Gene

KWMTBOMO11975  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004377

Annotation

Der1-like_domain_family_member_1_[Bombyx_mori]

Location

Bomo_Chr20(-):4524327-4528149      View in EpiBrowser

Full name

Derlin      

Location in the cell

PlasmaMembrane   Reliability : 4.638

CDS

ATGTCGGAATTCCGAGATTGGTACAATGGTGTACCGTTTTTCACCAGATATTGGATGACTTTTACTATTGTATTGAGTTTGTTTGGTAAATTTGGGCTTGTGAGCCCTTATTATTTTATACTGGATTTCTATTATTTCTTCAATCAATTTCAGATATGGCGTCCATTAACAGCTTTGTTTTACTATCCAATAAATCCAGGCACAGGATTTCATTTCCTGATAAACTGTTACTTTTTGTACAACTACTCTCAAAGACTTGAGACCGGCATGTTTGCAGGGAAGCCAGCTGACTATTTCTACATGCTTTTGTTTAATTGGGTGTGCTGTGTTATCATTGGATTACTTGTCAAATTGCCAGTATTAATGGACCCGATGGTACTCTCGGTATTATATGTATGGTGTCAGCTTAACAAAGATGTAATTGTATCATTTTGGTTTGGCACAAGATTTAAGGCTATGTATTTACCTTGGGTACTACTCGCTTTCAACCTTGTCATCAGTGGAGGTGGGATAATGGAGCTCCTAGGCATTCTAATTGGTCACTTAGCATTCTTCCTTTTGTTCAAATACCCCCAAGAGTTTGGTGGCCCTGCATTACTCACACCACCAGCATTCTTGAAACAACTATTCCCGGACACTAGGTACGTGGGTGGTTTTGGTACAGCGCCACAAGCGAGAGTACCCACTCGCCCAGGCAACACCGTGTTCGGAGGACATAACTGGGGCAGAGGACAAACTCTTGGAGGAAACTGA

Protein

MSEFRDWYNGVPFFTRYWMTFTIVLSLFGKFGLVSPYYFILDFYYFFNQFQIWRPLTALFYYPINPGTGFHFLINCYFLYNYSQRLETGMFAGKPADYFYMLLFNWVCCVIIGLLVKLPVLMDPMVLSVLYVWCQLNKDVIVSFWFGTRFKAMYLPWVLLAFNLVISGGGIMELLGILIGHLAFFLLFKYPQEFGGPALLTPPAFLKQLFPDTRYVGGFGTAPQARVPTRPGNTVFGGHNWGRGQTLGGN

Description

May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.

Similarity

Belongs to the derlin family.

Uniprot

H9J4D8   Q2F6B5   A0A1E1W8Z3   A0A2A4JEB5   A0A2W1BXL7   I4DQY9   + More
A0A194Q5G7   A0A212F5Z7   S4PJW6   A0A0N1IGV5   U5EZG9   E9FQR1   A0A0P5U053   A0A0P6ERC4   D6WPF8   A0A0J7K3J6   A0A154NZS9   A0A1Y1KU85   A0A1W4X2Z2   A0A151IIF4   A0A026WJX5   F4WNI4   C4WWH3   A0A195FXL8   E2A1L2   A0A0M8ZRB1   A0A151WVJ3   A0A0L7QP74   J9JN94   A0A2P8YSR7   A0A2H8TIU3   A0A2M3ZHU3   A0A0P6BNB9   A0A2S2NM81   V9IJT8   A0A088A6M4   A0A2M4AG83   A0A0P6GVJ4   T1DLD5   A0A2M4BX90   A0A1B6E1M1   A0A195B891   A0A195ED21   A0A0P5AS76   A0A0P5MDF2   Q1HQM9   Q172Y9   A0A1S3DSK7   A0A1D1V639   W5JWC6   A0A1B6LVL5   A0A1B6GVF9   A0A0R3RZ64   A0A182E5H0   A0A2K6VFR7   A0A0B2UU68   W4YQI8   A0A0V0G5Z3   K1R606   A0A0P4VL95   A0A0N5CX61   A0A0P5IGJ1   A0A182TGY3   A0A182MR07   A0A1B6HKV4   A0A0B7BDI0   A0A0N8D1T5   V4B2N8   A0A023EJV1   A0A1S4H1G9   A0A2C9K2T2   A0A3P6UIP3   A0A2S2R0H3   A0A1C7CZP8   A0A182K639   A0A067RCR3   A0A3S1BC59   A0A1I7VXX0   A0A0A9W3J1   A0A182YP94   N6TN55   Q7PVG0   A0A183XCV6   A0A182VL38   A0A0L8GR20   U4UH75   A0A182IJ79   F7ASI0   A0A1S3KBN5   A0A210QQN9   A0A182X0R3   A0A182HGF0   C3YFB1   H2Z1B1   J3JV97   A0A0I9N9F4   A0A182SLZ2   A0A182PG21   A0A0N4TWP8  

Pubmed

19121390    28756777    22651552    26354079    22118469    23622113    + More
21292972    18362917    19820115    28004739    24508170    30249741    21719571    20798317    29403074    17204158    17510324    27649274    20920257    23761445    22919073    22992520    27129103    23254933    24945155    12364791    15562597    20966253    24845553    25217238    25401762    26823975    25244985    23537049    26850696    12481130    15114417    28812685    18563158    22516182    17885136   

EMBL

BABH01022069    DQ311157    ABD36102.1    GDQN01007611    GDQN01006678    JAT83443.1    + More
JAT84376.1    NWSH01001732    PCG70301.1    KZ149954    PZC76513.1    AK404849    BAM20329.1    KQ459460    KPJ00788.1    AGBW02010110    OWR49156.1    GAIX01004785    JAA87775.1    KQ459838    KPJ19732.1    GANO01000819    JAB59052.1    GL732523    EFX90326.1    GDIP01119658    LRGB01002568    JAL84056.1    KZS07108.1    GDIQ01072378    JAN22359.1    KQ971354    EFA06805.1    LBMM01015210    KMQ84889.1    KQ434786    KZC05175.1    GEZM01077523    JAV63285.1    KQ977477    KYN02456.1    KK107167    QOIP01000010    EZA56352.1    RLU18106.1    GL888237    EGI64177.1    AK342065    BAH72243.1    KQ981215    KYN44589.1    GL435766    EFN72685.1    KQ435955    KOX68043.1    KQ982706    KYQ51858.1    KQ414843    KOC60301.1    ABLF02005025    PYGN01000381    PSN47291.1    GFXV01002164    MBW13969.1    GGFM01007328    MBW28079.1    GDIP01012547    JAM91168.1    GGMR01005618    MBY18237.1    JR048749    AEY60751.1    GGFK01006479    MBW39800.1    GDIQ01027819    JAN66918.1    GAMD01000506    JAB01085.1    GGFJ01008555    MBW57696.1    GEDC01030786    GEDC01005494    JAS06512.1    JAS31804.1    KQ976565    KYM80465.1    KQ979074    KYN22717.1    GDIP01209203    JAJ14199.1    GDIQ01161340    JAK90385.1    DQ440415    ABF18448.1    CH477429    EAT41090.1    BDGG01000003    GAU96340.1    ADMH02000176    ETN67500.1    GEBQ01012246    JAT27731.1    GECZ01003436    JAS66333.1    UYRW01000601    VDK68447.1    CMVM020000024    JPKZ01003226    KHN72637.1    AAGJ04146733    GECL01003012    JAP03112.1    JH823229    EKC29406.1    GDKW01001420    JAI55175.1    UYYF01004313    VDN02149.1    GDIQ01217319    JAK34406.1    AXCM01004997    GECU01032394    JAS75312.1    HACG01044153    CEK91018.1    GDIP01077167    JAM26548.1    KB203854    ESO82769.1    GAPW01004268    JAC09330.1    AAAB01008984    UYRX01000270    VDK79008.1    GGMS01013679    MBY82882.1    KK852722    KDR17716.1    RQTK01000411    RUS80103.1    JH712250    EFO25036.1    GBHO01041623    GBRD01013198    GDHC01000253    JAG01981.1    JAG52628.1    JAQ18376.1    APGK01058320    KB741288    ENN70655.1    EAA14829.4    UYWW01012185    VDM19424.1    KQ420813    KOF79269.1    KB632322    ERL92357.1    NEDP02002396    OWF51050.1    APCN01004219    GG666509    EEN60874.1    BT127164    AEE62126.1    LN857024    CTP81790.1    UZAD01013373    VDN94479.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000053240    UP000000305    + More
UP000076858    UP000007266    UP000036403    UP000076502    UP000192223    UP000078542    UP000053097    UP000279307    UP000007755    UP000078541    UP000000311    UP000053105    UP000075809    UP000053825    UP000007819    UP000245037    UP000005203    UP000078540    UP000078492    UP000008820    UP000079169    UP000186922    UP000000673    UP000050640    UP000077448    UP000271087    UP000024404    UP000031036    UP000007110    UP000005408    UP000046394    UP000276776    UP000075902    UP000075883    UP000030746    UP000076420    UP000277928    UP000075882    UP000075881    UP000027135    UP000271974    UP000095285    UP000076408    UP000019118    UP000007062    UP000093561    UP000270924    UP000075903    UP000053454    UP000030742    UP000075880    UP000008144    UP000085678    UP000242188    UP000076407    UP000075840    UP000001554    UP000007875    UP000006672    UP000075901    UP000075885    UP000038020    UP000278627   

PRIDE

H9J4D8    Q2F6B5   

Pfam

PF04511   DER1        + More
PF03896   TRAP_alpha
PF00561   Abhydrolase_1

Interpro

IPR007599   DER1        + More
IPR005595   TRAP_alpha       
IPR029058   AB_hydrolase       
IPR000073   AB_hydrolase_1       

SUPFAM

SSF53474   SSF53474       

Gene 3D

3.40.50.1820    

ProteinModelPortal

H9J4D8   Q2F6B5   A0A1E1W8Z3   A0A2A4JEB5   A0A2W1BXL7   I4DQY9   + More
A0A194Q5G7   A0A212F5Z7   S4PJW6   A0A0N1IGV5   U5EZG9   E9FQR1   A0A0P5U053   A0A0P6ERC4   D6WPF8   A0A0J7K3J6   A0A154NZS9   A0A1Y1KU85   A0A1W4X2Z2   A0A151IIF4   A0A026WJX5   F4WNI4   C4WWH3   A0A195FXL8   E2A1L2   A0A0M8ZRB1   A0A151WVJ3   A0A0L7QP74   J9JN94   A0A2P8YSR7   A0A2H8TIU3   A0A2M3ZHU3   A0A0P6BNB9   A0A2S2NM81   V9IJT8   A0A088A6M4   A0A2M4AG83   A0A0P6GVJ4   T1DLD5   A0A2M4BX90   A0A1B6E1M1   A0A195B891   A0A195ED21   A0A0P5AS76   A0A0P5MDF2   Q1HQM9   Q172Y9   A0A1S3DSK7   A0A1D1V639   W5JWC6   A0A1B6LVL5   A0A1B6GVF9   A0A0R3RZ64   A0A182E5H0   A0A2K6VFR7   A0A0B2UU68   W4YQI8   A0A0V0G5Z3   K1R606   A0A0P4VL95   A0A0N5CX61   A0A0P5IGJ1   A0A182TGY3   A0A182MR07   A0A1B6HKV4   A0A0B7BDI0   A0A0N8D1T5   V4B2N8   A0A023EJV1   A0A1S4H1G9   A0A2C9K2T2   A0A3P6UIP3   A0A2S2R0H3   A0A1C7CZP8   A0A182K639   A0A067RCR3   A0A3S1BC59   A0A1I7VXX0   A0A0A9W3J1   A0A182YP94   N6TN55   Q7PVG0   A0A183XCV6   A0A182VL38   A0A0L8GR20   U4UH75   A0A182IJ79   F7ASI0   A0A1S3KBN5   A0A210QQN9   A0A182X0R3   A0A182HGF0   C3YFB1   H2Z1B1   J3JV97   A0A0I9N9F4   A0A182SLZ2   A0A182PG21   A0A0N4TWP8  

KEGG

693079    K11519 Derlin-1 | (RefSeq) Der1-like domain family member 1

PATHWAY

04141    Protein processing in endoplasmic reticulum - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0005789   GO:0097038   GO:0051788   GO:0005769   GO:0006897  

Subcellular location

Endoplasmic reticulum membrane  

Length:

250

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

105.99449

Exp number, first 60 AAs:

25.82124

Total prob of N-in:

0.93136

POSSIBLE N-term signal

sequence

inside

1  -  20

TMhelix

21  -  43

outside

44  -  57

TMhelix

58  -  80

inside

81  -  99

TMhelix

100  -  122

outside

123  -  156

TMhelix

157  -  179

inside

180  -  250

 

 

Pi

228.189427

Theta

184.67821

Tajima's D

0.840377

CLR

0

CSRT

0.607469626518674

Interpretation

Uncertain