Gene

KWMTBOMO12011

Pre Gene Modal

BGIBMGA004358

Annotation

PREDICTED:_focal_adhesion_kinase_1_[Bombyx_mori]

Location

Bomo_Chr20(-):5413372-5433230      View in EpiBrowser

Location in the cell

Nuclear   Reliability : 2.134

CDS

ATGCTGAAGTACTTGGAAACGATGCACACACACTACGGGTACGACCGCGAGACGTTCGCAGGGGCCCTCGGCACCGGCTGGTTCATACCGGTCGAACTGGCCATCGGTCCTGATATAGATATATCGTACGTGTCCCACAAGGCCGGCGAGCCACCCACCTACACGAAGATAGCTTCGTTCAGCGACATCGAAGCCGTACAGACGCTCAAGTCGAACTGCACACAACAATCGCAGACTCAGACCGGTTCGTGCGGCAAGGCGGCGCTGCAACTGCGCGTCAAGGGCGCTGCGGAAACATTGACGATCACTTGCAGCAGTGTAGAGGCCGCAGAGAGCTTAGCCGATCTGGTAGATGGATACTGTAGACTGGTCACAGATTCTCAAACTTCTCTATGGAATCGAACGACTAACGTGTGGAAGCAACTTAACTGTCAATGCAAAACTGAGATGAGCAGCAGTTCGTCAGAAGGGAAGACGAGTTCCTGGGAGGCGAACACCGCCACTCTGCTGTCTGAGGACTACGCAGAGATTGTCGATGACGATGCGGACTACTCTACTCCTGCAGTTCGCGATTACGAATTAGTTCGTAATCAGATCGAGTTGACGGGAATCATTGGGGAGGGACAGTTCGGCGATGTACACAAAGGCACGTGCCGGGTGACGTCAGCCAACCACCCGTCGCTGCGTCGCCAGCTGTCCATCCAGAAGCAGCAGGGCAAGAGCCAGAGCGGCGAGTACGTGCTGCCGGTGGCCGTGAAGACATGCAAGATGGACGCCGACTTGGACACCGCCGAGAAGTTTCTAGAAGAAGCATATATAATGCAGCAGTTCTCCCACCCCCACATCATCGGCCTGGTCGGCGTGTGCAGCTCGTCGCCGATATGGATCGTCATGGAGCTGGCAACACTCGGCGAGATGCGGGCCTACTTACAGCAAAACGCGCACAGGTTGGAGACGTGTCAGCTAGTGCTGTACATATACCAGCTGTCGACCGCGCTCAGCTACCTCGAGAGCAAGAAGTTTGTCCACCGAGACATCGCCGCCAGGAACGTTCTGGTCTCAACGCCCACCTGTGTTAAATTGGCCGATTTCGGGCTATCGAAAATGGTCGAGGACAAGTCTTACTACAAGGCCTCGAGGGGCAAACTGCCTATTAAATGGATGGCGCCAGAGTCGATTAACTTCAGGCGATTCACGTCCGCTTCCGACGTATGGATGTTCGGCGTCTGCATGTGGGAGATCCTGATGCTGGGAGTGAAGCCGTTCAGCGGGGTTAAGAACAACGACGTGATCGGCAAGCTGGAGAACGGCGAGCGGCTGGCCCTCCCCCCGCGCTGCCCCCCGCGCCTCTACTCCGTCATGTCGCGCTGCTGGGCCTACGAGCCCTCGCACCGCCCCGCCGCGCACCTCCTCAAGGAGACGCTCTTTGAGATATTACAAGAGGAGCGCAACACCGCGTGGGACACAATGCGGCGTGAGAACCGACGCGTGGCCGCCGCCTCGTGGGGCGAGCAGCCTCCGCCCAAACCGTCCAGACCTCATACCAACCTCAACGCAGCGGAGGGGAGCGCGGCGGCGGCGGGCGGGGCGCCGCAGACTTACATCGTGGCGCAGAACCCGCTCGTGCTGGCGCACCTGCTGCGGGAGAACAAGGCGCGCGCGCTGGAGCCGCGGGCCTACACCACGCCCGCCTCGGTATTCAACACCGTCGCCGTAGACTTCGCGGAGACTCTACCGGAGAACGACCCCGCCATCGTCGATAAGATCATCCACCCCAAACCAGACGAGACCATCGACATCCCCCTCCAGACCGCCCCCATCCCCGCCGCCAGCCTGCAGAAGCTAGACCCGGTCGTGCCGCCGCCCGAGGAATCTGACGAGACTCTCACAGTGGTGGTCGGCGCCCGCGAGAGCTGCGACAATCTGTGTCAGAATATGCAGAGTGCGTCTCCCGGCGAGGAGGCCGCCGCGGAGTCCTACAGCAACCGCGTCAGGTCTCTGGAGAGGAGCACTCGCGCCCCGCTGTCCACTGTGGAGCGCGGCCCCGTGCGCGTGGGGTCGCTGGAGCGGACCGCACGCGTGTCTCGGCGTGGGTCCCCGGTGGGTGCGGCGCCGCTCGCCCGGCAGCACTCGGTGCCCGCGTCGCCGCCGCCGCGCGCGCGCCGGGACCGCGACGTGGGGCAGTTCTCGGTGCAGGGCACGACCAACGCGCAGCTGGCCGCCAGCGTCGTCAACAAGATGCGGCAGCAGCCCGAGCCGCCGCTGGTGGAGGAGATATACGACTTCGGCGGCGACAACGTGAGGAGCTGCGTGGCGGTGGCCGCCCAGCGCGCCCGGGGGGGGCCGCGGGGGCGGGGGGCGGCGGGGGGCGCGCGCGCGCAGGTGATGCCCGCAGCATGTGTCGGTTGGCCGGCAGTAGGCCCGCGCCCTGTAGATACACCGCTAGAGCATGCTCGTGTCACGGTTTTGTGTTCCTTTGATTTAGTTGTTTCCGCTGGCAAATCGGTTTTTTTGGTAGCTGTTTTTTGTAGTCGAATGTAA

Protein

MLKYLETMHTHYGYDRETFAGALGTGWFIPVELAIGPDIDISYVSHKAGEPPTYTKIASFSDIEAVQTLKSNCTQQSQTQTGSCGKAALQLRVKGAAETLTITCSSVEAAESLADLVDGYCRLVTDSQTSLWNRTTNVWKQLNCQCKTEMSSSSSEGKTSSWEANTATLLSEDYAEIVDDDADYSTPAVRDYELVRNQIELTGIIGEGQFGDVHKGTCRVTSANHPSLRRQLSIQKQQGKSQSGEYVLPVAVKTCKMDADLDTAEKFLEEAYIMQQFSHPHIIGLVGVCSSSPIWIVMELATLGEMRAYLQQNAHRLETCQLVLYIYQLSTALSYLESKKFVHRDIAARNVLVSTPTCVKLADFGLSKMVEDKSYYKASRGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMLGVKPFSGVKNNDVIGKLENGERLALPPRCPPRLYSVMSRCWAYEPSHRPAAHLLKETLFEILQEERNTAWDTMRRENRRVAAASWGEQPPPKPSRPHTNLNAAEGSAAAAGGAPQTYIVAQNPLVLAHLLRENKARALEPRAYTTPASVFNTVAVDFAETLPENDPAIVDKIIHPKPDETIDIPLQTAPIPAASLQKLDPVVPPPEESDETLTVVVGARESCDNLCQNMQSASPGEEAAAESYSNRVRSLERSTRAPLSTVERGPVRVGSLERTARVSRRGSPVGAAPLARQHSVPASPPPRARRDRDVGQFSVQGTTNAQLAASVVNKMRQQPEPPLVEEIYDFGGDNVRSCVAVAAQRARGGPRGRGAAGGARAQVMPAACVGWPAVGPRPVDTPLEHARVTVLCSFDLVVSAGKSVFLVAVFCSRM

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Uniprot

A0A2A4IZB3   A0A2H1VD97   A0A194QFF4   A0A194QQA5   A0A088AN13   A0A2P8ZLI5   + More
A0A3L8DXL9   A0A2J7RP39   A0A067R8A5   A0A026W508   E9JCV7   A0A2J7RP41   E2AKA8   A0A0L7RDW5   A0A154PBB2   E2BTJ2   A0A0C9RQQ4   A0A232EXM7   A0A139WEU8   D6WQS4   A0A0M8ZYC2   A0A1S4F8A3   Q17C76   Q7QHB8   A0A1Q3G2P4   A0A1Q3G2R2   A0A0K8V9H7   A0A0Q9W4B7   A0A0Q9WET7   A0A0Q9X909   A0A034W678   A0A0K8VV62   A0A182RAR1   B4MRQ5   B4KME3  

Pubmed

26354079    29403074    30249741    24845553    24508170    21282665    + More
20798317    28648823    18362917    19820115    17510324    12364791    17994087    18057021    25348373   

EMBL

NWSH01004533    PCG64979.1    ODYU01001925    SOQ38808.1    KQ459053    KPJ04144.1    + More
KQ461181    KPJ07688.1    PYGN01000022    PSN57364.1    QOIP01000003    RLU24689.1    NEVH01002141    PNF42592.1    KK852816    KDR15787.1    KK107419    EZA51098.1    GL771866    EFZ09187.1    PNF42593.1    GL440210    EFN66133.1    KQ414613    KOC69043.1    KQ434864    KZC09131.1    GL450410    EFN81020.1    GBYB01009576    JAG79343.1    NNAY01001731    OXU23095.1    KQ971354    KYB26419.1    EFA06030.2    KQ435824    KOX72079.1    CH477311    EAT43915.1    AAAB01008816    EAA05272.4    GFDL01000950    JAV34095.1    GFDL01000974    JAV34071.1    GDHF01016797    JAI35517.1    CH940648    KRF79805.1    KRF79804.1    KRF79806.1    KRF79807.1    CH933808    KRG04928.1    GAKP01009150    JAC49802.1    GDHF01009553    JAI42761.1    CH963850    EDW74794.2    EDW09831.1   

Proteomes

UP000218220    UP000053268    UP000053240    UP000005203    UP000245037    UP000279307    + More
UP000235965    UP000027135    UP000053097    UP000000311    UP000053825    UP000076502    UP000008237    UP000215335    UP000007266    UP000053105    UP000008820    UP000007062    UP000008792    UP000009192    UP000075900    UP000007798   

Pfam

PF07714   Pkinase_Tyr        + More
PF00373   FERM_M
PF18038   FERM_N_2
PF03623   Focal_AT

Interpro

IPR019748   FERM_central        + More
IPR011993   PH-like_dom_sf       
IPR041390   FADK_N       
IPR000299   FERM_domain       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR029071   Ubiquitin-like_domsf       
IPR011009   Kinase-like_dom_sf       
IPR019749   Band_41_domain       
IPR036137   Focal_adhe_kin_target_dom_sf       
IPR000719   Prot_kinase_dom       
IPR014352   FERM/acyl-CoA-bd_prot_sf       
IPR035963   FERM_2       
IPR041784   FAK1/PYK2_FERM_C       
IPR008266   Tyr_kinase_AS       
IPR020635   Tyr_kinase_cat_dom       
IPR005189   Focal_adhesion_kin_target_dom       
IPR017441   Protein_kinase_ATP_BS       

SUPFAM

SSF68993   SSF68993        + More
SSF56112   SSF56112       
SSF47031   SSF47031       
SSF54236   SSF54236       

Gene 3D

1.20.80.10     2.30.29.30    

CDD

cd13190  FERM_C_FAK1
cd14473  FERM_B-lobe

ProteinModelPortal

A0A2A4IZB3   A0A2H1VD97   A0A194QFF4   A0A194QQA5   A0A088AN13   A0A2P8ZLI5   + More
A0A3L8DXL9   A0A2J7RP39   A0A067R8A5   A0A026W508   E9JCV7   A0A2J7RP41   E2AKA8   A0A0L7RDW5   A0A154PBB2   E2BTJ2   A0A0C9RQQ4   A0A232EXM7   A0A139WEU8   D6WQS4   A0A0M8ZYC2   A0A1S4F8A3   Q17C76   Q7QHB8   A0A1Q3G2P4   A0A1Q3G2R2   A0A0K8V9H7   A0A0Q9W4B7   A0A0Q9WET7   A0A0Q9X909   A0A034W678   A0A0K8VV62   A0A182RAR1   B4MRQ5   B4KME3  

PDB

2J0J     E-value=1.21392e-128,     Score=1181

KEGG

101745942    K05725 focal adhesion kinase 1 [EC:2.7.10.2] | (RefSeq) focal adhesion kinase 1

GO

GO:0005524   GO:0007172   GO:0005925   GO:0004713   GO:0005856   GO:0061176   GO:0045886   GO:0061177   GO:0001920   GO:0004672   GO:0006468   GO:0004890   GO:0005216   GO:0043564   GO:0006418   GO:0003824  

Length:

846

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.36635

Exp number, first 60 AAs:

0.29191

Total prob of N-in:

0.03613

outside

1  -  846

 

 

Pi

308.267658

Theta

17.53648

Tajima's D

2.344532

CLR

0.252876

CSRT

0.931653417329134

Interpretation

Uncertain