGTCGGGATCTACACATACGCGGGCCTCTATCAAGCCGCTGCAGCGCTGAGCACCGAAATATCTGCGCAACTTGTTGGTGAAACAGAAAGGACGATAGCTTATATGTGTGGCAACGACGCTTCGCATGTCATCGTGCAATGGGCTATATGGATGACGGGGAATATTGCCGTCCCTTTAACTCCTCTGCATCCACCGGAGATGTTAAAGTATTTCCTTACGGATAGCATGTCGACGATAGTTATATGCACCCAAGATTACGAAAAGCTTCTGCGTCCAATCGCCCTTGACCTCTCCAGGCCTTTACTGGTCACCGGGAAAGATAAAGAGATAACGGCTCAACTGTACCAGCCGAATAGCGCTTTCATGAAACCGAGGGTAGTTGATAATTTGAGCGACGTGGGTAGATCGAACTCTTGGTACGGATCGAAGGATGCGCTTATCATTTACACCAGCGGTACGACCAGTAAGCCGAAGGGCGTGGTCTGGACGCACAGCATGCTGCAGACGCAGATTGCAGCGCTGCACAGCGCCTGGCATTACAGCGGCAACGACGTCGTCTTACACACGCTGCCGTTACACCACATACACGGGCAGCTGAACTCGATGCTCGCGTCTCTGGCCGCCGGCGCCAGAATACGGATGCTGCCTTCGTTCGTATCGCACGCGGTGTGGGCCCGCCTCCTCGGCATGGGCGAGAGGGACGACTCCAAAGTGAGCGTGTTCCACGGCGTGCCGGCCATGTACATGCGGCTGGCGGCCGACCACGACAAGATGTTCGCGGACGCCCGCACCGCGGAGTACGTGCGGAACACGCTCGCCACCCGCGTGAGGCTCATGTGCGCGGGATCCGCTCCGCTACCCAGCACGCTCTTCGACAAATGGGAAAAGATATCGGGACACCGTCTCCTCGAGCGGTACGGGATGACGGAGGTGGGTATGGCGCTGAGCAACCCGTACCGTCCGCTGGAGGGTCGCACGGTGAGCTGCGTGGGGGCTCCGCTGCCGGCCGTCAGCGCCAGGATCGCGACCACCGGCACCCTCGAGCCGCTCGTCACTGTCGAGTCTCCAGCCCCCGATTTGTTGGATGGCTCCGGAGATGAATACCGGTGGGATCGGCCCAAGGTCACTGTGCACGCGCAGAGCGAGACCGAAGTCTATGAAGGGGAGCTGCTGCTGAAAGGTCCTGCAGTGTTCTCCAGATACTGGAACCGCGCGCCGAAATTAAACTCGGACGATTTCACGTCGGACGGCTGGTTCCGCACCGGCGACACCGCCTCGTACGACGGCAAGTTCAAGATCCTGGGCCGCACGTCCGTGGACATCATCAAGACGGGCGGGTACAAGGTGAGCGCCCTGCAGGTCGAGTCGGCCATCTTGGAGCACCCCGACGTCGAGGACGTGGCGGTGCTCGGCTTCGAGGATGAAAGCTTCGGGGAGATGGTCACGGCGGTGGTCGTGCTAAAAGAGAACAAAAAGCTGACCCTAAAAGACCTCAAGGACGAGGCCGGCAAGCGACTGGCGCCCTACCAGCTGCCCAAAGTCTTGCTGGTGGTGGAGCAGATGCCGAGAAACGCTATGGGCAAACTCGACAAGAAGGAGATCAGAAGACTGTACGGTGATAAACTTGGAACCAAAAAGTAG

Protein

MEITFRSCRLINRLLRKPLALTSYRSVVNVAAKDEVNTELLTSFNKDIQDGGAVPVFRRALLFPTRVALQDEVGIYTYAGLYQAAAALSTEISAQLVGETERTIAYMCGNDASHVIVQWAIWMTGNIAVPLTPLHPPEMLKYFLTDSMSTIVICTQDYEKLLRPIALDLSRPLLVTGKDKEITAQLYQPNSAFMKPRVVDNLSDVGRSNSWYGSKDALIIYTSGTTSKPKGVVWTHSMLQTQIAALHSAWHYSGNDVVLHTLPLHHIHGQLNSMLASLAAGARIRMLPSFVSHAVWARLLGMGERDDSKVSVFHGVPAMYMRLAADHDKMFADARTAEYVRNTLATRVRLMCAGSAPLPSTLFDKWEKISGHRLLERYGMTEVGMALSNPYRPLEGRTVSCVGAPLPAVSARIATTGTLEPLVTVESPAPDLLDGSGDEYRWDRPKVTVHAQSETEVYEGELLLKGPAVFSRYWNRAPKLNSDDFTSDGWFRTGDTASYDGKFKILGRTSVDIIKTGGYKVSALQVESAILEHPDVEDVAVLGFEDESFGEMVTAVVVLKENKKLTLKDLKDEAGKRLAPYQLPKVLLVVEQMPRNAMGKLDKKEIRRLYGDKLGTKK

Description

Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates (By similarity).
Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. May have some preference toward very-long-chain substrates (By similarity).

Similarity

Belongs to the ATP-dependent AMP-binding enzyme family.

Keywords

Alternative splicing   ATP-binding   Complete proteome   Fatty acid metabolism   Ligase   Lipid metabolism   Mitochondrion   Nucleotide-binding   Reference proteome   Transit peptide  

Feature

chain  Acyl-CoA synthetase family member 3, mitochondrial
splice variant  In isoform 2.

Uniprot

A0A2A4JMG4   A0A2W1BSA1   A0A194QGW6   D6WR85   K7IMN4   A0A232ERZ4   + More
A0A336MR71   A0A336LS73   J9K8Q8   A0A2J7QJN4   A0A067RBM6   A0A2S2QZR2   A0A2H8TKU3   A0A182MCY5   A0A182RSW3   N6TPN7   E0W0C8   A0A182WD24   U4UCD0   A0A182QV14   J3JTI5   A0A1S3AAI1   A0A3B4DVN8   A0A3B4DX61   W5JEL9   A0A182P1E7   A0A2M4BFL5   A0A182N3Q6   A0A2M4BFI6   A0A3B3S5L4   A0A182FTX5   A0A182YCA0   A0A2M3Z3H0   A0A093HS36   A0A0P7U821   A0A2M4BFI4   A0A182KB70   A0A2M3Z2T9   A0A1W5A4U7   A0A1U8C6D9   A0A2M3ZKQ5   A0A3Q2XT07   A0A146S230   A0A3B4AJW7   A0A3Q2PT34   A0A3Q1EB75   Q3URE1   A0A091UQW1   A0A093QZR8   U5EYT6   A0A091RYI0   A0A091PB62   A0A3B5B1G5   F1P6L8   A0A1S3KVJ8   A0A087QQ46   A0A131XXR9   V5IDV6   M4AAA2   F7DM96   I3N4B0   Q6GLK6   A0A087XLG1   G3GRS3   A0A091JYQ8   A0A3Q2ZDN8   A0A2I0LLY9   A0A3B3YF20   A0A3B5KVK5   A0A3Q7SHT5   A0A3P9MBZ9   A0A3Q1BQZ3   B2GU01   A0A1L8GEQ0   A0A3P9HY06   D3ZUX7   A0A1A8J5Z1   A0A1Q3FHS8   A0A1Q3FHS6   A0A3B3CFR2   A0A3P9QGK9   A0A091F276   A0A1A8M1P9   A0A2J8RVD0   L5LZ95   A0A1A8QF80   A0A3P8TMX2   A0A099YXD2   A0A023GE59   A0A0Q3MBU0   E9FUT1   G1CSK7   A0A3P8TWE6   A0A3B3H2K4   G3MKT8   A0A3Q0SQT1  

EC Number

6.2.1.-

Pubmed

28756777    26354079    18362917    19820115    20075255    28648823    + More
24845553    23537049    20566863    22516182    20920257    23761445    29240929    25244985    25463417    16141072    15489334    21183079    16341006    25765539    23542700    19892987    21804562    23371554    17554307    20431018    27762356    15057822    15632090    29451363    21292972    21841779    22216098   

EMBL

NWSH01001038    PCG72976.1    KZ149954    PZC76524.1    KQ459053    KPJ04180.1    + More
KQ971354    EFA07690.2    NNAY01002537    OXU21111.1    UFQT01001485    SSX30757.1    UFQT01000092    SSX19573.1    ABLF02025797    NEVH01013550    PNF28801.1    KK852611    KDR20268.1    GGMS01014012    MBY83215.1    GFXV01002467    MBW14272.1    AXCM01006957    APGK01059415    KB741293    ENN70246.1    DS235858    EEB19084.1    KB632046    ERL88256.1    AXCN02001102    BT126542    AEE61506.1    ADMH02001457    ETN62506.1    GGFJ01002676    MBW51817.1    GGFJ01002674    MBW51815.1    GGFM01002311    MBW23062.1    KL206429    KFV82305.1    JARO02007616    KPP63744.1    GGFJ01002675    MBW51816.1    GGFM01002086    MBW22837.1    GGFM01008358    MBW29109.1    GCES01111637    JAQ74685.1    AK141579    BC022709    KL410018    KFQ93344.1    KL224807    KFW64234.1    GANO01001820    JAB58051.1    KK936210    KFQ47249.1    KK847485    KFP88755.1    AAEX03003962    KL225802    KFM03350.1    GEFM01004781    JAP71015.1    GANP01011272    JAB73196.1    AGTP01083437    AGTP01083438    AGTP01083439    AGTP01083440    BC074473    AYCK01005499    AYCK01005500    JH000004    EGV94067.1    KK501616    KFP16651.1    AKCR02000203    PKK18431.1    AAMC01025524    AAMC01025525    AAMC01025526    AAMC01025527    AAMC01025528    AAMC01025529    BC166077    AAI66077.1    CM004473    OCT82340.1    AABR07044072    CH473972    EDL92769.1    HAED01017668    SBR04113.1    GFDL01007956    JAV27089.1    GFDL01007947    JAV27098.1    KK719441    KFO63366.1    HAEF01010480    SBR50461.1    ABGA01101904    ABGA01101905    ABGA01101906    ABGA01306119    ABGA01306120    ABGA01306121    NDHI03003646    PNJ12478.1    PNJ12479.1    PNJ12480.1    KB106264    ELK31377.1    HAEH01011542    SBR92495.1    KL886576    KGL74016.1    GBBM01003294    JAC32124.1    LMAW01002545    KQK80125.1    GL732525    EFX88868.1    JF907588    AEI69377.1    JO842489    AEO34106.1   

Proteomes

UP000218220    UP000053268    UP000007266    UP000002358    UP000215335    UP000007819    + More
UP000235965    UP000027135    UP000075883    UP000075900    UP000019118    UP000009046    UP000075920    UP000030742    UP000075886    UP000079721    UP000261440    UP000000673    UP000075885    UP000075884    UP000261540    UP000069272    UP000076408    UP000053584    UP000034805    UP000075881    UP000192224    UP000189706    UP000264820    UP000265000    UP000261520    UP000257200    UP000000589    UP000053283    UP000054081    UP000261400    UP000002254    UP000087266    UP000053286    UP000002852    UP000002281    UP000005215    UP000028760    UP000001075    UP000053119    UP000264800    UP000053872    UP000261480    UP000261380    UP000286640    UP000265180    UP000257160    UP000008143    UP000186698    UP000265200    UP000002494    UP000261560    UP000242638    UP000052976    UP000001595    UP000265080    UP000053641    UP000051836    UP000000305    UP000001038    UP000261340   

PRIDE

Q3URE1    G3GRS3    D3ZUX7   

Pfam

PF00501   AMP-binding        + More
PF13193   AMP-binding_C

Interpro

IPR025110   AMP-bd_C        + More
IPR000873   AMP-dep_Synth/Lig       
IPR042099   AMP-dep_Synthh-like_sf       
IPR020845   AMP-binding_CS       

Gene 3D

3.40.50.12780    

ProteinModelPortal

A0A2A4JMG4   A0A2W1BSA1   A0A194QGW6   D6WR85   K7IMN4   A0A232ERZ4   + More
A0A336MR71   A0A336LS73   J9K8Q8   A0A2J7QJN4   A0A067RBM6   A0A2S2QZR2   A0A2H8TKU3   A0A182MCY5   A0A182RSW3   N6TPN7   E0W0C8   A0A182WD24   U4UCD0   A0A182QV14   J3JTI5   A0A1S3AAI1   A0A3B4DVN8   A0A3B4DX61   W5JEL9   A0A182P1E7   A0A2M4BFL5   A0A182N3Q6   A0A2M4BFI6   A0A3B3S5L4   A0A182FTX5   A0A182YCA0   A0A2M3Z3H0   A0A093HS36   A0A0P7U821   A0A2M4BFI4   A0A182KB70   A0A2M3Z2T9   A0A1W5A4U7   A0A1U8C6D9   A0A2M3ZKQ5   A0A3Q2XT07   A0A146S230   A0A3B4AJW7   A0A3Q2PT34   A0A3Q1EB75   Q3URE1   A0A091UQW1   A0A093QZR8   U5EYT6   A0A091RYI0   A0A091PB62   A0A3B5B1G5   F1P6L8   A0A1S3KVJ8   A0A087QQ46   A0A131XXR9   V5IDV6   M4AAA2   F7DM96   I3N4B0   Q6GLK6   A0A087XLG1   G3GRS3   A0A091JYQ8   A0A3Q2ZDN8   A0A2I0LLY9   A0A3B3YF20   A0A3B5KVK5   A0A3Q7SHT5   A0A3P9MBZ9   A0A3Q1BQZ3   B2GU01   A0A1L8GEQ0   A0A3P9HY06   D3ZUX7   A0A1A8J5Z1   A0A1Q3FHS8   A0A1Q3FHS6   A0A3B3CFR2   A0A3P9QGK9   A0A091F276   A0A1A8M1P9   A0A2J8RVD0   L5LZ95   A0A1A8QF80   A0A3P8TMX2   A0A099YXD2   A0A023GE59   A0A0Q3MBU0   E9FUT1   G1CSK7   A0A3P8TWE6   A0A3B3H2K4   G3MKT8   A0A3Q0SQT1  

PDB

3NYR     E-value=1.78268e-52,     Score=522

KEGG

101739309    K18660 malonyl-CoA/methylmalonyl-CoA synthetase [EC:6.2.1.-] | (RefSeq) acyl-CoA synthetase family m

PATHWAY

00061    Fatty acid biosynthesis - Bombyx mori (domestic silkworm)
00280    Valine, leucine and isoleucine degradation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01212    Fatty acid metabolism - Bombyx mori (domestic silkworm)

GO

GO:0003824   GO:0003996   GO:0004467   GO:0102391   GO:0090410   GO:0005739   GO:0031957   GO:0090409   GO:0006633   GO:0006631   GO:0005524   GO:0016878   GO:0016874   GO:0016021   GO:0008152   GO:0008270   GO:0019001   GO:0031683   GO:0007165   GO:0005525   GO:0008033   GO:0003676   GO:0016787  

Subcellular location

Mitochondrion  

Length:

618

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.56422

Exp number, first 60 AAs:

0.00021

Total prob of N-in:

0.07244

outside

1  -  618

 

 

Pi

357.464784

Theta

169.220465

Tajima's D

0.579733

CLR

0.262483

CSRT

0.533423328833558

Interpretation

Uncertain