Gene

KWMTBOMO12085

Pre Gene Modal

BGIBMGA004280

Annotation

PREDICTED:_glutamine_synthetase_2_cytoplasmic_[Papilio_machaon]

Location

Bomo_Chr20(-):7031887-7048245      View in EpiBrowser

Full name

Glutamine synthetase       + More
Glutamine synthetase 2 cytoplasmic      

Alternative Name

Glutamate--ammonia ligase 2

Location in the cell

Cytoplasmic   Reliability : 1.954 Nuclear   Reliability : 1.453

CDS

ATGTCGGAAACTCAAAACAAAGTGCAAGATAATCCAAAAATTTTATCGGGTCCCGTGCTACAGAACTCTCCGAATGCATTCCTCTCGAAGACACTGTTGGACCGGTATAGAGATCTACCGCTGCCGGAAGACAAGGTCCTCGCCACATACGTATGGATCGACGGCTCCGGCGAGCATGTTCGTTGCAAAGACAGGACTTTGAACTACATTCCAGAAACTCCTAAAGACCTGCCGATATGGAATTACGACGGCAGCTCTACAGGCCAGACGACAAGCACGAACTCAGACACGCACCTGAAGCCCCAGGCCATATACAGGGACCCGTTCCGGCGCGGAAACCACGTGCTTGTCATGTGCGACACATACGATTACAGCATGCAACCAACAAAGACAAACCACCGTATTAAATGCCAAGAAGCGTACGACCGCTGCAGAGACCACGAGCCGTGGTTCGGCATAGAGCAAGAGTACGTGCTCCTCGACTCTGACCTTAGACCGTTTGGGTGGCCTACAACTGGAAGCCCTCCTGCCCAGGGACCATATTATTGCGGCGTTGGAGCTAACAAGGTCTTCGCGAGGGATCTCATTGAAGCCCATTATAAATGCTGTCTGTATGCTGGAGTGCCGATCACAGGTACGAACGCTGAGGCGATGCTCTCGCAGTGGGAGTTCCAAGTCGGGCCCTCCGTTGGCGTGTCAGCTGGAGATGACCTGTGGATAGCTCGTTTTATCCTGCATCGTCTGGCTGAAGAGTTCGGAGTCATCGTCACTTTCGACCCCAAACCGGTGTCGGATTGGAATGGTTCGGGTGCTCACCACAATTTCTCGACAAAGAAAATGCGAGATGAAGGGGGAATTACTGAAATCGAGAGGGCGATTGAAAAGCTCTCCAAAGTGCACATGAAGCACATTAAGGTATACGACCCTCGCGGCGGCAAGGATAACGAGCGCCGACTGACAGGACTCCACGAAACCGCTAGCATTCATGATTTTAGTTCGGGTGTTGCTAGCCGCAGTGCCAGTATAAGAATACCTCGGCAGGTGGAGGCAGAAAAACGCGGGTACCTCGAGGATCGGCGCCCGGCTTCGAACTGCGATCCGTACTCTGTGACCGATGCACTCATGCGCACTTGTATACTTGACGAATTATAA

Protein

MSETQNKVQDNPKILSGPVLQNSPNAFLSKTLLDRYRDLPLPEDKVLATYVWIDGSGEHVRCKDRTLNYIPETPKDLPIWNYDGSSTGQTTSTNSDTHLKPQAIYRDPFRRGNHVLVMCDTYDYSMQPTKTNHRIKCQEAYDRCRDHEPWFGIEQEYVLLDSDLRPFGWPTTGSPPAQGPYYCGVGANKVFARDLIEAHYKCCLYAGVPITGTNAEAMLSQWEFQVGPSVGVSAGDDLWIARFILHRLAEEFGVIVTFDPKPVSDWNGSGAHHNFSTKKMRDEGGITEIERAIEKLSKVHMKHIKVYDPRGGKDNERRLTGLHETASIHDFSSGVASRSASIRIPRQVEAEKRGYLEDRRPASNCDPYSVTDALMRTCILDEL

Catalytic Activity

ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate

Subunit

Homooctamer.

Similarity

Belongs to the glutamine synthetase family.

Keywords

Alternative splicing   ATP-binding   Complete proteome   Cytoplasm   Ligase   Nucleotide-binding   Reference proteome  

Feature

chain  Glutamine synthetase 2 cytoplasmic
splice variant  In isoform A.

Uniprot

H9J441   A0A2A4J4U6   A0A2W1BMY2   I4DJ32   A0A0G3VIA2   S4PCI7   + More
H9ITV0   A0A194QUW7   A0A212ETE4   A0A2J7RJB5   D6WFH1   A0A067R5C5   D3TPP6   V5G3M6   A0A1A9UHR5   A0A0M9A1M4   A0A0M5J396   A0A1B0B749   A0A1B0AIW9   A0A068TK10   A0A1A9Y1D7   A0A1B6IB03   J3JTU0   A0A1J1HER3   A0A1Y1KMB3   A0A1I9WLM6   A0A0A1XT45   W8BUA3   A0A0A1WVL5   A0A0K8VEK6   A0A034VVT9   A0A0K8VUW5   A0A034VRN0   A0A0L0C841   A0A1B6IKT6   A0A2L1DH34   R4G5A5   A0A1I8NDX3   A0A0P4VPJ5   M9V250   A0A0L7R3F9   A0A1W4V0I0   A0A1B6EY34   A0A195BGP1   Q16J32   A0A1B6FLE3   Q2KQ97   S5NFE0   A0A1W4UNL4   A0A195C1J9   A0A0A9WUK9   A0A151XJR8   B4N1T9   A0A1Q3G582   B4L4A8   B4MCX6   A0A3B0JXI0   V9IDX6   A0A0Q9VZ95   A0A2A3E9Y7   B4JIW8   A0A088A2A8   A0A0Q9WMW7   A0A194PS35   E2BUV7   A0A1Q3G4Z2   A0A151JWT9   D0QWE3   A0A026W7I7   Q29H28   B4H0G6   B4PYB1   X2JJG8   P20478   C8VV58   X2JDA5   A0A1L8E2I2   A0A1B6CN61   F4WK81   A0A336LVS2   B3NUD5   P20478-3   Q494K4   A0A0R1EIC3   B4IK13   A0A0G2QRP6   A0A3B0JXJ2   A0A182U6F2   A0A182XIC8   A0A182LFG0   Q7QBX9   A0A084VJR5   G9C5D9   A0A0V0G2W8   E2ATW3   A0A182V4E1   F5HK76   A0A182HTB3   A0A023EQU3   A0A0Q5T3A2  

EC Number

6.3.1.2

Pubmed

19121390    28756777    22651552    23622113    26354079    22118469    + More
18362917    19820115    24845553    20353571    29403074    22516182    28004739    27538518    25830018    24495485    25348373    26108605    25315136    27129103    17510324    15804581    23791183    25401762    17994087    20798317    19859648    24508170    15632085    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    1969491    12537569    21719571    20966253    12364791    14747013    17210077    24438588    21835214    24945155   

EMBL

BABH01032611    NWSH01003020    PCG67105.1    KZ150069    PZC74080.1    AK401300    + More
BAM17922.1    KP657638    RSAL01000006    AKL78863.1    RVE54315.1    GAIX01004181    JAA88379.1    BABH01007020    KQ461108    KPJ09262.1    AGBW02012593    OWR44772.1    NEVH01002994    PNF40921.1    KQ971327    EEZ99821.1    KK852685    KDR18484.1    CCAG010007360    EZ423398    ADD19674.1    GALX01003841    JAB64625.1    KQ435762    KOX75490.1    CP012528    ALC49436.1    JXJN01009401    HG965789    PYGN01000753    CDO39385.1    PSN41298.1    GECU01023633    JAS84073.1    BT126649    AEE61612.1    CVRI01000001    CRK86464.1    GEZM01081263    GEZM01081262    JAV61728.1    KU932410    APA34046.1    GBXI01000554    JAD13738.1    GAMC01006052    JAC00504.1    GBXI01011834    JAD02458.1    GDHF01015334    JAI36980.1    GAKP01012982    JAC45970.1    GDHF01009632    JAI42682.1    GAKP01012981    JAC45971.1    JRES01000777    KNC28415.1    GECU01020177    JAS87529.1    KY681699    AVD29897.1    GAHY01000111    JAA77399.1    GDKW01001673    JAI54922.1    KC445137    AGJ70738.1    KQ414663    KOC65354.1    GECZ01026871    JAS42898.1    KQ976491    KYM83318.1    CH478033    EAT34276.1    GECZ01018741    JAS51028.1    AY623406    AAV31915.1    EAT34277.1    KF021980    AGR65729.1    KQ978379    KYM94490.1    GBHO01033421    GBHO01005375    GBHO01005374    GBHO01005369    GBRD01014272    GBRD01011329    JAG10183.1    JAG38229.1    JAG38230.1    JAG38235.1    JAG51554.1    KQ982068    KYQ60545.1    CH963925    EDW78328.1    GFDL01000119    JAV34926.1    CH933810    EDW07386.1    CH940660    EDW58048.1    OUUW01000011    SPP86775.1    JR039080    AEY58519.1    KRF78088.1    KZ288311    PBC28530.1    CH916370    EDV99532.1    KRF94024.1    KQ459594    KPI96122.1    GL450772    EFN80494.1    GFDL01000209    JAV34836.1    KQ981622    KYN39215.1    FJ821026    ACN94650.1    KK107374    EZA51576.1    CH379064    EAL31931.1    CH479200    EDW29761.1    CM000162    EDX01973.1    AE014298    AHN59592.1    X52759    AY060701    BT099804    ACV91641.1    AHN59591.1    GFDF01001163    JAV12921.1    GEDC01022402    JAS14896.1    GL888197    EGI65384.1    UFQS01000234    UFQT01000234    SSX01768.1    SSX22146.1    CH954180    EDV46050.1    BT023772    AAZ41780.1    KRK06487.1    CH480851    EDW51385.1    KC344400    AGY46258.1    SPP86774.1    AAAB01008859    EAA08219.5    ATLV01013858    KE524905    KFB38209.1    HQ851380    AEV89758.1    GECL01003697    JAP02427.1    GL442742    EFN63125.1    EGK96917.1    APCN01000435    GAPW01002121    GAPW01002120    GAPW01002119    JAC11478.1    KQS29805.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053240    UP000007151    UP000235965    + More
UP000007266    UP000027135    UP000092444    UP000078200    UP000053105    UP000092553    UP000092460    UP000092445    UP000245037    UP000092443    UP000183832    UP000037069    UP000095301    UP000053825    UP000192221    UP000078540    UP000008820    UP000078542    UP000075809    UP000007798    UP000009192    UP000008792    UP000268350    UP000242457    UP000001070    UP000005203    UP000053268    UP000008237    UP000078541    UP000053097    UP000001819    UP000008744    UP000002282    UP000000803    UP000007755    UP000008711    UP000001292    UP000075902    UP000076407    UP000075882    UP000007062    UP000030765    UP000000311    UP000075903    UP000075840   

PRIDE

H9J441    H9ITV0    P20478    C8VV58    X2JDA5    Q494K4    + More

Pfam

PF00120   Gln-synt_C        + More
PF03951   Gln-synt_N

Interpro

IPR008146   Gln_synth_cat_dom        + More
IPR008147   Gln_synt_b-grasp       
IPR036651   Gln_synt_N       
IPR027302   Gln_synth_N_conserv_site       
IPR014746   Gln_synth/guanido_kin_cat_dom       
IPR027303   Gln_synth_gly_rich_site       

SUPFAM

SSF54368   SSF54368        + More
SSF55931   SSF55931       

Gene 3D

3.10.20.70    

ProteinModelPortal

H9J441   A0A2A4J4U6   A0A2W1BMY2   I4DJ32   A0A0G3VIA2   S4PCI7   + More
H9ITV0   A0A194QUW7   A0A212ETE4   A0A2J7RJB5   D6WFH1   A0A067R5C5   D3TPP6   V5G3M6   A0A1A9UHR5   A0A0M9A1M4   A0A0M5J396   A0A1B0B749   A0A1B0AIW9   A0A068TK10   A0A1A9Y1D7   A0A1B6IB03   J3JTU0   A0A1J1HER3   A0A1Y1KMB3   A0A1I9WLM6   A0A0A1XT45   W8BUA3   A0A0A1WVL5   A0A0K8VEK6   A0A034VVT9   A0A0K8VUW5   A0A034VRN0   A0A0L0C841   A0A1B6IKT6   A0A2L1DH34   R4G5A5   A0A1I8NDX3   A0A0P4VPJ5   M9V250   A0A0L7R3F9   A0A1W4V0I0   A0A1B6EY34   A0A195BGP1   Q16J32   A0A1B6FLE3   Q2KQ97   S5NFE0   A0A1W4UNL4   A0A195C1J9   A0A0A9WUK9   A0A151XJR8   B4N1T9   A0A1Q3G582   B4L4A8   B4MCX6   A0A3B0JXI0   V9IDX6   A0A0Q9VZ95   A0A2A3E9Y7   B4JIW8   A0A088A2A8   A0A0Q9WMW7   A0A194PS35   E2BUV7   A0A1Q3G4Z2   A0A151JWT9   D0QWE3   A0A026W7I7   Q29H28   B4H0G6   B4PYB1   X2JJG8   P20478   C8VV58   X2JDA5   A0A1L8E2I2   A0A1B6CN61   F4WK81   A0A336LVS2   B3NUD5   P20478-3   Q494K4   A0A0R1EIC3   B4IK13   A0A0G2QRP6   A0A3B0JXJ2   A0A182U6F2   A0A182XIC8   A0A182LFG0   Q7QBX9   A0A084VJR5   G9C5D9   A0A0V0G2W8   E2ATW3   A0A182V4E1   F5HK76   A0A182HTB3   A0A023EQU3   A0A0Q5T3A2  

PDB

2QC8     E-value=1.10236e-126,     Score=1160

KEGG

101740405    K01915 glutamine synthetase [EC:6.3.1.2] | (RefSeq) glutamine synthetase 2 cytoplasmic-like

PATHWAY

00220    Arginine biosynthesis - Bombyx mori (domestic silkworm)
00250    Alanine, aspartate and glutamate metabolism - Bombyx mori (domestic silkworm)
00630    Glyoxylate and dicarboxylate metabolism - Bombyx mori (domestic silkworm)
00910    Nitrogen metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01230    Biosynthesis of amino acids - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0004356   GO:0006542   GO:0005737   GO:0045213   GO:0007416   GO:0006538   GO:0006807   GO:0003824   GO:0006432   GO:0000049   GO:0000287   GO:0008033   GO:0003676   GO:0016787  

Subcellular location

Cytoplasm  

Length:

383

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00486

Exp number, first 60 AAs:

0.0002

Total prob of N-in:

0.03947

outside

1  -  383

 

 

Pi

212.813192

Theta

156.671089

Tajima's D

1.132225

CLR

0.24629

CSRT

0.698065096745163

Interpretation

Uncertain