Gene

KWMTBOMO11983

Pre Gene Modal

BGIBMGA004491

Annotation

PREDICTED:_uncharacterized_protein_LOC100302602_[Bombyx_mori]

Location

Bomo_Chr20(+):4762159-4767350      View in EpiBrowser

Full name

Dihydrolipoyl dehydrogenase      

Transcription factor

AP-2

Location in the cell

Nuclear   Reliability : 2.819

CDS

ATGAAGTCAAATGTGGAAAAGCAACAAGATGATACGTACATTTTCAATGCAAAAGTTCAAAATGGGTCAATTGGCCCGTTACGAGCGAAAAGCAAAAATGGCGGGAGATTACTTCGGGAGAAATTGGAGAAAATCGGCCTGAACTTACCGGCGGGGAGACGGAAAGCCGCTAATGTTACGTTATTAACCTCTTTAGTTGAAGCCGAAGCGGTACACCTGGCCAGAGACTTCGGTTACGTATGCGAGACGGAGTTCCCGGCGCGAGCCCTAGCCGAGTACCTCGCGAGACAGTACGCGGAACATGACGCCAGACGACGCCGAGACCTGCTGCAGGCCACTAAACAGGTAACGAAAGAACTTATGGATCTGCTGAACCAGGATCGGTCCCCGTTGTGCAACACCAGACCCCCACATTTACTGGAGCCGGCCATACAGCGACACCTCACACATTTCTCACTCATATCACACGGATTCGGAGGGCCGGCTATAGTGGCCGCGTTAACAGCAATACAGAACTTTCTCAACGAATCGCTCAAGCATCTAGACAAATTGTATCCACAAAGCGGTATGGTCTCGTCTTCGATGGACAAAACAAAAATGGATCCCGACATCAAGAAGTAA

Protein

MKSNVEKQQDDTYIFNAKVQNGSIGPLRAKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEAEAVHLARDFGYVCETEFPARALAEYLARQYAEHDARRRRDLLQATKQVTKELMDLLNQDRSPLCNTRPPHLLEPAIQRHLTHFSLISHGFGGPAIVAALTAIQNFLNESLKHLDKLYPQSGMVSSSMDKTKMDPDIKK

Catalytic Activity

(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH

Cofactor

FAD

Miscellaneous

The active site is a redox-active disulfide bond.

Similarity

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Uniprot

A0A1E1WSE4   A0A194QF52   A0A2H1WRL9   A0A2A4J329   A0A2W1BN89   A0A3S2NI55   + More
A0A212ELV1   C5NS68   A0A182G7F1   A0A182MCS4   A0A182RHQ7   A0A182SB06   Q174D7   A0A182YNH5   B0X2P2   A0A182LNV7   A0A182JAK0   A0A182HN40   A0A182UV75   A0A182UGG9   A0A1S4H748   A0A182WEM2   A0A182WX66   Q7PYX4   A0A182MXM0   A0A182QBZ5   A0A182P0M4   A0A336KSH5   A0A336M859   A0A2A3E8A1   A0A0J7L3H4   A0A0L7QQE2   A0A232FHV7   N6SY98   A0A195BE62   A0A1B6I738   A0A1J1IUX5   E0W0C5   A0A1Y1MA99   D6WQF7   A0A195DIC7   A0A154P6E2   A0A1B0CSX2   A0A026WNJ9   A0A088AH30   A0A0C9QNG1   U4UF13   A0A0C9QJX8   K7J212   A0A195FU71   A0A1B6J3G5   A0A3L8E3U9   A0A3Q0IKR4   A0A195C4X2   A0A3Q0IQ59   A0A158NW16   A0A3Q0IKD4   A0A310SUM3   A0A151XHL0   A0A2S2P1B7   A0A0K8SFH1   A0A1B6D9Y6   A0A084VEX4   A0A2S2QQM6   T1HS28   A0A182FBF0   A0A0P5FQL4   E9HK22   A0A0P5STF5   A0A0P5TK13   A0A0N8B257   A0A0N7ZRH5   A0A0P5GAC4   A0A0N8BDJ4   A0A0P6E0Q7   A0A0P5BDT9   J9JJM3   A0A2H8TWZ1   A0A0P5E3G4   A0A0P5E945   A0A0P5PLW1   A0A0P5JSE6   A0A0P5HWQ8   A0A0P5JIP0   A0A0P5C5D3   A0A2P2ICF5   A0A0P4YVB0   A0A0P4YBS6   A0A0N8B6D7   A0A0P5YTZ3   A0A0P5D988   A0A1D2NJ65   A0A0P5DWL8   A0A0P6C0V6   A0A0N8A7A0   A0A0P5SST9   A0A0P5CEA6   A0A0P5VYK7   A0A090BZQ8  

EC Number

1.8.1.4

Pubmed

26354079    28756777    22118469    26483478    17510324    25244985    + More
20966253    12364791    28648823    23537049    20566863    28004739    18362917    19820115    24508170    20075255    30249741    21347285    24438588    21292972    27289101   

EMBL

GDQN01001982    GDQN01001156    JAT89072.1    JAT89898.1    KQ459053    KPJ04173.1    + More
ODYU01010539    SOQ55715.1    NWSH01003537    PCG66146.1    KZ149954    PZC76519.1    RSAL01000030    RVE51664.1    AGBW02013984    OWR42441.1    AB474579    BAH83642.1    JXUM01046525    KQ561480    KXJ78448.1    AXCM01016809    CH477413    EAT41426.1    DS232293    EDS39366.1    APCN01001833    AAAB01008986    EAA00423.4    AXCN02001065    UFQS01000860    UFQT01000860    SSX07327.1    SSX27669.1    UFQS01000239    UFQT01000239    SSX01851.1    SSX22228.1    KZ288330    PBC27920.1    LBMM01000923    KMQ97206.1    KQ414787    KOC60794.1    NNAY01000221    OXU29917.1    APGK01052205    APGK01052206    KB741211    ENN72769.1    KQ976511    KYM82499.1    GECU01024964    JAS82742.1    CVRI01000060    CRL03983.1    DS235858    EEB19081.1    GEZM01038901    JAV81490.1    KQ971354    EFA07527.2    KQ980824    KYN12587.1    KQ434827    KZC07505.1    AJWK01026739    AJWK01026740    AJWK01026741    KK107159    EZA56674.1    GBYB01005109    JAG74876.1    KB632263    ERL90903.1    GBYB01015118    JAG84885.1    KQ981280    KYN43434.1    GECU01013995    JAS93711.1    QOIP01000001    RLU27085.1    KQ978317    KYM95208.1    ADTU01027685    ADTU01027686    ADTU01027687    ADTU01027688    ADTU01027689    ADTU01027690    ADTU01027691    ADTU01027692    ADTU01027693    ADTU01027694    KQ759852    OAD62539.1    KQ982123    KYQ59892.1    GGMR01010545    MBY23164.1    GBRD01013790    JAG52036.1    GEDC01014903    JAS22395.1    ATLV01012343    KE524784    KFB36518.1    GGMS01010811    MBY80014.1    ACPB03025228    GDIQ01251844    JAJ99880.1    GL732666    EFX67922.1    GDIQ01100149    JAL51577.1    GDIQ01126639    GDIP01125251    JAL25087.1    JAL78463.1    GDIQ01220203    JAK31522.1    GDIP01219737    GDIQ01262212    GDIQ01080788    JAJ03665.1    JAJ89512.1    GDIQ01244554    JAK07171.1    GDIQ01262706    GDIQ01188307    JAK63418.1    GDIQ01069455    JAN25282.1    GDIP01185941    JAJ37461.1    ABLF02040788    ABLF02040842    ABLF02040844    ABLF02040848    GFXV01006237    MBW18042.1    GDIP01147602    JAJ75800.1    GDIP01163187    JAJ60215.1    GDIQ01131998    JAL19728.1    GDIQ01220204    JAK31521.1    GDIQ01227709    JAK24016.1    GDIQ01202370    GDIP01065204    JAK49355.1    JAM38511.1    GDIP01175386    JAJ48016.1    IACF01006043    LAB71626.1    GDIP01223125    JAJ00277.1    GDIP01233384    JAI90017.1    GDIQ01208363    JAK43362.1    GDIP01053465    JAM50250.1    GDIP01175539    GDIQ01202369    GDIQ01003528    JAJ47863.1    JAK49356.1    LJIJ01000025    ODN05323.1    GDIP01151491    JAJ71911.1    GDIP01007590    JAM96125.1    GDIP01175537    JAJ47865.1    GDIP01135792    JAL67922.1    GDIP01175538    JAJ47864.1    GDIP01093388    JAM10327.1    AB851459    BAP63968.1   

Proteomes

UP000053268    UP000218220    UP000283053    UP000007151    UP000069940    UP000249989    + More
UP000075883    UP000075900    UP000075901    UP000008820    UP000076408    UP000002320    UP000075882    UP000075880    UP000075840    UP000075903    UP000075902    UP000075920    UP000076407    UP000007062    UP000075884    UP000075886    UP000075885    UP000242457    UP000036403    UP000053825    UP000215335    UP000019118    UP000078540    UP000183832    UP000009046    UP000007266    UP000078492    UP000076502    UP000092461    UP000053097    UP000005203    UP000030742    UP000002358    UP000078541    UP000279307    UP000079169    UP000078542    UP000005205    UP000075809    UP000030765    UP000015103    UP000069272    UP000000305    UP000007819    UP000094527   

PRIDE

C5NS68   

Pfam

PF03299   TF_AP-2        + More
PF02852   Pyr_redox_dim
PF07992   Pyr_redox_2

Interpro

IPR004979   TF_AP2        + More
IPR013854   TF_AP2_C       
IPR016021   MIF4-like_sf       
IPR006258   Lipoamide_DH       
IPR004099   Pyr_nucl-diS_OxRdtase_dimer       
IPR016156   FAD/NAD-linked_Rdtase_dimer_sf       
IPR012999   Pyr_OxRdtase_I_AS       
IPR023753   FAD/NAD-binding_dom       
IPR016024   ARM-type_fold       
IPR036188   FAD/NAD-bd_sf       
IPR003890   MIF4G-like_typ-3       

SUPFAM

SSF51905   SSF51905        + More
SSF55424   SSF55424       
SSF48371   SSF48371       

Gene 3D

1.25.40.180     3.30.390.30     3.50.50.60    

ProteinModelPortal

A0A1E1WSE4   A0A194QF52   A0A2H1WRL9   A0A2A4J329   A0A2W1BN89   A0A3S2NI55   + More
A0A212ELV1   C5NS68   A0A182G7F1   A0A182MCS4   A0A182RHQ7   A0A182SB06   Q174D7   A0A182YNH5   B0X2P2   A0A182LNV7   A0A182JAK0   A0A182HN40   A0A182UV75   A0A182UGG9   A0A1S4H748   A0A182WEM2   A0A182WX66   Q7PYX4   A0A182MXM0   A0A182QBZ5   A0A182P0M4   A0A336KSH5   A0A336M859   A0A2A3E8A1   A0A0J7L3H4   A0A0L7QQE2   A0A232FHV7   N6SY98   A0A195BE62   A0A1B6I738   A0A1J1IUX5   E0W0C5   A0A1Y1MA99   D6WQF7   A0A195DIC7   A0A154P6E2   A0A1B0CSX2   A0A026WNJ9   A0A088AH30   A0A0C9QNG1   U4UF13   A0A0C9QJX8   K7J212   A0A195FU71   A0A1B6J3G5   A0A3L8E3U9   A0A3Q0IKR4   A0A195C4X2   A0A3Q0IQ59   A0A158NW16   A0A3Q0IKD4   A0A310SUM3   A0A151XHL0   A0A2S2P1B7   A0A0K8SFH1   A0A1B6D9Y6   A0A084VEX4   A0A2S2QQM6   T1HS28   A0A182FBF0   A0A0P5FQL4   E9HK22   A0A0P5STF5   A0A0P5TK13   A0A0N8B257   A0A0N7ZRH5   A0A0P5GAC4   A0A0N8BDJ4   A0A0P6E0Q7   A0A0P5BDT9   J9JJM3   A0A2H8TWZ1   A0A0P5E3G4   A0A0P5E945   A0A0P5PLW1   A0A0P5JSE6   A0A0P5HWQ8   A0A0P5JIP0   A0A0P5C5D3   A0A2P2ICF5   A0A0P4YVB0   A0A0P4YBS6   A0A0N8B6D7   A0A0P5YTZ3   A0A0P5D988   A0A1D2NJ65   A0A0P5DWL8   A0A0P6C0V6   A0A0N8A7A0   A0A0P5SST9   A0A0P5CEA6   A0A0P5VYK7   A0A090BZQ8  

KEGG

100302602    K09180 transcription factor AP-2, invertebrate | (RefSeq) Ap-2; transcription factor AP-2

GO

GO:0003700   GO:0005634   GO:0000981   GO:0006357   GO:0000977   GO:0045454   GO:0050660   GO:0004148   GO:0005623   GO:0003723  

PANTHER

PTHR10812  

Length:

206

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

12.26053

Exp number, first 60 AAs:

0.00141

Total prob of N-in:

0.68797

outside

1  -  206

 

 

Pi

204.286182

Theta

151.695539

Tajima's D

0.549562

CLR

1.152109

CSRT

0.529623518824059

Interpretation

Possibly Positive selection