Gene

KWMTBOMO11845

Annotation

reverse_transcriptase_[Bombyx_mori]

Location

Bomo_Chr20(+):1827594-1831702      View in EpiBrowser

Full name

RNA-directed DNA polymerase from mobile element jockey       + More
Probable RNA-directed DNA polymerase from transposon BS      

Alternative Name

Reverse transcriptase

Location in the cell

Nuclear   Reliability : 2.829

CDS

ATGGATTTCGAATCCGCGTCAAGCCCTCAGCCTGGAACTTCGGATGGGTTCCAAACCGTAACGCGCGGTAAAAAGCGTACTCGCGCCGTGGAGTCCCGGAACTCCACGACAAAACAAACGAAATCCGCGTCCGCCTCTCGACCAAAAGTAGTAGTAACACCGGAGTCGGACTCCGCGCGCCGCGTAACCCCACCGCCGCGTCCCAAGCCCGCGCCCGCTCCCAAAGTAGCTGCCCCGCCCCCGCTGATACTTCAAGAGAAGACAGCGTGGAATCGCGTGTCCCAGGCCCTTCAGGCAAATAAAATTAACTACACCCATGCGCGTAACGTCGCGCATGGGATTCAGATCAAGGTCGCAACGCCGGGCGACCATAGGGCCCTCTCAGCATACCTCCGAAAGGAGAACATAGGTTTCCACACCTATGCTCTTCAGGAGGACCGCGAGCTCCGCGTAGTAATACGCGGAGTCCCTAAGGAGCTAGAAATAGACTACATTAAGGAGGATCTGACCGCTCAGGCCCTCCCGATAGTTAGTGTGCACCGGATGCACAGCGGGCGGGGCAAACAGCCCTATAATATGATACTCGTGGCGTTAGAACCCACCCCGGAGGCCAAAAAGAAGATCGCATGTCTCACGACAATTTGCGGCCTATCCGGGATATCGATCGAAGCCCCCCATAAGCGTGGCACTCCCGGGCAGTGCTACAGGTGCCAACTCTATGGCCACTCGGCGCGTAACTGCCACGCGCGCCCCCGCTGCGTGAAATGCCTCGGCGATCACGCTACCAAGGGCACCCCGCGAACTACCGTGGATGTCCCAGGGCTCCGCGAAAACGCCCAACCCACCCAGCTCCGCGAACCGTCGGCCCAAAGACTTCGACACCAGCCGATCGTCATCGCATCCGTTTATCTCCCCCCGGACAAGCCCCTCCTGAGCAGTGACATCGAGTCACTGCTCGGCATGGGAGACTCTGTCATCCTGGCAGGCGATTTAAATTGCCACCACACTAGGTGGAACTGCCATCGTACAAACGTTAACGGTAGGCGTCTCGACGCGTTTATAGACGACCTCACCTTCGAAATAGTCGGTCCCCCAACTCCAACATGTTATCCGTATAACATCGCGCTCCGTCCGAGCACTATAGACCTGGCATTGCTTAGGAACGTAACTCTGCGCTTGCGTTCCATCGAAGCAATGTCAGAGCTCGACTCAGACCACCGACCTGTCGTTATGCAGCTCGGTCGCCCTCACAACCCAGTCACTGTTACGAGGACCATGGTGGATTGGAATAAGCTGGGCACGTGCCTAGCCGACGCCGCTCCGCCAATCCTCCCTTACGGCCCGGATTCGAATCCATCCCCCGAGGACACCGTCGAATCCATAAACATCATTACCGATCACATCTCTTCCGCGATCATTAGATCTTCTAAAGAAGTCGATGTGGAGGACAGCTTCCACCGCATCAGACTGTCCCCCGATCTTAGGAATCTCTTAAGAGTTAGGAACGCGGCAATCCGGGCCTACGATCGTCTTCCCACGCATTCAAACCGGATTCAGATGCGTCGTCTACAACGCGAAGTCCACTCCCGCTTAAGCGACGCGCGTAACGATAATTGGCATAGTTATTTAGAACAACTCGCGCCCTCCCACCAAGCATACTGGCGACTAGCTAGGACTCTCAAATCCGAAACTACCGCTACTATGCCTCCCCTCTTACGCCCTTCAGGCCAACCACCGGCATTCGACGACGATGACAAGGCTGAGCTGCTGGCCGATGCACTGCAAGAGCAATGCACCACCAGCACTCAACACGCGGACCCCGAACACACCGAGTTAGTCGACAGGGAGGTCGAGCACAGAGCCTCCCTGCCGCCCTCGGACGCGTTACCCCCCATTACCACGGACGAAGTTAGAGACGCGATCCACAACCTCCAACCTAGGAAGGCACCAGGCTCCGACGGCATCCACAACCGCGCGCTAAAATTTTTGCCAGTCCAACTGATAGCAATGTTGGCTACAATTTTAAATGCCGCTATGACGCACTGCATCTTTCCCGCGGTGTGGAAAGAAGCGGACGTTATCGGTATACATAAGCCGGGCAAACCGACAAACGAAACTTCTAGTTACCGTCCGATTAGTCTCCTCTCGACGATAGGAAAAATCTACGAACGGCTCCTTAGGAAACGCCTCTGGGATTTTGTTACCGCGAACAAAATTCTCATAGACGAACAATTCGGATTCCGCTCTAAACACTCGTGCGTACAACAAGTGCACCGCCTCACGGAGCACATTCTGATAGGACTAAATAGGCGTAAACAAATCCCGACCGGCGCCCTCTTCTTCGACATCGCGAAGGCGTTCGACAAAGTCTGGCACAACGGTTTAATTTATAAACTGTACAACATGGGAGTGCCAGACAGACTCGTGCTCATCATACGAGACTTCTTGTCGAACCGTTCGTTTCGATATCGAGTAGAGGGAACTCGTTCTCGTCCCCGTCAACTGACCGCCGGAGTCCCGCAAGGCTCCGCGCTCTCCCCGTTATTATTTAGTTTGTATATCAATGATATACCCCGGTCTCCGGAGACCCATCTAGCGCTCTTCGCCGATGACACGGCTATCTACTACTCGTGTAGGAAGATGTCGCTGCTTCATCGGCGACTCCAGATCGCAGTAGCCACCATGGGACAGTGGTTCCGGAAGTGGCGAATAGACATCAACCCCACGAAAAGCGCAGCGGTGCTCTTCAAAAGGGGTCGCCCTCCGAACATCACTTCGAGCATCCCACTCCGTAGTAGGCGCGCAAACACCTCCGCCGTTAGTCCCATCACTCTCTTTGGCCAGCCCATACCGTGGGTCTCGAAGGTCAAATATCTAGGCGTCACCCTCGACAGAGGGATGACATTCCGTCCCCATATAAAAACGGTACGCGACCGCGCCGCGTTTATTCTAGGACGACTCTATCCAATGCTTTGTTGTCGAAGCAAGCTGTCCCTCCGTAATAAGGTAACTCTCTACAAAACTTGTATACGCCCCGTCATGACGTATGCAAGTGTAGTGTTCGCTCACGCAGCCCGCACCAACTTGAAATCCCTTCAGGTTATTCAATCACGATTCTGCAGGATAGCCGTCGGAGCGCCTTGGTTCCTTAGGAATGTGGATCTCCACGACGACCTGGAGCTCGACTCTGTTAGTAAGTATCTACAGTCGGCATCGCTGCGCCATTTTGAGAAGGCGGCACGACATGAGAACCCTCTCATCGTAGCCGCTGGAAATTACATACCCGACCCAGTAGACCGAATGGAATCAAAAAGTGACATCGTTTTACTTGGTGTTCAACAAGATAATGTCTACCCTCAAGCCTACATACTCTATTACGTCTATAATGGCTATGGACTCCGATAA

Protein

MDFESASSPQPGTSDGFQTVTRGKKRTRAVESRNSTTKQTKSASASRPKVVVTPESDSARRVTPPPRPKPAPAPKVAAPPPLILQEKTAWNRVSQALQANKINYTHARNVAHGIQIKVATPGDHRALSAYLRKENIGFHTYALQEDRELRVVIRGVPKELEIDYIKEDLTAQALPIVSVHRMHSGRGKQPYNMILVALEPTPEAKKKIACLTTICGLSGISIEAPHKRGTPGQCYRCQLYGHSARNCHARPRCVKCLGDHATKGTPRTTVDVPGLRENAQPTQLREPSAQRLRHQPIVIASVYLPPDKPLLSSDIESLLGMGDSVILAGDLNCHHTRWNCHRTNVNGRRLDAFIDDLTFEIVGPPTPTCYPYNIALRPSTIDLALLRNVTLRLRSIEAMSELDSDHRPVVMQLGRPHNPVTVTRTMVDWNKLGTCLADAAPPILPYGPDSNPSPEDTVESINIITDHISSAIIRSSKEVDVEDSFHRIRLSPDLRNLLRVRNAAIRAYDRLPTHSNRIQMRRLQREVHSRLSDARNDNWHSYLEQLAPSHQAYWRLARTLKSETTATMPPLLRPSGQPPAFDDDDKAELLADALQEQCTTSTQHADPEHTELVDREVEHRASLPPSDALPPITTDEVRDAIHNLQPRKAPGSDGIHNRALKFLPVQLIAMLATILNAAMTHCIFPAVWKEADVIGIHKPGKPTNETSSYRPISLLSTIGKIYERLLRKRLWDFVTANKILIDEQFGFRSKHSCVQQVHRLTEHILIGLNRRKQIPTGALFFDIAKAFDKVWHNGLIYKLYNMGVPDRLVLIIRDFLSNRSFRYRVEGTRSRPRQLTAGVPQGSALSPLLFSLYINDIPRSPETHLALFADDTAIYYSCRKMSLLHRRLQIAVATMGQWFRKWRIDINPTKSAAVLFKRGRPPNITSSIPLRSRRANTSAVSPITLFGQPIPWVSKVKYLGVTLDRGMTFRPHIKTVRDRAAFILGRLYPMLCCRSKLSLRNKVTLYKTCIRPVMTYASVVFAHAARTNLKSLQVIQSRFCRIAVGAPWFLRNVDLHDDLELDSVSKYLQSASLRHFEKAARHENPLIVAAGNYIPDPVDRMESKSDIVLLGVQQDNVYPQAYILYYVYNGYGLR

Catalytic Activity

a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)

Cofactor

Mg(2+)
Mn(2+)

Miscellaneous

Prefers poly(rC) and poly(rA) as template and activated DNA is not effective.

Keywords

Nucleotidyltransferase   RNA-directed DNA polymerase   Transferase   Transposable element  

Feature

chain  RNA-directed DNA polymerase from mobile element jockey

Uniprot

Q9XXW0   Q93137   Q9BPQ0   A0A0N1PFV1   O96546   A0A1Y1NA23   + More
A0A139WA11   V5GNJ2   X1WLB2   V5GNF3   A0A087UCW3   A0A224XF24   A0A2S2QEE0   A0A2S2Q383   X1WNI2   J9JS95   X1WZH0   A0A224X6Q4   A0A2M4BDA5   A0A2S2NGV8   A0A2M4BD62   A0A2M4BD66   A0A2M4BEF4   A0A2M4BEZ9   A0A2J7R7D0   A0A1Y1LKN6   A0A2J7QR37   A0A2S2N814   A0A2J7PDM0   A0A2M4CV42   K7IN67   A0A2J7PBY3   A0A2J7QY69   A0A2M4CV52   A0A224XB44   A0A0A9YJ00   A0A224X6S1   A0A0A9YU04   A0A224X6U5   A0A087UGF5   A0A069DZL8   A0A2J7PU96   A0A2J7PQB5   A0A2M4BD67   A0A2S2R9D4   A0A2M4BDV6   A0A224XI99   A0A224X6T4   A0A1Y1KFR3   A0A2J7Q6J2   A0A1B6EGD8   A0A2H8TF37   P21329   A0A2S2P698   A0A0A9YSX4   A0A2J7PVX3   A0A224XJI0   J9LBQ6   A0A2A4IUM2   A0A224X6R6   P21328   A0A2S2NPG3   A0A2S2NH02   A0A2S2PJG2   A0A2A4K918   A0A0V0G5B6   A0A069DX78   Q95SX7   A0A224XHW8   A0A2J7QB68   A0A2S2N6Q7  

EC Number

2.7.7.49

Pubmed

10333566    26354079    10380107    28004739    18362917    19820115    + More
20075255    25401762    26334808    1701254    2463954    3040362    1714378    7753626    12537569   

EMBL

AB018558    BAA76304.1    U07847    AAA17752.1    AB055391    BAB21761.1    + More
KQ459265    KPJ02064.1    AF081103    AAC72921.1    GEZM01008457    JAV94772.1    KQ971729    KYB24751.1    GALX01005299    JAB63167.1    ABLF02042518    ABLF02057746    GALX01005359    JAB63107.1    KK119261    KFM75202.1    GFTR01008038    JAW08388.1    GGMS01006359    MBY75562.1    GGMS01002992    MBY72195.1    ABLF02008153    ABLF02008462    ABLF02008464    ABLF02028535    ABLF02028545    ABLF02034467    GFTR01008279    JAW08147.1    GGFJ01001842    MBW50983.1    GGMR01003407    MBY16026.1    GGFJ01001843    MBW50984.1    GGFJ01001844    MBW50985.1    GGFJ01002256    MBW51397.1    GGFJ01002257    MBW51398.1    NEVH01006736    PNF36716.1    GEZM01053022    JAV74219.1    NEVH01011985    PNF31054.1    GGMR01000676    MBY13295.1    NEVH01026386    PNF14434.1    GGFL01005012    MBW69190.1    NEVH01027074    PNF13841.1    NEVH01009134    PNF33528.1    GGFL01004957    MBW69135.1    GFTR01008262    JAW08164.1    GBHO01010547    GBHO01010546    JAG33057.1    JAG33058.1    GFTR01008271    JAW08155.1    GBHO01021814    GBHO01010549    JAG21790.1    JAG33055.1    GFTR01008251    JAW08175.1    KK119692    KFM76444.1    GBGD01000415    JAC88474.1    NEVH01021205    PNF19912.1    NEVH01022639    PNF18527.1    GGFJ01001858    MBW50999.1    GGMS01017365    MBY86568.1    GGFJ01001857    MBW50998.1    GFTR01008256    JAW08170.1    GFTR01008261    JAW08165.1    GEZM01084969    JAV60363.1    NEVH01017470    PNF24199.1    GEDC01000337    JAS36961.1    GFXV01000908    MBW12713.1    M38437    GGMR01012305    MBY24924.1    GBHO01008295    JAG35309.1    NEVH01020940    PNF20481.1    GFTR01008257    JAW08169.1    ABLF02040877    ABLF02040900    NWSH01007753    PCG62823.1    GFTR01008269    JAW08157.1    M22874    M38643    GGMR01006408    MBY19027.1    GGMR01003864    MBY16483.1    GGMR01016905    MBY29524.1    NWSH01000032    PCG80496.1    GECL01003538    JAP02586.1    GBGD01000389    JAC88500.1    AY060438    AAL25477.1    GFTR01008254    JAW08172.1    NEVH01016302    PNF25823.1    GGMR01000226    MBY12845.1   

Proteomes

UP000053268    UP000007266    UP000007819    UP000054359    UP000235965    UP000002358    + More
UP000218220   

PRIDE

Q9XXW0    Q93137    Q9BPQ0    P21329    P21328    Q95SX7    + More

Pfam

PF14529   Exo_endo_phos_2        + More
PF00078   RVT_1
PF07530   PRE_C2HC
PF03372   Exo_endo_phos
PF07727   RVT_2

Interpro

IPR000477   RT_dom        + More
IPR005135   Endo/exonuclease/phosphatase       
IPR036691   Endo/exonu/phosph_ase_sf       
IPR006579   Pre_C2HC_dom       
IPR013103   RVT_2       

SUPFAM

SSF56219   SSF56219       

Gene 3D

3.60.10.10    

ProteinModelPortal

Q9XXW0   Q93137   Q9BPQ0   A0A0N1PFV1   O96546   A0A1Y1NA23   + More
A0A139WA11   V5GNJ2   X1WLB2   V5GNF3   A0A087UCW3   A0A224XF24   A0A2S2QEE0   A0A2S2Q383   X1WNI2   J9JS95   X1WZH0   A0A224X6Q4   A0A2M4BDA5   A0A2S2NGV8   A0A2M4BD62   A0A2M4BD66   A0A2M4BEF4   A0A2M4BEZ9   A0A2J7R7D0   A0A1Y1LKN6   A0A2J7QR37   A0A2S2N814   A0A2J7PDM0   A0A2M4CV42   K7IN67   A0A2J7PBY3   A0A2J7QY69   A0A2M4CV52   A0A224XB44   A0A0A9YJ00   A0A224X6S1   A0A0A9YU04   A0A224X6U5   A0A087UGF5   A0A069DZL8   A0A2J7PU96   A0A2J7PQB5   A0A2M4BD67   A0A2S2R9D4   A0A2M4BDV6   A0A224XI99   A0A224X6T4   A0A1Y1KFR3   A0A2J7Q6J2   A0A1B6EGD8   A0A2H8TF37   P21329   A0A2S2P698   A0A0A9YSX4   A0A2J7PVX3   A0A224XJI0   J9LBQ6   A0A2A4IUM2   A0A224X6R6   P21328   A0A2S2NPG3   A0A2S2NH02   A0A2S2PJG2   A0A2A4K918   A0A0V0G5B6   A0A069DX78   Q95SX7   A0A224XHW8   A0A2J7QB68   A0A2S2N6Q7  

PDB

6AR3     E-value=0.000347863,     Score=109

KEGG

105842112    no KO assigned | (RefSeq) actin cytoskeleton-regulatory complex protein pan1-like

GO

GO:0003964   GO:0004519   GO:0006313   GO:0003676   GO:0008270   GO:0007631   GO:0016499   GO:0004930   GO:0004890   GO:0005216   GO:0043564   GO:0006418   GO:0003824  

Length:

1134

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.27331

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00008

outside

1  -  1134

 

 

Pi

17.635923

Theta

4.237406

Tajima's D

3.830874

CLR

2.244151

CSRT

0.998650067496625

Interpretation

Possibly Balancing Selection