Silkworm Genome Informatics Database

Gene

KWMTBOMO12006 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004500

Annotation

PREDICTED:_ubiquitin_carboxyl-terminal_hydrolase_20_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr20(+):5349831-5370803 View in EpiBrowser

Full name

Ubiquitinyl hydrolase 1

Location in the cell

Nuclear Reliability : 2.885

CDS

ATGGAAAAAGGAATGACATGCGAACATTTAAACAAACTGGTCCACGTACTCGGGAAAGAATTATGGCAGTCAAAAGAGGCTTTGACATGTTTCGACTGTGGCTGTCCCGGCCCGAACTTATGGATCTGCCTGCAGCCTGAGTGTCATCATGTTGGCTGCTCTGAAGTAAAAAATGATCACAGTACATTCCACCACAAGAATTTCGCCACACATTGCGTTCACATGAATGTTTCAACTGAAAGAATATGGTGTTATTCATGCGAAAAAGAAGTGCACATAAGAGCTGCTATGGCCCATTCAGCTCAGAGTCCAGATTCGACAACAGCAGATGGATCGGTGAGGATTGGTTCTGTTGGCCTATATGCTGATGATGATGTGGATCCTGATGAAATGGAATACGACGAGGACAGTAGACCTAGAGGTCTAGTGGGGCTCCAAAACATGGGTAACACGTGTTACATGAACGCGGCGCTACAAGCCCTGAGCCACACCGCGCCTCTGACGTCATACTTCCTGGAGTGCGCCGCTGCCGTCAACATACTCGCCGGAGACAAGAAACCAGGCATTAGCCGAGCATACCAAAAATTAATTCAAGAAATGTGGAGTAGAAAATCTAGAGGCTACGTTGTACCTAACGGAATCCTGTATGGTATTAGAAATGTCCACCCGATGTTTCGTGGATACCACCAACACGACACGCAGGAGTTCTTGCGCTGCTTCATGGATCAGCTACACGAAGAACTAAAAGAACCGATATATAATTGTACACCAAATGATAAGCTCGACTCGGAAGCTGACGGTGACCACCACGGGAACAGAAAGATACACGTGCGTCGTAGGGCCGCGTCATCGGGAGCAAGTGACGCGCCTTTCTTCGCGAGGATGAGGCGGAAATCGCCGGCCCCCGCCTCGTACAACGACTCCGCTGCAGACGGATATTATAGAATACATAATCAAGAAACAGCCGGTACAAGACACAAGAGATCTGCCAGTTTCGCCGGCATGCACCAGTTCACGTACAACGCTCACACGCAGCAACTTAATGGCCCAACGTCAAATCAAAGAGACGTAGGTTCAGAATCGGAATTATCGTGTTCGAGTGAACCCGAAGAGCGGTACGAGACTTGTTCGAGCGGCGCTAGTGACGCGCCCGACTCCAAGGATAGAGAGAACACAAAAAGCGGTTCATCAGGCGACGGCAGCAACGTGAAGTACCGAAGCATCATATCCGACGTGTTCGACGGGAAGTTACTATCAGCCGTTCAGTGCCTAATATGTGACAGGGTATCAACGAGAATAGAAACATTCCAAGACTTGTCGCTGCCGATCCCGTCCCGGGAACACTTGGCCGTGCTGCGCTGCCAGCAGCCCATGCTGAACCACCACGCGGCCCACAACGCACAGGAATCCTGGGTGTGGTGGTTGCTCAGCTGGCTGCGGTCCTGGTTCTACGGGCCGGTGGTGTCGTTGCAAGACTGTCTGGCCGCCTTCTTCAGCGCCGACGAACTCAAAGGCGACAACATGTACAGCTGCTCCCGCTGCAAGAAATTACGTAACGGCGTGAAGCTATCCGGCATCGTGGTGCTGCCCGAGGTGCTGTGCGTCCACTTGAAGCGCTTCCGGCACGAGCTGCTGTTCAGCGCCAAGGTGGCCGCCAGGGTCGCCTTCCCCATCAACGATCTGGACATGACGCCTTACACGCACAAAGAGTGCACCTCGTCCGTGTCGCGGTACTCGCTGGCGGCGGTGATCAGCCACACGGGCACGGCGGGCGGCGGGCACTACACGTGCGCGGTGCGCGCCGGCGCCGGCTGGTACTCCTTCGACGACCACGCCGTCGCGCCGCTGCACGTGCACCAGCTCGCCGCCGCCGAGGCCTACGTGCTCTTCTACAGAAAAGTCAATCCCCAAATGGCCGTGCTGAGAGAGAAAGCCGCCGAGATATTGGAATCATCGAGTATTGGACCGAACGACCCTAAATATTATATTTCAAAGCAATGGATCAACAAGTTCAACACGTGGGCGGAACCAGGGCCCGTGGACAACAGCGACTTTGTGTGCTCGCATGGCGAAGTGAGGCCGGACAGAGAGCCGTACTTGGCCGCACTAGCGGTCGCCTTGCCACCGGCGCTCTGGGACTTCTTACACAAACAGTTCGGTGGCGGGCCGGCGGTGCGTGCGTGCGCGGCGTGCGGCGCGTGCGGGCGCGCGGCGAGGCGCGTGCGGGCGCGGGCCGCCGCCGAGCTGCACGCCTTCTCCGCGCTGCACGCCGCCTTCCAGGAACAAGAGCAGCCGTGCGCTCTGTACGCTGTGAGCATGCACTGGTTCCGGCAGTGGCAGGCGTTCGTCCGGAACAAGTCGCCGCAGCCGCCGCCGCCCGTCGACAACACCGGCATCGTCACCAAGCAGGACGTCGACGGCGTTGTGACGTACACCCTGAAGCAGGGCTCCGACCACGCTCAGCTCAACCACGAGCTGTGGAGGTTCTTCGTGGACATCTACGGAGGTGGGCCCGAGGTCAAGATTAGATCGCACAGCTGCCATCAGATCGAGACCACGCTCGACAACAGGCGCCTCTCGAGGAAGTACTCGGAGTCGGACAAGGAAGATTACTGCTCGAAGTCCACTTCAGAAGCTGACATCAGAGACAGCATACAAGCAGCCGAACTGCAGAAGAACCAGTCGCTTCAGAACATCAATGGGCGGAAGATCTCTCGAGCGTCTGGAGACTCGGACGATGACGTCACTTACCAGTACAAGCGCCACGAGCCGAACGGGAACTACGGGGATTCAGGGGACGAGCCCGCGTCAAAGCCTCGCCAACACCGGACTCGACGGCTCCGATCACGACGCCTACGACAACCCGCTCTATCTGACGAGGTCCGACAACGAACCGCCGAGCCTAGACGGCATGCCGCTCAGGAACAAACCGACGGAGACCGGTAA

Protein

MEKGMTCEHLNKLVHVLGKELWQSKEALTCFDCGCPGPNLWICLQPECHHVGCSEVKNDHSTFHHKNFATHCVHMNVSTERIWCYSCEKEVHIRAAMAHSAQSPDSTTADGSVRIGSVGLYADDDVDPDEMEYDEDSRPRGLVGLQNMGNTCYMNAALQALSHTAPLTSYFLECAAAVNILAGDKKPGISRAYQKLIQEMWSRKSRGYVVPNGILYGIRNVHPMFRGYHQHDTQEFLRCFMDQLHEELKEPIYNCTPNDKLDSEADGDHHGNRKIHVRRRAASSGASDAPFFARMRRKSPAPASYNDSAADGYYRIHNQETAGTRHKRSASFAGMHQFTYNAHTQQLNGPTSNQRDVGSESELSCSSEPEERYETCSSGASDAPDSKDRENTKSGSSGDGSNVKYRSIISDVFDGKLLSAVQCLICDRVSTRIETFQDLSLPIPSREHLAVLRCQQPMLNHHAAHNAQESWVWWLLSWLRSWFYGPVVSLQDCLAAFFSADELKGDNMYSCSRCKKLRNGVKLSGIVVLPEVLCVHLKRFRHELLFSAKVAARVAFPINDLDMTPYTHKECTSSVSRYSLAAVISHTGTAGGGHYTCAVRAGAGWYSFDDHAVAPLHVHQLAAAEAYVLFYRKVNPQMAVLREKAAEILESSSIGPNDPKYYISKQWINKFNTWAEPGPVDNSDFVCSHGEVRPDREPYLAALAVALPPALWDFLHKQFGGGPAVRACAACGACGRAARRVRARAAAELHAFSALHAAFQEQEQPCALYAVSMHWFRQWQAFVRNKSPQPPPPVDNTGIVTKQDVDGVVTYTLKQGSDHAQLNHELWRFFVDIYGGGPEVKIRSHSCHQIETTLDNRRLSRKYSESDKEDYCSKSTSEADIRDSIQAAELQKNQSLQNINGRKISRASGDSDDDVTYQYKRHEPNGNYGDSGDEPASKPRQHRTRRLRSRRLRQPALSDEVRQRTAEPRRHAAQEQTDGDR

Catalytic Activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Similarity

Belongs to the peptidase C19 family.

Uniprot

H9J4R0 A0A2A4JHF3 A0A194QF87 A0A212FA97 A0A2H1WBC3 A0A026WY31 + More
A0A0J7L5K2 A0A0C9QRS2 A0A1W4X7C2 A0A3B5MQY3 A0A3B5R2C8 A0A2Y9P0E4 T1D7D3 A0A2A3ETC0 A0A087ZP71 A0A341ALC1 A0A2U4A1E0 A0A0F7Z2A8 A0A384AWP2 A0A2Y9SA80 A0A093T929 A0A091VC26 A0A2D4I2F7 A0A2D4I2J7

EC Number

3.4.19.12

Pubmed

19121390 26354079 22118469 24508170 30249741 23542700 + More
23758969

EMBL

BABH01022137 BABH01022138 BABH01022139 NWSH01001376 PCG71477.1 KQ459053 + More
KPJ04147.1 AGBW02009503 OWR50675.1 ODYU01007533 SOQ50385.1 KK107085 QOIP01000008 EZA60049.1 RLU19952.1 LBMM01000668 KMQ97828.1 GBYB01006424 GBYB01006425 GBYB01012215 JAG76191.1 JAG76192.1 JAG81982.1 GAAZ01002799 JAA95144.1 KZ288186 PBC34744.1 GBEX01003804 JAI10756.1 KL428878 KFW91044.1 KL410872 KFR00330.1 IACK01077914 LAA78397.1 IACK01077911 LAA78392.1

Proteomes

UP000005204 UP000218220 UP000053268 UP000007151 UP000053097 UP000279307 + More
UP000036403 UP000192223 UP000261380 UP000002852 UP000248483 UP000242457 UP000005203 UP000252040 UP000245320 UP000261681 UP000248484 UP000053283

PRIDE

H9J4R0

Pfam

PF00443   UCH        + More
PF02148   zf-UBP
PF06337   DUSP

Interpro

IPR013083   Znf_RING/FYVE/PHD        + More
IPR028889   USP_dom
IPR035927   DUSP-like_sf
IPR038765   Papain-like_cys_pep_sf
IPR018200   USP_CS
IPR006615   Pept_C19_DUSP
IPR001394   Peptidase_C19_UCH
IPR001607   Znf_UBP

SUPFAM

SSF54001 SSF54001 + More
SSF143791 SSF143791

Gene 3D

3.30.40.10

ProteinModelPortal

H9J4R0 A0A2A4JHF3 A0A194QF87 A0A212FA97 A0A2H1WBC3 A0A026WY31 + More
A0A0J7L5K2 A0A0C9QRS2 A0A1W4X7C2 A0A3B5MQY3 A0A3B5R2C8 A0A2Y9P0E4 T1D7D3 A0A2A3ETC0 A0A087ZP71 A0A341ALC1 A0A2U4A1E0 A0A0F7Z2A8 A0A384AWP2 A0A2Y9SA80 A0A093T929 A0A091VC26 A0A2D4I2F7 A0A2D4I2J7

PDB

3MTN E-value=1.35234e-24, Score=284

KEGG

101741337 K11848 ubiquitin carboxyl-terminal hydrolase 20/33 [EC:3.4.19.12] | (RefSeq) ubiquitin carboxyl-term

GO

GO:0006511 GO:0008270 GO:0004843 GO:0016579 GO:0016422 GO:0004890 GO:0005216 GO:0043564 GO:0006418 GO:0003824 GO:0036459

Length:

981

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0319

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00125

outside

1 - 981

Pi

213.79056

Theta

168.371674

Tajima's D

0.639639

CLR

0.179312

CSRT

0.560221988900555

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics