Gene

KWMTBOMO11881  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004408

Annotation

PREDICTED:_tRNA_(cytosine(34)-C(5))-methyltransferase_[Amyelois_transitella]

Location

Bomo_Chr20(-):2796533-2808067      View in EpiBrowser

Full name

Histone acetyltransferase       + More
tRNA (cytosine(34)-C(5))-methyltransferase      

Alternative Name

NOP2/Sun domain family member 2 ortholog

Location in the cell

Nuclear   Reliability : 2.504

CDS

ATGGGTAGAAAAAATCGGAACGTCAACAAATTCGCGCAAAGGAAACGTGACCGCAAGGAGCAAGAGAAAAATCCACAAGAGAAACCGAACGGGGATAATCGAAAGGCTTATGAAGATATTGTTCGAGAAAATGCCGCATTCGAAGAATACTATAAGATGCAAAAGATCTGCCCAGAAGAGCAGTGGCCGGTCTTCATGCAAACTCTCAAAGAGAATCTACCTACGGCATTCCGTATCACAGGATCTAAGGGCGAAGCTGACGCTCTAATGAAGATTGTGAACAGTGATTACTTCTCACAGCTTCTGAATATAAAATTGAAAATTGATGGAAAAGATGAAGAGGAAGAAATTAAGCCAGTTAATTTGCCTTGGTACCCTGGAGGTTTTGCATGGCAATTACGGCTCACCCGTATGGATATCAGGCGTAACGAGGCATTGTATCGGCTTCATAACTTTCTTGTAGCAGAGACGGCAGCAGGAGGAGTCTCGAGACAAGAACAGGTGTCGATGATACCTCCCGTAGTATTAGATGTGAAACCTCACCATAAGGTGCTTGACATGTGTGCTGCCCCGGGGTCTAAGACCGCACAACTCATAGAATTCCTACATGCAGATGAAGATAAAATGCCTACAGGTTTTGTGATGGCAAACGACGTAGACAACAGCCGATGCTACATGTTGGTACATCAGGCCAAGCGCCTCAACTCACCCTGCATAGTGATCACGAACCACGACTCTGCTTTCATGCCTTCCATTGAAGTAACCGATGAACAGGATCCAAGCAAAACAAAGCCCTTGAAGTTCGACCGGATATTGTGCGACGTACCGTGCTCCGGCGACGCGACACTACGCAAGAACCCGGATATTTGGCTCAAGTGGTCCACGGGCAACGGCAATAATTTACACGGCGTGCAGTACCGCATACTGCGACGCGGCTGCACGCTGCTCGCGGCGGGGGGCCGGCTGGTGTACTCCACGTGCTCCTTCAACCCCCTGGAGAACGAGGCCGTGCTGCTGAGGCTGCTGCGGGAGGCCGGGGGCGCCGTGCACCTGTGTGACGTCACGCACATGCTGCCCGGACTCGAGTTCGCGAAAGGCATGACCCACTGGCGCCCAGCCTCCAAGGACATGGTGTTCTACGACAAATACGAGGACGTACCAGAGAAGTGGCAGACCGTGGTCAGACCTCAGATGTTCCCGCCCACCGCTGAAGAAATAGAGAAGTACCAATTAGAAAATTGCATAAGGATCCTGCCCCACCAGCAGGACACCGGCGGATTTTTCGTGGCTGTTCTAGAGAAGACCGCCAGCCTGCCCTGGGAGAAGGAGGACGCTGATCCGCAGTTAGAGCAGCCGCAGGAGGTCAAGAGTGCTCCGCCACAGAAACGCAGGAGGATGGGCGGCTACCGGGAGGACCCTTTCGTGTTCTTCGGGAATGATGAAGACGTTTTCCCATCAATCAAATCGTACTACGACCTCAAAGACGACTTCGATCCTAAATGCCTGTTGACCAGATGTCACGTCGGCAAGAAGAAAAATATATACCTCGTGTCGCCGGTGGTGAAGGACGTGGTGCAGAGGAACGAACGGAATATAAAGATCATCAACACCGGCGTGAAGACCTTCGTAAGGTGTGACAACAAGAATATGACGTGTCCGTTCAGATTGTCCCAGGAAGGTCTCCTGAGCATAGCGCAGTACATCGGACCTAAACGAAGAATAGAGATACTCAAAGACGACTTGATACTTGTCCTGCAGTGCGACAACCCCAGCAACCCGCCCGATATCAAACTCTTCTCGGAGCACACGCAGAACCTGGTCAAAGATTTAGCCACAGGCAGCTGCGTGCTGGAGTACCGCGATCGGGAATCGAAGCTGGAACTGACTCTGGTGGGATGGCGCGGCGTGCACTCGCTGCGCGCCTACACCGCCGCGCCGGACGCCGTGCACTACCTCCGGATACTAGGAGCCGATATCAGTAAATACGACGTAAACAAATTCAAAGTGGTTGAAAACGCTGATGCCCAAACTTCAGAAACTACAGAAACTGATGTAATCCTCAATGAGAATCTAGAGGAAGAAGTGGAAACTATCGAGGAACAGAAAAACACAGAGACGACAACTACAGGGTGTAGTGAAATATAA

Protein

MGRKNRNVNKFAQRKRDRKEQEKNPQEKPNGDNRKAYEDIVRENAAFEEYYKMQKICPEEQWPVFMQTLKENLPTAFRITGSKGEADALMKIVNSDYFSQLLNIKLKIDGKDEEEEIKPVNLPWYPGGFAWQLRLTRMDIRRNEALYRLHNFLVAETAAGGVSRQEQVSMIPPVVLDVKPHHKVLDMCAAPGSKTAQLIEFLHADEDKMPTGFVMANDVDNSRCYMLVHQAKRLNSPCIVITNHDSAFMPSIEVTDEQDPSKTKPLKFDRILCDVPCSGDATLRKNPDIWLKWSTGNGNNLHGVQYRILRRGCTLLAAGGRLVYSTCSFNPLENEAVLLRLLREAGGAVHLCDVTHMLPGLEFAKGMTHWRPASKDMVFYDKYEDVPEKWQTVVRPQMFPPTAEEIEKYQLENCIRILPHQQDTGGFFVAVLEKTASLPWEKEDADPQLEQPQEVKSAPPQKRRRMGGYREDPFVFFGNDEDVFPSIKSYYDLKDDFDPKCLLTRCHVGKKKNIYLVSPVVKDVVQRNERNIKIINTGVKTFVRCDNKNMTCPFRLSQEGLLSIAQYIGPKRRIEILKDDLILVLQCDNPSNPPDIKLFSEHTQNLVKDLATGSCVLEYRDRESKLELTLVGWRGVHSLRAYTAAPDAVHYLRILGADISKYDVNKFKVVENADAQTSETTETDVILNENLEEEVETIEEQKNTETTTTGCSEI

Description

RNA methyltransferase that methylates tRNAs. Methylates cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Required for short-term memory.

Catalytic Activity

acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]
cytidine(34) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine

Similarity

Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
Belongs to the MYST (SAS/MOZ) family.
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. TRM4 subfamily.

Keywords

Complete proteome   Methyltransferase   Nucleus   Phosphoprotein   Reference proteome   RNA-binding   S-adenosyl-L-methionine   Transferase   tRNA processing   tRNA-binding  

Feature

chain  tRNA (cytosine(34)-C(5))-methyltransferase

Uniprot

H9J4G8   S4PTH8   A0A194Q589   A0A3S2PGS4   A0A212EHC9   A0A2A4JBC2   + More
A0A2W1BCV2   A0A2H1WXJ3   A0A1B0DPW5   F4WW34   A0A067R999   A0A195B285   A0A195EY07   A0A195CS75   A0A2J7PSH1   A0A195E646   A0A1B6DIS1   A0A1L8DS14   A0A026WYK1   A0A087ZZ14   A0A0C9RQI6   A0A023F2Y7   A0A224X8R9   U5ETH1   E9J798   A0A182G410   A0A182GIX4   A0A0V0G5T9   A0A069DWD4   B0WSS4   Q16HN8   A0A023EUQ0   A0A2J7PSH6   E2BHX7   E0VW57   A0A1I8MXI6   A0A310SJB9   A0A1Q3EY29   A0A1B6ES03   A0A084VAP8   A0A0N0BEX2   A0A1I8NZS4   W8C460   A0A154PSR4   A0A182J0W5   A0A2M4CGW2   A0A2A3EEM4   A0A2M4CY43   A0A0L0C882   W5JBT3   A0A2M4AI86   A0A1W4V218   B4R497   A0A182K346   B3MSL5   A0A182VWR7   A0A0A1XNA8   A0A182FSA9   A0A182XHX2   A0A182LEZ4   A0A0L7RGK3   A0A182UL20   A0A034VFT5   A0A3B0J8L2   A0A182P977   A0A182HSV4   A0A1B3PDK9   A0A1A9WT17   Q5TTT3   A0A0K8WKT8   A0A182VHC2   Q29I46   B4JNG7   B4HA95   B4L6N0   B4M7M3   A0A182YHM1   A0A1B6MD92   B4I123   A0A182QHG6   T1HWY2   A0A0M4EN12   A0A1A9UQB8   B4NPB1   B3NSU5   A0A1A9ZEH6   A0A1Y1L3E4   A0A0J7NTI5   Q9W4M9   A0A1B0GA11   B4Q0F3   A0A182RGW6   A0A1A9XBV4   K7JBV7   A0A2H8U0Y1   A0A1B3PDB7   A0A182N4V9   A0A1Q3EYJ8   X1WJP2   N6TFU6  

EC Number

2.3.1.48
2.1.1.203

Pubmed

19121390    23622113    26354079    22118469    28756777    21719571    + More
24845553    24508170    30249741    25474469    21282665    26483478    26334808    17510324    24945155    20798317    20566863    25315136    24438588    24495485    26108605    20920257    23761445    17994087    25830018    20966253    25348373    12364791    14747013    17210077    15632085    25244985    28004739    10731132    12537572    10731137    12537569    22541559    17550304    20075255    23537049   

EMBL

BABH01021887    GAIX01012013    JAA80547.1    KQ459460    KPJ00712.1    RSAL01000039    + More
RVE51000.1    AGBW02014916    OWR40889.1    NWSH01002109    PCG69149.1    KZ150205    PZC72251.1    ODYU01011825    SOQ57789.1    AJVK01018653    GL888404    EGI61623.1    KK852611    KDR20256.1    KQ976662    KYM78314.1    KQ981914    KYN33108.1    KQ977349    KYN03352.1    NEVH01021928    PNF19281.1    KQ979579    KYN20670.1    GEDC01011788    JAS25510.1    GFDF01004821    JAV09263.1    KK107063    QOIP01000005    EZA61105.1    RLU22746.1    GBYB01009481    JAG79248.1    GBBI01003134    JAC15578.1    GFTR01007700    JAW08726.1    GANO01002785    JAB57086.1    GL768455    EFZ11287.1    JXUM01041704    KQ561294    KXJ79083.1    JXUM01067006    KQ562428    KXJ75933.1    GECL01002789    JAP03335.1    GBGD01000733    JAC88156.1    DS232075    EDS34033.1    CH478156    EAT33764.1    GAPW01000443    JAC13155.1    PNF19280.1    GL448376    EFN84713.1    DS235817    EEB17613.1    KQ759820    OAD62721.1    GFDL01014855    JAV20190.1    GECZ01029246    JAS40523.1    ATLV01004135    KE524190    KFB35042.1    KQ435824    KOX72241.1    GAMC01005734    JAC00822.1    KQ435037    KZC14150.1    GGFL01000409    MBW64587.1    KZ288269    PBC29924.1    GGFL01006049    MBW70227.1    JRES01000767    KNC28471.1    ADMH02001952    ETN60330.1    GGFK01007184    MBW40505.1    CM000366    EDX17039.1    CH902622    EDV34770.1    GBXI01001786    JAD12506.1    KQ414596    KOC70112.1    GAKP01017975    JAC40977.1    OUUW01000003    SPP78205.1    APCN01000367    KU659990    AOG17788.1    AAAB01008859    EAL40906.3    GDHF01000640    JAI51674.1    CH379064    EAL31560.3    CH916371    EDV92260.1    CH479239    EDW37489.1    CH933812    EDW06026.1    CH940653    EDW62790.1    GEBQ01006081    JAT33896.1    CH480819    EDW53204.1    AXCN02000010    ACPB03008617    CP012528    ALC49271.1    CH964291    EDW86351.1    CH954180    EDV45775.1    GEZM01066093    JAV68192.1    LBMM01001796    KMQ95735.1    AE014298    AL033125    AY061496    CCAG010018793    CM000162    EDX01237.1    AAZX01004810    AAZX01005239    AAZX01021505    AAZX01022194    AAZX01022467    GFXV01007677    MBW19482.1    KU659912    AOG17711.1    GFDL01014727    JAV20318.1    ABLF02029075    ABLF02029079    APGK01029400    APGK01029401    APGK01029402    APGK01029403    KB740734    ENN79254.1   

Proteomes

UP000005204    UP000053268    UP000283053    UP000007151    UP000218220    UP000092462    + More
UP000007755    UP000027135    UP000078540    UP000078541    UP000078542    UP000235965    UP000078492    UP000053097    UP000279307    UP000005203    UP000069940    UP000249989    UP000002320    UP000008820    UP000008237    UP000009046    UP000095301    UP000030765    UP000053105    UP000095300    UP000076502    UP000075880    UP000242457    UP000037069    UP000000673    UP000192221    UP000000304    UP000075881    UP000007801    UP000075920    UP000069272    UP000076407    UP000075882    UP000053825    UP000075902    UP000268350    UP000075885    UP000075840    UP000091820    UP000007062    UP000075903    UP000001819    UP000001070    UP000008744    UP000009192    UP000008792    UP000076408    UP000001292    UP000075886    UP000015103    UP000092553    UP000078200    UP000007798    UP000008711    UP000092445    UP000036403    UP000000803    UP000092444    UP000002282    UP000075900    UP000092443    UP000002358    UP000075884    UP000007819    UP000019118   

PRIDE

H9J4G8    Q9W4M9   

Pfam

PF01189   Methyltr_RsmB-F        + More
PF00520   Ion_trans
PF00501   AMP-binding
PF13193   AMP-binding_C
PF01853   MOZ_SAS
PF17772   zf-MYST
PF11717   Tudor-knot

Interpro

IPR029063   SAM-dependent_MTases        + More
IPR018314   Fmu/NOL1/Nop2p_CS       
IPR001678   MeTrfase_RsmB/NOP2       
IPR023267   RCMT       
IPR023270   RCMT_NCL1       
IPR027359   Volt_channel_dom_sf       
IPR005821   Ion_trans_dom       
IPR025110   AMP-bd_C       
IPR000873   AMP-dep_Synth/Lig       
IPR042099   AMP-dep_Synthh-like_sf       
IPR020845   AMP-binding_CS       
IPR002717   HAT_MYST-type       
IPR000953   Chromo/chromo_shadow_dom       
IPR036388   WH-like_DNA-bd_sf       
IPR040706   Zf-MYST       
IPR025995   Tudor-knot       
IPR016181   Acyl_CoA_acyltransferase       
IPR016197   Chromo-like_dom_sf       

SUPFAM

SSF53335   SSF53335        + More
SSF54160   SSF54160       
SSF55729   SSF55729       

Gene 3D

1.20.120.350     3.40.50.12780     1.10.10.10    

CDD

cd00024  CHROMO

ProteinModelPortal

H9J4G8   S4PTH8   A0A194Q589   A0A3S2PGS4   A0A212EHC9   A0A2A4JBC2   + More
A0A2W1BCV2   A0A2H1WXJ3   A0A1B0DPW5   F4WW34   A0A067R999   A0A195B285   A0A195EY07   A0A195CS75   A0A2J7PSH1   A0A195E646   A0A1B6DIS1   A0A1L8DS14   A0A026WYK1   A0A087ZZ14   A0A0C9RQI6   A0A023F2Y7   A0A224X8R9   U5ETH1   E9J798   A0A182G410   A0A182GIX4   A0A0V0G5T9   A0A069DWD4   B0WSS4   Q16HN8   A0A023EUQ0   A0A2J7PSH6   E2BHX7   E0VW57   A0A1I8MXI6   A0A310SJB9   A0A1Q3EY29   A0A1B6ES03   A0A084VAP8   A0A0N0BEX2   A0A1I8NZS4   W8C460   A0A154PSR4   A0A182J0W5   A0A2M4CGW2   A0A2A3EEM4   A0A2M4CY43   A0A0L0C882   W5JBT3   A0A2M4AI86   A0A1W4V218   B4R497   A0A182K346   B3MSL5   A0A182VWR7   A0A0A1XNA8   A0A182FSA9   A0A182XHX2   A0A182LEZ4   A0A0L7RGK3   A0A182UL20   A0A034VFT5   A0A3B0J8L2   A0A182P977   A0A182HSV4   A0A1B3PDK9   A0A1A9WT17   Q5TTT3   A0A0K8WKT8   A0A182VHC2   Q29I46   B4JNG7   B4HA95   B4L6N0   B4M7M3   A0A182YHM1   A0A1B6MD92   B4I123   A0A182QHG6   T1HWY2   A0A0M4EN12   A0A1A9UQB8   B4NPB1   B3NSU5   A0A1A9ZEH6   A0A1Y1L3E4   A0A0J7NTI5   Q9W4M9   A0A1B0GA11   B4Q0F3   A0A182RGW6   A0A1A9XBV4   K7JBV7   A0A2H8U0Y1   A0A1B3PDB7   A0A182N4V9   A0A1Q3EYJ8   X1WJP2   N6TFU6  

PDB

1IXK     E-value=1.13474e-22,     Score=266

KEGG

101745118    K15335 tRNA (cytosine34-C5)-methyltransferase [EC:2.1.1.203] | (RefSeq) tRNA (cytosine(34)-C(5))-met

GO

GO:0003723   GO:0016428   GO:0008168   GO:0016021   GO:0005216   GO:0016874   GO:0006355   GO:0004402   GO:0005634   GO:0007614   GO:0030488   GO:0005737   GO:0000049   GO:0005730   GO:0001510   GO:0006470   GO:0008138   GO:0004890   GO:0043564   GO:0006418   GO:0003824  

Subcellular location

Nucleus  
  

Length:

714

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.09811

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00730

outside

1  -  714

 

 

Pi

288.451842

Theta

37.520779

Tajima's D

2.950325

CLR

1.069981

CSRT

0.974301284935753

Interpretation

Uncertain