Gene

KWMTBOMO11837

Pre Gene Modal

BGIBMGA004265

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_guanine_nucleotide_exchange_factor_MSS4_homolog_[Papilio_machaon]

Location

Bomo_Chr20(-):1599044-1600210      View in EpiBrowser

Full name

Guanine nucleotide exchange factor MSS4 homolog      

Alternative Name

Guanine nucleotide exchange factor stratum

Location in the cell

Nuclear   Reliability : 3.278

CDS

ATGGCTGAAATGGAAAATGATGTATCGCCAATCGAAACGGAGCAAAGGGAATATGTTGAAGACGGAAAAAACAAACTCGTAGTGCAATGCAAATTTTGCGGTTCGAAAATTTTGGATAAGAAATCATCTAATTATATCGCTCAAGAGAAAGATCTGCCACTTATGCAGCAAGCCAGTAACAACGATAGAGAAGTACAGAACGAGACTATAAAGGAATTTTATCATGTCGAGAACATGTATACATTTGAAAATATAGGTTTTACGCACACCGTTGACAATCATAAATATTTGAGTTGTGCAGATTGTGATGCGGGTCCAGTTGGGTACCATGATACAAACACAAGACACAGCTATGTAGCTATATCTAGGATTGTACATTCCAAATAA

Protein

MAEMENDVSPIETEQREYVEDGKNKLVVQCKFCGSKILDKKSSNYIAQEKDLPLMQQASNNDREVQNETIKEFYHVENMYTFENIGFTHTVDNHKYLSCADCDAGPVGYHDTNTRHSYVAISRIVHSK

Description

Guanine-nucleotide-releasing protein that acts on members of the sec4/ypt1/rab subfamily such as Rab8. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins such as trol/Pcan and vkg/Coll IV to the basal surface of follicular epithelial (FE) cells. Likely to function by restricting the activity of the vesicle transport regulator Rab8 to the basal membrane, and thus directs BM protein-containing vesicles to the basal side of the FE cells. This function is independent of the Crag/Rab10 regulation of polarized BM protein secretion in the FE.

Subunit

Interacts with Rab8.

Miscellaneous

The name stratum (strat) refers to the geological term for a layer of rock as mutants accumulate basal membrane proteins as a continuous apical sheet/layer. The name also highlights the similarity of the mislocalization phenotype to Crag mutant cells, as both names are based upon geological descriptions of rock formations.

Similarity

Belongs to the DSS4/MSS4 family.

Keywords

Cell membrane   Complete proteome   Guanine-nucleotide releasing factor   Membrane   Metal-binding   Protein transport   Reference proteome   Transport   Zinc  

Feature

chain  Guanine nucleotide exchange factor MSS4 homolog

Uniprot

H9J426   A0A2H1W6I8   A0A1E1WAU3   A0A2W1BWC4   A0A2A4K5D2   A0A0N1IJ67   + More
S4PYC6   A0A212F747   A0A0L7LEN9   D6WSW3   A0A182UVV7   A0A182TXK9   A0A0K8TLE5   A0A182MNS6   A0A182IB42   A0A182X618   A0A182LHU1   Q7Q852   B4HYI6   B4Q6Q4   A0A182VTP2   A0A1L8DLM2   A0A182P5H5   A0A1D2MDP9   B4G7D7   Q29LU9   A0A2R5L9J0   A0A182NB53   A0A182Y8H3   A0A0T6B0I0   A0A1B2AJA9   Q9VLP3   B4NWW2   B4N153   A0A182RA93   B3N741   A0A3B0JAT1   B3MPG1   A0A1W4V7E1   A0A1W4XIT4   A0A182QXS2   A0A2P8YF29   A0A182IJE0   B4KJN2   A0A1L8DLP0   A0A293LDS2   A0A310S7G7   B4LSI0   A0A0M5J1F1   B7QEH3   A0A067RB28   A0A0K8RJN2   A0A0L7QKR2   A0A1J1IPT2   A0A1I8MD02   A0A1E1WZZ7   A0A0A9W2B6   A0A131XJM0   A0A154PF70   A0A224Z5F1   A0A131Z669   A0A084VIG2   A0A026WAU4   L7LZF1   A0A1E1XUL7   A0A023FGR0   A0A2A3EE06   A0A088AEY2   A0A0A1WFI6   A0A0K8VG52   A0A0L0CDJ2   A0A034WSG6   A0A023GH72   G3MQV7   A0A2J7QFN6   W8C742   A0A1S3JKA3   A0A1B0CZD7   A0A0P4WC63   A0A3M6UBU9   A0A3R7MHK8   A0A195C3A2   A0A2B4SNJ6   A0A0P4VNK6   R4G2W1   A0A158NW02   Q175L5   E2A3A5   T1G4L0   A0A2R7W0X1   Q1HRE0   A0A151WEY9   A0A195FZS5   A0A1I8Q6A7   B4JBW5   A0A023FUC1   A0A1A9Y4C7   N6U8U7   A0A1A9WKS8  

Pubmed

19121390    28756777    26354079    23622113    22118469    26227816    + More
18362917    19820115    26369729    20966253    12364791    14747013    17210077    17994087    22936249    27289101    15632085    23185243    25244985    10731132    12537572    12537569    28228250    17550304    29403074    24845553    25315136    28503490    25401762    26823975    28049606    28797301    26830274    24438588    24508170    30249741    25576852    29209593    25830018    26108605    25348373    22216098    24495485    30382153    27129103    21347285    17510324    20798317    23254933    17204158    23537049   

EMBL

BABH01041300    ODYU01006592    SOQ48566.1    GDQN01006960    JAT84094.1    KZ149937    + More
PZC77100.1    NWSH01000141    PCG79128.1    LADI01012895    KPJ20747.1    GAIX01003523    JAA89037.1    AGBW02009924    OWR49566.1    JTDY01001433    KOB73865.1    KQ971352    EFA07674.2    GDAI01002863    JAI14740.1    AXCM01005143    APCN01000637    AAAB01008944    EAA10267.3    CH480818    EDW52116.1    CM000361    CM002910    EDX04213.1    KMY89041.1    GFDF01006773    JAV07311.1    LJIJ01001669    ODM91110.1    CH479180    EDW29270.1    CH379060    CH674818    EAL33946.1    EDY71697.1    GGLE01002038    MBY06164.1    LJIG01016313    KRT80976.1    KX531439    ANY27249.1    AE014134    BT001655    CM000157    EDW88492.1    CH963920    EDW78035.1    CH954177    EDV59337.1    OUUW01000004    SPP79437.1    CH902620    EDV31257.1    AXCN02000642    PYGN01000648    PSN42859.1    CH933807    EDW11477.2    GFDF01006824    JAV07260.1    GFWV01002143    MAA26873.1    KQ777939    OAD52049.1    CH940649    EDW64802.1    CP012523    ALC38906.1    ABJB010394186    DS921134    EEC17229.1    KK852767    KDR16959.1    GADI01003069    JAA70739.1    KQ414940    KOC59199.1    CVRI01000055    CRL01102.1    GFAC01006827    JAT92361.1    GBHO01044594    GBHO01044588    GBHO01044586    GBHO01044584    GBRD01009926    GBRD01009924    GDHC01021490    GDHC01014146    GDHC01005152    JAF99009.1    JAF99015.1    JAF99017.1    JAF99019.1    JAG55898.1    JAP97138.1    JAQ04483.1    JAQ13477.1    GEFH01002850    JAP65731.1    KQ434892    KZC10503.1    GFPF01011155    MAA22301.1    GEDV01002272    JAP86285.1    ATLV01013356    KE524854    KFB37756.1    KK107320    QOIP01000009    EZA52796.1    RLU18445.1    GACK01007578    JAA57456.1    GFAA01000608    JAU02827.1    GBBK01004293    JAC20189.1    KZ288287    PBC29406.1    GBXI01016846    JAC97445.1    GDHF01014410    JAI37904.1    JRES01000536    KNC30330.1    GAKP01001822    JAC57130.1    GBBM01003075    JAC32343.1    JO844258    AEO35875.1    NEVH01014852    PNF27407.1    GAMC01003850    GAMC01003849    JAC02707.1    AJVK01009541    GDRN01053275    JAI66178.1    RCHS01001811    RMX51135.1    QCYY01001612    ROT76755.1    KQ978350    KYM94671.1    LSMT01000025    PFX32254.1    GDKW01002655    JAI53940.1    GAHY01002241    JAA75269.1    ADTU01027601    ADTU01027602    CH477398    EAT41787.1    GL436354    EFN72077.1    AMQM01005043    KB096785    ESO01266.1    KK854174    PTY12580.1    DQ440154    ABF18187.1    KQ983238    KYQ46376.1    KQ981169    KYN45309.1    CH916368    EDW04068.1    GBBL01002306    JAC25014.1    APGK01034929    KB740923    KB631963    ENN78085.1    ERL87491.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000037510    UP000007266    + More
UP000075903    UP000075902    UP000075883    UP000075840    UP000076407    UP000075882    UP000007062    UP000001292    UP000000304    UP000075920    UP000075885    UP000094527    UP000008744    UP000001819    UP000075884    UP000076408    UP000000803    UP000002282    UP000007798    UP000075900    UP000008711    UP000268350    UP000007801    UP000192221    UP000192223    UP000075886    UP000245037    UP000075880    UP000009192    UP000008792    UP000092553    UP000001555    UP000027135    UP000053825    UP000183832    UP000095301    UP000076502    UP000030765    UP000053097    UP000279307    UP000242457    UP000005203    UP000037069    UP000235965    UP000085678    UP000092462    UP000275408    UP000283509    UP000078542    UP000225706    UP000005205    UP000008820    UP000000311    UP000015101    UP000075809    UP000078541    UP000095300    UP000001070    UP000092443    UP000019118    UP000030742    UP000091820   

PRIDE

H9J426    Q9VLP3   

Pfam

PF04421   Mss4

Interpro

IPR007515   Mss4        + More
IPR011323   Mss4/transl-control_tumour       
IPR011057   Mss4-like_sf       

SUPFAM

SSF51316   SSF51316       

Gene 3D

2.170.150.10    

CDD

cd00246  RabGEF

ProteinModelPortal

H9J426   A0A2H1W6I8   A0A1E1WAU3   A0A2W1BWC4   A0A2A4K5D2   A0A0N1IJ67   + More
S4PYC6   A0A212F747   A0A0L7LEN9   D6WSW3   A0A182UVV7   A0A182TXK9   A0A0K8TLE5   A0A182MNS6   A0A182IB42   A0A182X618   A0A182LHU1   Q7Q852   B4HYI6   B4Q6Q4   A0A182VTP2   A0A1L8DLM2   A0A182P5H5   A0A1D2MDP9   B4G7D7   Q29LU9   A0A2R5L9J0   A0A182NB53   A0A182Y8H3   A0A0T6B0I0   A0A1B2AJA9   Q9VLP3   B4NWW2   B4N153   A0A182RA93   B3N741   A0A3B0JAT1   B3MPG1   A0A1W4V7E1   A0A1W4XIT4   A0A182QXS2   A0A2P8YF29   A0A182IJE0   B4KJN2   A0A1L8DLP0   A0A293LDS2   A0A310S7G7   B4LSI0   A0A0M5J1F1   B7QEH3   A0A067RB28   A0A0K8RJN2   A0A0L7QKR2   A0A1J1IPT2   A0A1I8MD02   A0A1E1WZZ7   A0A0A9W2B6   A0A131XJM0   A0A154PF70   A0A224Z5F1   A0A131Z669   A0A084VIG2   A0A026WAU4   L7LZF1   A0A1E1XUL7   A0A023FGR0   A0A2A3EE06   A0A088AEY2   A0A0A1WFI6   A0A0K8VG52   A0A0L0CDJ2   A0A034WSG6   A0A023GH72   G3MQV7   A0A2J7QFN6   W8C742   A0A1S3JKA3   A0A1B0CZD7   A0A0P4WC63   A0A3M6UBU9   A0A3R7MHK8   A0A195C3A2   A0A2B4SNJ6   A0A0P4VNK6   R4G2W1   A0A158NW02   Q175L5   E2A3A5   T1G4L0   A0A2R7W0X1   Q1HRE0   A0A151WEY9   A0A195FZS5   A0A1I8Q6A7   B4JBW5   A0A023FUC1   A0A1A9Y4C7   N6U8U7   A0A1A9WKS8  

PDB

2FU5     E-value=2.2068e-17,     Score=211

KEGG

101738396    K19952 guanine nucleotide exchange factor | (RefSeq) guanine nucleotide exchange factor MSS4 homolog

GO

GO:0005085   GO:0007264   GO:0005829   GO:0006892   GO:0016020   GO:0008270   GO:0045180   GO:0043547   GO:0061865   GO:0017112   GO:0009925   GO:0015031   GO:0022857   GO:0006810   GO:0004890   GO:0005216   GO:0043564   GO:0006418   GO:0003824  

PANTHER

PTHR13276  

Subcellular location

Basal cell membrane   Diffuse intracellular localization early in oogenesis which later becomes basally enriched in follicular epithelial cells.   With evidence from 2 publications.

Length:

128

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00017

Exp number, first 60 AAs:

0

Total prob of N-in:

0.15055

outside

1  -  128

 

 

Pi

226.689173

Theta

161.142141

Tajima's D

1.012532

CLR

0

CSRT

0.662116894155292

Interpretation

Uncertain