Gene

KWMTBOMO12081  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004333

Annotation

PREDICTED:_dysbindin_protein_homolog_[Bombyx_mori]

Location

Bomo_Chr20(+):6915947-6920095      View in EpiBrowser

Full name

Dysbindin protein homolog      

Alternative Name

Biogenesis of lysosome-related organelles complex 1 subunit 8

Location in the cell

Cytoplasmic   Reliability : 2.378

CDS

ATGTTGGGAAATCTGAAAGATTTCCTGTCCGTCGTCCAAGAAGGTTTAACTTCAAACAATAATTTGCGTCAAACGCTACAAGAAGTTCAAAAAGTGACAGGAATTTTCAAGGAAAAACAGAAAGTCGCAACCGAGGACAAAGTTAACTACGGAACTGGCGGTGCCTTACTAGAGAAATATCAAGATGCTTGGGTTGAAATACATGGCAACGCTGATAGTAATTCTAAAGCCGCCGATGAAGTAGATAAATTGATTCTAGAACTACACCAAGAGACGTCATCGCGATTAAAAAGTGCTCACGATTTGGCACAGGGATTGAGTCACATACCCGCCTTGACTGCAGCGGTGGCAGAATGCATGGACAGCATGAAAACCCTGCAAGCCTTAATGAAGACTGTGGAGGAGGAATTAGCAGAATTTGAGGATATTGTAGAGAAAAGCAAACAAGAAAACTGGAAACTAGATCATCAGTATCATCTAACATTGTATAAAGAGAAGAAAATGGCGTCATTGGAAGAAGTTCGCAACAAACTGGCCAGAGAGAACACAGAGAAGAGCATAGAGAAAGAGAAGCAACAAATAGCTAATTTACAAGTTAAAAGAGAAGACAGTGAGATGGCCTTTAAATATGATGTCGCCAAATATTTAGCTAATGGAAATTTACCTACAGTTCCAAAGCCAGTTTCGTCAAAAGTGACTTTAGAACAGATACAGTTGGACGAAGACAAAACAGATCTTGAGAAGTTCCTGGATAGTTGA

Protein

MLGNLKDFLSVVQEGLTSNNNLRQTLQEVQKVTGIFKEKQKVATEDKVNYGTGGALLEKYQDAWVEIHGNADSNSKAADEVDKLILELHQETSSRLKSAHDLAQGLSHIPALTAAVAECMDSMKTLQALMKTVEEELAEFEDIVEKSKQENWKLDHQYHLTLYKEKKMASLEEVRNKLARENTEKSIEKEKQQIANLQVKREDSEMAFKYDVAKYLANGNLPTVPKPVSSKVTLEQIQLDEDKTDLEKFLDS

Description

Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis and membrane trafficking in synapses (PubMed:20015953, PubMed:28317021). In response to high synaptic activity at neuromuscular junctions, stabilizes Pldn protein levels and, together with Pldn, plays a role in promoting efficient synaptic vesicle recycling and re-formation through early endosomes (PubMed:28317021).

Subunit

Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed of Blos1, Blos2, Blos3, Blos4, Dysb, Muted, Pldn and Snapin. Interacts with Pldn and Snapin.

Similarity

Belongs to the dysbindin family.

Keywords

Coiled coil   Complete proteome   Reference proteome  

Feature

chain  Dysbindin protein homolog

Uniprot

H9J494   I7GVK6   I7H180   A0A2H1WPU5   A0A2A4JJN5   A0A1E1W7K3   + More
A0A3S2LE66   A0A0N0PEQ6   S4PH32   A0A2W1BHW3   A0A212EXM4   I4DPI2   K7ILZ2   A0A067REH6   A0A2J7PUN4   A0A195BPY5   A0A158NRU5   A0A195ERS1   A0A195D9I7   E1ZWI9   E2C5C4   A0A1Y1L5R3   A0A151X3U9   A0A154PNK1   A0A226DG35   A0A026W5E5   A0A0M9A118   A0A088A7Z2   A0A0K8TQJ6   A0A3L8D3I4   A0A195CZX0   A0A1B0B1A6   J9K5V3   A0A1B6J9C8   A0A2A3ENX3   A0A0L7RBH2   C4WVV6   A0A1B6E5N0   E9IY65   A0A1I8M8B6   A0A1S3KDV1   A0A1Z5LEN4   A0A1B6FG93   A0A1S3KED0   W8CDK7   A0A1B6KQZ3   A0A2H8TPP8   A0A0A1X687   A0A1L8DD77   A0A0K8U0H9   A0A034WDF1   A0A293N632   B3NDU2   A0A131YTP8   V5I7N4   V5HTK5   B4IFW3   A0A1B0C9V0   A0A1I8P1C8   A0A3B0JU00   Q2M0D9   A0A131YA97   M9PI95   Q9VVT5   A0A1B0A2I7   A0A1B0FDB3   B4KXR8   B4ITP1   A0A1W4UP45   A0A1A9VMZ3   A0A0J9RXR0   A0A023GHD8   G3MLK7   A0A0C9SDS5   A0A224YDY4   A0A131XRR9   A0A1W4X685   E9G5E5   A0A1E1XRE8   B3M865   A0A0V0G700   A0A0L0C6K6   A0A1E1X3L3   A0A3R7SZH1   A0A2P8XEL7   A0A3S3PKQ8   A0A069DXT2   T1IAC7   A0A0P4VLC2   B4LFP9   A0A2Y9SNF2   A0A0N8D1W0   A0A0N8A7D6   C0H7T3   A0A0P4ZEI7   A0A0P5C5F8  

Pubmed

19121390    26354079    23622113    28756777    22118469    22651552    + More
20075255    24845553    21347285    20798317    28004739    24508170    26369729    30249741    21282665    25315136    28528879    24495485    25830018    25348373    17994087    26830274    25765539    15632085    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    12537569    20015953    28317021    17550304    22936249    22216098    26131772    28797301    28049606    21292972    29209593    26108605    28503490    29403074    26334808    27129103    20433749   

EMBL

BABH01032603    AB728505    BAM24364.1    AB728504    BAM24362.1    AB728503    + More
BAM24361.1    ODYU01010165    SOQ55095.1    NWSH01001227    PCG72039.1    GDQN01008223    JAT82831.1    RSAL01000029    RVE51804.1    KQ459838    KPJ19699.1    GAIX01003412    JAA89148.1    KZ150194    PZC72350.1    AGBW02011712    OWR46243.1    AK403618    KQ459460    BAM19822.1    KPJ00822.1    KK852513    KDR22276.1    NEVH01021194    PNF20034.1    KQ976424    KYM88565.1    ADTU01024332    ADTU01024333    KQ981993    KYN30876.1    KQ981153    KYN09064.1    GL434853    EFN74426.1    GL452770    EFN76857.1    GEZM01063911    JAV68914.1    KQ982562    KYQ54950.1    KQ434977    KZC12888.1    LNIX01000021    OXA43541.1    KK107405    EZA51223.1    KQ435793    KOX74196.1    GDAI01000984    JAI16619.1    QOIP01000014    RLU14764.1    KQ977041    KYN06152.1    JXJN01007042    ABLF02028896    GECU01011890    JAS95816.1    KZ288203    PBC33400.1    KQ414617    KOC68165.1    AK341696    BAH72026.1    GEDC01004073    JAS33225.1    GL766908    EFZ14480.1    GFJQ02001098    JAW05872.1    GECZ01020547    JAS49222.1    GAMC01001776    JAC04780.1    GEBQ01026127    JAT13850.1    GFXV01003817    MBW15622.1    GBXI01008037    JAD06255.1    GFDF01009661    JAV04423.1    GDHF01032499    JAI19815.1    GAKP01006792    JAC52160.1    GFWV01022921    MAA47648.1    CH954178    EDV52296.1    GEDV01007041    JAP81516.1    GALX01006130    JAB62336.1    GANP01002739    JAB81729.1    CH480834    EDW46550.1    AJWK01002865    AJWK01002866    AJWK01002867    AJWK01002868    AJWK01002869    AJWK01002870    AJWK01002871    OUUW01000002    SPP76191.1    CH379069    EAL30995.1    GEFM01000426    JAP75370.1    AE014296    AGB94716.1    AY071009    CCAG010006850    CH933809    EDW19775.1    CM000159    CH891726    EDW95409.2    EDW99754.2    KRK02423.1    CM002912    KMZ00454.1    GBBM01002119    JAC33299.1    JO842758    AEO34375.1    GBZX01001702    JAG91038.1    GFPF01000896    MAA12042.1    GEFH01000330    JAP68251.1    GL732532    EFX85193.1    GFAA01001591    JAU01844.1    CH902618    EDV41004.1    GECL01002234    JAP03890.1    JRES01000836    KNC27866.1    GFAC01005345    JAT93843.1    QCYY01000752    ROT83008.1    PYGN01002468    PSN30438.1    NCKU01000694    NCKU01000031    NCKU01000030    RWS14544.1    RWS17830.1    RWS17838.1    GBGD01002720    JAC86169.1    ACPB03005088    GDKW01000685    JAI55910.1    CH940647    EDW70367.1    GDIP01076967    LRGB01000568    JAM26748.1    KZS18022.1    GDIP01175249    JAJ48153.1    BT058389    BT060090    ACN10102.1    ACN12450.1    GDIP01214402    JAJ09000.1    GDIP01175250    JAJ48152.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053240    UP000007151    UP000053268    + More
UP000002358    UP000027135    UP000235965    UP000078540    UP000005205    UP000078541    UP000078492    UP000000311    UP000008237    UP000075809    UP000076502    UP000198287    UP000053097    UP000053105    UP000005203    UP000279307    UP000078542    UP000092460    UP000007819    UP000242457    UP000053825    UP000095301    UP000085678    UP000008711    UP000001292    UP000092461    UP000095300    UP000268350    UP000001819    UP000000803    UP000092445    UP000092444    UP000009192    UP000002282    UP000192221    UP000078200    UP000192223    UP000000305    UP000007801    UP000037069    UP000283509    UP000245037    UP000285301    UP000015103    UP000008792    UP000248484    UP000076858   

PRIDE

H9J494    I7GVK6    I7H180    M9PI95    Q9VVT5   

Pfam

PF04440   Dysbindin

Interpro

IPR007531   Dysbindin       

ProteinModelPortal

H9J494   I7GVK6   I7H180   A0A2H1WPU5   A0A2A4JJN5   A0A1E1W7K3   + More
A0A3S2LE66   A0A0N0PEQ6   S4PH32   A0A2W1BHW3   A0A212EXM4   I4DPI2   K7ILZ2   A0A067REH6   A0A2J7PUN4   A0A195BPY5   A0A158NRU5   A0A195ERS1   A0A195D9I7   E1ZWI9   E2C5C4   A0A1Y1L5R3   A0A151X3U9   A0A154PNK1   A0A226DG35   A0A026W5E5   A0A0M9A118   A0A088A7Z2   A0A0K8TQJ6   A0A3L8D3I4   A0A195CZX0   A0A1B0B1A6   J9K5V3   A0A1B6J9C8   A0A2A3ENX3   A0A0L7RBH2   C4WVV6   A0A1B6E5N0   E9IY65   A0A1I8M8B6   A0A1S3KDV1   A0A1Z5LEN4   A0A1B6FG93   A0A1S3KED0   W8CDK7   A0A1B6KQZ3   A0A2H8TPP8   A0A0A1X687   A0A1L8DD77   A0A0K8U0H9   A0A034WDF1   A0A293N632   B3NDU2   A0A131YTP8   V5I7N4   V5HTK5   B4IFW3   A0A1B0C9V0   A0A1I8P1C8   A0A3B0JU00   Q2M0D9   A0A131YA97   M9PI95   Q9VVT5   A0A1B0A2I7   A0A1B0FDB3   B4KXR8   B4ITP1   A0A1W4UP45   A0A1A9VMZ3   A0A0J9RXR0   A0A023GHD8   G3MLK7   A0A0C9SDS5   A0A224YDY4   A0A131XRR9   A0A1W4X685   E9G5E5   A0A1E1XRE8   B3M865   A0A0V0G700   A0A0L0C6K6   A0A1E1X3L3   A0A3R7SZH1   A0A2P8XEL7   A0A3S3PKQ8   A0A069DXT2   T1IAC7   A0A0P4VLC2   B4LFP9   A0A2Y9SNF2   A0A0N8D1W0   A0A0N8A7D6   C0H7T3   A0A0P4ZEI7   A0A0P5C5F8  

KEGG

101740133    K20189 dysbindin | (RefSeq) Bmdysb; dysbindin-like protein

GO

GO:0005737   GO:0048047   GO:0007616   GO:0008021   GO:0008355   GO:0048167   GO:0045963   GO:0051968   GO:0008344   GO:0031083   GO:0007614   GO:1900073   GO:0036466   GO:0098527   GO:0008057   GO:0050807  

PANTHER

PTHR16294  

Length:

252

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00052

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00828

outside

1  -  252

 

 

Pi

24.195789

Theta

35.902676

Tajima's D

-0.794959

CLR

2339.059105

CSRT

0.178641067946603

Interpretation

Uncertain