Gene

KWMTBOMO12098  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004340

Annotation

salivary_cysteine-rich_peptide_precursor_[Bombyx_mori]

Location

Bomo_Chr20(+):7305356-7307183      View in EpiBrowser

Full name

NAD-dependent protein deacylase      

Alternative Name

Regulatory protein SIR2 homolog 5

Location in the cell

Extracellular   Reliability : 4.333

CDS

ATGACATTCCTGTTGGGTGTGTTCGCGTTGGTTACCTTTGTCTTCTACGCCGAAGCCGCTGGCACGTGCCCTCTTCCTTCGAAAGTGTACGGTTGCAGCCCTAAATGCAAGGAGGACTACGAATGTACACACGGCAAGGTCTGCTGTTCTAATTCGTGCAACGCCAAGTCGTGTTCAGAGCCGGCTGCTTACGGCGGAGGCACCGGGAGCTCCAGCAAACACGCAACCGGCGGAACGGGCGTTTACTGCGAAAACGTCAAGTGTAACTCTTACGAAATATGCAAGCGTGATCCAATGACGAAGAGAATGAAATGCAGCAGAGCTTAA

Protein

MTFLLGVFALVTFVFYAEAAGTCPLPSKVYGCSPKCKEDYECTHGKVCCSNSCNAKSCSEPAAYGGGTGSSSKHATGGTGVYCENVKCNSYEICKRDPMTKRMKCSRA

Description

NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.

Catalytic Activity

H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) = 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) = 2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide

Cofactor

Zn(2+)

Similarity

Belongs to the sirtuin family. Class III subfamily.
Belongs to the peptidase S1 family.

Uniprot

H9J4A1   Q2F5L7   A0A2A4J4S4   A0A2H1WEN5   A0A1E1W0N8   I4DJI2   + More
A0A194Q5I6   A0A0N0PEC3   I4DME0   A0A2W1AYL1   B0WGW5   Q6TS02   B8RJ27   A0A1I8NYZ9   B8RJ73   U5ESJ3   A0A2A4J4P9   A0A336L5S8   T1DJ53   A0A0T6AZZ9   B4MRJ9   B4J690   A0A1A9WC59   A0A1L8E9B7   A0A1L8E8X8   A0A1L8E9C8   A0A1B0BFS7   A0A1L8DP95   A0A1A9Y1T5   Q291D9   B4GAV0   A0A1L8E959   A0A1L8E9E2   A0A1L8E8W9   A0A1A9VSF7   A0A0K8VYK3   A0A1S3DI78   B4LLP0   A0A0L0CPL9   A0A0K8UBV8   A0A0M4EV16   T1H3T2   A0A0K8V321   A0A023EEW1   A0A023EF48   A0A1I8MRC7   A0A1L8E8L7   A0A034WMT9   A0A1I8M4C9   A0A023EF50   A0A0L0CPZ0   A0A0A1XAB4   A0A026WL57   N6UHB8   B3NR33   B4QFV2   A0A182V7J1   A0A182XC99   Q7Q332   A0A182HNK0   A0A0C9R9D0   A0A1W6EVZ4   B4P770   Q8MKJ5   B4KP03   A0A348G5X8   A0A1W4UHL7   A0A310SA66   D6X3Z4   A0A154PFW7   B4HRE2   A0A2A3E681   E2AH81   W5JSZ0   A0A182P9C4   A0A087ZR77   A0A2M3ZB73   W8C475   Q16PH2   A0A2P8ZKJ5   A0A1A9Z4T8   A0A2M4CZF3   B3ME19   A0A182QP64   A0A158NA96   W5JPJ3   A0A2M3ZBD0   A0A182J089   A0A182UHK7   A0A182YPF3   A0A182FTD9   A0A1Y1KSH3   A0A2M4ACT1   A0A2M4ACS1   A0A182WF61   A0A1I8JU61   A0A2M3YW39  

EC Number

3.5.1.-

Pubmed

19121390    22651552    26354079    28756777    24330624    17994087    + More
15632085    26108605    24945155    25315136    25348373    26483478    25830018    24508170    30249741    23537049    22936249    12364791    14747013    17210077    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    18362917    19820115    20798317    20920257    23761445    24495485    17510324    29403074    21347285    25244985    28004739   

EMBL

BABH01032641    DQ311406    ABD36350.1    NWSH01003389    PCG66392.1    ODYU01008163    + More
SOQ51533.1    GDQN01010518    JAT80536.1    AK401450    BAM18072.1    KQ459460    KPJ00808.1    KQ459838    KPJ19711.1    AK402458    BAM19080.1    KZ150735    PZC70352.1    DS231930    EDS27259.1    AY388547    DS233801    AAR18435.1    EDS31649.1    EZ000452    ACJ64326.1    EZ000498    ACJ64372.1    GANO01004810    JAB55061.1    PCG66393.1    UFQS01001098    UFQT01001098    SSX09000.1    SSX28911.1    GALA01000506    JAA94346.1    LJIG01016430    KRT80626.1    CH963850    EDW74738.2    CH916367    EDW00863.1    GFDG01003590    JAV15209.1    GFDG01003592    JAV15207.1    GFDG01003593    JAV15206.1    JXJN01013644    JXJN01013645    JXJN01013646    GFDF01005887    JAV08197.1    CM000071    EAL25173.2    CH479181    EDW32052.1    GFDG01003595    JAV15204.1    GFDG01003594    JAV15205.1    GFDG01003591    JAV15208.1    GDHF01019816    GDHF01008372    JAI32498.1    JAI43942.1    CH940648    EDW60903.2    JRES01000080    KNC34323.1    GDHF01028162    JAI24152.1    CP012524    ALC41637.1    CAQQ02071450    GDHF01019088    JAI33226.1    GAPW01006208    GAPW01006207    GAPW01006206    GAPW01006205    JAC07391.1    GAPW01006209    JAC07389.1    GFDG01003702    JAV15097.1    GAKP01002983    JAC55969.1    JXUM01122149    GAPW01006204    KQ566574    JAC07394.1    KXJ70015.1    KNC34331.1    GBXI01006679    JAD07613.1    KK107167    QOIP01000010    EZA56401.1    RLU18038.1    APGK01035417    KB740925    KB631924    ENN78032.1    ERL87273.1    CH954179    EDV56022.1    CM000362    CM002911    EDX07097.1    KMY93783.1    AAAB01008966    EAA12985.4    APCN01001938    GBYB01013009    JAG82776.1    KY563487    ARK19896.1    CM000158    EDW91035.1    AY113384    AE013599    KX531668    AAM29389.1    AAM68554.1    ANY27478.1    CH933808    EDW10069.1    FX985515    BBF97851.1    KQ765605    OAD53818.1    KQ971379    EEZ97346.1    KQ434896    KZC10759.1    CH480816    EDW47871.1    KZ288375    PBC26679.1    GL439483    EFN67198.1    ADMH02000540    ETN66045.1    GGFM01005000    MBW25751.1    GAMC01002442    JAC04114.1    CH477781    EAT36276.1    PYGN01000028    PSN57021.1    GGFL01006509    MBW70687.1    CH902619    EDV37564.2    AXCN02002114    ADTU01010081    ETN66046.1    GGFM01005034    MBW25785.1    GEZM01075029    JAV64333.1    GGFK01005258    MBW38579.1    GGFK01005248    MBW38569.1    GGFF01000001    MBW20468.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000002320    UP000095300    + More
UP000007798    UP000001070    UP000091820    UP000092460    UP000092443    UP000001819    UP000008744    UP000078200    UP000079169    UP000008792    UP000037069    UP000092553    UP000015102    UP000095301    UP000069940    UP000249989    UP000053097    UP000279307    UP000019118    UP000030742    UP000008711    UP000000304    UP000075903    UP000076407    UP000007062    UP000075840    UP000002282    UP000000803    UP000009192    UP000192221    UP000007266    UP000076502    UP000001292    UP000242457    UP000000311    UP000000673    UP000075885    UP000005203    UP000008820    UP000245037    UP000092445    UP000007801    UP000075886    UP000005205    UP000075880    UP000075902    UP000076408    UP000069272    UP000075920    UP000075900   

PRIDE

H9J4A1    Q2F5L7    Q8MKJ5   

Pfam

PF00095   WAP        + More
PF02146   SIR2
PF00089   Trypsin

Interpro

IPR008197   WAP_dom        + More
IPR036645   Elafin-like_sf       
IPR027546   Sirtuin_class_III       
IPR029035   DHS-like_NAD/FAD-binding_dom       
IPR003000   Sirtuin       
IPR026591   Sirtuin_cat_small_dom_sf       
IPR026590   Ssirtuin_cat_dom       
IPR018114   TRYPSIN_HIS       
IPR001254   Trypsin_dom       
IPR001314   Peptidase_S1A       
IPR009003   Peptidase_S1_PA       

SUPFAM

SSF57256   SSF57256        + More
SSF52467   SSF52467       
SSF50494   SSF50494       

Gene 3D

4.10.75.10     3.30.1600.10    

CDD

cd01412  SIRT5_Af1_CobB
cd00190  Tryp_SPc

ProteinModelPortal

H9J4A1   Q2F5L7   A0A2A4J4S4   A0A2H1WEN5   A0A1E1W0N8   I4DJI2   + More
A0A194Q5I6   A0A0N0PEC3   I4DME0   A0A2W1AYL1   B0WGW5   Q6TS02   B8RJ27   A0A1I8NYZ9   B8RJ73   U5ESJ3   A0A2A4J4P9   A0A336L5S8   T1DJ53   A0A0T6AZZ9   B4MRJ9   B4J690   A0A1A9WC59   A0A1L8E9B7   A0A1L8E8X8   A0A1L8E9C8   A0A1B0BFS7   A0A1L8DP95   A0A1A9Y1T5   Q291D9   B4GAV0   A0A1L8E959   A0A1L8E9E2   A0A1L8E8W9   A0A1A9VSF7   A0A0K8VYK3   A0A1S3DI78   B4LLP0   A0A0L0CPL9   A0A0K8UBV8   A0A0M4EV16   T1H3T2   A0A0K8V321   A0A023EEW1   A0A023EF48   A0A1I8MRC7   A0A1L8E8L7   A0A034WMT9   A0A1I8M4C9   A0A023EF50   A0A0L0CPZ0   A0A0A1XAB4   A0A026WL57   N6UHB8   B3NR33   B4QFV2   A0A182V7J1   A0A182XC99   Q7Q332   A0A182HNK0   A0A0C9R9D0   A0A1W6EVZ4   B4P770   Q8MKJ5   B4KP03   A0A348G5X8   A0A1W4UHL7   A0A310SA66   D6X3Z4   A0A154PFW7   B4HRE2   A0A2A3E681   E2AH81   W5JSZ0   A0A182P9C4   A0A087ZR77   A0A2M3ZB73   W8C475   Q16PH2   A0A2P8ZKJ5   A0A1A9Z4T8   A0A2M4CZF3   B3ME19   A0A182QP64   A0A158NA96   W5JPJ3   A0A2M3ZBD0   A0A182J089   A0A182UHK7   A0A182YPF3   A0A182FTD9   A0A1Y1KSH3   A0A2M4ACT1   A0A2M4ACS1   A0A182WF61   A0A1I8JU61   A0A2M3YW39  

KEGG

692973    no KO assigned | (RefSeq) salivary cysteine-rich peptide

GO

GO:0030414   GO:0005576   GO:0034979   GO:0005739   GO:0036055   GO:0070403   GO:0036054   GO:0008270   GO:0016021   GO:0004252   GO:0017076   GO:0005525   GO:0004613   GO:0000049   GO:0000287   GO:0008033   GO:0003676   GO:0016787  

Subcellular location

Mitochondrion  

SignalP

Position:   1 - 19,         Likelihood:  0.999794

 

 

Length:

108

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

9.75621

Exp number, first 60 AAs:

9.75332

Total prob of N-in:

0.20062

outside

1  -  108

 

 

Pi

22.258078

Theta

62.39927

Tajima's D

-1.951073

CLR

1.216461

CSRT

0.0184990750462477

Interpretation

Uncertain