Gene

KWMTBOMO12060

Pre Gene Modal

BGIBMGA004301

Annotation

PREDICTED:_E3_ubiquitin-protein_ligase_RNF123-like_[Bombyx_mori]

Location

Bomo_Chr20(-):6546994-6549809      View in EpiBrowser

Full name

E3 ubiquitin-protein ligase RNF123      

Alternative Name

Kip1 ubiquitination-promoting complex protein 1
RING finger protein 123
RING-type E3 ubiquitin transferase RNF123

Location in the cell

Mitochondrial   Reliability : 1.233

CDS

ATGGCCGTGGTGTCTCGAGTGTGTATTCGTGGAGGCGGGGGGGCCAGCTTCGCGCGTCTTATAGCGCGCGGTCTCCCTGACACCGACAGGGTCCATTATTACGTAGCCTTGGCTCCCGTTGCGGGATGTCTCTTAGGGCTACTAGAGCCGAAATTACCACCGGAGCACTTAGATAAAGTGACGAAAGCGCTGATAATGGAACCGTTGTTCCGCATTGACGGTCTAGACTTCATGCTGGGAAAAACCAAGGACAAGAGCTTCTCCTTTTACCGATATCCGGAAGACGTGGCAGCGTCAGACTTGAAAGCGTTGGAGGTAGCGGTAGACCGTCTGCGAGTGGCACGCGATATAGTAACGAGGGCGCGGTCCCCGGGCTCCAGTGGGGCGCAGTCCGACTTGCTCTGCACCATATGCTACGCGAGACCCGCCGACACTGCCTTCGTACCGTGCGGACATCATTCTTGCAGAGCCTGCGTAATGCAGCATCTGCTCAACAGCAAACAATGTTTCTTCTGCAAAGCGGAAATCGATACAGTCCAAGAAATCGAGCCGGCTAACAATTAA

Protein

MAVVSRVCIRGGGGASFARLIARGLPDTDRVHYYVALAPVAGCLLGLLEPKLPPEHLDKVTKALIMEPLFRIDGLDFMLGKTKDKSFSFYRYPEDVAASDLKALEVAVDRLRVARDIVTRARSPGSSGAQSDLLCTICYARPADTAFVPCGHHSCRACVMQHLLNSKQCFFCKAEIDTVQEIEPANN

Description

Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.

Catalytic Activity

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Subunit

Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2. Interacts with UBAC1 and CDKN1B via its N-terminal domain.

Keywords

Acetylation   Alternative splicing   Complete proteome   Cytoplasm   Metal-binding   Methylation   Phosphoprotein   Reference proteome   Transferase   Ubl conjugation   Ubl conjugation pathway   Zinc   Zinc-finger   3D-structure   Polymorphism  

Feature

chain  E3 ubiquitin-protein ligase RNF123
splice variant  In isoform 2.
sequence variant  In dbSNP:rs2960546.

Uniprot

A0A2W1B8F0   A0A2A4JZP7   A0A2H1W864   A0A0L7LBE9   A0A194QQ69   A0A194Q638   + More
A0A232ETI7   K7IRA5   A0A2L2YC53   A0A2L2YC59   A0A088A2B9   A0A2A3E9Z9   E2AXN8   A0A1D2N598   A0A067RFY2   T1DCJ6   A0A1S3KH47   E2BUD9   A0A0B6XY99   A0A087U4A8   A0A158NPK7   A0A3L8D5W7   A0A026VY39   A0A0L7QZT7   F6TXP6   A0A195ELB7   G3TAQ7   G3UDJ9   F6TZ28   A0A1A6H0F7   A0A2T7NUJ8   A0A2K6BNB1   A0A2K5M3B5   A0A2K5JPN0   A0A2J8TGM6   A0A2K5ZHR4   G3S6F3   A0A2R9AZZ6   A0A1Z5LCS5   A0A2K6L3K7   T2MCA6   A0A2K6NBE4   H0X5J3   A0A1L8GP90   K7DHN4   K7AI08   V4A671   A0A0N0BH43   G1PTN3   A0A2J8TGR0   A0A226DAC8   A0A2K5EDK2   E0VGB7   A0A2K5S5G3   Q5XPI3-2   A0A2K5S5K0   A0A2K6BND4   A0A2K5ZHP9   A0A2I3LM12   A0A2K5M3D3   A0A2K5JPQ0   A0A2R9AW47   G3R4Y6   A0A1U7TU49   A0A2K6NBC6   A0A2K6L3M1   A0A2I3TW30   G1R5C7   U3DTN3   Q5XPI4   V8PA58   B3KU09   G3H8E8   A0A093PE73   A0A250YM69   A0A2K5UN43   G7ML89   G8F4N4   I0FU39   A0A2K5EDN6   D3ZXK7   A0A2K5S5K7   F1SPR6   C9JI97   E1C5W8   A0A3Q0CY04   I3LFZ7   A0A2R5LIJ3   A0A218UQG7   T1IK83  

EC Number

2.3.2.27

Pubmed

28756777    26227816    26354079    28648823    20075255    26561354    + More
20798317    27289101    24845553    26383154    21347285    30249741    24508170    19892987    22398555    22722832    28528879    24065732    25362486    27762356    16136131    23254933    21993624    20566863    15531880    15489334    21183079    24129315    25243066    16641997    15498874    14702039    11230166    16227581    21269460    22814378    24297900    21804562    28087693    17431167    22002653    25319552    15057822    19015242    22673903    15592404    30723633   

EMBL

KZ150458    PZC70805.1    NWSH01000349    PCG77158.1    ODYU01006952    SOQ49271.1    + More
JTDY01001920    KOB72541.1    KQ461181    KPJ07658.1    KQ459460    KPJ00829.1    NNAY01002280    OXU21637.1    IAAA01018209    LAA05746.1    IAAA01018210    IAAA01018211    LAA05752.1    KZ288311    PBC28540.1    GL443628    EFN61784.1    LJIJ01000233    ODN00116.1    KK852486    KDR22786.1    GAKT01000022    JAA93040.1    GL450640    EFN80666.1    HACG01001973    CEK48838.1    KK118079    KFM72197.1    ADTU01022570    ADTU01022571    ADTU01022572    ADTU01022573    QOIP01000012    RLU15862.1    KK107599    EZA48585.1    KQ414673    KOC64134.1    KQ978730    KYN29013.1    LZPO01058615    OBS71320.1    PZQS01000009    PVD24832.1    NDHI03003498    PNJ32205.1    CABD030021308    AJFE02064353    AJFE02064354    GFJQ02001952    JAW05018.1    HAAD01003298    CDG69530.1    AAQR03164084    AAQR03164085    AAQR03164086    CM004472    OCT85640.1    GABE01005829    NBAG03000218    JAA38910.1    PNI80599.1    AACZ04000315    GABC01003989    GABF01004529    JAA07349.1    JAA17616.1    KB202620    ESO88781.1    KQ435762    KOX75498.1    AAPE02059061    AAPE02059062    AAPE02059063    PNJ32211.1    LNIX01000028    OXA41687.1    DS235135    EEB12423.1    AY744153    BC057082    AHZZ02020133    AHZZ02020134    PNI80601.1    ADFV01173171    ADFV01173172    GAMT01005086    GAMS01010006    GAMP01001055    JAB06775.1    JAB13130.1    JAB51700.1    AY744152    AC099668    BC041145    BC057392    BC088801    BC130632    AF370367    AK022627    AK026968    AL136729    AZIM01000463    ETE70883.1    AK096353    BAG53271.1    JH000209    EGW08931.1    KL668904    KFW74716.1    GFFW01000071    JAV44717.1    AQIA01039642    JSUE03023699    JU476736    JU476737    CM001254    AFH33540.1    EHH16359.1    JH330954    EHH62248.1    JV047894    AFI37965.1    AEMK02000086    AADN05000356    DQIR01100801    HDA56277.1    GGLE01005021    MBY09147.1    MUZQ01000178    OWK56015.1    JH430443   

Proteomes

UP000218220    UP000037510    UP000053240    UP000053268    UP000215335    UP000002358    + More
UP000005203    UP000242457    UP000000311    UP000094527    UP000027135    UP000085678    UP000008237    UP000054359    UP000005205    UP000279307    UP000053097    UP000053825    UP000002281    UP000078492    UP000007646    UP000092124    UP000245119    UP000233120    UP000233060    UP000233080    UP000233140    UP000001519    UP000240080    UP000233180    UP000233200    UP000005225    UP000186698    UP000002277    UP000030746    UP000053105    UP000001074    UP000198287    UP000233020    UP000009046    UP000233040    UP000000589    UP000028761    UP000189704    UP000001073    UP000008225    UP000005640    UP000001075    UP000053258    UP000233100    UP000006718    UP000009130    UP000002494    UP000008227    UP000000539    UP000189706    UP000197619   

PRIDE

Q5XPI3    Q5XPI4    B3KU09    G3H8E8    D3ZXK7    F1SPR6    + More
C9JI97   

Pfam

PF00622   SPRY

Interpro

IPR013083   Znf_RING/FYVE/PHD        + More
IPR001841   Znf_RING       
IPR001870   B30.2/SPRY       
IPR013320   ConA-like_dom_sf       
IPR003877   SPRY_dom       
IPR035773   SPRY_RNF123       
IPR016024   ARM-type_fold       

SUPFAM

SSF49899   SSF49899        + More
SSF48371   SSF48371       

Gene 3D

3.30.40.10    

CDD

cd12882  SPRY_RNF123

ProteinModelPortal

A0A2W1B8F0   A0A2A4JZP7   A0A2H1W864   A0A0L7LBE9   A0A194QQ69   A0A194Q638   + More
A0A232ETI7   K7IRA5   A0A2L2YC53   A0A2L2YC59   A0A088A2B9   A0A2A3E9Z9   E2AXN8   A0A1D2N598   A0A067RFY2   T1DCJ6   A0A1S3KH47   E2BUD9   A0A0B6XY99   A0A087U4A8   A0A158NPK7   A0A3L8D5W7   A0A026VY39   A0A0L7QZT7   F6TXP6   A0A195ELB7   G3TAQ7   G3UDJ9   F6TZ28   A0A1A6H0F7   A0A2T7NUJ8   A0A2K6BNB1   A0A2K5M3B5   A0A2K5JPN0   A0A2J8TGM6   A0A2K5ZHR4   G3S6F3   A0A2R9AZZ6   A0A1Z5LCS5   A0A2K6L3K7   T2MCA6   A0A2K6NBE4   H0X5J3   A0A1L8GP90   K7DHN4   K7AI08   V4A671   A0A0N0BH43   G1PTN3   A0A2J8TGR0   A0A226DAC8   A0A2K5EDK2   E0VGB7   A0A2K5S5G3   Q5XPI3-2   A0A2K5S5K0   A0A2K6BND4   A0A2K5ZHP9   A0A2I3LM12   A0A2K5M3D3   A0A2K5JPQ0   A0A2R9AW47   G3R4Y6   A0A1U7TU49   A0A2K6NBC6   A0A2K6L3M1   A0A2I3TW30   G1R5C7   U3DTN3   Q5XPI4   V8PA58   B3KU09   G3H8E8   A0A093PE73   A0A250YM69   A0A2K5UN43   G7ML89   G8F4N4   I0FU39   A0A2K5EDN6   D3ZXK7   A0A2K5S5K7   F1SPR6   C9JI97   E1C5W8   A0A3Q0CY04   I3LFZ7   A0A2R5LIJ3   A0A218UQG7   T1IK83  

PDB

2MA6     E-value=4.50388e-13,     Score=176

KEGG

101738337    K12169 Kip1 ubiquitination-promoting complex protein 1 [EC:2.3.2.27] | (RefSeq) E3 ubiquitin-protein

GO

GO:0046872   GO:0016874   GO:0031965   GO:0005829   GO:0051603   GO:0004842   GO:0005737   GO:0016579   GO:0005515   GO:0008270   GO:0003743   GO:0006432   GO:0000049   GO:0000287   GO:0008033   GO:0003676   GO:0016787  

Subcellular location

Cytoplasm  

Length:

187

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.80277000000001

Exp number, first 60 AAs:

2.79572

Total prob of N-in:

0.35808

outside

1  -  187

 

 

Pi

79.429119

Theta

122.366672

Tajima's D

-0.717116

CLR

132.267746

CSRT

0.193040347982601

Interpretation

Uncertain