Gene

KWMTBOMO12019  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001383

Annotation

PREDICTED:_UDP-glucose_4-epimerase_isoform_X2_[Amyelois_transitella]

Location

Bomo_Chr20(+):5627291-5641885      View in EpiBrowser

Full name

UDP-glucose 4-epimerase      

Alternative Name

Galactowaldenase
UDP-N-acetylgalactosamine 4-epimerase
UDP-N-acetylglucosamine 4-epimerase
UDP-galactose 4-epimerase

Location in the cell

Cytoplasmic   Reliability : 2.844

CDS

ATGTCACGAGCAGTTTTAGTGACGGGTGGTGCGGGCTATGTCGGCTCCCACACCGTGATAACGTTATTAGAACGACAGTCGGACGGCGATCCTTTGGAAATCGTGGTGGTGGATAACTTGTCGAACGCCTACTGCGCCGAGGGGGAGAAGAAACCGGAAGCGTTGAAGAGAATCGAAGAGTTGACCGGGAAGACGGTGCATTTTTATAAAGTAGACATCAGATGTGCCGAGGCCTTGGACAGGATATTTGAAAATCACAACATCGATTGTGTAATACATTTCGCGGCTTTGAAGGCCGTCGGAGAGTCGGTGGAGAAGCCTCTAGAATATTATCAGGTTAATATCAACGGAACTTGCACGCTGTTCGAGATAATGCGGAAACACGGCGTCTACAAGCTGGTCTACAGTTCGTCGTGCACGGTTTACGGTGAGCCGGAGTATCTGCCAATCAACGAGTCGCACCCTACGGGCAAGTCCCTGACCAGCCCCTACGGAAAGTCGAAGTACTTCTGCGAGGAGATCATGAAAGATTTGTGTGTGAGCGATAAGAAATGGGCGATAATATCTTTACGATACTTCAATCCGGTCGGGGCCCACGAAAGCGGCCGAATAGGAGAGGATCCCTCTGGCATACCCAACAACCTAATGCCTTACATTTCCCAGGTAGCAGTCGGTCGGCTAAAGGAGCTGAAAGTGTTCGGCGACGATTATCCCACCGCGGACGGGACCGGCGTCCGGGACTATATCCACGTGTGCGACCTCGCCGCGGGACACGTGCAGGCCATAAAACTGTTCCACCAGCCGGGCTTCAACGGTTTCCATGCTATTAATTTGGGTACGGGCACTGGTTACTCGGTGCTGGAGATGGTAGCGGCGTTCTCCAACGCGAGCGGGCGGGCCGTGCCGCACGCCGTGGCGCCGCGTCGCGCCGGTGACGTCACCGCGAACGTTGCCGACGTCGCGCTGGCGACGCGCTCGCTCGGCTGGCGCGCGACTCGGAGCCTGCACGACATGTGTCGCGACACGTGGCGCTGGCAGGAGGCCAACCCCAACGGGTATCATCGAATTTAA

Protein

MSRAVLVTGGAGYVGSHTVITLLERQSDGDPLEIVVVDNLSNAYCAEGEKKPEALKRIEELTGKTVHFYKVDIRCAEALDRIFENHNIDCVIHFAALKAVGESVEKPLEYYQVNINGTCTLFEIMRKHGVYKLVYSSSCTVYGEPEYLPINESHPTGKSLTSPYGKSKYFCEEIMKDLCVSDKKWAIISLRYFNPVGAHESGRIGEDPSGIPNNLMPYISQVAVGRLKELKVFGDDYPTADGTGVRDYIHVCDLAAGHVQAIKLFHQPGFNGFHAINLGTGTGYSVLEMVAAFSNASGRAVPHAVAPRRAGDVTANVADVALATRSLGWRATRSLHDMCRDTWRWQEANPNGYHRI

Description

Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine (PubMed:20519568, PubMed:22654673). The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited (PubMed:22654673). Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.

Catalytic Activity

UDP-alpha-D-glucose = UDP-alpha-D-galactose
UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine

Cofactor

NAD(+)

Subunit

Homodimer.

Similarity

Belongs to the NAD(P)-dependent epimerase/dehydratase family.

Keywords

Carbohydrate metabolism   Complete proteome   Galactose metabolism   Isomerase   NAD   Reference proteome  

Feature

chain  UDP-glucose 4-epimerase

Uniprot

H9IVV2   A0A2W1BQF2   A0A3S2LWN2   A0A2A4JNG8   A0A194QQQ9   A0A194Q666   + More
A0A2H1VIP0   A0A212EHH2   A0A139WFL0   A0A336LBY7   D6WSX2   V5GPP8   A0A2C9GQV4   A0A182VMD8   A0A182UCF9   A0A182KSR0   Q7PV85   B0WMJ0   U4UDS4   T1E2S2   A0A1Q3FLC5   A0A182LX25   A0A1L8E3I8   Q172F3   A0A1L8E441   A0A1Y1LQ25   A0A1A9ZKG0   D3TMH4   A0A023EP92   T1DPN5   A0A0L0CLR4   A0A182J1E6   A0A1I8NLK2   A0A1L8EE46   A0A1A9UG26   A0A1A9Y049   A0A2M3ZFI5   A0A084WHZ7   A0A1B0BC58   A0A0P9AJQ7   B3M510   T1PAU7   A0A023ERJ5   A0A023EQC7   A0A2M4A0A9   W5JRQ4   A0A182FTV0   B4LGL1   A0A0K8TT63   A0A2M4A031   A0A1B6DWH8   B4L0A3   A0A182QFI6   B3NER7   A0A0N7ZA49   A0A2M4BSX0   A0A2P8Y926   M9ND19   Q9W0P5   B4MLB3   B4HVH8   A0A1W4W2M6   B4PCL3   B4QLD3   A0A131XAL5   U5ETM2   A0A067RNT6   B4J2S9   Q29DV7   A0A1J1IAW3   A0A131Y0T9   A0A182Y1V0   L7MH49   L7MFJ6   A0A0M4EY01   A0A1B6KVW1   A0A087U2J7   A0A3B0KGG8   L7MG60   A0A023GLB2   G3MLG7   A0A224Z373   A0A154PQA9   A0A2J7QHA8   A0A2J7QHF1   A0A0K8RJQ9   A0A023FKK4   E0VTM8   A0A131YI57   W8C4J0   E9GAX9   A0A1B6FBE9   A0A0A1WQQ2   A0A034W6A1   B4H4C0   N6UEA9   A0A023ER70   A0A088AN42   E9JD64   A0A1B6HGQ9  

EC Number

5.1.3.2

Pubmed

19121390    28756777    26354079    22118469    18362917    19820115    + More
20966253    12364791    14747013    17210077    23537049    24330624    17510324    28004739    20353571    24945155    26483478    26108605    24438588    17994087    25315136    20920257    23761445    18057021    26369729    29403074    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    12537569    20519568    22654673    17550304    22936249    28049606    24845553    15632085    25244985    25576852    22216098    28797301    20566863    26830274    24495485    21292972    25830018    25348373    21282665   

EMBL

BABH01041895    KZ149954    PZC76531.1    RSAL01000153    RVE45684.1    NWSH01001038    + More
PCG72983.1    KQ461181    KPJ07684.1    KQ459460    KPJ00859.1    ODYU01002580    SOQ40272.1    AGBW02014898    OWR40920.1    KQ971352    KYB26631.1    UFQS01002627    UFQT01002627    SSX14391.1    SSX33801.1    EFA06670.2    GALX01004909    JAB63557.1    APCN01003286    AAAB01008986    EAA00282.3    DS231998    EDS31061.1    KB632095    ERL88746.1    GALA01001040    JAA93812.1    GFDL01006656    JAV28389.1    AXCM01004494    GFDF01000793    JAV13291.1    CH477438    EAT40915.1    GFDF01000792    JAV13292.1    GEZM01049938    GEZM01049937    JAV75749.1    CCAG010023541    EZ422626    ADD18902.1    JXUM01032454    GAPW01002306    KQ560956    JAC11292.1    KXJ80217.1    GAMD01003194    JAA98396.1    JRES01000215    KNC33235.1    GFDG01001894    JAV16905.1    GGFM01006477    MBW27228.1    ATLV01023900    KE525347    KFB49841.1    JXJN01011850    CH902618    KPU78064.1    EDV39489.1    KA645862    AFP60491.1    GAPW01002307    JAC11291.1    GAPW01002305    JAC11293.1    GGFK01000839    MBW34160.1    ADMH02000662    ETN65404.1    CH940647    EDW69449.1    KRF84396.1    KRF84397.1    GDAI01000056    JAI17547.1    GGFK01000832    MBW34153.1    GEDC01007254    JAS30044.1    CH933809    EDW18049.1    AXCN02001044    CH954178    EDV50062.1    GDRN01104782    JAI57856.1    GGFJ01006953    MBW56094.1    PYGN01000792    PSN40758.1    AE014296    AFH04208.1    AY058582    CH963847    EDW73371.1    CH480817    EDW49943.1    CM000159    EDW92736.1    CM000363    CM002912    EDX08706.1    KMY96698.1    GEFH01004448    JAP64133.1    GANO01001851    JAB58020.1    KK852513    KDR22270.1    CH916366    EDV96070.1    CH379070    EAL30306.3    CVRI01000042    CRK95577.1    GEFM01002927    JAP72869.1    GACK01002461    JAA62573.1    GACK01002462    JAA62572.1    CP012525    ALC43275.1    GEBQ01024378    JAT15599.1    KK117848    KFM71586.1    OUUW01000012    SPP87500.1    GACK01002217    JAA62817.1    GBBM01001525    JAC33893.1    JO842718    AEO34335.1    GFPF01013172    MAA24318.1    KQ435037    KZC14091.1    NEVH01013982    PNF27975.1    PNF27973.1    GADI01002466    JAA71342.1    GBBK01002808    JAC21674.1    DS235767    EEB16703.1    GEDV01010342    JAP78215.1    GAMC01009571    GAMC01009570    JAB96984.1    GL732537    EFX83336.1    GECZ01022308    GECZ01003021    JAS47461.1    JAS66748.1    GBXI01013482    GBXI01006023    JAD00810.1    JAD08269.1    GAKP01007838    GAKP01007837    GAKP01007836    GAKP01007835    GAKP01007834    GAKP01007833    JAC51116.1    CH479208    EDW31235.1    APGK01025901    KB740605    ENN80050.1    GAPW01002454    JAC11144.1    GL771866    EFZ09276.1    GECU01034193    GECU01033854    JAS73513.1    JAS73852.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000053240    UP000053268    UP000007151    + More
UP000007266    UP000075840    UP000075903    UP000075902    UP000075882    UP000007062    UP000002320    UP000030742    UP000075883    UP000008820    UP000092445    UP000092444    UP000069940    UP000249989    UP000037069    UP000075880    UP000095300    UP000078200    UP000092443    UP000030765    UP000092460    UP000007801    UP000095301    UP000000673    UP000069272    UP000008792    UP000009192    UP000075886    UP000008711    UP000245037    UP000000803    UP000007798    UP000001292    UP000192221    UP000002282    UP000000304    UP000027135    UP000001070    UP000001819    UP000183832    UP000076408    UP000092553    UP000054359    UP000268350    UP000076502    UP000235965    UP000009046    UP000000305    UP000008744    UP000019118    UP000005203   

PRIDE

H9IVV2    M9ND19    Q9W0P5   

Pfam

PF16363   GDP_Man_Dehyd        + More
PF01370   Epimerase

Interpro

IPR036291   NAD(P)-bd_dom_sf        + More
IPR016040   NAD(P)-bd_dom       
IPR005886   UDP_G4E       
IPR001509   Epimerase_deHydtase       

SUPFAM

SSF51735   SSF51735       

CDD

cd05247  UDP_G4E_1_SDR_e

ProteinModelPortal

H9IVV2   A0A2W1BQF2   A0A3S2LWN2   A0A2A4JNG8   A0A194QQQ9   A0A194Q666   + More
A0A2H1VIP0   A0A212EHH2   A0A139WFL0   A0A336LBY7   D6WSX2   V5GPP8   A0A2C9GQV4   A0A182VMD8   A0A182UCF9   A0A182KSR0   Q7PV85   B0WMJ0   U4UDS4   T1E2S2   A0A1Q3FLC5   A0A182LX25   A0A1L8E3I8   Q172F3   A0A1L8E441   A0A1Y1LQ25   A0A1A9ZKG0   D3TMH4   A0A023EP92   T1DPN5   A0A0L0CLR4   A0A182J1E6   A0A1I8NLK2   A0A1L8EE46   A0A1A9UG26   A0A1A9Y049   A0A2M3ZFI5   A0A084WHZ7   A0A1B0BC58   A0A0P9AJQ7   B3M510   T1PAU7   A0A023ERJ5   A0A023EQC7   A0A2M4A0A9   W5JRQ4   A0A182FTV0   B4LGL1   A0A0K8TT63   A0A2M4A031   A0A1B6DWH8   B4L0A3   A0A182QFI6   B3NER7   A0A0N7ZA49   A0A2M4BSX0   A0A2P8Y926   M9ND19   Q9W0P5   B4MLB3   B4HVH8   A0A1W4W2M6   B4PCL3   B4QLD3   A0A131XAL5   U5ETM2   A0A067RNT6   B4J2S9   Q29DV7   A0A1J1IAW3   A0A131Y0T9   A0A182Y1V0   L7MH49   L7MFJ6   A0A0M4EY01   A0A1B6KVW1   A0A087U2J7   A0A3B0KGG8   L7MG60   A0A023GLB2   G3MLG7   A0A224Z373   A0A154PQA9   A0A2J7QHA8   A0A2J7QHF1   A0A0K8RJQ9   A0A023FKK4   E0VTM8   A0A131YI57   W8C4J0   E9GAX9   A0A1B6FBE9   A0A0A1WQQ2   A0A034W6A1   B4H4C0   N6UEA9   A0A023ER70   A0A088AN42   E9JD64   A0A1B6HGQ9  

PDB

1HZJ     E-value=3.86337e-113,     Score=1043

KEGG

101741353    K01784 UDP-glucose 4-epimerase [EC:5.1.3.2] | (RefSeq) UDP-glucose 4-epimerase

PATHWAY

00052    Galactose metabolism - Bombyx mori (domestic silkworm)
00520    Amino sugar and nucleotide sugar metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006012   GO:0003978   GO:0016853   GO:0050662   GO:0005829   GO:0019388   GO:0016021   GO:0033499   GO:0035167   GO:0003974   GO:0005840   GO:0006412   GO:0005856   GO:0004890   GO:0005216   GO:0043564   GO:0006418   GO:0003824  

Length:

356

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.48188

Exp number, first 60 AAs:

0.33313

Total prob of N-in:

0.02687

outside

1  -  356

 

 

Pi

239.024323

Theta

163.333142

Tajima's D

1.873495

CLR

0.252073

CSRT

0.866856657167142

Interpretation

Uncertain