Gene

KWMTBOMO11977  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004376

Annotation

proteasome_subunit_beta_5_[Danaus_plexippus]

Location

Bomo_Chr20(-):4535181-4537979      View in EpiBrowser

Full name

Proteasome subunit beta      

Location in the cell

Cytoplasmic   Reliability : 1.507

CDS

ATGGCTCTACTCGATTTCTGCCGTTTAAATGAAAAAATTAACTTGAAACCCGTTGATTCTCTAGCATCATTCAATAATGACATTACCGGCTACAGTGAAAACTTTGTAAACAGCGCTCAGCTCGCTTCTCCCCCATTTGCGAATCCTGCTGAAACCTTAGCACACTTCAACACAAAGGATGAGACTGGAAAGGAAATCAAAATTCAGTTTGACCACGGCACCACCACTCTTGGTTTCCGATACAAAGGAGGAGTCTTATTAGCCGTCGACTCTCGAGCTACAGGTGGCCAATTTATTGGTTCTCAATCCATGAAGAAAATAGTAGAAATCAACGACTATTTGCTTGGTACTCTCGCTGGTGGTGCAGCAGACTGTGTCTACTGGGACAGAGTACTCGCAAAGCAATGCCGTCTCTATGAGCTTCGGAATAGGGAGCGTATTTCTGTAGCAGCAGCCAGTAAACTCATGGCTAACATGGTGTACAACTACAAAGGAATGGGCCTCAGCATGGGAATGATGTTAGCTGGTATTGACAAGAGAGGAGCACAACTATACTATGTAGACAGTGAAGGTACTCGCACTCCAGGCAAGGTGTTCTCAGTGGGCTCAGGTTCTGTGTATGCTTTTGGTGTACTTGACTCTGGATACAGCTGGGATCTGTCAGATGAGGACGCACAAGAGCTGGGTCGACGTGCGATTTACCACGCTACTCACCGCGACGCGTACTCTGGCGGGATCATAAGAGTGTACCACATCAACGACAAGGGTTGGGTCAACATCTCCAACGAGGATTGCTCCGACCTCCACTACAAGTACCAAGCAGAGAAGGGCATCAAGGATGATCAGTTTTAA

Protein

MALLDFCRLNEKINLKPVDSLASFNNDITGYSENFVNSAQLASPPFANPAETLAHFNTKDETGKEIKIQFDHGTTTLGFRYKGGVLLAVDSRATGGQFIGSQSMKKIVEINDYLLGTLAGGAADCVYWDRVLAKQCRLYELRNRERISVAAASKLMANMVYNYKGMGLSMGMMLAGIDKRGAQLYYVDSEGTRTPGKVFSVGSGSVYAFGVLDSGYSWDLSDEDAQELGRRAIYHATHRDAYSGGIIRVYHINDKGWVNISNEDCSDLHYKYQAEKGIKDDQF

Catalytic Activity

Cleavage of peptide bonds with very broad specificity.

Subunit

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

Similarity

Belongs to the peptidase T1B family.
Belongs to the adaptor complexes medium subunit family.

Uniprot

H9J4D7   A0A212F601   A0A3S2M573   I4DK56   B6VAH6   A0A194QGW1   + More
S4NVJ1   A0A194QRV6   A0A2H1W5W8   A0A2A4JF15   A0A2W1BV39   A0A0C9R7F9   A0A212ELS5   D6WS19   A0A2J7RLW8   A0A067RER6   N6T1U7   A0A154PSP5   A0A026WYA0   E2C480   A0A2A3EGK1   J3JUE5   A0A310SGA1   A0A087ZZ62   V5I819   E9IU49   A0A0J7NQV4   A0A195CYC7   A0A0L7RED0   A0A2D1QUF6   A0A1W4XKW1   E2AA23   A0A195F2L5   A0A195E697   A0A151XCJ7   A0A158NLG2   R4V132   F4WW96   T1E2V0   A0A195B1M5   A0A1Q3G3E2   A0A0M8ZXD6   Q16JS7   A0A1S4FYT3   B0XE79   A0A182IYT1   U5EPP8   A0A1Y1MKC7   A0A182SLZ9   A0A2M4BW17   A0A2M3Z5K6   A0A023EPN1   A0A182JX91   A0A182N2N6   A0A182RW77   A0A182VER3   A0A182TEI4   A0A182I5Y4   A0A2M4ABV1   A0A2M3ZHA6   A0A2M4ABW2   A0A2M3Z5I0   T1DQ70   A0A084WNK8   A0A182WXW3   A0A182KV30   Q5TUI7   A0A182PD94   W5JKI9   A0A182Y9M9   A0A0L0CBS6   A0A232FCJ4   A0A336LR91   A0A182GBA9   A0A1W4VRA0   A0A1L8EDY1   B4KUC4   A0A1A9WV52   A0A182QC70   A0A2P8ZCE1   B4LPI3   B4QAN5   B4HN07   D3TNF8   A0A1B0G9Z3   A0A3B0JL10   Q28XK4   A0A1B0BSR9   A0A0M4E7U9   A0A1A9XP87   Q7K148   T1PFL1   Q9NHX7   A0A1L8DT01   A0A1I8PZ12   B4MRJ3   B3MIK9   A0A182WE47   B3NN46   A0A0K8TNU6  

EC Number

3.4.25.1

Pubmed

19121390    22118469    22651552    26354079    23622113    28756777    + More
18362917    19820115    24845553    23537049    24508170    30249741    20798317    22516182    21282665    21347285    21719571    24330624    17510324    28004739    24945155    24438588    20966253    12364791    14747013    17210077    20920257    23761445    25244985    26108605    28648823    26483478    17994087    29403074    22936249    20353571    15632085    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    25315136    26369729   

EMBL

BABH01022070    AGBW02010110    OWR49154.1    RSAL01000030    RVE51665.1    AK401674    + More
BAM18296.1    FJ358434    ACJ09226.1    KQ459053    KPJ04175.1    GAIX01011511    JAA81049.1    KQ461181    KPJ07715.1    ODYU01006507    SOQ48413.1    NWSH01001732    PCG70298.1    KZ149954    PZC76516.1    GBYB01012258    GBYB01012259    JAG82025.1    JAG82026.1    AGBW02013984    OWR42443.1    OWR42444.1    KQ971351    EFA07659.2    NEVH01002601    PNF41825.1    KK852513    KDR22252.1    APGK01055449    KB741266    KB631940    ENN71488.1    ERL87344.1    KQ435037    KZC14130.1    KK107063    QOIP01000005    EZA61045.1    RLU22808.1    GL452426    EFN77251.1    KZ288262    PBC30349.1    BT126858    AEE61820.1    KQ760243    OAD61274.1    GALX01005455    JAB63011.1    GL765841    EFZ15921.1    LBMM01002422    KMQ94845.1    KQ977115    KYN05658.1    KQ414613    KOC69086.1    KY285055    ATP16158.1    GL438001    EFN69722.1    KQ981864    KYN34417.1    KQ979568    KYN20725.1    KQ982314    KYQ58067.1    ADTU01019398    KC571853    AGM32352.1    GL888404    EGI61567.1    GALA01000960    JAA93892.1    KQ976662    KYM78371.1    GFDL01000723    JAV34322.1    KQ435804    KOX73060.1    CH477994    EAT34534.1    DS232809    EDS45912.1    GANO01003631    JAB56240.1    GEZM01028959    JAV86189.1    GGFJ01008051    MBW57192.1    GGFM01003034    MBW23785.1    GAPW01003124    JAC10474.1    APCN01003537    GGFK01004918    MBW38239.1    GGFM01007152    MBW27903.1    GGFK01004955    MBW38276.1    GGFM01003021    MBW23772.1    GAMD01002709    JAA98881.1    ATLV01024620    KE525353    KFB51802.1    AAAB01008848    EAL41084.2    ADMH02001177    ETN63828.1    JRES01000735    KNC28889.1    NNAY01000485    OXU28057.1    UFQS01000051    UFQT01000051    SSW98643.1    SSX19029.1    JXUM01008958    JXUM01008959    GFDG01001887    JAV16912.1    CH933808    EDW09720.1    AXCN02001080    PYGN01000106    PSN54168.1    CH940648    EDW61242.1    CM000362    CM002911    EDX06540.1    KMY92860.1    CH480816    EDW47311.1    EZ422960    ADD19236.1    CCAG010011403    OUUW01000001    SPP74159.1    CM000071    EAL26312.1    JXJN01019826    CP012524    ALC40671.1    AE013599    AY069381    AAF58748.1    AAL39526.1    KA647526    AFP62155.1    AF217726    AAF26416.1    GFDF01004543    JAV09541.1    CH963850    EDW74732.1    CH902619    EDV38085.1    CH954179    EDV56566.1    GDAI01001564    JAI16039.1   

Proteomes

UP000005204    UP000007151    UP000283053    UP000053268    UP000053240    UP000218220    + More
UP000007266    UP000235965    UP000027135    UP000019118    UP000030742    UP000076502    UP000053097    UP000279307    UP000008237    UP000242457    UP000005203    UP000036403    UP000078542    UP000053825    UP000192223    UP000000311    UP000078541    UP000078492    UP000075809    UP000005205    UP000007755    UP000078540    UP000053105    UP000008820    UP000002320    UP000075880    UP000075901    UP000075881    UP000075884    UP000075900    UP000075903    UP000075902    UP000075840    UP000030765    UP000076407    UP000075882    UP000007062    UP000075885    UP000000673    UP000076408    UP000037069    UP000215335    UP000069940    UP000192221    UP000009192    UP000091820    UP000075886    UP000245037    UP000008792    UP000000304    UP000001292    UP000092444    UP000268350    UP000001819    UP000092460    UP000092553    UP000092443    UP000000803    UP000095301    UP000095300    UP000007798    UP000007801    UP000075920    UP000008711   

PRIDE

H9J4D7    Q7K148    Q9NHX7   

Pfam

PF00227   Proteasome        + More
PF00928   Adap_comp_sub
PF01217   Clat_adaptor_s

Interpro

IPR023333   Proteasome_suB-type        + More
IPR001353   Proteasome_sua/b       
IPR016050   Proteasome_bsu_CS       
IPR029055   Ntn_hydrolases_N       
IPR000243   Pept_T1A_subB       
IPR027059   Coatomer_dsu       
IPR036168   AP2_Mu_C_sf       
IPR028565   MHD       
IPR022775   AP_mu_sigma_su       
IPR011012   Longin-like_dom_sf       
IPR027417   P-loop_NTPase       
IPR007694   DNA_helicase_DnaB-like_C       

SUPFAM

SSF56235   SSF56235        + More
SSF64356   SSF64356       
SSF49447   SSF49447       
SSF52540   SSF52540       

Gene 3D

3.60.20.10    

ProteinModelPortal

H9J4D7   A0A212F601   A0A3S2M573   I4DK56   B6VAH6   A0A194QGW1   + More
S4NVJ1   A0A194QRV6   A0A2H1W5W8   A0A2A4JF15   A0A2W1BV39   A0A0C9R7F9   A0A212ELS5   D6WS19   A0A2J7RLW8   A0A067RER6   N6T1U7   A0A154PSP5   A0A026WYA0   E2C480   A0A2A3EGK1   J3JUE5   A0A310SGA1   A0A087ZZ62   V5I819   E9IU49   A0A0J7NQV4   A0A195CYC7   A0A0L7RED0   A0A2D1QUF6   A0A1W4XKW1   E2AA23   A0A195F2L5   A0A195E697   A0A151XCJ7   A0A158NLG2   R4V132   F4WW96   T1E2V0   A0A195B1M5   A0A1Q3G3E2   A0A0M8ZXD6   Q16JS7   A0A1S4FYT3   B0XE79   A0A182IYT1   U5EPP8   A0A1Y1MKC7   A0A182SLZ9   A0A2M4BW17   A0A2M3Z5K6   A0A023EPN1   A0A182JX91   A0A182N2N6   A0A182RW77   A0A182VER3   A0A182TEI4   A0A182I5Y4   A0A2M4ABV1   A0A2M3ZHA6   A0A2M4ABW2   A0A2M3Z5I0   T1DQ70   A0A084WNK8   A0A182WXW3   A0A182KV30   Q5TUI7   A0A182PD94   W5JKI9   A0A182Y9M9   A0A0L0CBS6   A0A232FCJ4   A0A336LR91   A0A182GBA9   A0A1W4VRA0   A0A1L8EDY1   B4KUC4   A0A1A9WV52   A0A182QC70   A0A2P8ZCE1   B4LPI3   B4QAN5   B4HN07   D3TNF8   A0A1B0G9Z3   A0A3B0JL10   Q28XK4   A0A1B0BSR9   A0A0M4E7U9   A0A1A9XP87   Q7K148   T1PFL1   Q9NHX7   A0A1L8DT01   A0A1I8PZ12   B4MRJ3   B3MIK9   A0A182WE47   B3NN46   A0A0K8TNU6  

PDB

6EPF     E-value=4.24929e-74,     Score=705

KEGG

101740220    K02737 20S proteasome subunit beta 5 [EC:3.4.25.1] | (RefSeq) proteasome subunit beta type-5

PATHWAY

03050    Proteasome - Bombyx mori (domestic silkworm)

GO

GO:0051603   GO:0004298   GO:0005839   GO:0005737   GO:0005634   GO:0000502   GO:0010498   GO:0004175   GO:0043161   GO:0010499   GO:0045786   GO:0007098   GO:0030126   GO:0015031   GO:0006890   GO:0019774   GO:0005829   GO:0005654   GO:0008063   GO:0007623   GO:0003678   GO:0006260   GO:0005524   GO:0022857   GO:0004890   GO:0005216   GO:0043564   GO:0006418   GO:0003824  

PANTHER

PTHR10121  

Subcellular location

Cytoplasm  
Nucleus  

Length:

283

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.338

Exp number, first 60 AAs:

0

Total prob of N-in:

0.02239

outside

1  -  283

 

 

Pi

206.580713

Theta

181.713042

Tajima's D

0.51258

CLR

0

CSRT

0.515624218789061

Interpretation

Uncertain